BLASTP 2.2.21 [Jun-14-2009] Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), "Gapped BLAST and PSI-BLAST: a new generation of protein database search programs", Nucleic Acids Res. 25:3389-3402. Reference for compositional score matrix adjustment: Altschul, Stephen F., John C. Wootton, E. Michael Gertz, Richa Agarwala, Aleksandr Morgulis, Alejandro A. Schaffer, and Yi-Kuo Yu (2005) "Protein database searches using compositionally adjusted substitution matrices", FEBS J. 272:5101-5109. Query= 0003.0105.p (300 letters) Database: COGmodified 192,987 sequences; 59,019,183 total letters Searching..................................................done Score E Sequences producing significant alignments: (bits) Value RSc2225 [GER] COG0697 Permeases of the drug/metabolite transport... 242 7e-64 NMA1785 [GER] COG0697 Permeases of the drug/metabolite transport... 150 5e-36 NMB1593 [GER] COG0697 Permeases of the drug/metabolite transport... 149 7e-36 PA2628 [GER] COG0697 Permeases of the drug/metabolite transporte... 106 8e-23 YPO1348 [GER] COG0697 Permeases of the drug/metabolite transport... 98 3e-20 >RSc2225 [GER] COG0697 Permeases of the drug/metabolite transporter (DMT) superfamily Rso Ralstonia solanacearum Length = 324 Score = 242 bits (618), Expect = 7e-64, Method: Compositional matrix adjust. Identities = 136/293 (46%), Positives = 189/293 (64%), Gaps = 6/293 (2%) Query: 1 MLVASFLFAVMGVCVKLASQYYTTSEIVLCRGVIGVLFILCLIRLRGGTLRTPFPRDHFI 60 M++A+F F+ MGVCVKLAS +Y+T EIV R +IGV + ++ G +RTP H Sbjct: 23 MVLAAFAFSAMGVCVKLASAHYSTGEIVFYRSLIGVALMGAVLYHTGAGVRTPHFASHIK 82 Query: 61 RGGVGVVSLWMWFYSFSLLPIATATTLNYMSSIWIAVMLFVAGWWQGHK-KFEWGLAGTV 119 R GV SL +WF S SLLP+ATA TLNYMS +WIA+++ G + + + Sbjct: 83 RSVFGVTSLLLWFSSISLLPLATAMTLNYMSPVWIALIIGAGATLAGKAGGADRKMVTAI 142 Query: 120 ALSFLGVALLMRPSLNAEQLLGGAISLASGVLSALVYLQVRKLGLLGEPEYRVVFYFSAT 179 +SF+GV L++PS+ Q+ GG I L SGV +AL Y++VR+LG LGE E R+VFYFS Sbjct: 143 LMSFVGVICLLQPSVGPSQMTGGMIGLVSGVFTALAYVEVRQLGDLGENEARIVFYFSLV 202 Query: 180 GVLAGLVGSVVTGRVPLWHSHSWIGALLVLMIGLTATTAQIAMTRAYRLGNTLVTANLQY 239 +AG ++ G H+H+W A L++ +GL AT Q AMTRAY+ GNTL+TANLQY Sbjct: 203 SSIAGGAWMLIAGA----HAHTWQSAWLLVAVGLLATLGQTAMTRAYKRGNTLLTANLQY 258 Query: 240 TGIVFSSLFGVLIWDDAPGWIGWLGMAIILASGMLATYRNQRKSQAVAKNVPK 292 TGIVF+S +G+L+W D + W+GMA+I+ SG++ T R+S VA P+ Sbjct: 259 TGIVFASGWGMLLWHDHLNALSWMGMALIIGSGIVTTVMRARQS-GVAHPTPQ 310 >NMA1785 [GER] COG0697 Permeases of the drug/metabolite transporter (DMT) superfamily NmA Neisseria meningitidis Z2491 Length = 300 Score = 150 bits (378), Expect = 5e-36, Method: Compositional matrix adjust. Identities = 104/280 (37%), Positives = 155/280 (55%), Gaps = 10/280 (3%) Query: 1 MLVASFLFAVMGVCVKLASQYYT--TSEIVLCRGVIGVLFILCLIRLRGGTLRTPFPRDH 58 MLVA+ F +M V +K AS + + E+V R + + + LR T RTP ++H Sbjct: 14 MLVAAACFTIMNVLIKEASAKFALGSGELVFWRMLFSTVALGAAAVLRRDTFRTPHWKNH 73 Query: 59 FIRGGVGVVSLWMWFYSFSLLPIATATTLNYMSSIWIAVMLFVAGWWQGHKKFEWGLAGT 118 R VG ++ + FY+ + LP+AT TL+Y SSI++AV F+ ++ Sbjct: 74 LNRSMVGTGAMLLLFYAVTHLPLATGVTLSYTSSIFLAVFSFLIL----KERISVYTQAV 129 Query: 119 VALSFLGVALLMRPSLNAEQLLGGAISLASGVLSALVYLQVRKLGLLGEPEYRVVFYFSA 178 + L F GV LL+ PS + Q LA G +S YL+VR+L L GEP +RVVFY S Sbjct: 130 LLLGFAGVVLLLNPSFRSGQETAALAGLAGGAMSGWAYLKVRELSLAGEPGWRVVFYLSV 189 Query: 179 TGVLAGLVGSVVTGRVPLWHSHSWIGALLVLMIGLTATTAQIAMTRAYRLGNTLVTANLQ 238 TGV V + +TG WH+ S+ A+ + IG++A AQ++MTRAY++G+ A+L Sbjct: 190 TGVAMSSVWATLTG----WHTLSFPSAVYLSCIGVSALIAQLSMTRAYKVGDKFTVASLS 245 Query: 239 YTGIVFSSLFGVLIWDDAPGWIGWLGMAIILASGMLATYR 278 Y +VFS+L + W LGM II+ SG+L++ R Sbjct: 246 YMTVVFSALSAAFFLAEELFWQEILGMCIIILSGILSSIR 285 >NMB1593 [GER] COG0697 Permeases of the drug/metabolite transporter (DMT) superfamily Nme Neisseria meningitidis MC58 Length = 287 Score = 149 bits (377), Expect = 7e-36, Method: Compositional matrix adjust. Identities = 104/280 (37%), Positives = 155/280 (55%), Gaps = 10/280 (3%) Query: 1 MLVASFLFAVMGVCVKLASQYYT--TSEIVLCRGVIGVLFILCLIRLRGGTLRTPFPRDH 58 MLVA+ F +M V +K AS + + E+V R + + + LR T RTP ++H Sbjct: 1 MLVAAACFTIMNVLIKEASAKFALGSGELVFWRMLFSTVALGAAAVLRRDTFRTPHWKNH 60 Query: 59 FIRGGVGVVSLWMWFYSFSLLPIATATTLNYMSSIWIAVMLFVAGWWQGHKKFEWGLAGT 118 R VG ++ + FY+ + LP+AT TL+Y SSI++AV F+ ++ Sbjct: 61 LNRSMVGTGAMLLLFYAVTHLPLATGVTLSYTSSIFLAVFSFLIL----KERISVYTQAV 116 Query: 119 VALSFLGVALLMRPSLNAEQLLGGAISLASGVLSALVYLQVRKLGLLGEPEYRVVFYFSA 178 + L F GV LL+ PS + Q LA G +S YL+VR+L L GEP +RVVFY S Sbjct: 117 LLLGFAGVVLLLNPSFRSGQETAALAGLAGGAMSGWAYLKVRELSLAGEPGWRVVFYLSV 176 Query: 179 TGVLAGLVGSVVTGRVPLWHSHSWIGALLVLMIGLTATTAQIAMTRAYRLGNTLVTANLQ 238 TGV V + +TG WH+ S+ A+ + IG++A AQ++MTRAY++G+ A+L Sbjct: 177 TGVAMSSVWATLTG----WHTLSFPSAVYLSCIGVSALIAQLSMTRAYKVGDKFTVASLS 232 Query: 239 YTGIVFSSLFGVLIWDDAPGWIGWLGMAIILASGMLATYR 278 Y +VFS+L + W LGM II+ SG+L++ R Sbjct: 233 YMTVVFSALSAAFFLGEELFWQEILGMCIIILSGILSSIR 272 >PA2628 [GER] COG0697 Permeases of the drug/metabolite transporter (DMT) superfamily Pae Pseudomonas aeruginosa Length = 296 Score = 106 bits (264), Expect = 8e-23, Method: Compositional matrix adjust. Identities = 86/286 (30%), Positives = 142/286 (49%), Gaps = 18/286 (6%) Query: 3 VASFLFAVMGVCVKLASQYYTTSEIVLCRGVIGVLFILCLIRLRG-GTLRTPFPRDHFIR 61 +++ FA+MG ++ AS +V R ++GVLF L L RG G LRT P H +R Sbjct: 23 LSALFFALMGGLIREASSTVNNETVVFFRNLVGVLFFLPLALTRGIGPLRTRRPLSHLLR 82 Query: 62 GGVGVVSLWMWFYSFSLLPIATATTLNYMSSIWIAVMLFVAGWWQGHKKFEWGLAGTVAL 121 G+ ++ +FY+ + LP+ A +Y + ++ + +A W + T+ + Sbjct: 83 TTYGLGGMYCYFYALAHLPLTDAMLFSYAAPVFTPL---IAHLWIKEPLTRRMMVATL-V 138 Query: 122 SFLGVALLMRPSLNAEQLLGGAISLASGVLSALVYLQVRKLGLLGEPEYRVVFYFSATGV 181 FLGV L+ RPS A + +AS +++A ++ +R++ EP YR+VFYF+ G Sbjct: 139 GFLGVLLVARPS-GAVVAPIALVGIASSLMAACAFVSIREMSD-SEPAYRIVFYFALFGT 196 Query: 182 LAGLVGSVVTGRVPL---WHSHSWIGALLVLMIGLTATTAQIAMTRAYRLGNTLVTANLQ 238 L VPL W + LL+L GL A+ Q+ M++AY L + V + Sbjct: 197 L--------FSAVPLAWAWQPLNGQELLLLLGAGLFASLGQLTMSQAYALASPGVIGPIA 248 Query: 239 YTGIVFSSLFGVLIWDDAPGWIGWLGMAIILASGMLATYRNQRKSQ 284 Y IVF+ + L WD+ P LG A+I A+ ++ N+ + Sbjct: 249 YMAIVFAGVIAWLRWDELPSHTSLLGAALIFAASLIPLLGNRPAER 294 >YPO1348 [GER] COG0697 Permeases of the drug/metabolite transporter (DMT) superfamily Ype Yersinia pestis Length = 281 Score = 97.8 bits (242), Expect = 3e-20, Method: Compositional matrix adjust. Identities = 84/291 (28%), Positives = 142/291 (48%), Gaps = 28/291 (9%) Query: 2 LVASFLFAVMGVCVKLASQYYTTSEIVLCRGVIGVLFILCLIRLRGGTLRTPFPRDH--- 58 ++AS +F+VM V VK + T EIV R IG L I L+ RG F R+ Sbjct: 9 ILASLIFSVMNVLVKTIADEIPTGEIVFFRSSIGCLLIGLLMYQRG----IAFSREDRPL 64 Query: 59 -FIRGGVGVVSLWMWFYSFSLLPIATATTLNYMSSIW-IAVMLFVAGWWQGHKKFEWGLA 116 +RG +G + L +FYS + L +A A+ L Y+S + I + L V ++ +A Sbjct: 65 LVLRGTMGALYLICYFYSIAHLTLADASMLAYLSPFFSIVLSLLVL-----RERVNATMA 119 Query: 117 GTVALSFLGVALLMRPSLNAEQLLGGAISLASGVLSALVYLQVRKLGLLGEPEYRVVFYF 176 + + +G +L+RP + L + + S V +A+ YL V KL Y +VFYF Sbjct: 120 FWLVMVIIGAIILIRPWNFSTYTLASLVGVMSAVFAAIAYLSVNKLTK-RHHNYEIVFYF 178 Query: 177 SATGVLAGLVGSVVTGRVPL-WHSHSWIGAL---LVLMIGLTATTAQIAMTRAYRLGNTL 232 L +PL WH+ W +++ I L + Q+ +T+A+ N + Sbjct: 179 LFITTLIS---------IPLMWHNFVWPSGYQFGILIAIALVSLLGQVVLTQAFSSDNLI 229 Query: 233 VTANLQYTGIVFSSLFGVLIWDDAPGWIGWLGMAIILASGMLATYRNQRKS 283 V + ++Y GIVF+ +G L WD+ P + +G +++ S + R+++K+ Sbjct: 230 VVSVVRYIGIVFNITWGWLFWDEVPLMLSLMGGGLVVVSCIQLGLRSKKKA 280