BLASTP 2.2.21 [Jun-14-2009] Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), "Gapped BLAST and PSI-BLAST: a new generation of protein database search programs", Nucleic Acids Res. 25:3389-3402. Reference for compositional score matrix adjustment: Altschul, Stephen F., John C. Wootton, E. Michael Gertz, Richa Agarwala, Aleksandr Morgulis, Alejandro A. Schaffer, and Yi-Kuo Yu (2005) "Protein database searches using compositionally adjusted substitution matrices", FEBS J. 272:5101-5109. Query= 0003.0014.p (319 letters) Database: COGmodified 192,987 sequences; 59,019,183 total letters Searching..................................................done Score E Sequences producing significant alignments: (bits) Value BS_yoaV [GER] COG0697 Permeases of the drug/metabolite transport... 94 5e-19 ZyijE [GER] COG0697 Permeases of the drug/metabolite transporter... 72 1e-12 yijE [GER] COG0697 Permeases of the drug/metabolite transporter ... 72 1e-12 ECs4872 [GER] COG0697 Permeases of the drug/metabolite transport... 71 3e-12 DR0135 [GER] COG0697 Permeases of the drug/metabolite transporte... 65 2e-10 >BS_yoaV [GER] COG0697 Permeases of the drug/metabolite transporter (DMT) superfamily Bsu Bacillus subtilis Length = 292 Score = 93.6 bits (231), Expect = 5e-19, Method: Compositional matrix adjust. Identities = 74/285 (25%), Positives = 136/285 (47%), Gaps = 11/285 (3%) Query: 36 IWGGNWPVMKFGSQFIPPLWFAASRFLSAAILSFIIAAALGKLRLPTRQEWPVVAGVGVL 95 IWG W MK G IPPL F+ R A+ F+I K +L ++E + L Sbjct: 14 IWGYTWVAMKVGIHDIPPLLFSGLRLFIGAVPLFLILFIQRK-KLSIQKEHLKSYIIMSL 72 Query: 96 QMGL-FTALVTGALHFVMPGRASLIAYATSIWVVPGAALVLKHKLSTQQSLATVCSYAGM 154 MGL + ++T + FV G+ S++ Y I+V + L K++ +++ VC G+ Sbjct: 73 LMGLGYMGILTYGMQFVDSGKTSVLVYTMPIFVTVISHFSLNEKMNVYKTMGLVCGLFGL 132 Query: 155 AVIVLPALLHADMHSMIGYLMLGAASLSWAM-NI---LQIKMTPGVKLDFDLLPWQTLVA 210 I +L+ D ++ G L + A+LSW + N+ LQ K + ++ W ++ Sbjct: 133 LFIFGKEMLNIDQSALFGELCVLVAALSWGIANVFSKLQFKHIDIIHMN----AWHLMMG 188 Query: 211 AVPLSVLALLVDGAPTFLADPHSWGVIAYTGPLATALTFLIVLQMTQRLSPVTVSVCMLG 270 AV L V + + + P+ + + + G L+T TF++ + ++ S+ ++ Sbjct: 189 AVMLLVFSFIFEAVPSAEWTYQAVWSLLFNGLLSTGFTFVVWFWVLNQIQASKASMALMF 248 Query: 271 VPVVGLTLSSLVFGETLSADLLLGMGLLCLGLVLPALPSLGLRRV 315 VPV+ L L E ++ +++LG L+C G+ + + R+V Sbjct: 249 VPVLALFFGWLQLHEQITINIILGALLICCGIFMNTF-TFSRRKV 292 >ZyijE [GER] COG0697 Permeases of the drug/metabolite transporter (DMT) superfamily EcZ Escherichia coli O157:H7 EDL933 Length = 312 Score = 72.4 bits (176), Expect = 1e-12, Method: Compositional matrix adjust. Identities = 88/304 (28%), Positives = 140/304 (46%), Gaps = 21/304 (6%) Query: 9 TRSASPASSRPQPMSRLFLVCVVVAICIWGGNWPVMKFGSQFIPPLWFAASRFLSAAILS 68 T S A+ + P++ + +VV IW +W MK + +I F A R + A++ Sbjct: 8 TGSLMSAAGKSNPLA---ISGLVVLTLIWSYSWIFMKQVTSYIGAFDFTALRCIFGALVL 64 Query: 69 FIIAAALGKLRLPTRQEWPVVAGVGVLQMGLFTALVTGALHFVMPGRASLIAYATSIWVV 128 FI+ G+ PT ++ + + +LQ L AL G+ ++++Y WVV Sbjct: 65 FIVLLLRGRGMRPTPFKYTL--AIALLQTCGMVGLAQWALVSGGAGKVAILSYTMPFWVV 122 Query: 129 PGAALVLKHKLSTQQSLATVCSYAGMAVIVLPALLHADMHSMIGYLMLGAASLSWAMNIL 188 AA+ L +L Q A + + G+ +++ P L D SM ++ + +SW + + Sbjct: 123 IFAAVFLGERLRRGQYFAILIAAFGLFLVLQPWQL--DFSSMKSAMLAILSGVSWGASAI 180 Query: 189 QIKMTPGVKLDFDLLP---WQTLVAAVPLSVLALLV-----DGAPTFLADPHSWGVIAYT 240 K DLL WQ L AA+ +SV+ALLV D PT W +AY+ Sbjct: 181 VAKRLYARHPRVDLLSLTSWQMLYAALVMSVVALLVPQREIDWQPTVF-----WA-LAYS 234 Query: 241 GPLATALTFLIVLQMTQRLSPVTVSVCMLGVPVVGLTLSSLVFGETLSADLLLGMGLLCL 300 LATAL + + L + + L S+ L VPV G+ S + GE A G+ L+ L Sbjct: 235 AILATALAWSLWLFVLKNLPASIASLSTLAVPVCGVLFSWWLLGENPGAVEXSGIVLIVL 294 Query: 301 GLVL 304 L L Sbjct: 295 ALAL 298 >yijE [GER] COG0697 Permeases of the drug/metabolite transporter (DMT) superfamily Eco Escherichia coli K12 Length = 312 Score = 72.4 bits (176), Expect = 1e-12, Method: Compositional matrix adjust. Identities = 89/304 (29%), Positives = 140/304 (46%), Gaps = 21/304 (6%) Query: 9 TRSASPASSRPQPMSRLFLVCVVVAICIWGGNWPVMKFGSQFIPPLWFAASRFLSAAILS 68 T S A+ + P++ + +VV IW +W MK + +I F A R + A++ Sbjct: 8 TGSLMSAAGKSNPLA---ISGLVVLTLIWSYSWIFMKQVTSYIGAFDFTALRCIFGALVL 64 Query: 69 FIIAAALGKLRLPTRQEWPVVAGVGVLQMGLFTALVTGALHFVMPGRASLIAYATSIWVV 128 FI+ G+ PT ++ + + +LQ L AL G+ ++++Y WVV Sbjct: 65 FIVLLLRGRGMRPTPFKYTL--AIALLQTCGMVGLAQWALVSGGAGKVAILSYTMPFWVV 122 Query: 129 PGAALVLKHKLSTQQSLATVCSYAGMAVIVLPALLHADMHSMIGYLMLGAASLSWAMNIL 188 AAL L +L Q A + + G+ +++ P L D SM ++ + +SW + + Sbjct: 123 IFAALFLGERLRRGQYFAILIAAFGLFLVLQPWQL--DFSSMKSAMLAILSGVSWGASAI 180 Query: 189 QIKMTPGVKLDFDLLP---WQTLVAAVPLSVLALLV-----DGAPTFLADPHSWGVIAYT 240 K DLL WQ L AA+ +SV+ALLV D PT W +AY+ Sbjct: 181 VAKRLYARHPRVDLLSLTSWQMLYAALVMSVVALLVPQREIDWQPTVF-----WA-LAYS 234 Query: 241 GPLATALTFLIVLQMTQRLSPVTVSVCMLGVPVVGLTLSSLVFGETLSADLLLGMGLLCL 300 LATAL + + L + + L S+ L VPV G+ S + GE A G+ L+ L Sbjct: 235 AILATALAWSLWLFVLKNLPASIASLSTLAVPVCGVLFSWWLLGENPGAVEGSGIVLIVL 294 Query: 301 GLVL 304 L L Sbjct: 295 ALAL 298 >ECs4872 [GER] COG0697 Permeases of the drug/metabolite transporter (DMT) superfamily Ecs Escherichia coli O157:H7 Length = 312 Score = 70.9 bits (172), Expect = 3e-12, Method: Compositional matrix adjust. Identities = 88/304 (28%), Positives = 140/304 (46%), Gaps = 21/304 (6%) Query: 9 TRSASPASSRPQPMSRLFLVCVVVAICIWGGNWPVMKFGSQFIPPLWFAASRFLSAAILS 68 T S A+ + P++ + +VV IW +W MK + +I F A R + A++ Sbjct: 8 TGSLMSAAGKSNPLA---ISGLVVLTLIWSYSWIFMKQVTSYIGAFDFTALRCIFGALVL 64 Query: 69 FIIAAALGKLRLPTRQEWPVVAGVGVLQMGLFTALVTGALHFVMPGRASLIAYATSIWVV 128 FI+ G+ PT ++ + + +LQ L AL G+ ++++Y WVV Sbjct: 65 FIVLLLRGRGMRPTPFKYTL--AIALLQTCGMVGLAQWALVSGGAGKVAILSYTMPFWVV 122 Query: 129 PGAALVLKHKLSTQQSLATVCSYAGMAVIVLPALLHADMHSMIGYLMLGAASLSWAMNIL 188 AA+ L +L Q A + + G+ +++ P L D SM ++ + +SW + + Sbjct: 123 IFAAVFLGERLRRGQYFAILIAAFGLFLVLQPWQL--DFSSMKSAMLAILSGVSWGASAI 180 Query: 189 QIKMTPGVKLDFDLLP---WQTLVAAVPLSVLALLV-----DGAPTFLADPHSWGVIAYT 240 K DLL WQ L AA+ +SV+ALLV D PT W +AY+ Sbjct: 181 VAKRLYARHPRVDLLSLTSWQMLYAALVMSVVALLVPQREIDWQPTVF-----WA-LAYS 234 Query: 241 GPLATALTFLIVLQMTQRLSPVTVSVCMLGVPVVGLTLSSLVFGETLSADLLLGMGLLCL 300 LATAL + + L + + L S+ L VPV G+ S + GE A G+ L+ L Sbjct: 235 AILATALAWSLWLFVLKNLPASIASLSTLAVPVCGVLFSWWLLGENPGAVEGSGIVLIVL 294 Query: 301 GLVL 304 L L Sbjct: 295 ALAL 298 >DR0135 [GER] COG0697 Permeases of the drug/metabolite transporter (DMT) superfamily Dra Deinococcus radiodurans Length = 325 Score = 64.7 bits (156), Expect = 2e-10, Method: Compositional matrix adjust. Identities = 87/296 (29%), Positives = 131/296 (44%), Gaps = 17/296 (5%) Query: 15 ASSRPQPMSRLFLVCVVVAICIWGGNWPVMKFGSQFIPPLWFAASRFLSAAILSFIIAAA 74 AS+ P++ L ++ IWG N+ V+K+ PL AA RFL AA + + Sbjct: 3 ASAPASPLNARSLGLALLITLIWGVNFVVIKWSVAGASPLLVAALRFLLAAFPAVLFVP- 61 Query: 75 LGKLRLPTRQEWPVVAGVGVLQMGL-FTALVTGALHFVMPGRASLIAYATSIWVVPGAAL 133 + + R W VGV+Q GL + A+ G + G SL+ + + AA Sbjct: 62 --RPTIAPRLLWGYGLAVGVMQFGLLYLAIQLG----MSAGMGSLLMQTQAFFTALLAAR 115 Query: 134 VLKHKLSTQQSLATVCSYAGMAVIVLPALLHADMHSMIGYLMLGAASLSWAMNILQIKMT 193 K+ Q+ ++ GMA+I L A ++ + A+L WA++ L +K + Sbjct: 116 FFGEKVMPWQAAGITLAFGGMALIGLTAGHDVPFFPLL---LTLTAALGWAISNLVVKAS 172 Query: 194 PGVKLDFDLLPWQTLVAAVPLSVLALLVDG-APTFLADPHS----WGVIAYTGPLATALT 248 P F L+ W L+ +PL++LA L G P HS W + + G T L Sbjct: 173 PQAN-GFGLVVWSALIPPIPLALLAGLTAGWGPVMQTLTHSDWKFWAAVLFMGLGNTVLG 231 Query: 249 FLIVLQMTQRLSPVTVSVCMLGVPVVGLTLSSLVFGETLSADLLLGMGLLCLGLVL 304 F I + QR V+ L VPV G S+L F E +LG L+ GLVL Sbjct: 232 FGIWSGLIQRHGASRVAPLSLLVPVFGTLASALAFHEGFPPGKVLGAALIAAGLVL 287