BLASTP 2.2.21 [Jun-14-2009] Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), "Gapped BLAST and PSI-BLAST: a new generation of protein database search programs", Nucleic Acids Res. 25:3389-3402. Reference for compositional score matrix adjustment: Altschul, Stephen F., John C. Wootton, E. Michael Gertz, Richa Agarwala, Aleksandr Morgulis, Alejandro A. Schaffer, and Yi-Kuo Yu (2005) "Protein database searches using compositionally adjusted substitution matrices", FEBS J. 272:5101-5109. Query= 0002.0258.p (379 letters) Database: COGmodified 192,987 sequences; 59,019,183 total letters Searching..................................................done Score E Sequences producing significant alignments: (bits) Value YPO3263 [GEPR] COG0477 Permeases of the major facilitator superf... 124 4e-28 ECs3543 [GEPR] COG0477 Permeases of the major facilitator superf... 122 9e-28 Z3982 [GEPR] COG0477 Permeases of the major facilitator superfam... 122 2e-27 b2681m [GEPR] COG0477 Permeases of the major facilitator superfa... 120 5e-27 STM2812 [GEPR] COG0477 Permeases of the major facilitator superf... 115 2e-25 >YPO3263 [GEPR] COG0477 Permeases of the major facilitator superfamily Ype Yersinia pestis Length = 399 Score = 124 bits (311), Expect = 4e-28, Method: Compositional matrix adjust. Identities = 105/351 (29%), Positives = 165/351 (47%) Query: 1 MLAVAAGSAIASNYAMQPALPEIAADFGVEVASLTTVISGAIAGYLIGLVLLVPLVDRLS 60 +++VA G A+ASNY QP L IA +F + V +++ A GY +GL+ LVPL D Sbjct: 16 LMSVATGLAVASNYYAQPLLETIATNFNLSVNQAGFIVTAAQLGYAVGLMFLVPLGDMFE 75 Query: 61 PRVLIPGQFLALALSLALAARAASPDALIGCFVLIGATTTVAAQSSAIVGKLADASRRAL 120 R LI G L A + + A + + +I L G + VA + LA +R Sbjct: 76 RRGLIVGMTLLAAGGMLITAMSQNLTMMIIGTALTGLFSVVAQLLVPLAATLAAPEKRGK 135 Query: 121 SMAAISAGISAGILLSRFIGGLLVQWLGWRGALLVLAALTAVCGLCVFPLLPAQRPVGHI 180 + I +G+ GILL+R + G L GWR V +AL + L ++ LP + + Sbjct: 136 VVGIIMSGLLLGILLARTVAGALATLGGWRTIYWVASALMFIMALVLWRCLPRYKQHTGL 195 Query: 181 GYFSTLRALPSLLRQSRELRLRICAGMLWFFAFNLIWVGLVVRLAAPPYHLNAASIGLYS 240 Y L ++ +L + LR R G L F F+++W + LAAPP+ + A+IGL+ Sbjct: 196 NYGQLLGSIFALFIHTPVLRTRALLGALSFANFSVLWTSMAFLLAAPPFGYSEATIGLFG 255 Query: 241 LAGVTGLAMTRIAGGLADRFGNCSVMVCGLLCASLAASTLGVVLDHVPATLVALAIFDAG 300 L G G M AG LAD+ GL+ L+ + + A ++ + + D Sbjct: 256 LVGAAGALMATKAGQLADKGKARVTTSAGLVLLLLSWLPIAFGQHSIIALIIGIIVLDLA 315 Query: 301 CFAAQVANQAGVVAIDPLRSGVLNSAYLFFYYGAGAAGTAIAGSLALRGSW 351 A V NQ+ + + P L + Y+ Y+ GA G+ I+ + W Sbjct: 316 VQAVHVTNQSVMYRMMPEARNRLTAGYMTSYFIGGALGSLISAAAYQHAGW 366 >ECs3543 [GEPR] COG0477 Permeases of the major facilitator superfamily Ecs Escherichia coli O157:H7 Length = 394 Score = 122 bits (307), Expect = 9e-28, Method: Compositional matrix adjust. Identities = 111/353 (31%), Positives = 168/353 (47%), Gaps = 4/353 (1%) Query: 1 MLAVAAGSAIASNYAMQPALPEIAADFGVEVASLTTVISGAIAGYLIGLVLLVPLVDRLS 60 ++++A G A+ASNY QP L IA +F + +S +++ A GY GL+ LVPL D Sbjct: 15 LMSIATGLAVASNYYAQPLLDTIARNFSLSASSAGFIVTAAQLGYAAGLLFLVPLGDMFE 74 Query: 61 PRVLIPGQFLALALSLALAARAASPDALIGCFVLIGATTTVAAQSSAIVGKLADASRRAL 120 R LI L A + + A + S +I L G + VA + LA +R Sbjct: 75 RRRLIVSMTLLAAGGMLITASSQSLAMMILGTALTGLFSVVAQILVPLAATLASPDKRGK 134 Query: 121 SMAAISAGISAGILLSRFIGGLLVQWLGWRGALLVLAALTAVCGLCVFPLLPAQRPVGHI 180 + I +G+ GILL+R + GLL GWR V + L A+ L ++ LP + H+ Sbjct: 135 VVGTIMSGLLLGILLARTVAGLLANLGGWRTVFWVASVLMALMALALWRGLPQMKSETHL 194 Query: 181 GYFSTLRALPSLLRQSRELRLRICAGMLWFFAFNLIWVGLVVRLAAPPYHLNAASIGLYS 240 Y L ++ S+ ++ LR R G L F F+++W + LAAPP++ + IGL+ Sbjct: 195 NYPQLLGSVFSMFISNKILRTRALLGCLTFANFSILWTSMAFLLAAPPFNYSDGVIGLFG 254 Query: 241 LAGVTGLAMTRIAGGLADRFGNCSVMVCGLLCASLAASTLGVVLDH--VPATLVALAIFD 298 LAG G R AGG AD+ + G L S L + H V A ++ + + D Sbjct: 255 LAGAAGALGARPAGGFADKGKSHHTTTFG--LLLLLLSWLAIWFGHTSVLALIIGILVLD 312 Query: 299 AGCFAAQVANQAGVVAIDPLRSGVLNSAYLFFYYGAGAAGTAIAGSLALRGSW 351 + NQ + I P L + Y+ Y+ GAAG+ I+ S G W Sbjct: 313 LTVQGVHITNQTVIYRIHPDARNRLTAGYMTSYFIGGAAGSLISASAWQHGGW 365 >Z3982 [GEPR] COG0477 Permeases of the major facilitator superfamily EcZ Escherichia coli O157:H7 EDL933 Length = 394 Score = 122 bits (305), Expect = 2e-27, Method: Compositional matrix adjust. Identities = 111/353 (31%), Positives = 167/353 (47%), Gaps = 4/353 (1%) Query: 1 MLAVAAGSAIASNYAMQPALPEIAADFGVEVASLTTVISGAIAGYLIGLVLLVPLVDRLS 60 ++++A G A+ASNY QP L IA +F + +S +++ A GY GL+ LVPL D Sbjct: 15 LMSIATGLAVASNYYAQPLLDTIARNFSLSASSAGFIVTAAQLGYAAGLLFLVPLGDMFE 74 Query: 61 PRVLIPGQFLALALSLALAARAASPDALIGCFVLIGATTTVAAQSSAIVGKLADASRRAL 120 R LI L A + + A + S +I L G + VA + LA +R Sbjct: 75 RRRLIVSMTLLAAGGMLITASSQSLAMMILGTALTGLFSVVAQILVPLAATLASPDKRGK 134 Query: 121 SMAAISAGISAGILLSRFIGGLLVQWLGWRGALLVLAALTAVCGLCVFPLLPAQRPVGHI 180 + I +G+ GILL+R + GLL GWR V + L A+ L ++ LP + H+ Sbjct: 135 VVGTIMSGLLLGILLARTVAGLLANLGGWRTVFWVASVLMALMALALWRGLPQMKSETHL 194 Query: 181 GYFSTLRALPSLLRQSRELRLRICAGMLWFFAFNLIWVGLVVRLAAPPYHLNAASIGLYS 240 Y L ++ S+ ++ LR R G L F F++ W + LAAPP++ + IGL+ Sbjct: 195 NYPQLLGSVFSMFISNKILRTRALLGCLTFANFSIXWTSMAFLLAAPPFNYSDGVIGLFG 254 Query: 241 LAGVTGLAMTRIAGGLADRFGNCSVMVCGLLCASLAASTLGVVLDH--VPATLVALAIFD 298 LAG G R AGG AD+ + G L S L + H V A ++ + + D Sbjct: 255 LAGAAGALGARPAGGFADKGKSHHTTTFG--LLLLLLSWLAIWFGHTSVLALIIGILVLD 312 Query: 299 AGCFAAQVANQAGVVAIDPLRSGVLNSAYLFFYYGAGAAGTAIAGSLALRGSW 351 + NQ + I P L + Y+ Y+ GAAG+ I+ S G W Sbjct: 313 LTVQGVHITNQTVIYRIHPDARNRLTAGYMTSYFIGGAAGSLISASAWQHGGW 365 >b2681m [GEPR] COG0477 Permeases of the major facilitator superfamily Eco Escherichia coli K12 Length = 392 Score = 120 bits (302), Expect = 5e-27, Method: Compositional matrix adjust. Identities = 110/353 (31%), Positives = 167/353 (47%), Gaps = 6/353 (1%) Query: 1 MLAVAAGSAIASNYAMQPALPEIAADFGVEVASLTTVISGAIAGYLIGLVLLVPLVDRLS 60 ++++A G A+ASNY QP L IA +F + +S +++ A GY GL+ LVPL D Sbjct: 15 LMSIATGLAVASNYYAQPLLDTIARNFSLSASSAGFIVTAAQLGYAAGLLFLVPLGDMFE 74 Query: 61 PRVLIPGQFLALALSLALAARAASPDALIGCFVLIGATTTVAAQSSAIVGKLADASRRAL 120 R LI + L + + A + S +I L G + VA + LA +R Sbjct: 75 RRRLIVS--MTLLXXMLITASSQSLAMMILGTALTGLFSVVAQILVPLAATLASPDKRGK 132 Query: 121 SMAAISAGISAGILLSRFIGGLLVQWLGWRGALLVLAALTAVCGLCVFPLLPAQRPVGHI 180 + I +G+ GILL+R + GLL GWR V + L A+ L ++ LP + H+ Sbjct: 133 VVGTIMSGLLLGILLARTVAGLLANLGGWRTVFWVASVLMALMALALWRGLPQMKSETHL 192 Query: 181 GYFSTLRALPSLLRQSRELRLRICAGMLWFFAFNLIWVGLVVRLAAPPYHLNAASIGLYS 240 Y L ++ S+ + LR R G L F F+++W + LAAPP++ + IGL+ Sbjct: 193 NYPQLLGSVFSMFISDKILRTRALLGCLTFANFSILWTSMAFLLAAPPFNYSDGVIGLFG 252 Query: 241 LAGVTGLAMTRIAGGLADRFGNCSVMVCGLLCASLAASTLGVVLDH--VPATLVALAIFD 298 LAG G R AGG AD+ + G L S L + H V A ++ + + D Sbjct: 253 LAGAAGALGARPAGGFADKGKSHHTTTFG--LLLLLLSWLAIWFGHTSVLALIIGILVLD 310 Query: 299 AGCFAAQVANQAGVVAIDPLRSGVLNSAYLFFYYGAGAAGTAIAGSLALRGSW 351 + NQ + I P L + Y+ Y+ GAAG+ I+ S G W Sbjct: 311 LTVQGVHITNQTVIYRIHPDARNRLTAGYMTSYFIGGAAGSLISASAWQHGGW 363 >STM2812 [GEPR] COG0477 Permeases of the major facilitator superfamily Sty Salmonella typhimurium LT2 Length = 394 Score = 115 bits (287), Expect = 2e-25, Method: Compositional matrix adjust. Identities = 110/351 (31%), Positives = 166/351 (47%) Query: 1 MLAVAAGSAIASNYAMQPALPEIAADFGVEVASLTTVISGAIAGYLIGLVLLVPLVDRLS 60 +++VA G A+ASNY QP L IA F + +S +++ A GY GL+ LVPL D Sbjct: 15 LMSVATGLAVASNYYAQPLLDTIAHHFSLSASSAGFIVTAAQLGYAAGLLFLVPLGDMFE 74 Query: 61 PRVLIPGQFLALALSLALAARAASPDALIGCFVLIGATTTVAAQSSAIVGKLADASRRAL 120 R LI L A + + A + S +I L G + VA + LA + R Sbjct: 75 RRTLIVSMTLLAAGGMLITASSQSLSMMILGTALTGLFSVVAQILVPLAATLATPATRGK 134 Query: 121 SMAAISAGISAGILLSRFIGGLLVQWLGWRGALLVLAALTAVCGLCVFPLLPAQRPVGHI 180 + I +G+ GILL+R + GLL GWR V +AL A+ + ++ LP + H+ Sbjct: 135 VVGTIMSGLLLGILLARTVAGLLANLGGWRTVFWVASALMALMAVALWRGLPKLKSDTHL 194 Query: 181 GYFSTLRALPSLLRQSRELRLRICAGMLWFFAFNLIWVGLVVRLAAPPYHLNAASIGLYS 240 Y L ++ SL + LR R G L F F+++W + LAAPP+ + IGL+ Sbjct: 195 NYPQLLGSVFSLFIHDKLLRTRALLGCLTFANFSILWTSMAFLLAAPPFSYSEGMIGLFG 254 Query: 241 LAGVTGLAMTRIAGGLADRFGNCSVMVCGLLCASLAASTLGVVLDHVPATLVALAIFDAG 300 LAG G R AGG AD+ + GLL L+ + + V A ++ + + D Sbjct: 255 LAGAAGALGARPAGGFADKGKSHLTTTFGLLLLLLSWLAIWLGHTSVLALIIGILVLDLT 314 Query: 301 CFAAQVANQAGVVAIDPLRSGVLNSAYLFFYYGAGAAGTAIAGSLALRGSW 351 + NQ + + P L + Y+ Y+ GAAG+ I+ S W Sbjct: 315 VQGVHITNQTVIYRLHPDARNRLTAGYMTSYFIGGAAGSLISASAWQHAGW 365