BLASTP 2.2.21 [Jun-14-2009] Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), "Gapped BLAST and PSI-BLAST: a new generation of protein database search programs", Nucleic Acids Res. 25:3389-3402. Reference for compositional score matrix adjustment: Altschul, Stephen F., John C. Wootton, E. Michael Gertz, Richa Agarwala, Aleksandr Morgulis, Alejandro A. Schaffer, and Yi-Kuo Yu (2005) "Protein database searches using compositionally adjusted substitution matrices", FEBS J. 272:5101-5109. Query= 0002.0241.p (206 letters) Database: COGmodified 192,987 sequences; 59,019,183 total letters Searching..................................................done Score E Sequences producing significant alignments: (bits) Value PA4467 [P] COG0428 Predicted divalent heavy-metal cations transp... 149 5e-36 all0473 [P] COG0428 Predicted divalent heavy-metal cations trans... 146 3e-35 lin0435 [P] COG0428 Predicted divalent heavy-metal cations trans... 127 2e-29 TM1738 [P] COG0428 Predicted divalent heavy-metal cations transp... 123 3e-28 MTH473 [P] COG0428 Predicted divalent heavy-metal cations transp... 110 1e-24 >PA4467 [P] COG0428 Predicted divalent heavy-metal cations transporter Pae Pseudomonas aeruginosa Length = 310 Score = 149 bits (375), Expect = 5e-36, Method: Compositional matrix adjust. Identities = 100/210 (47%), Positives = 129/210 (61%), Gaps = 6/210 (2%) Query: 1 MLAASVFSLILPALHSLQEAGAGKQMASLIAGASVLCGALLVLALQRAGQGHDDLARQAA 60 ML+A+ FSLI+PAL + + G K A + + G + + L R A Sbjct: 101 MLSATAFSLIMPALSAAGDLGYSKFGAGFLVSFGLAVGVMGLFILGRLMPDVHPGCEGAP 160 Query: 61 LR-----RVWLFVLTVGLHNLPEGLAVGVAYGGVAPEQASVLTFGIALQDIPEGMIVATA 115 L R+ LFV + LHN+PEG+AVGV+ G ++A+ L GIALQD+PEG++VA Sbjct: 161 LSGGIPPRILLFVTAIVLHNIPEGMAVGVS-AGAGLDEANGLALGIALQDVPEGLVVALV 219 Query: 116 LRGIGYSRADAIGCGILSGLVEPLAAVAGAALVSLSAAMLPWALGGAAGAMLFVLAHEVI 175 L G+G SR A+ G SGLVEPL AV A LV LSA +LPW L AAGAMLFV+ HE+I Sbjct: 220 LAGVGMSRFKAMLVGAASGLVEPLFAVLCAWLVGLSALLLPWGLAAAAGAMLFVVTHEII 279 Query: 176 PDPHRRRDALAATCCLIIGFVLMMVMDTAL 205 P+ HR+ A AT L+ GF LMMV+DTAL Sbjct: 280 PESHRQGHAAEATLGLVFGFCLMMVLDTAL 309 >all0473 [P] COG0428 Predicted divalent heavy-metal cations transporter Nos Nostoc sp. PCC 7120 Length = 257 Score = 146 bits (368), Expect = 3e-35, Method: Compositional matrix adjust. Identities = 88/211 (41%), Positives = 126/211 (59%), Gaps = 7/211 (3%) Query: 1 MLAASVFSLILPALHSLQEAGAGKQMASLIAGASVLCG------ALLVLALQRAGQGHDD 54 MLAA+ FSLI+P S G A+LI VL G A L + +G ++ Sbjct: 47 MLAATSFSLIVPGTESAITQGQSPINAALIMVGGVLLGGLFLQLAHRFLPHEHFFKGKEN 106 Query: 55 LARQAALRRVWLFVLTVGLHNLPEGLAVGVAYGGVAPEQASVLTFGIALQDIPEGMIVAT 114 R L+R+WLF+ + +HN PEGLAVGV +G + GIALQ+IPEG++VA Sbjct: 107 -CRGQKLKRIWLFIAAITIHNFPEGLAVGVNFGNNDINNGIPIALGIALQNIPEGLVVAL 165 Query: 115 ALRGIGYSRADAIGCGILSGLVEPLAAVAGAALVSLSAAMLPWALGGAAGAMLFVLAHEV 174 +L YS AI +L+GLVEP+ A+ G A+VS++ +LPWA+ AAGAMLFV++ E+ Sbjct: 166 SLVTEKYSPIYAIWISLLTGLVEPIGALVGVAVVSVANHILPWAMAFAAGAMLFVISDEI 225 Query: 175 IPDPHRRRDALAATCCLIIGFVLMMVMDTAL 205 IP+ HR+ T +++GFV+M+ +D L Sbjct: 226 IPESHRQGLEKEGTIGVMVGFVIMIFLDITL 256 >lin0435 [P] COG0428 Predicted divalent heavy-metal cations transporter Lin Listeria innocua Length = 269 Score = 127 bits (318), Expect = 2e-29, Method: Compositional matrix adjust. Identities = 86/218 (39%), Positives = 122/218 (55%), Gaps = 16/218 (7%) Query: 1 MLAASVFSLILPALHSLQEAGAGKQMASLIAGASVLCGALLVLALQRA----GQGHDDLA 56 MLAAS +SL+ PA+ ++ G + +L+ L G + + + R G + A Sbjct: 54 MLAASFWSLLAPAIEMSKDLGKFSFVPALVG---FLLGGIFLRVIDRIIPHLHFGFPEQA 110 Query: 57 RQ---AALRRVWLFVLTVGLHNLPEGLAVGVAYGGVAPEQ------ASVLTFGIALQDIP 107 ++ +LR+ L VL++ +HN+PEG AVGVA+G V A VL GI +Q+ P Sbjct: 111 KEGPKTSLRKSILLVLSITIHNIPEGAAVGVAFGAVITGDTETLITAIVLALGIGIQNFP 170 Query: 108 EGMIVATALRGIGYSRADAIGCGILSGLVEPLAAVAGAALVSLSAAMLPWALGGAAGAML 167 EG V+ LRG G SR + G LS +VEP+ AV GA LV +LP+AL AAGAM+ Sbjct: 171 EGAAVSIPLRGEGLSRGKSFWYGQLSAVVEPIFAVIGAVLVVFVTPILPFALAFAAGAMI 230 Query: 168 FVLAHEVIPDPHRRRDALAATCCLIIGFVLMMVMDTAL 205 FV+ E+IP+ A AT + GF +MMV+D AL Sbjct: 231 FVIVEELIPESQVEGSADLATAATMAGFSVMMVLDVAL 268 >TM1738 [P] COG0428 Predicted divalent heavy-metal cations transporter Tma Thermotoga maritima Length = 245 Score = 123 bits (308), Expect = 3e-28, Method: Compositional matrix adjust. Identities = 76/207 (36%), Positives = 122/207 (58%), Gaps = 11/207 (5%) Query: 1 MLAASVFSLILPALHSLQEAGAGKQMASLIAGASVLCGALLVLALQRAGQGHD--DLARQ 58 MLAAS FSL+ P SL+ G + + + G + A ++ + +GH+ D R Sbjct: 47 MLAASAFSLVAP---SLEMGGIVRFLIGFVLGGLFVNLADKLIPHEHLLKGHEGPDTKR- 102 Query: 59 AALRRVWLFVLTVGLHNLPEGLAVGVAYGGVAPEQASVLTFGIALQDIPEGMIVATALRG 118 L+ VWLF++ + +HN PEG+AVGV+ P QA + I +Q+IPEG V +L Sbjct: 103 --LKGVWLFIIAITIHNFPEGMAVGVS--AFTP-QALAIAIAIGVQNIPEGAAVMASLIP 157 Query: 119 IGYSRADAIGCGILSGLVEPLAAVAGAALVSLSAAMLPWALGGAAGAMLFVLAHEVIPDP 178 + Y + A L+GLVE + + GA +VS+S +LP+ + AAGAM++V++ EVIP+ Sbjct: 158 MKYKKGKAFLITFLTGLVEAIGGLLGAGIVSISQRLLPYMMAFAAGAMIYVVSDEVIPET 217 Query: 179 HRRRDALAATCCLIIGFVLMMVMDTAL 205 H + + L +T +++GF++M +D AL Sbjct: 218 HSKGNELLSTWWIMVGFLVMASLDVAL 244 >MTH473 [P] COG0428 Predicted divalent heavy-metal cations transporter Mth Methanothermobacter thermautotrophicus Length = 259 Score = 110 bits (276), Expect = 1e-24, Method: Compositional matrix adjust. Identities = 82/214 (38%), Positives = 117/214 (54%), Gaps = 12/214 (5%) Query: 1 MLAASVFSLILPALHSLQEAGAGKQMASLIAGASVLCGALLVLALQRA----GQGHDDLA 56 M+AAS +SL++PA+ L G A + A L G L + A+ R G D Sbjct: 50 MIAASFWSLLVPAIE-LSPTGV---YAWVPPAAGFLAGGLFLSAMDRIIPHLHPGCDPEG 105 Query: 57 RQAALRRVWLFVLTVGLHNLPEGLAVGVAYGGVAPEQASVLTFG----IALQDIPEGMIV 112 RR L +L V +HNLPEGLA+GVA+G A I +Q++PEG V Sbjct: 106 LPTTWRRNRLLLLAVVIHNLPEGLAIGVAFGAAASTGGLAAPLALALGIGIQNLPEGAAV 165 Query: 113 ATALRGIGYSRADAIGCGILSGLVEPLAAVAGAALVSLSAAMLPWALGGAAGAMLFVLAH 172 + L G G SR + G LSG++E L + GA +V + ++P+ALG AAGAM+FV+ Sbjct: 166 SLPLLGEGLSRWRSFIYGQLSGVIEVLGGIGGALMVYSFSGIMPYALGFAAGAMIFVVIE 225 Query: 173 EVIPDPHRRRDALAATCCLIIGFVLMMVMDTALS 206 ++IP+ + AT ++GFVLMMV+D AL+ Sbjct: 226 DLIPECQSGGNTDLATVSALMGFVLMMVLDLALA 259