BLASTP 2.2.21 [Jun-14-2009] Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), "Gapped BLAST and PSI-BLAST: a new generation of protein database search programs", Nucleic Acids Res. 25:3389-3402. Reference for compositional score matrix adjustment: Altschul, Stephen F., John C. Wootton, E. Michael Gertz, Richa Agarwala, Aleksandr Morgulis, Alejandro A. Schaffer, and Yi-Kuo Yu (2005) "Protein database searches using compositionally adjusted substitution matrices", FEBS J. 272:5101-5109. Query= 0002.0206.p (317 letters) Database: COGmodified 192,987 sequences; 59,019,183 total letters Searching..................................................done Score E Sequences producing significant alignments: (bits) Value YPO2536 [CHR] COG1052 Lactate dehydrogenase and related dehydrog... 263 4e-70 SMa0085 [CHR] COG1052 Lactate dehydrogenase and related dehydrog... 246 4e-65 AGl379 [CHR] COG1052 Lactate dehydrogenase and related dehydroge... 242 7e-64 SMa0510 [CHR] COG1052 Lactate dehydrogenase and related dehydrog... 229 5e-60 mlr5162 [CHR] COG1052 Lactate dehydrogenase and related dehydrog... 194 2e-49 >YPO2536 [CHR] COG1052 Lactate dehydrogenase and related dehydrogenases Ype Yersinia pestis Length = 316 Score = 263 bits (672), Expect = 4e-70, Method: Compositional matrix adjust. Identities = 133/316 (42%), Positives = 212/316 (67%), Gaps = 6/316 (1%) Query: 2 KRHVLQLNPILVPAINDKLESLYHMHRLFEQEDKEAYIDRHGAVIEGVITGGHTGISNAL 61 K+ VL + P++ + +KLE + +H+L++ D ++ G I+G++T G G++N + Sbjct: 5 KQAVLIIAPVM-DYLTEKLEQTFTVHKLYQVTDHAEFLADQGKNIKGIVTRGDIGVTNEV 63 Query: 62 MDRLPALKVVAVNGVGTDAVDLSHARSKGLPVTGTFGALTEDVADLALGLMLAVSRQICP 121 + LP ++++++ GVGTDAVDL + R + + VT T G LT+DVAD ALGL++A SR+ Sbjct: 64 LALLPEVQIISIFGVGTDAVDLDYTRERNIIVTTTPGVLTDDVADTALGLIIATSRRFYQ 123 Query: 122 GHAFVQRGDWVRHPSPTAIPLSRRLSGKRVGIVGMGKVGRAIAQRAAAFGCPIAYTDLRA 181 F++ G+W P+ ++PLS +++GKR+GI GMG++GRAIA+RA F IAYTD Sbjct: 124 ASQFLRSGEW---PN-GSLPLSSKVTGKRLGIFGMGRIGRAIARRAVGFDMQIAYTDTVH 179 Query: 182 MEDLPYTFQAELLQLARESDVLVLAAAADK-AQGIINAAVLDALGREGILINIARGKLVV 240 LPY + +L+ LA++SD+LV+A + K + G+++ A+ A+ GILINIARG +V Sbjct: 180 DSSLPYQYVPDLISLAKQSDILVVAISGGKDSAGLVDKAIFAAMPNHGILINIARGSMVN 239 Query: 241 EEDLVDALQRGVIAGAGLDVFVDEPNVPAALLQMDQVVLQAHRASATVESRTAMGEMVLA 300 ++DL+ ALQ+ I GAGLDVF DEP+VP AL++MD V L H ASAT ++R M ++V + Sbjct: 240 QDDLISALQQQQIGGAGLDVFADEPHVPQALIEMDNVFLLPHIASATTDTRIQMSDIVFS 299 Query: 301 SLAQGLAGQRPEGSLT 316 ++ +G+ ++T Sbjct: 300 NILAHFSGETAPTAIT 315 >SMa0085 [CHR] COG1052 Lactate dehydrogenase and related dehydrogenases Sme Sinorhizobium meliloti Length = 317 Score = 246 bits (629), Expect = 4e-65, Method: Compositional matrix adjust. Identities = 135/311 (43%), Positives = 203/311 (65%), Gaps = 6/311 (1%) Query: 1 MKRHVLQLNPILVPAINDKLESLYHMHRLFEQEDKEAYIDRHGAVIEGVITGGHTGISNA 60 +K +L + P++ P + D+L+ Y +HRL++ D+ A ++ I V TGG G+SN Sbjct: 6 VKPDLLLVEPMM-PFVMDELQRNYSVHRLYQAADRPA-LEAALPSIRAVATGGGAGLSNE 63 Query: 61 LMDRLPALKVVAVNGVGTDAVDLSHARSKGLPVTGTFGALTEDVADLALGLMLAVSRQIC 120 M++LP+L ++A+NGVGTD VDL+ AR + + VT T G L +DVADL + LMLAV R++ Sbjct: 64 WMEKLPSLGIIAINGVGTDKVDLARARRRNIDVTTTPGVLADDVADLGIALMLAVLRRVG 123 Query: 121 PGHAFVQRGDWVRHPSPTAIPLSRRLSGKRVGIVGMGKVGRAIAQRAAAFGCPIAYTDLR 180 G V+ G W + +PL GKR+G++G+G++GRA+A RA AFG + Y + Sbjct: 124 DGDRLVREGRWA---AGEQLPLGHSPKGKRIGVLGLGQIGRALASRAEAFGMSVRYWNRS 180 Query: 181 AMEDLPYTFQAELLQLARESDVLVLAAAADKA-QGIINAAVLDALGREGILINIARGKLV 239 + + + + LAR+SDVL + AA A Q I++A++L ALG EGI++N+ARG +V Sbjct: 181 TLSGVDWIAHQSPVDLARDSDVLAVCVAASAATQNIVDASLLQALGPEGIVVNVARGNVV 240 Query: 240 VEEDLVDALQRGVIAGAGLDVFVDEPNVPAALLQMDQVVLQAHRASATVESRTAMGEMVL 299 E+ L++AL+ G IAGAGLDVFV+EP + + VL H+ SATVE+R AMG++VL Sbjct: 241 DEDALIEALKSGTIAGAGLDVFVNEPAIRSEFHTTPNTVLMPHQGSATVETRMAMGKLVL 300 Query: 300 ASLAQGLAGQR 310 A+LA AG++ Sbjct: 301 ANLAAHFAGEK 311 >AGl379 [CHR] COG1052 Lactate dehydrogenase and related dehydrogenases Atu Agrobacterium tumefaciens strain C58 (Cereon) Length = 311 Score = 242 bits (618), Expect = 7e-64, Method: Compositional matrix adjust. Identities = 139/310 (44%), Positives = 198/310 (63%), Gaps = 7/310 (2%) Query: 1 MKRHVLQLNPILVPAINDKLESLYHMHRLFEQEDKEAYIDRHGAVIEGVITGGHTGISNA 60 M ++QL P L+PA+ ++L + +HRLFE DK A++ GA I GV+TGGH G+ Sbjct: 1 MTAEIVQLCP-LIPALEEELAQRFTVHRLFEAADKAAFLSEKGAAIRGVVTGGHIGLPAD 59 Query: 61 LMDRLPALKVVAVNGVGTDAVDLSHARSKGLPVTGTFGALTEDVADLALGLMLAVSRQIC 120 + LP L++VA+NGVG D VDL A+ +G V+ T LT DVADLALGL+LA +R++ Sbjct: 60 VGAALPNLEIVAINGVGFDKVDLGEAKRRGFRVSNTPDVLTADVADLALGLVLAQARKVP 119 Query: 121 PGHAFVQRGDWVRHPSPTAIPLSRRLSGKRVGIVGMGKVGRAIAQRAAAFGCPIAYTDLR 180 V+ G W++ + LS R++G+R GI G+G++G+AIA+R F I+YT R Sbjct: 120 QADQHVRTGQWLKGD----MGLSTRVAGRRYGIFGLGRIGQAIAKRLEGFDARISYT-AR 174 Query: 181 AMEDLPYTFQAELLQLARESDVLVL-AAAADKAQGIINAAVLDALGREGILINIARGKLV 239 D+ Y + + +LA DVL++ AAA + + I+NA VL ALG +G+L+N+ARG LV Sbjct: 175 NRRDVAYDYHDSIEELAANCDVLIIAAAATAETRHIVNADVLKALGPQGVLVNVARGSLV 234 Query: 240 VEEDLVDALQRGVIAGAGLDVFVDEPNVPAALLQMDQVVLQAHRASATVESRTAMGEMVL 299 E+ LV+AL G+I GA LDVF DEP VP AL + V L H S T ++R AM ++VL Sbjct: 235 DEKALVEALSSGMIGGAALDVFEDEPRVPEALFAFENVTLAPHIGSGTHQTRRAMADLVL 294 Query: 300 ASLAQGLAGQ 309 A+L AG+ Sbjct: 295 ANLDAHFAGR 304 >SMa0510 [CHR] COG1052 Lactate dehydrogenase and related dehydrogenases Sme Sinorhizobium meliloti Length = 315 Score = 229 bits (585), Expect = 5e-60, Method: Compositional matrix adjust. Identities = 133/314 (42%), Positives = 199/314 (63%), Gaps = 11/314 (3%) Query: 2 KRHVLQLNPILVPAIND-KLESLYHMHRLFEQEDKEAYIDRHGAVIEGVITGGHTGISNA 60 K +LQ+ P P+ ++ +L + + MHR FE DK A++ HGA I G+ T G G + A Sbjct: 3 KIELLQVGP--YPSWDEERLNANFTMHRYFEAADKAAFLAEHGAAIRGIATRGELGANWA 60 Query: 61 LMDRLPALKVVAVNGVGTDAVDLSHARSKGLPVTGTFGALTEDVADLALGLMLAVSRQIC 120 +++ LP L++++V GVG DAVDL+ AR +G+ VT T LT+DVADL + +MLA +R + Sbjct: 61 MIEALPRLEIISVYGVGYDAVDLAAARERGIRVTNTPDVLTKDVADLGVAMMLAHARGMI 120 Query: 121 PGHAFVQRGDWVRHPSPTAIPLSRRLSGKRVGIVGMGKVGRAIAQRAAAFGCPIAYTDLR 180 G +V+ GDW + PL RR+ GKR G++G+G++G +A+R A F IAY+D Sbjct: 121 GGETWVKSGDWAKK---GLYPLKRRVHGKRAGVLGLGRIGFEVAKRLAGFDMEIAYSDTG 177 Query: 181 AMEDLP--YTFQAELLQLARESDVL-VLAAAADKAQGIINAAVLDALGREGILINIARGK 237 A +D ++F A+ ++LA SD L V AA+ + + I+ V++ALG +G+LINI+R Sbjct: 178 A-KDFARDWSFIADPVELAARSDFLFVTLAASAETRHIVGRRVIEALGPDGMLINISRAS 236 Query: 238 LVVEEDLVDALQRGVIAGAGLDVFVDEPNVPAALLQMDQVVLQAHRASATVESRTAMGEM 297 + EE L+DAL+ V+ A LDVF EPN+ L +D V+LQ H AS T E+R AMG++ Sbjct: 237 NIDEEALLDALESKVLGAAALDVFEGEPNLNPRFLALDNVLLQPHMASGTAETRKAMGQL 296 Query: 298 VLASLAQGLAGQRP 311 V +L+ G RP Sbjct: 297 VFDNLSAHFGG-RP 309 >mlr5162 [CHR] COG1052 Lactate dehydrogenase and related dehydrogenases Mlo Mesorhizobium loti Length = 327 Score = 194 bits (494), Expect = 2e-49, Method: Compositional matrix adjust. Identities = 128/317 (40%), Positives = 176/317 (55%), Gaps = 13/317 (4%) Query: 2 KRHVLQLNPILVPAINDKLESLYHMHRLFEQ-----EDKEAYIDRHGAVIEGVITGGHTG 56 K LQ ILVPA + ++ + R F+Q D D ++ G+ + G Sbjct: 3 KAEQLQAVAILVPA-DFSDHAVRRIDRTFKQVSIERADPALVTDEMRRMVRGIAS--FAG 59 Query: 57 ISNALMDRLPALKVVAVNGVGTDAVDLSHARSKGLPVTGTFGALTEDVADLALGLMLAVS 116 IS A+MD LP L+++A GVG D+VD+ HA +K + VT T LTE+VAD A+GL++ Sbjct: 60 ISAAMMDALPNLELIASFGVGYDSVDVGHAAAKNIMVTNTPDVLTEEVADTAIGLLINTI 119 Query: 117 RQICPGHAFVQRGDWVRHPSPTAIPLSR-RLSGKRVGIVGMGKVGRAIAQRAAAFGCPIA 175 R + +++ G WVR + PLSR L +RVGI GMG++G+AIA+R AFG PIA Sbjct: 120 RDLPRAENWLRDGSWVRKGN---YPLSRLTLRARRVGIFGMGRIGQAIARRLEAFGLPIA 176 Query: 176 YTDLRAMEDLPYTFQAELLQLARESDVLV-LAAAADKAQGIINAAVLDALGREGILINIA 234 Y + R +E L Y + L LA D L+ +A Q +NA +L ALG G+ +NI Sbjct: 177 YHNRRRVEGLAYQYHPTLRGLAEAVDTLISVAPGGASTQKAVNAEILSALGANGVFVNIG 236 Query: 235 RGKLVVEEDLVDALQRGVIAGAGLDVFVDEPNVPAALLQMDQVVLQAHRASATVESRTAM 294 RG V E L AL G IA AGLDVF DEPNVP ALL L H SA+ +R AM Sbjct: 237 RGSTVDEAALAAALADGTIAAAGLDVFADEPNVPKALLDAPNASLLPHVGSASEHTRRAM 296 Query: 295 GEMVLASLAQGLAGQRP 311 ++ + +L ++P Sbjct: 297 ADLCVDNLVSWFTERQP 313