BLASTP 2.2.21 [Jun-14-2009] Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), "Gapped BLAST and PSI-BLAST: a new generation of protein database search programs", Nucleic Acids Res. 25:3389-3402. Reference for compositional score matrix adjustment: Altschul, Stephen F., John C. Wootton, E. Michael Gertz, Richa Agarwala, Aleksandr Morgulis, Alejandro A. Schaffer, and Yi-Kuo Yu (2005) "Protein database searches using compositionally adjusted substitution matrices", FEBS J. 272:5101-5109. Query= 0002.0184.p (249 letters) Database: COGmodified 192,987 sequences; 59,019,183 total letters Searching..................................................done Score E Sequences producing significant alignments: (bits) Value mll5766 [IQR] COG1028 Dehydrogenases with different specificitie... 305 5e-83 SMc00268 [IQR] COG1028 Dehydrogenases with different specificiti... 281 1e-75 TM1724 [IQR] COG1028 Dehydrogenases with different specificities... 173 3e-43 BH2491 [IQR] COG1028 Dehydrogenases with different specificities... 171 2e-42 PM1916 [IQR] COG1028 Dehydrogenases with different specificities... 168 1e-41 >mll5766 [IQR] COG1028 Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) Mlo Mesorhizobium loti Length = 250 Score = 305 bits (782), Expect = 5e-83, Method: Compositional matrix adjust. Identities = 156/249 (62%), Positives = 184/249 (73%) Query: 1 MLLKNKVAVITGGAGLNGLGFSTARLMAAQGARVVILDLERAEPSTAAARLGEGHLGLVA 60 MLLK K VI+G A G+G STA LMA QGAR+ ILDL+ + AAA LG H+GL Sbjct: 1 MLLKGKAVVISGAASPRGIGRSTATLMAEQGARIAILDLDEEQARDAAASLGPEHIGLAC 60 Query: 61 DVTDKASCEAAAQAILQQFGRIDILVNNAGITQPAKFLDISGKDYDRILDVSLRGTLYMS 120 +V D SC+ AA + + FGR+++L N AGITQP K LDI D+DRILDV+LRG LY+S Sbjct: 61 NVADLDSCKRAAAEVTEAFGRVEVLCNIAGITQPVKTLDIGPADWDRILDVNLRGVLYLS 120 Query: 121 QAVLPAMRAQQGGSIVCISSVSAQRGGGILGGPHYSAAKAGVLGLARAMAREFGADGIRV 180 QA +P MR GGSI+C+SSVSAQRGGGI GGPHYSAAKAGVLGLA+AMAREFG DGIR+ Sbjct: 121 QAFIPHMRENGGGSIICMSSVSAQRGGGIFGGPHYSAAKAGVLGLAKAMAREFGPDGIRI 180 Query: 181 NCVTPGLISTDINKDILSAEKKAEIAQTIPLGRLGGPDDVGGVCVFLASDLSQYCTGITL 240 NCVTPGLI TDI L+ +A+I + IPL RLG DV G +FLASDL+ Y TG + Sbjct: 181 NCVTPGLIQTDITGGKLTDAMRADIIKGIPLSRLGDARDVAGAYLFLASDLASYITGAVI 240 Query: 241 DVNGGMLIH 249 DVNGGMLIH Sbjct: 241 DVNGGMLIH 249 >SMc00268 [IQR] COG1028 Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) Sme Sinorhizobium meliloti Length = 252 Score = 281 bits (718), Expect = 1e-75, Method: Compositional matrix adjust. Identities = 149/248 (60%), Positives = 180/248 (72%) Query: 2 LLKNKVAVITGGAGLNGLGFSTARLMAAQGARVVILDLERAEPSTAAARLGEGHLGLVAD 61 LL+ AVITG A GLG +TARL A GA V ILDL+ A+ AAA LG H+G+ + Sbjct: 5 LLEGNFAVITGAASRRGLGKATARLFAEHGATVAILDLDEADAREAAASLGPRHVGMACN 64 Query: 62 VTDKASCEAAAQAILQQFGRIDILVNNAGITQPAKFLDISGKDYDRILDVSLRGTLYMSQ 121 VTD AS A++ Q+GRIDILVNNAGITQP K ++I+ ++YD +LDV+LRGTLY SQ Sbjct: 65 VTDLASVRTVMDALVSQWGRIDILVNNAGITQPLKIMEIAPENYDAVLDVNLRGTLYCSQ 124 Query: 122 AVLPAMRAQQGGSIVCISSVSAQRGGGILGGPHYSAAKAGVLGLARAMAREFGADGIRVN 181 AV+P MR+++ G IV +SSVSAQRGGGI GGPHYSAAKAGVLGL +AMARE D +RVN Sbjct: 125 AVIPHMRSRKQGKIVNLSSVSAQRGGGIFGGPHYSAAKAGVLGLTKAMARELAPDNVRVN 184 Query: 182 CVTPGLISTDINKDILSAEKKAEIAQTIPLGRLGGPDDVGGVCVFLASDLSQYCTGITLD 241 + PG I+TDI +L+ EK EI IP+GR G DDV G +FLASDLS Y TG +D Sbjct: 185 AICPGFIATDITGGLLTPEKLEEIKAGIPMGRPGTADDVAGCALFLASDLSAYVTGSEVD 244 Query: 242 VNGGMLIH 249 VNGG LIH Sbjct: 245 VNGGSLIH 252 >TM1724 [IQR] COG1028 Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) Tma Thermotoga maritima Length = 246 Score = 173 bits (439), Expect = 3e-43, Method: Compositional matrix adjust. Identities = 103/256 (40%), Positives = 157/256 (61%), Gaps = 18/256 (7%) Query: 1 MLLKNKVAVITGGAGLNGLGFSTARLMAAQGARVVILDLERAEPSTAAARLGEGHLG--- 57 M L+ KV +ITG A +G+G +T L A +GA V+ D+ + E + + EG G Sbjct: 1 MRLEGKVCLITGAA--SGIGKATTLLFAQEGATVIAGDISK-ENLDSLVKEAEGLPGKVD 57 Query: 58 -LVADVTDKASCEAAAQAILQQFGRIDILVNNAGITQPAKFLDISGKDYDRILDVSLRGT 116 V +VTD+ + + ++Q++GRID+LVNNAGIT+ A + + +D+D +++V+L+G Sbjct: 58 PYVLNVTDRDQIKEVVEKVVQKYGRIDVLVNNAGITRDALLVRMKEEDWDAVINVNLKGV 117 Query: 117 LYMSQAVLPAMRAQQGGSIVCISSVSAQRGGGILGGP---HYSAAKAGVLGLARAMAREF 173 ++Q V+P M Q+ GSIV +SSV GI G P +Y+A+KAGV+G+ + A+E Sbjct: 118 FNVTQMVVPYMIKQRNGSIVNVSSVV-----GIYGNPGQTNYAASKAGVIGMTKTWAKEL 172 Query: 174 GADGIRVNCVTPGLISTDINKDILSAEKKAEIAQT-IPLGRLGGPDDVGGVCVFLASDLS 232 IRVN V PG I T + + + EK E A + IPLGR G P++V V +FLASD S Sbjct: 173 AGRNIRVNAVAPGFIETPMTEKL--PEKARETALSRIPLGRFGKPEEVAQVILFLASDES 230 Query: 233 QYCTGITLDVNGGMLI 248 Y TG + ++GG++I Sbjct: 231 SYVTGQVIGIDGGLVI 246 >BH2491 [IQR] COG1028 Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) Bha Bacillus halodurans Length = 246 Score = 171 bits (432), Expect = 2e-42, Method: Compositional matrix adjust. Identities = 102/251 (40%), Positives = 149/251 (59%), Gaps = 9/251 (3%) Query: 2 LLKNKVAVITGGAGLNGLGFSTARLMAAQGARVVIL---DLERAEPSTAAAR-LGEGHLG 57 +L+ K A++TG + G+G +TA +A GA VV+ + E+AE A + LG + Sbjct: 1 MLQGKTAIVTGAS--RGIGRATAMELARHGANVVVNYAGNKEKAEKVVAEIKELGVEAIA 58 Query: 58 LVADVTDKASCEAAAQAILQQFGRIDILVNNAGITQPAKFLDISGKDYDRILDVSLRGTL 117 + ADV D S +A + + FG +DILVNNAGIT+ F+ + +D+D ++D +L+G Sbjct: 59 IQADVADSESVQAMVKETIDTFGAVDILVNNAGITRDNLFMRMKEEDWDAVIDTNLKGVF 118 Query: 118 YMSQAVLPAMRAQQGGSIVCISSVSAQRGGGILGGPHYSAAKAGVLGLARAMAREFGADG 177 + S+AV M Q+ G I+ +SSV G G +Y AAKAGV+GL + +ARE Sbjct: 119 HCSKAVTRPMMKQRFGRIINVSSVVGAIGNA--GQANYVAAKAGVIGLTKTLARELANRN 176 Query: 178 IRVNCVTPGLISTDINKDILSAEKKAEIAQTIPLGRLGGPDDVGGVCVFLASDLSQYCTG 237 I VN V PG I TD+ + L + KA++ IPL RLG P++V FLASD + Y TG Sbjct: 177 ITVNAVAPGFIETDMTGE-LPEDVKAQMLGQIPLARLGQPEEVAKAVRFLASDDASYLTG 235 Query: 238 ITLDVNGGMLI 248 T+ VNGGM++ Sbjct: 236 QTIHVNGGMVM 246 >PM1916 [IQR] COG1028 Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) Pmu Pasteurella multocida Length = 242 Score = 168 bits (426), Expect = 1e-41, Method: Compositional matrix adjust. Identities = 98/247 (39%), Positives = 147/247 (59%), Gaps = 5/247 (2%) Query: 3 LKNKVAVITGGAGLNGLGFSTARLMAAQGARVVILDLERAEPSTAAARLGEGHLGLVADV 62 ++ K+A++TG G+G + A ++A+GA V+ + +A LGE GLV +V Sbjct: 1 MQGKIALVTGAT--RGIGRAIAEELSAKGAFVIGTATSEKGAESISAYLGEKGKGLVLNV 58 Query: 63 TDKASCEAAAQAILQQFGRIDILVNNAGITQPAKFLDISGKDYDRILDVSLRGTLYMSQA 122 +D AS E + I FG IDILVNNAGIT+ + + +++ I+ +L ++S+A Sbjct: 59 SDLASIETTLEKIKADFGEIDILVNNAGITRDNLLMRMKDEEWFDIMQTNLTSVYHLSKA 118 Query: 123 VLPAMRAQQGGSIVCISSVSAQRGGGILGGPHYSAAKAGVLGLARAMAREFGADGIRVNC 182 +L +M ++ G I+ I SV G G +Y AAKAG++G ++A+A+E + GI VN Sbjct: 119 MLRSMMKKRFGRIITIGSVVGSMGNP--GQTNYCAAKAGLIGFSKALAKEVASRGITVNV 176 Query: 183 VTPGLISTDINKDILSAEKKAEIAQTIPLGRLGGPDDVGGVCVFLASDLSQYCTGITLDV 242 V PG I+TD+ D+L+ E+KA I +P GRLG P D+ FLASD + Y TG TL V Sbjct: 177 VAPGFIATDMT-DVLTEEQKAGILSQVPAGRLGDPKDIAKAVAFLASDDAGYITGTTLHV 235 Query: 243 NGGMLIH 249 NGGM + Sbjct: 236 NGGMYTN 242