BLASTP 2.2.21 [Jun-14-2009] Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), "Gapped BLAST and PSI-BLAST: a new generation of protein database search programs", Nucleic Acids Res. 25:3389-3402. Reference for compositional score matrix adjustment: Altschul, Stephen F., John C. Wootton, E. Michael Gertz, Richa Agarwala, Aleksandr Morgulis, Alejandro A. Schaffer, and Yi-Kuo Yu (2005) "Protein database searches using compositionally adjusted substitution matrices", FEBS J. 272:5101-5109. Query= 0002.0144.p (337 letters) Database: COGmodified 192,987 sequences; 59,019,183 total letters Searching..................................................done Score E Sequences producing significant alignments: (bits) Value VC0262 [MG] COG0451 Nucleoside-diphosphate-sugar epimerases Vch ... 335 8e-92 PA3146 [MG] COG0451 Nucleoside-diphosphate-sugar epimerases Pae ... 207 3e-53 BMEI1237 [MG] COG0451 Nucleoside-diphosphate-sugar epimerases Bm... 152 8e-37 FN1694 [MG] COG0451 Nucleoside-diphosphate-sugar epimerases Fnu ... 125 1e-28 BH3715 [MG] COG0451 Nucleoside-diphosphate-sugar epimerases Bha ... 113 7e-25 >VC0262 [MG] COG0451 Nucleoside-diphosphate-sugar epimerases Vch Vibrio cholerae Length = 323 Score = 335 bits (859), Expect = 8e-92, Method: Compositional matrix adjust. Identities = 177/323 (54%), Positives = 215/323 (66%), Gaps = 8/323 (2%) Query: 14 MRILVTGASGFVGSALLRHLAPRPDLALRAALRTAASGGLLPAGVEVVETGDLGPQTNWH 73 ++ILVTGASGFVG +L A AL A R+ P E V D+ P T+W Sbjct: 9 LKILVTGASGFVGLRVLTQ-AQNIGYALVAQSRSQQ-----PYSFEQVLL-DITPNTDWE 61 Query: 74 AALTGIDTVVHCAARVHVMNETAGDPLSLFRRVNVEGSLALAQQARDAGVKRLVFLSSIK 133 AL G+D VVHCAARVH M ET D L +R VN +G+L LA+QA AGVKR +FLSSIK Sbjct: 62 RALVGVDCVVHCAARVHQMQETEADALKAYRDVNTQGTLNLAKQAVSAGVKRFIFLSSIK 121 Query: 134 VNGEQTAPGRPFTADDTPAPVDAYGISKMEAEQALMALAAEGGMEVVVIRPVLVYGPGVK 193 VNGEQT G F DD P D YG+SK EAEQ L+ LAAE G+EVV+IRP LVYG GVK Sbjct: 122 VNGEQTKAGSAFQHDDQHIPSDPYGLSKYEAEQQLLELAAETGLEVVIIRPPLVYGEGVK 181 Query: 194 ANFRSMMRWLQKGIPLPLGAITGNRRSLVALDNLVDLMTLCMHHPAAANEIFLVSDGEDL 253 ANF SMM W++K IPLPLGA+ GN RSLV LDNLVDL+ +C HP AA EIFLVSD D+ Sbjct: 182 ANFLSMMNWVKKQIPLPLGAV-GNMRSLVYLDNLVDLILVCCQHPKAAGEIFLVSDNHDV 240 Query: 254 STTELLRRMGQALGSPARLIPVPARVLEWGARLLGKGAVAQRLCGSLQVEIGKTRSVLDW 313 S T LLR + QA+ RL+P+P L+W RLLGK + QRLCG+LQ++I T+ L W Sbjct: 241 SLTTLLRTIAQAMQIRPRLLPIPQTGLQWLLRLLGKPELGQRLCGNLQLDIAHTQKTLHW 300 Query: 314 SPPVSTDVALRRAASAVYADAER 336 SPPVS + + R + + + + Sbjct: 301 SPPVSFEQGIARTVNFYLSQSSK 323 >PA3146 [MG] COG0451 Nucleoside-diphosphate-sugar epimerases Pae Pseudomonas aeruginosa Length = 316 Score = 207 bits (526), Expect = 3e-53, Method: Compositional matrix adjust. Identities = 125/322 (38%), Positives = 177/322 (54%), Gaps = 8/322 (2%) Query: 17 LVTGASGFVGSALLRHLAPRPDLALRAALRTAASGGLLPAGVEVVETGDLGPQTNWHAAL 76 +VTGASGFVGSAL LA +P+ V +E DL + Sbjct: 1 MVTGASGFVGSALCCELA---RTGYAVIAVVRRVVERIPS-VTYIEA-DLTDPATFAGEF 55 Query: 77 TGIDTVVHCAARVHVMNETAGDPLSLFRRVNVEGSLALAQQARDAGVKRLVFLSSIKVNG 136 +D ++H A R H++ + DPL+ FR VN + ++ LA +A +AGVKR VF+SSI VNG Sbjct: 56 PTVDCIIHLAGRAHILTDKVADPLAAFREVNRDATVRLATRALEAGVKRFVFVSSIGVNG 115 Query: 137 EQTAPGRPFTADDTPAPVDAYGISKMEAEQALMALAAEGGMEVVVIRPVLVYGPGVKANF 196 T + F D P Y ISK EAEQ L L GME+VV+RP L+Y NF Sbjct: 116 NSTRQ-QAFNEDSPAGPHAPYAISKYEAEQELGTLLRGKGMELVVVRPPLIYANDAPGNF 174 Query: 197 RSMMRWLQKGIPLPLGAITGNRRSLVALDNLVDLMTLCMHHPAAANEIFLVSDGEDLSTT 256 +++ + G+PLPL + N RSLV+ N+V ++LC HP AA E+FLV+DGED+S Sbjct: 175 GRLLKLVASGLPLPLDGVR-NARSLVSRRNIVGFLSLCAEHPDAAGELFLVADGEDVSIA 233 Query: 257 ELLRRMGQALGSPARLIPVPARVLEWGARLLGKGAVAQRLCGSLQVEIGKTRSVLDWSPP 316 +++ + + +G L PA +L+ LLGK ++ ++LCGSLQV+ K R +L W P Sbjct: 234 QMIEALSRGMGRRPALFTFPAVLLKLVMCLLGKASMHEQLCGSLQVDASKARRLLGWVPV 293 Query: 317 VSTDVALRRAA-SAVYADAERR 337 + L+ A + ERR Sbjct: 294 ETIGAGLQAAGREYILRQRERR 315 >BMEI1237 [MG] COG0451 Nucleoside-diphosphate-sugar epimerases Bme Brucella melitensis Length = 289 Score = 152 bits (385), Expect = 8e-37, Method: Compositional matrix adjust. Identities = 103/290 (35%), Positives = 157/290 (54%), Gaps = 35/290 (12%) Query: 14 MRILVTGASGFVGSALLRHLAPRPDLALRAALRTAASGGLLPAGVEVVETGDLGPQTNWH 73 MR+ VTGA+GFVGSAL+ L AA ++P E + D Sbjct: 1 MRVAVTGAAGFVGSALVSKL-------------EAAGHNVMPLSREDIHDADF------- 40 Query: 74 AALTGIDTVVHCAARVHVMNETAGDPLSLFRRVNVEGSLALAQQARDAGVKRLVFLSSIK 133 +G++TVVHCAA H D + F VN ++ LA++A+ GV+R VF+S+I Sbjct: 41 ---SGVETVVHCAALAHRTGAERPDAKT-FDAVNHRLAVELARKAKAQGVRRFVFVSTIY 96 Query: 134 VNGEQTAPGRPFTADDTP-APVDAYGISKMEAEQALMALAAEGGMEVVVIRPVLVYGPGV 192 +P P D P AP D YG +K AE AL+A+ G+++V+ RPVLVYGPG Sbjct: 97 TIAGNPSPLAP----DMPLAPRDDYGRAKARAEAALLAMT---GLDIVIARPVLVYGPGA 149 Query: 193 KANFRSMMRWLQKGIPLPLGAITGNRRSLVALDNLVDLMTLCMHHPA--AANEIFLVSDG 250 +AN +++M+ IPLP GA N+RS V+L+N+ + PA A +F +++ Sbjct: 150 RANLKALMKLCDSRIPLPFGA-ANNKRSFVSLENVARALIFLSEAPAEKVAGRVFHLAEP 208 Query: 251 EDLSTTELLRRMGQALGSPARLIPVPARVLEWGARLLGKGAVAQRLCGSL 300 + ST E++ + A+ PARL+PVP ++++ +GK + +L G+L Sbjct: 209 QPRSTREIVGKARAAMQRPARLVPVPPLIMKFLLGGIGKRGLYDQLFGNL 258 >FN1694 [MG] COG0451 Nucleoside-diphosphate-sugar epimerases Fnu Fusobacterium nucleatum Length = 290 Score = 125 bits (314), Expect = 1e-28, Method: Compositional matrix adjust. Identities = 95/318 (29%), Positives = 155/318 (48%), Gaps = 37/318 (11%) Query: 14 MRILVTGASGFVGSALLRHLAPRPDLALRAALRTAASGGLLPAGVEVVETGDLGPQTNWH 73 + +++TGASGF+GS + + ++P DL + + Sbjct: 4 INLMITGASGFIGSNFID--------------KYKNEYNIIPV--------DLLKEKPEN 41 Query: 74 AALTGIDTVVHCAARVHVMNETAGDPLSLFRRVNVEGSLALAQQARDAGVKRLVFLSSIK 133 + G+D ++H AA VH M A + + VN E + +A++A+ GVK VF S++K Sbjct: 42 LSFDGVDCILHLAALVHQMKGAAKEK---YFEVNTELTRRIAEKAKIEGVKHFVFYSTVK 98 Query: 134 VNG-EQTAPGRPFTADDTPA---PVDAYGISKMEAEQALMALAAEGGMEVVVIRPVLVYG 189 V G + + ++ D YG SK EAE+ L L + V +IRP +VYG Sbjct: 99 VYGYDGDLKNHNYVLNELSECNPKNDPYGESKWEAEKILKKLENDN-FRVAIIRPPMVYG 157 Query: 190 PGVKANFRSMMRWLQKGIPLPLGAITGNRRSLVALDNLVDLMTLCMHHPAAANEIFLVSD 249 GVK N S+++ ++K LP N+RSLV ++NL+ L L ++ A IFL D Sbjct: 158 KGVKGNMESLIKLIKKSPILPF-KYDKNKRSLVNINNLLYLTYLVINQQAQG--IFLPLD 214 Query: 250 GEDLSTTELLRRMGQALGSPARLIPVP-ARVLEWGARLLGKGAVAQRLCGSLQVEIGKTR 308 ++LS E+ + +A+G R + + + L W L K + RL GSLQ KT+ Sbjct: 215 EKNLSLKEIFEGIEEAIG--IRRVNIRLFKPLFWMLTKL-KPKIMLRLYGSLQFNNEKTK 271 Query: 309 SVLDWSPPVSTDVALRRA 326 S +++ P +S ++ A Sbjct: 272 SEINYLPIISYKNGIKEA 289 >BH3715 [MG] COG0451 Nucleoside-diphosphate-sugar epimerases Bha Bacillus halodurans Length = 282 Score = 113 bits (282), Expect = 7e-25, Method: Compositional matrix adjust. Identities = 79/295 (26%), Positives = 146/295 (49%), Gaps = 45/295 (15%) Query: 15 RILVTGASGFVGSALLRHLAPRPD------LALRAALRTAASGGLLPAGVEVVETGDLGP 68 +L+TGA+ ++G + LA P+ ++LR GDL Sbjct: 3 NVLITGANSYIGLSFKNWLAKEPEKYKVDSISLR---------------------GDLWK 41 Query: 69 QTNWHAALTGIDTVVHCAARVHVMNETAGDPLSLFRRVNVEGSLALAQQARDAGVKRLVF 128 + ++ + D ++H A H+ ET + L+ +VN + + A++A+D G+K+ +F Sbjct: 42 EKDF----SQYDVLLHAAGIAHI-KETKENK-ELYFKVNRDVAYEAAKKAKDEGIKQFIF 95 Query: 129 LSSIKVNGEQTAPGRPFTADDTPAPVDAYGISKMEAEQALMALAAEGGMEVVVIRPVLVY 188 LSS+ V G++ D P P YG SK++AE+ L+ + + +VV IRP ++Y Sbjct: 96 LSSMSVYGKENG---IIDLDTLPKPTSNYGESKLQAEK-LIEMLDDDSFKVVTIRPPMIY 151 Query: 189 GPGVKANFRSMMRWLQKGIPLPLGAITGNRRSLVALDNLVDLMTLCMHHPAAANEIFLVS 248 G G K N+ + + +K LP+ N RS++ ++NL + M L + + A +FL Sbjct: 152 GKGCKGNYPKLAKLARK---LPVFPDVENERSMIHIENLCEFMKLIIDNNDAG--LFLPQ 206 Query: 249 DGEDLSTTELLRRMGQALGSPARLIPVPARVLEWGARLLGKGAVAQRLCGSLQVE 303 + + + T+E++R +G+ G +L VL +GK V ++ G+L+ + Sbjct: 207 NDDFVKTSEMVRLIGETNGKRIKLTKFFNPVLNL---FIGKIGVVNKVFGNLKYK 258