BLASTP 2.2.21 [Jun-14-2009] Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), "Gapped BLAST and PSI-BLAST: a new generation of protein database search programs", Nucleic Acids Res. 25:3389-3402. Reference for compositional score matrix adjustment: Altschul, Stephen F., John C. Wootton, E. Michael Gertz, Richa Agarwala, Aleksandr Morgulis, Alejandro A. Schaffer, and Yi-Kuo Yu (2005) "Protein database searches using compositionally adjusted substitution matrices", FEBS J. 272:5101-5109. Query= 0002.0095.p (367 letters) Database: COGmodified 192,987 sequences; 59,019,183 total letters Searching..................................................done Score E Sequences producing significant alignments: (bits) Value PA0142 [FR] COG0402 Cytosine deaminase and related metal-depende... 224 3e-58 RSc2119 [FR] COG0402 Cytosine deaminase and related metal-depend... 211 2e-54 VNG2249G [FR] COG0402 Cytosine deaminase and related metal-depen... 137 4e-32 aq_587 [FR] COG0402 Cytosine deaminase and related metal-depende... 137 4e-32 AF0997 [FR] COG0402 Cytosine deaminase and related metal-depende... 135 1e-31 >PA0142 [FR] COG0402 Cytosine deaminase and related metal-dependent hydrolases Pae Pseudomonas aeruginosa Length = 449 Score = 224 bits (571), Expect = 3e-58, Method: Compositional matrix adjust. Identities = 140/356 (39%), Positives = 193/356 (54%), Gaps = 16/356 (4%) Query: 1 MNTFLIRNLQAILTGLPAEAARHAGPDIRVADGVIAAI---GKLDALPGENVIDAGDCVA 57 M+ IRN AI T +AA + V DG I + G+ A P + DA V Sbjct: 1 MSRTWIRNPLAIFTANGLDAA----GGLVVEDGRIVELLGAGQQPAQPCASQFDASRHVV 56 Query: 58 YPAWVNTHHHLFQSLLKGDPLGINATLTPWLAATPYRYRAKFDAELFRLAARIGMVELMR 117 P VNTHHH +Q+L + +N L PWL T Y A+ E LA ++ + EL+ Sbjct: 57 LPGLVNTHHHFYQTLTRAWAPVVNQPLFPWLK-TLYPVWARLTPEKLELATKVALAELLL 115 Query: 118 SGCGTIADHNYLYYPGMPFDTSEILFEEAEKLGLRFVLCRGTATRTRQLEAELPSALRPE 177 SGC T ADH+YL+ PG ++ E+LG+R +L RG+ + + + LP + Sbjct: 116 SGCTTAADHHYLF-PGGLEQAIDVQAGVVEELGMRAMLTRGSMSLGEK-DGGLPPQQTVQ 173 Query: 178 TLDAFLTDMQRL-----ARXPASMRRVVMAPTTPLYSAAPEEMRTIADAARELGVRLHSH 232 + L D +RL R + ++ +AP +P +S PE MR A+ A VRLH+H Sbjct: 174 EAETILADSERLIARYHQRGDGARVQIALAPCSP-FSVTPEIMRASAEVAARHDVRLHTH 232 Query: 233 LSETVGYQDSAHAMHGCRPVEFCERIGWLGPDVWFAHLVKLDAEEIALLGRTGTGIAHCP 292 L+ET+ +D G R V++ + +GWLGP W AH + +AEEI LG GTGI HCP Sbjct: 233 LAETLDEEDFCLQRFGLRTVDYLDSVGWLGPRTWLAHGIHFNAEEIRRLGEAGTGICHCP 292 Query: 293 QSNGRLGSGIAPIRALEAAGVPVSIGVDGAASNEAADMISETHAAWLMQRARRGQE 348 SN RL SGI P LEAAG P+ +GVDG+ASN+A++MI E A +QR R G E Sbjct: 293 SSNMRLASGICPTVELEAAGAPIGLGVDGSASNDASNMILEARQALYLQRLRYGAE 348 >RSc2119 [FR] COG0402 Cytosine deaminase and related metal-dependent hydrolases Rso Ralstonia solanacearum Length = 474 Score = 211 bits (538), Expect = 2e-54, Method: Compositional matrix adjust. Identities = 134/321 (41%), Positives = 174/321 (54%), Gaps = 15/321 (4%) Query: 37 AIGKLDALPGENVIDAGDCVAYPAWVNTHHHLFQSLLKGDPLGINATLTPWLAATPYRYR 96 AIG+ P V++ D V P VNTHHH+ QSL + P +A L WL Y Sbjct: 58 AIGR----PNVRVLELRDHVVTPGLVNTHHHMAQSLTRALPAAQDAELFGWLTHL-YPVW 112 Query: 97 AKFDAELFRLAARIGMVELMRSGCGTIADHNYLYYPGMPFDTSEILFEEAEKLGLRFVLC 156 A E+ R++ M ELM SGC T +DH YLY G D + E A ++G+RF Sbjct: 113 AGLTPEMVRVSTLTAMAELMLSGCTTSSDHLYLYPNGCRLDDA---IEAARQIGMRFHAA 169 Query: 157 RGTATRTRQLEAELPSALRPETLDAFLTDMQRLARX-----PASMRRVVMAPTTPLYSAA 211 RG+ + R + LP E A L + QRL +M R+V+AP +P +S + Sbjct: 170 RGSMSVGRS-QGGLPPDRVVEGEPAILRETQRLIETWHDADRHAMLRIVVAPCSP-FSVS 227 Query: 212 PEEMRTIADAARELGVRLHSHLSETVGYQDSAHAMHGCRPVEFCERIGWLGPDVWFAHLV 271 + MR A AR GV +H+HL+E + G P E+ E +GW+G DVW AH V Sbjct: 228 RDLMRESARLARSYGVSMHTHLAENDSDIAYSRERFGMTPAEYAEDLGWVGHDVWHAHCV 287 Query: 272 KLDAEEIALLGRTGTGIAHCPQSNGRLGSGIAPIRALEAAGVPVSIGVDGAASNEAADMI 331 KLDA I L RTGTG+AHCP SN RL SGIAP+RA+ AG PV +GVDG+ASN+ A M+ Sbjct: 288 KLDAHGIELFARTGTGVAHCPCSNMRLASGIAPVRAMRDAGAPVGLGVDGSASNDGAHML 347 Query: 332 SETHAAWLMQRARRGQEATPA 352 E A L+ R G A A Sbjct: 348 GEARQAMLLARVGFGPAAMGA 368 >VNG2249G [FR] COG0402 Cytosine deaminase and related metal-dependent hydrolases Hbs Halobacterium sp. NRC-1 Length = 431 Score = 137 bits (345), Expect = 4e-32, Method: Compositional matrix adjust. Identities = 105/330 (31%), Positives = 154/330 (46%), Gaps = 29/330 (8%) Query: 26 PDIRVADG---------VIAAIGKLDALPGENVIDAGDCVAYPAWVNTHHHLFQSLLKGD 76 PD V+DG I A+G D G+ +DA C+ P VN H H+ +LL+G Sbjct: 15 PDFTVSDGDVLVDRDAGEIIAVG--DTPAGDETVDAAGCLVMPGLVNAHCHVAMTLLRG- 71 Query: 77 PLGINATLTPWLAATPYRYRAKFDAELFRLAARIGMVELMRSGCGTIADHNYLYYPGMPF 136 + L WL + A+ R AR+G+VE++R+G AD M F Sbjct: 72 -YADDKQLDAWLQEDIWPAEAELADGDIRAGARLGLVEMIRAGTTAFAD--------MYF 122 Query: 137 DTSEILFEEAEKLGLRFVLCRGTATRTRQLEAELPSALRPETLDAFLTDMQRLARXPASM 196 + E++ + + GLR + G T + +A+ A E L + R A Sbjct: 123 EVPEVV-DAITEAGLRARVGHGVVTVGKD-DAD-AVADNEEAL-----SVAREFNDAADG 174 Query: 197 RRVVMAPTTPLYSAAPEEMRTIADAARELGVRLHSHLSETVGYQDSAHAMHGCRPVEFCE 256 R L + E +R AARE V +H H +ET + HG RP+E+ Sbjct: 175 RITSAYMPHSLTTVGEEYLREFVAAAREADVPVHFHANETEQEVEPIVDEHGSRPLEYAA 234 Query: 257 RIGWLGPDVWFAHLVKLDAEEIALLGRTGTGIAHCPQSNGRLGSGIAPIRALEAAGVPVS 316 +G L D + AH V A EI LL +G + HCP SN +L SG+AP++A+ AGV V+ Sbjct: 235 DVGLLAEDDFLAHGVHTTAGEIELLAESGASVVHCPASNMKLASGMAPVQAMREAGVTVA 294 Query: 317 IGVDGAASNEAADMISETHAAWLMQRARRG 346 +G DGAASN D+ E A ++ + + G Sbjct: 295 LGTDGAASNNDLDVFDELRDAAMLGKLQTG 324 >aq_587 [FR] COG0402 Cytosine deaminase and related metal-dependent hydrolases Aae Aquifex aeolicus Length = 430 Score = 137 bits (345), Expect = 4e-32, Method: Compositional matrix adjust. Identities = 97/311 (31%), Positives = 151/311 (48%), Gaps = 24/311 (7%) Query: 27 DIRVADGVIAAIGKLDALPGENVIDAGDCVAYPAWVNTHHHLFQSLLKGDPLGINATLTP 86 DI V DG I IGK + I+ +A+P++ N H H+ +LL+G LG + L Sbjct: 21 DIAVKDGKIEKIGKNIVGEAKYTINGKGKIAFPSFANMHTHISMTLLRG--LGADLPLHD 78 Query: 87 WLAATPYRYRAKF-DAELFRLAARIGMVELMRSGCGTIADHNYLYYPGMPFDTSEILFEE 145 WL + +F E + A +G+VE +RSG D + E + E Sbjct: 79 WLQKVIWPLEGEFVSPEFVKDGALLGIVESIRSGTTLFMDMYFF---------EEAVAEA 129 Query: 146 AEKLGLRFVLCRGTATRTRQLEAELPSALRPETLDAFLTDMQRLARXPASMRRV--VMAP 203 E +G+R L G + P+ + +T + ++ ++ A + V V+ P Sbjct: 130 CEDVGIRAGLGFGIL--------DFPTKV-AKTPEEYIQRARKFAEEFKNRELVFPVICP 180 Query: 204 TTPLYSAAPEEMRTIADAARELGVRLHSHLSETVGYQDSAHAMHGCRPVEFCERIGWLGP 263 P Y+ +P +R + A E G+ LH H++ET + +G PVE E IG+L Sbjct: 181 HAP-YTCSPNTLRMAKELADEYGLLLHIHVAETKEEVERIKEQYGKTPVEHLESIGFLDK 239 Query: 264 DVWFAHLVKLDAEEIALLGRTGTGIAHCPQSNGRLGSGIAPIRALEAAGVPVSIGVDGAA 323 +V AH+V +E +L IAHCP+SN +L SGIAP+ G+ V++G DGAA Sbjct: 240 NVLCAHMVWTTEKEREILKERDVKIAHCPESNLKLASGIAPVPDYVKRGITVTLGTDGAA 299 Query: 324 SNEAADMISET 334 SN+ +M+ ET Sbjct: 300 SNDNLNMLEET 310 >AF0997 [FR] COG0402 Cytosine deaminase and related metal-dependent hydrolases Afu Archaeoglobus fulgidus Length = 416 Score = 135 bits (340), Expect = 1e-31, Method: Compositional matrix adjust. Identities = 112/364 (30%), Positives = 166/364 (45%), Gaps = 29/364 (7%) Query: 1 MNTFLIRNLQAILTGLPAEAARHAGPDIRVADGVIAAIGKLDALPGENVIDAGDCVAYPA 60 M+ +IRN + G E + + V I + K + GE IDA C+ P Sbjct: 1 MHDLVIRNGLCFINGEFVECS------VGVDGNRITHVAK-EVERGEIEIDAAGCLVMPG 53 Query: 61 WVNTHHHLFQSLLKGDPLGINATLTPWLAATPYRYRAKFDAELFRLAARIGMVELMRSGC 120 N H H +LL+G G+ L WL + A+ D + + VE+++SG Sbjct: 54 CFNAHTHAAMTLLRGYAEGL--PLREWLEKV-WEVEARLDEDAVYWGTMLACVEMLKSGV 110 Query: 121 GTIADHNYLYYPGMPFDTSEILFEEAEKLGLRFVLCRGTATRTRQLEAELPSALRPETLD 180 AD Y++ + E + G+R VL G A R + A R E L+ Sbjct: 111 TAFADM-YIHMDAVA--------EAVGESGMRAVLGYGMADRGDEERA------RKE-LE 154 Query: 181 AFLTDMQRLARXPASMRRVVMAPTTPLYSAAPEEMRTIADAARELGVRLHSHLSETVGYQ 240 L ++ ++AP P Y+ +PE ++ ++DA+++ G H H+SET+ Sbjct: 155 IGLEFAEKWNGGFEGRVTTMLAPHAP-YTCSPEFLKVVSDASKDKGFLKHIHVSETLWEV 213 Query: 241 DSAHAMHGCRPVEFCERIGWLGPDVWFAHLVKLDAEEIALLGRTGTGIAHCPQSNGRLGS 300 +G RPVEF + IG+L AH V L E+ +L G +AHCP SN +L S Sbjct: 214 KEVRERYGKRPVEFLDSIGFLDSSTVLAHAVWLSEAEMKILAERGVSVAHCPTSNLKLSS 273 Query: 301 GIAPIRALEAAGVPVSIGVDGAASNEAADMISETHAAWLMQRARRGQEATPA-FRGGAFE 359 GIA + L GV V IG DGAASN ++S+ L+Q RG+ P + A E Sbjct: 274 GIAKVSELLEMGVNVGIGTDGAASNNMLSVLSDARVGALLQNL-RGRTLKPGHWLEMATE 332 Query: 360 GGXR 363 GG R Sbjct: 333 GGYR 336