BLASTP 2.2.21 [Jun-14-2009] Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), "Gapped BLAST and PSI-BLAST: a new generation of protein database search programs", Nucleic Acids Res. 25:3389-3402. Reference for compositional score matrix adjustment: Altschul, Stephen F., John C. Wootton, E. Michael Gertz, Richa Agarwala, Aleksandr Morgulis, Alejandro A. Schaffer, and Yi-Kuo Yu (2005) "Protein database searches using compositionally adjusted substitution matrices", FEBS J. 272:5101-5109. Query= 0002.0055.p (223 letters) Database: COGmodified 192,987 sequences; 59,019,183 total letters Searching..................................................done Score E Sequences producing significant alignments: (bits) Value PA3975 [H] COG0351 Hydroxymethylpyrimidine/phosphomethylpyrimidi... 106 5e-23 SMb20962 [H] COG0351 Hydroxymethylpyrimidine/phosphomethylpyrimi... 101 1e-21 AGl3056 [H] COG0351 Hydroxymethylpyrimidine/phosphomethylpyrimid... 100 3e-21 HI0416 [H] COG0351 Hydroxymethylpyrimidine/phosphomethylpyrimidi... 91 2e-18 PH1155_1 [H] COG0351 Hydroxymethylpyrimidine/phosphomethylpyrimi... 91 2e-18 >PA3975 [H] COG0351 Hydroxymethylpyrimidine/phosphomethylpyrimidine kinase Pae Pseudomonas aeruginosa Length = 265 Score = 106 bits (264), Expect = 5e-23, Method: Compositional matrix adjust. Identities = 81/210 (38%), Positives = 111/210 (52%), Gaps = 20/210 (9%) Query: 4 QAQVLIDRFDIAAVKLGIAGSRENAEVIAGLIRQLRARDPHLPVVLDPVLANGKGDQLSR 63 QA ++ +AAVKLG+ GS E + +A ++ A PHLPVV DPVL G G L + Sbjct: 67 QANAVLADLPVAAVKLGMLGSLEMVDTVA----EILAAHPHLPVVCDPVLRAGGGGALGK 122 Query: 64 DDAARVI-EPLYELATVITPNLNEARRLCGDVE-PARQAALLMERGCAHVLLKGGHGPQE 121 D + E L AT+ TPNL EAR L E A Q A + C H+L+ GGHG E Sbjct: 123 GDVGFAMRERLLPRATIATPNLPEARLLADLPEGSADQCAERLLEHCEHLLITGGHG-DE 181 Query: 122 QDVINRWFGQLFRSEFAEEAIESARWRWT--RLPDEFHGSGCTLAAALSACLARGLPMRE 179 +V NR + + + +R +T RLP +HGSGCTLA+AL+ +A G + Sbjct: 182 SEVHNRLYSR-----------DGSRRTFTCQRLPGSYHGSGCTLASALAGRIALGEALHG 230 Query: 180 AIDLAQQYTQHALSTSYAIAEGQRIPNRVP 209 A+ A YT L + + GQ +P R+P Sbjct: 231 AVQSALDYTWRTLRDAESPGHGQYVPRRLP 260 >SMb20962 [H] COG0351 Hydroxymethylpyrimidine/phosphomethylpyrimidine kinase Sme Sinorhizobium meliloti Length = 266 Score = 101 bits (252), Expect = 1e-21, Method: Compositional matrix adjust. Identities = 79/209 (37%), Positives = 108/209 (51%), Gaps = 22/209 (10%) Query: 1 VRHQAQVLIDRFDIAAVKLGIAGSRENAEVIAGLIRQLRARDPHLPVVLDPVLANGKGDQ 60 V Q + D+ AVK+G+ RE IA +R+ R V+DPV+ GD Sbjct: 59 VSAQMDAVFSDLDVKAVKIGMVSRRETIAAIADGLRRFGKR-----AVVDPVMVATSGDA 113 Query: 61 LSRDDA-ARVIEPLYELATVITPNLNEA-----RRLCGD-VEPARQAALLMERGCAHVLL 113 L R DA A +IE L LA V+TPNL EA R + GD E ARQA +M G VL+ Sbjct: 114 LLRPDAVAALIEELLPLALVVTPNLAEAALMTGRAIAGDEAEMARQAEAIMRTGAHAVLV 173 Query: 114 KGGHGPQEQDVINRWFGQLFRSEFAEEAIESARWRWTRLPDEFHGSGCTLAAALSACLAR 173 KGGH + Q+ + +F IE TR HG+GCTL+AA++A LA+ Sbjct: 174 KGGH-LKGQEATDLFFDGDTLVRLPAGRIE------TR---NDHGTGCTLSAAIAAGLAK 223 Query: 174 GLPMREAIDLAQQYTQHALSTSYAIAEGQ 202 G+P+ EA+ A+ Y A+S + + GQ Sbjct: 224 GVPLIEAVSAAKAYLHAAISAADRLEIGQ 252 >AGl3056 [H] COG0351 Hydroxymethylpyrimidine/phosphomethylpyrimidine kinase Atu Agrobacterium tumefaciens strain C58 (Cereon) Length = 265 Score = 100 bits (248), Expect = 3e-21, Method: Compositional matrix adjust. Identities = 74/208 (35%), Positives = 106/208 (50%), Gaps = 26/208 (12%) Query: 4 QAQVLIDRFDIAAVKLGIAGSRENAEVIAGLIRQLRARDPHLPVVLDPVLANGKGDQLSR 63 Q + + AVK+G+ E IA + +LR + PVVLDPV+ GD+L Sbjct: 62 QMDAVFSDLAVNAVKIGMV---SRIETIAAIAERLRQQSQ--PVVLDPVMVATSGDRLLH 116 Query: 64 DDAARVI-EPLYELATVITPNLNEARRLCG------DVEPARQAALLMERGCAHVLLKGG 116 +DA + L LA ++TPNL EA L G + E RQA L++ G VL+KGG Sbjct: 117 EDAIETLRHALLPLAAIVTPNLPEAALLTGTPIAETEQEITRQAELILNAGAKAVLIKGG 176 Query: 117 HG--PQEQDVINRWFGQLFRSEFAEEAIESARWRWTRLPDEFHGSGCTLAAALSACLARG 174 HG P+ D + FA+ A+++ ++ HG+GCTLAAA++A LA G Sbjct: 177 HGDGPESTDYL-----------FADGAMQALSAPRVETKND-HGTGCTLAAAITAHLAMG 224 Query: 175 LPMREAIDLAQQYTQHALSTSYAIAEGQ 202 +REA+ LA+ Y AL +A G Sbjct: 225 HELREAVGLAKDYLNGALEAGRGLAVGS 252 >HI0416 [H] COG0351 Hydroxymethylpyrimidine/phosphomethylpyrimidine kinase Hin Haemophilus influenzae Length = 269 Score = 91.3 bits (225), Expect = 2e-18, Method: Compositional matrix adjust. Identities = 65/214 (30%), Positives = 108/214 (50%), Gaps = 18/214 (8%) Query: 1 VRHQAQVLIDRFDIAAVKLGIAGSRENAEVIAGLIRQLRARDPHLPVVLDPVL-ANGKGD 59 ++ Q + + + F IA+ K+G+ G+ E E +A + A P +VLDPV+ A G Sbjct: 61 IQAQLEAVKNDFQIASCKIGMLGNAEIIECVADFL----ADKPFGTLVLDPVMIAKGGAP 116 Query: 60 QLSRDDAARVIEPLYELATVITPNLNEARRLCG-----DVEPARQAALLMERGCAHVLLK 114 L R + + + L LA VITPN+ EA L G D+ + A L ++G +V++K Sbjct: 117 LLQRQAVSALSQKLLPLADVITPNIPEAEALTGIAIVDDISIQQAAKALQKQGAKNVIIK 176 Query: 115 GGHGPQEQ-DVINRWFGQLFRSEFAEEAIESARWRWTRLPDEFHGSGCTLAAALSACLAR 173 GGH Q ++ W + ++ ++S R+ HG+GCT +A L+A LA+ Sbjct: 177 GGHSLNSQSELCQDW---VLLADGRHFTLQSPRFNTPHT----HGTGCTFSACLTAELAK 229 Query: 174 GLPMREAIDLAQQYTQHALSTSYAIAEGQRIPNR 207 G P++ A+ A+ + A+S I +G N Sbjct: 230 GEPLQSAVKTAKDFITAAISHPLNIGQGHGPTNH 263 >PH1155_1 [H] COG0351 Hydroxymethylpyrimidine/phosphomethylpyrimidine kinase Pho Pyrococcus horikoshii Length = 260 Score = 90.9 bits (224), Expect = 2e-18, Method: Compositional matrix adjust. Identities = 64/211 (30%), Positives = 112/211 (53%), Gaps = 27/211 (12%) Query: 1 VRHQAQVLIDRFDIAAVKLGIAGSRENAEVIAGLIRQLRARDPHLPVVLDPVLANGKGDQ 60 V Q +V+ + + A K G+ NAE+I + + ++ D P+V+DPV+ G Sbjct: 61 VSEQIRVVAEDIGVDAAKTGM---LSNAEIIKAVAKTVKNYD--FPLVVDPVMIAKSGAP 115 Query: 61 LSRDDAAR-VIEPLYELATVITPNLNEARRLCG----DVEPARQAA--LLMERGCAHVLL 113 L R+DA +I+ + LAT++TPN EA +L G +V A+ AA + E G V++ Sbjct: 116 LLREDAVDALIKYILPLATLVTPNRFEAEKLTGMEIRNVNDAKLAAKKIAEETGAKAVIV 175 Query: 114 KGGH--GPQEQDVINRWFGQLFRSEFAEEAIESARWRWTRLPDEFHGSGCTLAAALSACL 171 KGGH G + DV+ + ++ +R ++ HG+GC+ +AA++A L Sbjct: 176 KGGHLEGKEAIDVL--YHNGAYK-----------LYRAPKVDGCTHGTGCSFSAAITANL 222 Query: 172 ARGLPMREAIDLAQQYTQHALSTSYAIAEGQ 202 A+GL + +A+ +A+++ +ST + I G Sbjct: 223 AKGLSLEDAVSVAKEFITLGISTGHKIGHGH 253