BLASTP 2.2.17 [Aug-26-2007] Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), "Gapped BLAST and PSI-BLAST: a new generation of protein database search programs", Nucleic Acids Res. 25:3389-3402. Reference for composition-based statistics: Schaffer, Alejandro A., L. Aravind, Thomas L. Madden, Sergei Shavirin, John L. Spouge, Yuri I. Wolf, Eugene V. Koonin, and Stephen F. Altschul (2001), "Improving the accuracy of PSI-BLAST protein database searches with composition-based statistics and other refinements", Nucleic Acids Res. 29:2994-3005. Query= 0001.5406.p (280 letters) Database: All non-redundant GenBank CDS translations+PDB+SwissProt+PIR+PRF excluding environmental samples from WGS projects 15,459,386 sequences; 5,307,515,862 total letters Searching..................................................done Score E Sequences producing significant alignments: (bits) Value ref|YP_003777664.1| 5,10-methylenetetrahydrofolate reductase oxi... 528 e-148 ref|YP_004754671.1| 5,10-methylenetetrahydrofolate reductase [Co... 483 e-134 ref|YP_001354884.1| 5,10-methylenetetrahydrofolate reductase (FA... 464 e-129 ref|YP_001101181.1| 5,10-methylenetetrahydrofolate reductase [He... 464 e-129 ref|ZP_08273864.1| 5,10-methylenetetrahydrofolate reductase [Oxa... 459 e-127 >ref|YP_003777664.1| 5,10-methylenetetrahydrofolate reductase oxidoreductase [Herbaspirillum seropedicae SmR1] gb|ADJ65756.1| 5,10-methylenetetrahydrofolate reductase oxidoreductase protein [Herbaspirillum seropedicae SmR1] Length = 282 Score = 528 bits (1359), Expect = e-148, Method: Composition-based stats. Identities = 261/278 (93%), Positives = 267/278 (96%) Query: 2 STHNFSIEFFPPKTAEGAEKLRATRARLAALAPKYFSVTFGAGGSTQQGTRDTVLEIIGE 61 STHNFSIEFFPPKTAEGAEKLRATRARLAAL PKYFSVTFGAGGSTQQGTRDTVLEI+ E Sbjct: 4 STHNFSIEFFPPKTAEGAEKLRATRARLAALQPKYFSVTFGAGGSTQQGTRDTVLEIVSE 63 Query: 62 GHEAAPHLSCIGSSRASLRAILEDYRAQGIKRLVALRGDLPSGYGAMDQASSEFRHANEL 121 GHEAAPHLSCIGSSRASLRAILEDYRA GIKRLVALRGDLPSGYGAMDQASSEFR+ANEL Sbjct: 64 GHEAAPHLSCIGSSRASLRAILEDYRANGIKRLVALRGDLPSGYGAMDQASSEFRYANEL 123 Query: 122 VEFVRAETGDWFHIEVAAYPEMHPQARSPQDDVQNFARKVKAGANSAITQYFYNADAYFR 181 VEFVRAETGDWFHIEVAAYPEMHPQARSPQDD QNFARKVKAGANSAITQYFYNADAYFR Sbjct: 124 VEFVRAETGDWFHIEVAAYPEMHPQARSPQDDAQNFARKVKAGANSAITQYFYNADAYFR 183 Query: 182 FVDEAARLGATVPVIAGIMPITNYTQLMRFSDMCGTEIPRWIRLKLASYGDDTESIRAFG 241 FVDEAARLGATVPVIAGIMPITNY+QLMRFSDMCGTEIPRWIRLKLASYGDDTESIRAFG Sbjct: 184 FVDEAARLGATVPVIAGIMPITNYSQLMRFSDMCGTEIPRWIRLKLASYGDDTESIRAFG 243 Query: 242 QDVVTQLCEQLLEGGAPGLHFYTLNQPAATMEIWQRLV 279 DVVTQLCE+LL GGAPGLHFY+LNQ T IWQ+LV Sbjct: 244 LDVVTQLCERLLAGGAPGLHFYSLNQAGPTQAIWQQLV 281 >ref|YP_004754671.1| 5,10-methylenetetrahydrofolate reductase [Collimonas fungivorans Ter331] gb|AAT42397.1| 5,10-methylenetetrahydrofolate reductase [Collimonas fungivorans Ter331] gb|AEK63848.1| 5,10-methylenetetrahydrofolate reductase [Collimonas fungivorans Ter331] Length = 284 Score = 483 bits (1243), Expect = e-134, Method: Composition-based stats. Identities = 232/274 (84%), Positives = 248/274 (90%) Query: 5 NFSIEFFPPKTAEGAEKLRATRARLAALAPKYFSVTFGAGGSTQQGTRDTVLEIIGEGHE 64 NFSIEFFPPKT EGAEKLR TRA+LA L P+YFSVTFGAGGSTQ+GT DTVL+I EGHE Sbjct: 9 NFSIEFFPPKTPEGAEKLRVTRAKLAELHPRYFSVTFGAGGSTQKGTLDTVLDIRSEGHE 68 Query: 65 AAPHLSCIGSSRASLRAILEDYRAQGIKRLVALRGDLPSGYGAMDQASSEFRHANELVEF 124 AAPHLSC+GSSR SLR IL Y+ GIKRLVALRGDLPSGYGAMD +S EFR+ANELVEF Sbjct: 69 AAPHLSCLGSSRESLRTILAQYKDHGIKRLVALRGDLPSGYGAMDISSGEFRYANELVEF 128 Query: 125 VRAETGDWFHIEVAAYPEMHPQARSPQDDVQNFARKVKAGANSAITQYFYNADAYFRFVD 184 +RAETGDWFHIEVAAYPEMHPQA+SPQDDVQ F KVKAGAN AITQYFYNADAYFRFVD Sbjct: 129 IRAETGDWFHIEVAAYPEMHPQAKSPQDDVQRFVSKVKAGANGAITQYFYNADAYFRFVD 188 Query: 185 EAARLGATVPVIAGIMPITNYTQLMRFSDMCGTEIPRWIRLKLASYGDDTESIRAFGQDV 244 EA +LGA VPVIAGIMPITNY+QLMRFSDMCGTEIPRWIRLKLASYGDD++SIRAFG DV Sbjct: 189 EAQKLGAAVPVIAGIMPITNYSQLMRFSDMCGTEIPRWIRLKLASYGDDSDSIRAFGLDV 248 Query: 245 VTQLCEQLLEGGAPGLHFYTLNQPAATMEIWQRL 278 VTQLCE+LL GGAPGLHFYTLNQ AT+ IWQRL Sbjct: 249 VTQLCERLLAGGAPGLHFYTLNQSPATIAIWQRL 282 >ref|YP_001354884.1| 5,10-methylenetetrahydrofolate reductase (FADH2) [Janthinobacterium sp. Marseille] gb|ABR88310.1| 5,10-methylenetetrahydrofolate reductase (FADH2) [Janthinobacterium sp. Marseille] Length = 283 Score = 464 bits (1194), Expect = e-129, Method: Composition-based stats. Identities = 221/278 (79%), Positives = 242/278 (87%) Query: 1 MSTHNFSIEFFPPKTAEGAEKLRATRARLAALAPKYFSVTFGAGGSTQQGTRDTVLEIIG 60 M NFSIEFFPPKT G EKLR T A+LA L PKYFSVTFGAGGSTQQGT +TVLEI G Sbjct: 1 MKDQNFSIEFFPPKTPAGVEKLRVTCAKLAELNPKYFSVTFGAGGSTQQGTLETVLEIRG 60 Query: 61 EGHEAAPHLSCIGSSRASLRAILEDYRAQGIKRLVALRGDLPSGYGAMDQASSEFRHANE 120 G +AAPHLSC+GSSR SLRAIL +Y++ GIKR+VALRGDLPSGYGAMD +SSEF HANE Sbjct: 61 AGQDAAPHLSCLGSSRDSLRAILAEYKSHGIKRIVALRGDLPSGYGAMDMSSSEFHHANE 120 Query: 121 LVEFVRAETGDWFHIEVAAYPEMHPQARSPQDDVQNFARKVKAGANSAITQYFYNADAYF 180 LVEF+RAETGDWFHIEVAAYPEMHPQA+SPQDD+ +F RK KAGA+SAITQYFYNADAYF Sbjct: 121 LVEFIRAETGDWFHIEVAAYPEMHPQAKSPQDDIASFVRKAKAGADSAITQYFYNADAYF 180 Query: 181 RFVDEAARLGATVPVIAGIMPITNYTQLMRFSDMCGTEIPRWIRLKLASYGDDTESIRAF 240 RFVD+A + G +PV AGIMPITNY+QLMRFSDMCG EIPRWIRLKLAS+GDD+ESIRAF Sbjct: 181 RFVDDARKAGTDIPVTAGIMPITNYSQLMRFSDMCGAEIPRWIRLKLASFGDDSESIRAF 240 Query: 241 GQDVVTQLCEQLLEGGAPGLHFYTLNQPAATMEIWQRL 278 G DVVT LCE+LL GGAPGLHFYTLNQ AT IW RL Sbjct: 241 GLDVVTDLCERLLAGGAPGLHFYTLNQAVATHTIWTRL 278 >ref|YP_001101181.1| 5,10-methylenetetrahydrofolate reductase [Herminiimonas arsenicoxydans] emb|CAL63060.1| 5,10-methylenetetrahydrofolate reductase [Herminiimonas arsenicoxydans] Length = 283 Score = 464 bits (1193), Expect = e-129, Method: Composition-based stats. Identities = 220/278 (79%), Positives = 244/278 (87%) Query: 1 MSTHNFSIEFFPPKTAEGAEKLRATRARLAALAPKYFSVTFGAGGSTQQGTRDTVLEIIG 60 M+ NFSIEFFPPKT G EKLR T A+LA L PKYFSVTFGAGGSTQ GT DTVLEI Sbjct: 1 MTQQNFSIEFFPPKTPLGVEKLRVTCAKLAELNPKYFSVTFGAGGSTQHGTLDTVLEIRS 60 Query: 61 EGHEAAPHLSCIGSSRASLRAILEDYRAQGIKRLVALRGDLPSGYGAMDQASSEFRHANE 120 GH+AAPHLSC+GSSR +LRAIL++Y++ GIKR+VALRGDLPSGYGAMD +SSEF +ANE Sbjct: 61 AGHDAAPHLSCLGSSRENLRAILQEYKSHGIKRIVALRGDLPSGYGAMDASSSEFHYANE 120 Query: 121 LVEFVRAETGDWFHIEVAAYPEMHPQARSPQDDVQNFARKVKAGANSAITQYFYNADAYF 180 LVEF+RAETGDWFHIEVAAYPEMHPQA+SP DD+ ++ RKVKAGA+SAITQYFYNADAYF Sbjct: 121 LVEFIRAETGDWFHIEVAAYPEMHPQAKSPSDDIASYVRKVKAGADSAITQYFYNADAYF 180 Query: 181 RFVDEAARLGATVPVIAGIMPITNYTQLMRFSDMCGTEIPRWIRLKLASYGDDTESIRAF 240 RFVD+A + GA VPV AG+MPITNY+QLMRFSDMCG EIPRWIRLKLASY DDT+SIRAF Sbjct: 181 RFVDDARKAGADVPVTAGVMPITNYSQLMRFSDMCGAEIPRWIRLKLASYNDDTDSIRAF 240 Query: 241 GQDVVTQLCEQLLEGGAPGLHFYTLNQPAATMEIWQRL 278 G DVVT LCE+LL GGAPGLHFYTLNQ AAT IW RL Sbjct: 241 GLDVVTDLCERLLAGGAPGLHFYTLNQAAATHAIWSRL 278 >ref|ZP_08273864.1| 5,10-methylenetetrahydrofolate reductase [Oxalobacteraceae bacterium IMCC9480] gb|EGF32668.1| 5,10-methylenetetrahydrofolate reductase [Oxalobacteraceae bacterium IMCC9480] Length = 283 Score = 459 bits (1181), Expect = e-127, Method: Composition-based stats. Identities = 219/278 (78%), Positives = 248/278 (89%) Query: 1 MSTHNFSIEFFPPKTAEGAEKLRATRARLAALAPKYFSVTFGAGGSTQQGTRDTVLEIIG 60 M++ +FSIEFFPPK AEGA+KLRATRAR+A L PKYFSVTFGAGGSTQQGT DTVL+I Sbjct: 1 MTSPDFSIEFFPPKPAEGADKLRATRARMAVLNPKYFSVTFGAGGSTQQGTLDTVLDIRS 60 Query: 61 EGHEAAPHLSCIGSSRASLRAILEDYRAQGIKRLVALRGDLPSGYGAMDQASSEFRHANE 120 EGH+AAPH+SC+GSSRA LR IL +YR+ GI+RLVALRGDLPSGYGAMD AS EFR+ANE Sbjct: 61 EGHQAAPHISCLGSSRARLREILAEYRSHGIERLVALRGDLPSGYGAMDAASGEFRYANE 120 Query: 121 LVEFVRAETGDWFHIEVAAYPEMHPQARSPQDDVQNFARKVKAGANSAITQYFYNADAYF 180 LVEF+RAE+GDWFH+EV AYPEMHPQARSP DD+Q+F RKV+AGA++AITQYFYNADAYF Sbjct: 121 LVEFIRAESGDWFHVEVGAYPEMHPQARSPSDDMQHFVRKVQAGADAAITQYFYNADAYF 180 Query: 181 RFVDEAARLGATVPVIAGIMPITNYTQLMRFSDMCGTEIPRWIRLKLASYGDDTESIRAF 240 RFVD A + G VP++AG+MPITNYTQLMRFSDMCG EIPRWIRL LASYGDD+ESIRAF Sbjct: 181 RFVDSARKHGVQVPIVAGVMPITNYTQLMRFSDMCGAEIPRWIRLALASYGDDSESIRAF 240 Query: 241 GQDVVTQLCEQLLEGGAPGLHFYTLNQPAATMEIWQRL 278 G DVVT +CE+LL GGAPGLHFY+LNQ A TM I QRL Sbjct: 241 GLDVVTAMCERLLVGGAPGLHFYSLNQAAPTMAICQRL 278