BLASTP 2.2.17 [Aug-26-2007] Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), "Gapped BLAST and PSI-BLAST: a new generation of protein database search programs", Nucleic Acids Res. 25:3389-3402. Reference for composition-based statistics: Schaffer, Alejandro A., L. Aravind, Thomas L. Madden, Sergei Shavirin, John L. Spouge, Yuri I. Wolf, Eugene V. Koonin, and Stephen F. Altschul (2001), "Improving the accuracy of PSI-BLAST protein database searches with composition-based statistics and other refinements", Nucleic Acids Res. 29:2994-3005. Query= 0001.3653.p (435 letters) Database: All non-redundant GenBank CDS translations+PDB+SwissProt+PIR+PRF excluding environmental samples from WGS projects 15,459,386 sequences; 5,307,515,862 total letters Searching..................................................done Score E Sequences producing significant alignments: (bits) Value ref|YP_003776430.1| 3-hydroxy-3-methylglutaryl-coenzyme A reduct... 701 0.0 ref|YP_004416465.1| HMG-CoA reductase [Pusillimonas sp. T7-7] >g... 588 e-166 ref|YP_003909446.1| hydroxymethylglutaryl-CoA reductase, degrada... 584 e-165 ref|YP_001777654.1| hydroxymethylglutaryl-CoA reductase, degrada... 574 e-161 ref|YP_002233154.1| 3-hydroxy-3-methylglutaryl-coenzyme A reduct... 571 e-161 >ref|YP_003776430.1| 3-hydroxy-3-methylglutaryl-coenzyme A reductase [Herbaspirillum seropedicae SmR1] gb|ADJ64522.1| 3-hydroxy-3-methylglutaryl-coenzyme A reductase protein [Herbaspirillum seropedicae SmR1] Length = 436 Score = 701 bits (1810), Expect = 0.0, Method: Composition-based stats. Identities = 383/435 (88%), Positives = 398/435 (91%) Query: 1 MHSDAHPAQLMDSRLPGLRTMTPPQRLAEVARVTGLDEHAQKLLGEPGGLPLATANGMIE 60 M D H DSRLPG RT TP QRLAEV R+ LD+ Q LLG+PG LPL TA+GMIE Sbjct: 1 MSQDVHAGATPDSRLPGFRTYTPAQRLAEVGRLAQLDQAEQALLGQPGALPLGTADGMIE 60 Query: 61 NVVGTFQLPLRVATNFQLNGRDVLVPMAVEEPSVVAAASFMAKLVRACGGFQTSSSTPLM 120 NVVG+FQLPL VA FQLNGRDVLVPMAVEEPSVVAAASFMAKLVR CGGFQTSSS PLM Sbjct: 61 NVVGSFQLPLGVAGYFQLNGRDVLVPMAVEEPSVVAAASFMAKLVRTCGGFQTSSSLPLM 120 Query: 121 RAQIQLLGVTDPHGARLAILKDRQAIIDIANSRDQLLNELGGGCRDIEVHVFPDTRRGAM 180 RAQIQL G++DPHGARLAILK+RQAIIDIANSRDQLL +LGGGCRDIEV VFPDTRRGAM Sbjct: 121 RAQIQLTGISDPHGARLAILKERQAIIDIANSRDQLLQQLGGGCRDIEVQVFPDTRRGAM 180 Query: 181 VVTHLIVDVRDAMGANTVNTMAEAVAGHIEEITGGKVRLRILSNLADLRLARARVKVSAK 240 VVTHLIVDVRDAMGANTVNTMAEAVA HIE +TGGKVRLRILSNLADLRLARARVKVSA Sbjct: 181 VVTHLIVDVRDAMGANTVNTMAEAVASHIERVTGGKVRLRILSNLADLRLARARVKVSAD 240 Query: 241 VLATSAYSGEEVIDGIVDAYEFAAVDPYRAATHNKGIMNGIDPVIVATGNDWRAVEAGAH 300 VL+T+ Y GEEVI+GIVDAYE AAVDPYRAATHNKGIMNGIDPVIVATGNDWRAVEAGAH Sbjct: 241 VLSTAQYRGEEVINGIVDAYELAAVDPYRAATHNKGIMNGIDPVIVATGNDWRAVEAGAH 300 Query: 301 AYACRHGRYTSLTHWEIAADGDLVGTLEIPMPVGLVGGATKTHPAARAALKILGVQSAQE 360 AYACRHGRYTSLTHWEIAADGDLVGTLEIPMPVGLVGGATKTHPAAR ALKILGVQSAQ Sbjct: 301 AYACRHGRYTSLTHWEIAADGDLVGTLEIPMPVGLVGGATKTHPAARVALKILGVQSAQA 360 Query: 361 LAEVAVAVGLAQNMAALRALATEGIQRGHMALHARNIALAAGAEPHEMDWLVQQMVARHD 420 LAEVAVAVGLAQNMAALRALATEGIQRGHMALHARNIALAAGAE EMDWLVQQMVARHD Sbjct: 361 LAEVAVAVGLAQNMAALRALATEGIQRGHMALHARNIALAAGAEASEMDWLVQQMVARHD 420 Query: 421 VRVDYARSLLAERRR 435 VRVDYA++LLAERRR Sbjct: 421 VRVDYAKALLAERRR 435 >ref|YP_004416465.1| HMG-CoA reductase [Pusillimonas sp. T7-7] gb|AEC19841.1| HMG-CoA reductase [Pusillimonas sp. T7-7] Length = 433 Score = 588 bits (1517), Expect = e-166, Method: Composition-based stats. Identities = 310/423 (73%), Positives = 362/423 (85%) Query: 11 MDSRLPGLRTMTPPQRLAEVARVTGLDEHAQKLLGEPGGLPLATANGMIENVVGTFQLPL 70 +DS LP RT++P +RL +A+ L + ++LL PG LPL TA+ MIENV+G F+LP Sbjct: 3 LDSSLPQFRTLSPDERLEHLAKKLQLSQEDRRLLAGPGALPLETADSMIENVIGKFELPY 62 Query: 71 RVATNFQLNGRDVLVPMAVEEPSVVAAASFMAKLVRACGGFQTSSSTPLMRAQIQLLGVT 130 VA FQ+NG+DVLVPMAVEEPSVVAAAS+MAKLVRA GGF TSSS P+MRAQ+Q++ + Sbjct: 63 AVAGYFQVNGKDVLVPMAVEEPSVVAAASYMAKLVRANGGFHTSSSGPIMRAQVQIVNLG 122 Query: 131 DPHGARLAILKDRQAIIDIANSRDQLLNELGGGCRDIEVHVFPDTRRGAMVVTHLIVDVR 190 DP+GAR AIL+ RQ IIDIANSRDQ+L LGGGC+DIEVHVFPDT RGAMVV HLIVDVR Sbjct: 123 DPYGARHAILQQRQDIIDIANSRDQVLMGLGGGCKDIEVHVFPDTARGAMVVVHLIVDVR 182 Query: 191 DAMGANTVNTMAEAVAGHIEEITGGKVRLRILSNLADLRLARARVKVSAKVLATSAYSGE 250 DAMGANTVNTMAEAVA +E+ITGG+VRLRILSNLADLRLARA ++++ ++L TS YSG Sbjct: 183 DAMGANTVNTMAEAVAPRMEQITGGRVRLRILSNLADLRLARAHLRLTPELLQTSEYSGV 242 Query: 251 EVIDGIVDAYEFAAVDPYRAATHNKGIMNGIDPVIVATGNDWRAVEAGAHAYACRHGRYT 310 +VIDGIVDAYEFAAVDPYRAATHNKGIMNGIDP+IVATGNDWRAVEAGAHAYACRHGRYT Sbjct: 243 DVIDGIVDAYEFAAVDPYRAATHNKGIMNGIDPIIVATGNDWRAVEAGAHAYACRHGRYT 302 Query: 311 SLTHWEIAADGDLVGTLEIPMPVGLVGGATKTHPAARAALKILGVQSAQELAEVAVAVGL 370 SL+ WE+A++G+LVGTLE+PMPVGLVGGATKTHP A+ +LKIL V SAQELAE+A AVGL Sbjct: 303 SLSTWEVASNGELVGTLEMPMPVGLVGGATKTHPLAQLSLKILNVASAQELAEIAAAVGL 362 Query: 371 AQNMAALRALATEGIQRGHMALHARNIALAAGAEPHEMDWLVQQMVARHDVRVDYARSLL 430 AQN+AALRAL+TEGIQRGHMALHARNIAL AGA+ ++ W+ Q+MV DVR D A LL Sbjct: 363 AQNLAALRALSTEGIQRGHMALHARNIALLAGAKGDDIAWVAQKMVEARDVRADLATELL 422 Query: 431 AER 433 + Sbjct: 423 QNK 425 >ref|YP_003909446.1| hydroxymethylglutaryl-CoA reductase, degradative [Burkholderia sp. CCGE1003] gb|ADN60155.1| hydroxymethylglutaryl-CoA reductase, degradative [Burkholderia sp. CCGE1003] Length = 428 Score = 584 bits (1506), Expect = e-165, Method: Composition-based stats. Identities = 308/426 (72%), Positives = 358/426 (84%) Query: 10 LMDSRLPGLRTMTPPQRLAEVARVTGLDEHAQKLLGEPGGLPLATANGMIENVVGTFQLP 69 + +S LP R++TP +RL+ + ++ LD+ L PG LPL ANGMIENV+GTF+LP Sbjct: 2 VTNSTLPNFRSLTPHERLSHLRKMLDLDDTQWTQLARPGALPLERANGMIENVIGTFELP 61 Query: 70 LRVATNFQLNGRDVLVPMAVEEPSVVAAASFMAKLVRACGGFQTSSSTPLMRAQIQLLGV 129 L VA FQ+NG+DV+VPMAVEEPS+VAAASFMAKL R GGF+TSS+ PLMRAQ+Q++GV Sbjct: 62 LAVAGYFQINGKDVIVPMAVEEPSIVAAASFMAKLAREGGGFRTSSTGPLMRAQVQIVGV 121 Query: 130 TDPHGARLAILKDRQAIIDIANSRDQLLNELGGGCRDIEVHVFPDTRRGAMVVTHLIVDV 189 +DP+GARLAIL + +I +ANSRDQ+L LGGGCRDIEVHVFPDT RGAM+V HLIVDV Sbjct: 122 SDPYGARLAILAHKDELIGLANSRDQVLLRLGGGCRDIEVHVFPDTPRGAMLVAHLIVDV 181 Query: 190 RDAMGANTVNTMAEAVAGHIEEITGGKVRLRILSNLADLRLARARVKVSAKVLATSAYSG 249 RDAMGANTVNTMAE+VAG IE +TGG VRLRILSNLADLRLARA V+ SA LAT YSG Sbjct: 182 RDAMGANTVNTMAESVAGRIEALTGGSVRLRILSNLADLRLARAHVRYSAATLATKEYSG 241 Query: 250 EEVIDGIVDAYEFAAVDPYRAATHNKGIMNGIDPVIVATGNDWRAVEAGAHAYACRHGRY 309 EEVID ++DAY FAA+DPYRAATHNKGIMNGIDPVIVATGNDWRAVEAGAHAYA R GRY Sbjct: 242 EEVIDRVIDAYLFAAIDPYRAATHNKGIMNGIDPVIVATGNDWRAVEAGAHAYAARGGRY 301 Query: 310 TSLTHWEIAADGDLVGTLEIPMPVGLVGGATKTHPAARAALKILGVQSAQELAEVAVAVG 369 TSLT WE AA+GDLVGT+E+PMPVGLVGGATKTHP AR +L+++GV +AQEL E+AVAVG Sbjct: 302 TSLTTWEKAANGDLVGTIEMPMPVGLVGGATKTHPLARVSLQMMGVTTAQELGEIAVAVG 361 Query: 370 LAQNMAALRALATEGIQRGHMALHARNIALAAGAEPHEMDWLVQQMVARHDVRVDYARSL 429 LAQNM ALRALATEGIQRGHM LHARNIALAAGA ++DWLV +M+ D R+D+A L Sbjct: 362 LAQNMGALRALATEGIQRGHMTLHARNIALAAGATGDDLDWLVNKMITSADFRMDFAIEL 421 Query: 430 LAERRR 435 LA R+ Sbjct: 422 LAGLRK 427 >ref|YP_001777654.1| hydroxymethylglutaryl-CoA reductase, degradative [Burkholderia cenocepacia MC0-3] gb|ACA93164.1| hydroxymethylglutaryl-CoA reductase, degradative [Burkholderia cenocepacia MC0-3] Length = 428 Score = 574 bits (1479), Expect = e-161, Method: Composition-based stats. Identities = 313/423 (73%), Positives = 358/423 (84%) Query: 11 MDSRLPGLRTMTPPQRLAEVARVTGLDEHAQKLLGEPGGLPLATANGMIENVVGTFQLPL 70 +DS LP R++TP QRL+ ++R+ GLD+ LL +PG LPL TANGMIENV+GTF+LP+ Sbjct: 3 IDSALPNFRSLTPEQRLSHLSRIVGLDDAEHALLAQPGALPLDTANGMIENVIGTFELPM 62 Query: 71 RVATNFQLNGRDVLVPMAVEEPSVVAAASFMAKLVRACGGFQTSSSTPLMRAQIQLLGVT 130 VA F++N RDV+VPMAVEEPS+VAAAS+MAKL RA GGF+TSSS PLMRAQ+Q++GV Sbjct: 63 AVAGYFRINDRDVIVPMAVEEPSIVAAASYMAKLSRAAGGFRTSSSGPLMRAQVQVIGVD 122 Query: 131 DPHGARLAILKDRQAIIDIANSRDQLLNELGGGCRDIEVHVFPDTRRGAMVVTHLIVDVR 190 DP+GARLAIL+ +I +ANSRD++L LGGGCRDIEVHVFPDT RGAM+V HLIVDVR Sbjct: 123 DPYGARLAILRHAAELIALANSRDKVLVGLGGGCRDIEVHVFPDTPRGAMIVAHLIVDVR 182 Query: 191 DAMGANTVNTMAEAVAGHIEEITGGKVRLRILSNLADLRLARARVKVSAKVLATSAYSGE 250 DAMGANTVNTMAE VA IE ITGG+VRLRILSNLADLRLARA V+ SA LAT Y+GE Sbjct: 183 DAMGANTVNTMAETVATRIEAITGGQVRLRILSNLADLRLARAEVRYSAATLATDDYAGE 242 Query: 251 EVIDGIVDAYEFAAVDPYRAATHNKGIMNGIDPVIVATGNDWRAVEAGAHAYACRHGRYT 310 VID ++DAY FAA DPYRAATHNKGIMNGIDPV+VATGNDWRAVEAGAHAYA R GRYT Sbjct: 243 AVIDRVIDAYVFAATDPYRAATHNKGIMNGIDPVVVATGNDWRAVEAGAHAYASRSGRYT 302 Query: 311 SLTHWEIAADGDLVGTLEIPMPVGLVGGATKTHPAARAALKILGVQSAQELAEVAVAVGL 370 SLT WE AA+GDLVGT+E+PMPVGLVGGATKTHP AR ALKI+ V SAQEL E+AVAVGL Sbjct: 303 SLTTWEKAANGDLVGTIEMPMPVGLVGGATKTHPLARLALKIMNVTSAQELGEIAVAVGL 362 Query: 371 AQNMAALRALATEGIQRGHMALHARNIALAAGAEPHEMDWLVQQMVARHDVRVDYARSLL 430 AQN+ ALRALATEGIQRGHMALHARNIA+AAGA ++D + QQMVA DVR D+A LL Sbjct: 363 AQNLGALRALATEGIQRGHMALHARNIAVAAGATGADIDRIAQQMVAAKDVRTDFAVELL 422 Query: 431 AER 433 A R Sbjct: 423 AGR 425 >ref|YP_002233154.1| 3-hydroxy-3-methylglutaryl-coenzyme A reductase [Burkholderia cenocepacia J2315] emb|CAR54389.1| 3-hydroxy-3-methylglutaryl-coenzyme A reductase [Burkholderia cenocepacia J2315] Length = 428 Score = 571 bits (1471), Expect = e-161, Method: Composition-based stats. Identities = 313/423 (73%), Positives = 356/423 (84%) Query: 11 MDSRLPGLRTMTPPQRLAEVARVTGLDEHAQKLLGEPGGLPLATANGMIENVVGTFQLPL 70 +DS LP R++TP QRL+ +ARV GLD+ LL PG LPL TANGMIENV+GTF+LP+ Sbjct: 3 IDSALPNFRSLTPEQRLSHLARVVGLDDAEHALLARPGALPLDTANGMIENVIGTFELPM 62 Query: 71 RVATNFQLNGRDVLVPMAVEEPSVVAAASFMAKLVRACGGFQTSSSTPLMRAQIQLLGVT 130 V F++N RDV+VPMAVEEPS+VAAAS+MAKL RA GGF+TSSS PLMRAQ+Q++GV Sbjct: 63 AVTGYFRINDRDVIVPMAVEEPSIVAAASYMAKLSRAAGGFRTSSSGPLMRAQVQVVGVD 122 Query: 131 DPHGARLAILKDRQAIIDIANSRDQLLNELGGGCRDIEVHVFPDTRRGAMVVTHLIVDVR 190 DP+GARLAIL+ +I +ANSRD++L LGGGCRDIEVHVFPDT RGAM+V HLIVDVR Sbjct: 123 DPYGARLAILRHAAELIALANSRDKVLVGLGGGCRDIEVHVFPDTPRGAMIVAHLIVDVR 182 Query: 191 DAMGANTVNTMAEAVAGHIEEITGGKVRLRILSNLADLRLARARVKVSAKVLATSAYSGE 250 DAMGANTVNTMAE VA IE ITGG+VRLRILSNLADLRLARA V+ SA LAT Y+GE Sbjct: 183 DAMGANTVNTMAETVATRIEAITGGQVRLRILSNLADLRLARAEVRYSAATLATDDYAGE 242 Query: 251 EVIDGIVDAYEFAAVDPYRAATHNKGIMNGIDPVIVATGNDWRAVEAGAHAYACRHGRYT 310 VID ++DAY FAA DPYRAATHNKGIMNGIDPV+VATGNDWRAVEAGAHAYA R GRYT Sbjct: 243 AVIDRVIDAYVFAATDPYRAATHNKGIMNGIDPVVVATGNDWRAVEAGAHAYASRSGRYT 302 Query: 311 SLTHWEIAADGDLVGTLEIPMPVGLVGGATKTHPAARAALKILGVQSAQELAEVAVAVGL 370 SLT WE AA+GDLVGT+E+PMPVGLVGGATKTHP AR ALKI+ V SAQEL E+AVAVGL Sbjct: 303 SLTTWEKAANGDLVGTIEMPMPVGLVGGATKTHPLARLALKIMNVTSAQELGEIAVAVGL 362 Query: 371 AQNMAALRALATEGIQRGHMALHARNIALAAGAEPHEMDWLVQQMVARHDVRVDYARSLL 430 AQN+ ALRALATEGIQRGHMALHARNIA+AAGA ++D + Q+MVA DVR D+A LL Sbjct: 363 AQNLGALRALATEGIQRGHMALHARNIAVAAGATGADIDRIAQRMVAAKDVRTDFAVELL 422 Query: 431 AER 433 A R Sbjct: 423 AGR 425