BLASTP 2.2.17 [Aug-26-2007] Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), "Gapped BLAST and PSI-BLAST: a new generation of protein database search programs", Nucleic Acids Res. 25:3389-3402. Reference for composition-based statistics: Schaffer, Alejandro A., L. Aravind, Thomas L. Madden, Sergei Shavirin, John L. Spouge, Yuri I. Wolf, Eugene V. Koonin, and Stephen F. Altschul (2001), "Improving the accuracy of PSI-BLAST protein database searches with composition-based statistics and other refinements", Nucleic Acids Res. 29:2994-3005. Query= 0001.3254.p (427 letters) Database: All non-redundant GenBank CDS translations+PDB+SwissProt+PIR+PRF excluding environmental samples from WGS projects 15,459,386 sequences; 5,307,515,862 total letters Searching..................................................done Score E Sequences producing significant alignments: (bits) Value ref|YP_001753451.1| putative DNA topoisomerase I [Methylobacteri... 404 e-110 ref|ZP_03628450.1| putative DNA topoisomerase I [bacterium Ellin... 399 e-109 ref|YP_001639444.1| putative DNA topoisomerase I [Methylobacteri... 392 e-107 ref|YP_002963036.1| DNA topoisomerase I [methylobacterium extorq... 391 e-106 ref|YP_002421026.1| DNA topoisomerase I [Methylobacterium chloro... 390 e-106 >ref|YP_001753451.1| putative DNA topoisomerase I [Methylobacterium radiotolerans JCM 2831] gb|ACB22768.1| putative DNA topoisomerase I [Methylobacterium radiotolerans JCM 2831] Length = 404 Score = 404 bits (1039), Expect = e-110, Method: Composition-based stats. Identities = 218/369 (59%), Positives = 274/369 (74%), Gaps = 1/369 (0%) Query: 58 LRYVNDGMPGIRRRRRGKGFAYHDAHGELIRDDDVVARLKSLAIPPAWEDVWISPHANGH 117 L YV+DG PG+ RRR G GF Y DA G +RD V+AR++SLAIPPA+ DVWI P NGH Sbjct: 22 LVYVDDGRPGLTRRRSGTGFRYLDAKGAPVRDKAVLARIRSLAIPPAYTDVWICPRRNGH 81 Query: 118 IQATGRDARGRKQYRYHARWRSVRDDAKYLRMISFARALPTIRRVVEQDLKRPGLHRQKV 177 IQATGRDA+GRKQYRYH +R R+ K+ R+++FA ALP IRR V+ D+KRPGL R KV Sbjct: 82 IQATGRDAKGRKQYRYHPDFRQAREANKFSRIMAFADALPGIRRRVDADMKRPGLSRDKV 141 Query: 178 LAAVVHLLQTTFMRVGNDEYAKQNQSFGLTTLRHRHVRVDGSDVLFRFRGKSGVQHDIKL 237 LA VVHLL+TT +RVGND+YA+ N+S+GLTTLR HVR++G+ + FRF+GKSG D+ L Sbjct: 142 LATVVHLLETTLIRVGNDDYARTNKSYGLTTLRDPHVRIEGAALSFRFKGKSGKTWDVSL 201 Query: 238 HDPYVARIIRKMRELPGQELFQYVDDEGERHCIDSGDVNAYLREAAGEDFSAKDFRTWAG 297 D VARI++ ++LPGQELFQY+D +G + + S DVNAYLRE G+DF+AKDFRTWAG Sbjct: 202 KDRRVARIVKACQDLPGQELFQYLDPDGTQRDVTSSDVNAYLREITGKDFTAKDFRTWAG 261 Query: 298 TVLATLALQAFERVDSQAQAKQNVVRAIENVARRLGNTPSICRKCYVHPAVIESYLDGSF 357 TVLA LAL+ FE DS+A AK+N+ AIENVA RLGNTP+ICRKCY+HP +++ YL+G Sbjct: 262 TVLAALALREFETFDSEAGAKRNIRAAIENVAGRLGNTPTICRKCYIHPQILDCYLEGGL 321 Query: 358 AERLEERVQAELVEELQDLSPEEAAVLALLQQRLQEAEQQPARKPRRKPA-ARTATASVP 416 ++++ V++EL E+L L PEEAAVL LLQ RL AE K R KPA AR A P Sbjct: 322 LLQVKDAVESELSEDLSSLRPEEAAVLGLLQARLSAAEDAVKAKGRVKPAGARGRGAKAP 381 Query: 417 RRKAARPTA 425 R + A Sbjct: 382 ERSKSGTAA 390 >ref|ZP_03628450.1| putative DNA topoisomerase I [bacterium Ellin514] gb|EEF61153.1| putative DNA topoisomerase I [bacterium Ellin514] Length = 367 Score = 399 bits (1024), Expect = e-109, Method: Composition-based stats. Identities = 193/345 (55%), Positives = 266/345 (77%) Query: 48 EAIDIARANQLRYVNDGMPGIRRRRRGKGFAYHDAHGELIRDDDVVARLKSLAIPPAWED 107 + ++ A+ +LRYV D GI R + G F + DA G+ + D+ + R+ SLAIPPAW + Sbjct: 3 DPVESAKIVRLRYVTDDTSGISREKAGDDFRFIDAEGKRVTDEKTLDRINSLAIPPAWTE 62 Query: 108 VWISPHANGHIQATGRDARGRKQYRYHARWRSVRDDAKYLRMISFARALPTIRRVVEQDL 167 VWI P+ANGH+QATGRDAR RKQ+RYH +WR +RD KY +MI+FA+ALP IR+ V+ DL Sbjct: 63 VWICPYANGHLQATGRDARKRKQHRYHPKWREIRDQNKYAQMIAFAKALPQIRQRVDADL 122 Query: 168 KRPGLHRQKVLAAVVHLLQTTFMRVGNDEYAKQNQSFGLTTLRHRHVRVDGSDVLFRFRG 227 G R KVLA VV LL+ T +RVGN+EYAK+N+S+GLTTL+ RHV + GS + F F+G Sbjct: 123 ALSGFPRAKVLATVVKLLEVTLIRVGNEEYAKENRSYGLTTLKDRHVDISGSKLHFHFKG 182 Query: 228 KSGVQHDIKLHDPYVARIIRKMRELPGQELFQYVDDEGERHCIDSGDVNAYLREAAGEDF 287 KSG H+I +HD +A+I++ +++LPGQELFQY+DD+G+R +DS DVN YL+E GEDF Sbjct: 183 KSGKNHEIDIHDRKLAKIVKGVQDLPGQELFQYIDDDGQRKQVDSDDVNTYLKEITGEDF 242 Query: 288 SAKDFRTWAGTVLATLALQAFERVDSQAQAKQNVVRAIENVARRLGNTPSICRKCYVHPA 347 +AK FRTWAGT+LA ALQ F++ DS+ +AK+NV++AI++V++RLGNTP+ICRKCYVHPA Sbjct: 243 TAKCFRTWAGTILAAQALQEFKKCDSEVEAKKNVIQAIKSVSQRLGNTPTICRKCYVHPA 302 Query: 348 VIESYLDGSFAERLEERVQAELVEELQDLSPEEAAVLALLQQRLQ 392 ++E Y+D + E L ++ L E LQ+LSP+EAAVLA+L++RL+ Sbjct: 303 ILELYMDAALVETLTQQAGKVLSESLQELSPQEAAVLAMLEKRLE 347 >ref|YP_001639444.1| putative DNA topoisomerase I [Methylobacterium extorquens PA1] gb|ABY30373.1| putative DNA topoisomerase I [Methylobacterium extorquens PA1] Length = 400 Score = 392 bits (1008), Expect = e-107, Method: Composition-based stats. Identities = 209/381 (54%), Positives = 281/381 (73%), Gaps = 10/381 (2%) Query: 51 DIARANQLRYVNDGMPGIRRRRRGKGFAYHDAHGELIRDDDVVARLKSLAIPPAWEDVWI 110 + AR LRYV+D PG+RR+R GKGF Y D G +RD + +ARLKSLAIPPA+ +VWI Sbjct: 15 EAARDAGLRYVDDSKPGLRRKRNGKGFRYIDPKGAPVRDAEEIARLKSLAIPPAYTEVWI 74 Query: 111 SPHANGHIQATGRDARGRKQYRYHARWRSVRDDAKYLRMISFARALPTIRRVVEQDLKRP 170 PH NGHIQATGRD +GRKQYRYH R+R R+ +K+ R+++FA ALP IR ++ D+ + Sbjct: 75 CPHPNGHIQATGRDEKGRKQYRYHPRFREAREASKFHRIMAFAEALPGIRARIDADMGKR 134 Query: 171 GLHRQKVLAAVVHLLQTTFMRVGNDEYAKQNQSFGLTTLRHRHVRVDGSDVLFRFRGKSG 230 GL R+KVLA VVHLL+TT +RVGND+YA+ N+S+GLTTLR HV+V GS++ FRF+GKSG Sbjct: 135 GLPREKVLATVVHLLETTLIRVGNDDYARSNKSYGLTTLRDPHVKVAGSEMRFRFKGKSG 194 Query: 231 VQHDIKLHDPYVARIIRKMRELPGQELFQYVDDEGERHCIDSGDVNAYLREAAGEDFSAK 290 + + + D VA+I++ ++LPGQELFQY+D+EGER + S DVNAYLRE GEDF+AK Sbjct: 195 KEWSVSVRDRRVAKIVKACQDLPGQELFQYLDEEGERRDVTSSDVNAYLREITGEDFTAK 254 Query: 291 DFRTWAGTVLATLALQAFERVDSQAQAKQNVVRAIENVARRLGNTPSICRKCYVHPAVIE 350 DFRTWAGTVLA LAL+ FE D+ A+AK+N+ AIE+V+ RLGNTP+ICRKCY+HP +++ Sbjct: 255 DFRTWAGTVLAALALREFEAFDNAAKAKKNLRAAIESVSSRLGNTPTICRKCYIHPQILD 314 Query: 351 SYLDGSFAERLEERVQAELVEELQDLSPEEAAVLALLQQRLQEAEQQPAR---------- 400 YL+G +++E V+ EL EL L PEEAAVL+LL+ RL+ A + ++ Sbjct: 315 CYLEGGMLLQVKEAVEGELKNELDVLRPEEAAVLSLLRARLERATKAASKGTTSESTTKI 374 Query: 401 KPRRKPAARTATASVPRRKAA 421 +P R+ R A A+ +R + Sbjct: 375 EPPRQTGGRKARATGTKRTSG 395 >ref|YP_002963036.1| DNA topoisomerase I [methylobacterium extorquens AM1] gb|ACS39759.1| putative DNA topoisomerase I [Methylobacterium extorquens AM1] Length = 400 Score = 391 bits (1004), Expect = e-106, Method: Composition-based stats. Identities = 207/381 (54%), Positives = 281/381 (73%), Gaps = 10/381 (2%) Query: 51 DIARANQLRYVNDGMPGIRRRRRGKGFAYHDAHGELIRDDDVVARLKSLAIPPAWEDVWI 110 + AR LRYV+D PG+RR+R GKGF Y D G +RD + +ARLKSLAIPPA+ +VWI Sbjct: 15 EAARDAGLRYVDDSKPGLRRKRNGKGFRYIDPKGAPVRDAEEIARLKSLAIPPAYTEVWI 74 Query: 111 SPHANGHIQATGRDARGRKQYRYHARWRSVRDDAKYLRMISFARALPTIRRVVEQDLKRP 170 PH NGHIQATGRD +GRKQYRYH R+R R+ +K+ R+++FA ALP IR ++ D+ + Sbjct: 75 CPHPNGHIQATGRDEKGRKQYRYHPRFREAREASKFHRIMAFAEALPGIRARIDADMGKR 134 Query: 171 GLHRQKVLAAVVHLLQTTFMRVGNDEYAKQNQSFGLTTLRHRHVRVDGSDVLFRFRGKSG 230 GL R+KVLA VVHLL+TT +RVGND+YA+ N+S+GLTTLR HV+V GS++ FRF+GKSG Sbjct: 135 GLPREKVLATVVHLLETTLIRVGNDDYARSNKSYGLTTLRDPHVKVAGSEMRFRFKGKSG 194 Query: 231 VQHDIKLHDPYVARIIRKMRELPGQELFQYVDDEGERHCIDSGDVNAYLREAAGEDFSAK 290 + + + D VA+I++ ++LPGQELFQY+D++G+R + S DVNAYLRE GEDF+AK Sbjct: 195 KEWSVSVRDRRVAKIVKACQDLPGQELFQYLDEDGQRRDVTSSDVNAYLREITGEDFTAK 254 Query: 291 DFRTWAGTVLATLALQAFERVDSQAQAKQNVVRAIENVARRLGNTPSICRKCYVHPAVIE 350 DFRTWAGTVLA LAL+ FE D+ A+AK+N+ AIE+V+ RLGNTP+ICRKCY+HP +++ Sbjct: 255 DFRTWAGTVLAALALREFEAFDNAAKAKKNLRAAIESVSSRLGNTPTICRKCYIHPQILD 314 Query: 351 SYLDGSFAERLEERVQAELVEELQDLSPEEAAVLALLQQRLQEAEQQPAR---------- 400 YL+G +++E V+ EL EL L PEEAAVL+LL+ RL+ A + ++ Sbjct: 315 CYLEGGMLLQVKEAVEGELKNELDVLRPEEAAVLSLLRARLERATKAASKGTTSESMTKI 374 Query: 401 KPRRKPAARTATASVPRRKAA 421 +P R+ R A A+ +R + Sbjct: 375 EPPRQTGGRKARATGTKRTSG 395 >ref|YP_002421026.1| DNA topoisomerase I [Methylobacterium chloromethanicum CM4] gb|ACK83098.1| putative DNA topoisomerase I [Methylobacterium chloromethanicum CM4] Length = 400 Score = 390 bits (1002), Expect = e-106, Method: Composition-based stats. Identities = 207/381 (54%), Positives = 281/381 (73%), Gaps = 10/381 (2%) Query: 51 DIARANQLRYVNDGMPGIRRRRRGKGFAYHDAHGELIRDDDVVARLKSLAIPPAWEDVWI 110 + AR LRYV+D PG+RR+R GKGF Y D G +RD + +ARLKSLAIPPA+ +VWI Sbjct: 15 EAARDAGLRYVDDSKPGLRRKRNGKGFRYIDPKGAPVRDAEEIARLKSLAIPPAYTEVWI 74 Query: 111 SPHANGHIQATGRDARGRKQYRYHARWRSVRDDAKYLRMISFARALPTIRRVVEQDLKRP 170 PH NGHIQATGRD +GRKQYRYH R+R R+ +K+ R+++FA ALP IR ++ D+ + Sbjct: 75 CPHPNGHIQATGRDEKGRKQYRYHPRFREAREASKFHRIMAFAEALPGIRARIDADMGKR 134 Query: 171 GLHRQKVLAAVVHLLQTTFMRVGNDEYAKQNQSFGLTTLRHRHVRVDGSDVLFRFRGKSG 230 GL R+KVLA VVHLL+TT +RVGND+YA+ N+S+GLTTLR HV+V GS++ FRF+GKSG Sbjct: 135 GLPREKVLATVVHLLETTLIRVGNDDYARSNKSYGLTTLRDPHVKVAGSEMRFRFKGKSG 194 Query: 231 VQHDIKLHDPYVARIIRKMRELPGQELFQYVDDEGERHCIDSGDVNAYLREAAGEDFSAK 290 + + + D VA+I++ ++LPGQELFQY+D++G+R + S DVNAYLRE GEDF+AK Sbjct: 195 KEWSVSVRDRRVAKIVKACQDLPGQELFQYLDEDGQRRDVTSSDVNAYLREITGEDFTAK 254 Query: 291 DFRTWAGTVLATLALQAFERVDSQAQAKQNVVRAIENVARRLGNTPSICRKCYVHPAVIE 350 DFRTWAGTVLA LAL+ FE D+ A+AK+N+ AIE+V+ RLGNTP+ICRKCY+HP +++ Sbjct: 255 DFRTWAGTVLAALALREFEAFDNAAKAKKNLRAAIESVSSRLGNTPTICRKCYIHPQILD 314 Query: 351 SYLDGSFAERLEERVQAELVEELQDLSPEEAAVLALLQQRLQEAEQQPAR---------- 400 YL+G +++E V+ EL EL L PEEAAVL+LL+ RL+ A + ++ Sbjct: 315 CYLEGGMLLQVKEAVEGELKNELDVLRPEEAAVLSLLRARLERATKAASKGTTSESTTKI 374 Query: 401 KPRRKPAARTATASVPRRKAA 421 +P R+ R A A+ +R + Sbjct: 375 EPPRQTGGRKARATGTKRTSG 395