BLASTP 2.2.17 [Aug-26-2007] Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), "Gapped BLAST and PSI-BLAST: a new generation of protein database search programs", Nucleic Acids Res. 25:3389-3402. Reference for composition-based statistics: Schaffer, Alejandro A., L. Aravind, Thomas L. Madden, Sergei Shavirin, John L. Spouge, Yuri I. Wolf, Eugene V. Koonin, and Stephen F. Altschul (2001), "Improving the accuracy of PSI-BLAST protein database searches with composition-based statistics and other refinements", Nucleic Acids Res. 29:2994-3005. Query= 0001.1794.p (635 letters) Database: All non-redundant GenBank CDS translations+PDB+SwissProt+PIR+PRF excluding environmental samples from WGS projects 15,459,386 sequences; 5,307,515,862 total letters Searching..................................................done Score E Sequences producing significant alignments: (bits) Value ref|YP_003778085.1| diguanylate cyclase/phosphodiesterase with P... 877 0.0 ref|YP_001863263.1| diguanylate cyclase/phosphodiesterase with P... 269 9e-70 ref|YP_001893446.1| diguanylate cyclase/phosphodiesterase with P... 242 2e-61 ref|ZP_08825478.1| diguanylate cyclase [Thiorhodococcus drewsii ... 234 5e-59 ref|YP_002279777.1| diguanylate cyclase [Rhizobium leguminosarum... 225 2e-56 >ref|YP_003778085.1| diguanylate cyclase/phosphodiesterase with PAS/PAC sensor domain-containing protein [Herbaspirillum seropedicae SmR1] gb|ADJ66177.1| diguanylate cyclase/phosphodiesterase with PAS/PAC sensor domain protein [Herbaspirillum seropedicae SmR1] Length = 573 Score = 877 bits (2265), Expect = 0.0, Method: Composition-based stats. Identities = 468/573 (81%), Positives = 511/573 (89%) Query: 63 MKKRLDFFWLGFLRKIEIRYRLINSFILVSLVPLVISGLLAYRETTRATQDKVRTYSVQV 122 M+KRLDF FLR+I I YRLI++FILVSL+PL+ISGLLAY ET+RATQDKVR YSVQV Sbjct: 1 MRKRLDFLSRHFLRRIAIGYRLISAFILVSLLPLLISGLLAYGETSRATQDKVRAYSVQV 60 Query: 123 VKQISQNLMLRMEKIEDTSEELALSDKLQRLLGDYYSGDEATSAAARSGVARVLLDTYGS 182 V+QISQNL+LRMEKIEDTSE LALS+K+QRLL DYYSGD SAAAR+ ARVLLDTYG+ Sbjct: 61 VQQISQNLLLRMEKIEDTSEALALSEKMQRLLADYYSGDADASAAARNSAARVLLDTYGA 120 Query: 183 LPDVNQKYLLDRKRQVIDPQIFAPLASNITRVAEDAPDLGGRGWWTLYNGGHGQKSVAML 242 L VNQKYLLDR RQVIDPQIFAPLAS+I RVAE+AP+L GRGWWTLY+ GHGQKS+AML Sbjct: 121 LTYVNQKYLLDRDRQVIDPQIFAPLASSIGRVAEEAPELTGRGWWTLYHAGHGQKSLAML 180 Query: 243 REIRFTGNNRGAGVLFIGVRPSYFFSIFEGVDLGYDSSLFIVDASDGTVVVQGRDTSFSS 302 RE+RFT NNR AGVLF+GV PSYFF IF G DLGY +S+ IVDASDG VVVQ R++S S Sbjct: 181 REVRFTANNRPAGVLFVGVHPSYFFDIFRGADLGYGASISIVDASDGAVVVQSRESSASQ 240 Query: 303 ADPALLEGITASVGQRRTSDFIAYTRADKTRYYAAIAQLPHTSWWVVSATPSDKLNADTR 362 ADPALL GIT S+ Q R SDFIAY ADKT YYAAIA+LPHTSWWV S TPSD+LNADTR Sbjct: 241 ADPALLGGITESLAQGRDSDFIAYVGADKTPYYAAIARLPHTSWWVASITPSDRLNADTR 300 Query: 363 SVRDKIIAIGLLCFAASLLLSALIARSISVPLQRLVGAMKEAGSGDTTVRVEQAGGDEIA 422 SVRDKIIAIGL+CFA SLLLSALI+RSISVPLQRLV AMKEAGSGDTTVRVEQ G DEIA Sbjct: 301 SVRDKIIAIGLVCFAVSLLLSALISRSISVPLQRLVAAMKEAGSGDTTVRVEQHGNDEIA 360 Query: 423 ILSRKFNEMAGKLQQNKEELEDQVARRTRELELANRKLEALSATDGLTGVANRRRFDEVL 482 +LSRKFNEMAGKLQQN+E LE+QV RTRELE ANRKLEALSATDGLTGVANRRRFDE L Sbjct: 361 VLSRKFNEMAGKLQQNREVLEEQVRLRTRELERANRKLEALSATDGLTGVANRRRFDEAL 420 Query: 483 DSELRRSVRSGHALALLMLDVDYFKKYNDRYGHVAGDECLRIVARVLQKSSRRATDLVAR 542 +E+RR+VRSG +LALLMLDVDYFKKYNDRYGH+AGDECLRIVARVLQKSSRRATDLVAR Sbjct: 421 ANEMRRAVRSGQSLALLMLDVDYFKKYNDRYGHLAGDECLRIVARVLQKSSRRATDLVAR 480 Query: 543 YGGEEFCVIIAESDTAHALQQAEHICQAIFELKLPHADSPFGYITASIGVASLQPDEHTS 602 YGGEEF VIIAE DT ALQQAE+ICQAIFELKLPHADSPFGYI+ASIGVA L PDEHT+ Sbjct: 481 YGGEEFSVIIAECDTTQALQQAENICQAIFELKLPHADSPFGYISASIGVAVLLPDEHTA 540 Query: 603 AEQLLRVADQALYHAKYQGRNRVVLGSDATQDL 635 EQ++R+ADQALYHAKYQGRNRVVLGSDATQ L Sbjct: 541 PEQMVRIADQALYHAKYQGRNRVVLGSDATQGL 573 >ref|YP_001863263.1| diguanylate cyclase/phosphodiesterase with PAS/PAC sensor(s) [Burkholderia phymatum STM815] gb|ACC76217.1| diguanylate cyclase/phosphodiesterase with PAS/PAC sensor(s) [Burkholderia phymatum STM815] Length = 980 Score = 269 bits (688), Expect = 9e-70, Method: Composition-based stats. Identities = 157/448 (35%), Positives = 263/448 (58%), Gaps = 30/448 (6%) Query: 62 SMKKRLDFFWLGFLRKIEIRYRLINSFILVSLVPLVISGLLAYRETTRATQDKVRTYSVQ 121 S+++ ++ LR++EIRYRL+ +FIL+SL+P++ISG ++Y E+T A ++K +S + Sbjct: 7 SLQRAFEYLSQDLLRRVEIRYRLMTAFILLSLLPVLISGYISYAESTAAIKEKAEIFSKE 66 Query: 122 VVKQISQNLMLRMEKIEDTSEELALSDKLQRLLGDYYSGDEATSAAARSGVARVLLDTYG 181 VVKQ+S+N++LRME++E S L LSD++Q L SG AR + R+LLD YG Sbjct: 67 VVKQVSRNVVLRMEQVETESSLLVLSDQVQAALMKVESGSPKEQNEARQDMTRLLLDHYG 126 Query: 182 SLPDVNQKYLLDRKRQVIDPQIFAPLASNITRVAEDAPDLGGRGWWTLYNGGHGQKSVAM 241 S+ +N+KYLLD+ +V+D Q FA L + R A GR +W Y+ G GQ+++ M Sbjct: 127 SVDFINEKYLLDQHDRVMDTQAFAQLTRGVMRFVRQALQHNGRPYWGSYDNGVGQQNLGM 186 Query: 242 LREIRFTGNNRGAGVLFIGVRPSYFFSIFEGVDLGYDSSLFIVDASDGTVVVQGRDT--- 298 +R + NNR G L + +RP +F +IF V LG + ++++D S+ ++V+ DT Sbjct: 187 VRAVIGKSNNRQLGHLVLVIRPEHFSTIFNDVALGTGTQIYVLDTSNNKLIVRADDTPAG 246 Query: 299 SFSSADPALLEGIT---ASVGQRRTSDFIAYTRADKTRYYAAIAQLPHTSWWVVSATPSD 355 + ++A+P L++ IT ++G+ + F+++ ++ Y+AA ++P T+W+VVS P Sbjct: 247 ADAAAEPGLIDKITHNNETLGE--PNGFVSFEGKNRAGYFAAYTRIPGTTWFVVSTIPEK 304 Query: 356 KLNADTRSVRDKIIAIGLLCFAASLLLSALIARSISVPLQRLVGAMKEAGS--GDTTVRV 413 KL A+ +SVR++++ +G+ F S+ + I+ SIS PL+ LV M + GS G + + Sbjct: 305 KLTAEAQSVRNQMVLVGISGFLLSIFFAYFISHSISAPLKNLVRKMHDTGSDAGAESEDL 364 Query: 414 EQA-----GGDEIAILSRKFNEMAGKLQQNKEE-------LEDQVARRTRELELANRKLE 461 QA G DE+ L ++F M ++Q ++ LE VA RT EL +R+LE Sbjct: 365 AQAPVGSDGQDELGRLEQRFERMRAAIRQKIQKINEINASLEQTVAERTA--ELVSRELE 422 Query: 462 ALSATDGLTGVANRRRFDEVLDSELRRS 489 + + + R D +LRR+ Sbjct: 423 SRTLIENSPDTITR------YDRDLRRT 444 Score = 106 bits (264), Expect = 2e-20, Method: Composition-based stats. Identities = 68/161 (42%), Positives = 96/161 (59%), Gaps = 7/161 (4%) Query: 467 DGLTGVANRRRFDEVLDSELRRSVRSGHALALLMLDVDYFKKYNDRYGHVAGDECLRIVA 526 D LT + NR+ F L+ E + + RSGH +AL+++D+D FK+ ND GH GD L A Sbjct: 549 DTLTQLPNRQMFQNRLEQEAKVAQRSGHRMALMLIDLDRFKEVNDSLGHDTGDTLLIEAA 608 Query: 527 RVLQKSSRRATDLVARYGGEEFCVIIAESDTAHALQQAEHICQAIFE-LKLPHADSP-FG 584 R + S R +D VAR GG+EF VI+ + D ++ E I + I E L P A P Sbjct: 609 RRI-TSCVRESDTVARLGGDEFTVILPDIDNCGSI---ERIARTIIETLSEPFALGPDEA 664 Query: 585 YITASIGVASLQPDEHTSAEQLLRVADQALYHAKYQGRNRV 625 +I+ASIGV ++ PD+ + L + ADQA+Y AK GRNR+ Sbjct: 665 FISASIGV-TVYPDDARELDVLFKNADQAMYAAKNAGRNRL 704 >ref|YP_001893446.1| diguanylate cyclase/phosphodiesterase with PAS/PAC sensor(s) [Ralstonia pickettii 12J] ref|YP_002983790.1| PAS/PAC sensor-containing diguanylate cyclase/phosphodiesterase [Ralstonia pickettii 12D] gb|ACD30019.1| diguanylate cyclase/phosphodiesterase with PAS/PAC sensor(s) [Ralstonia pickettii 12J] gb|ACS65118.1| diguanylate cyclase/phosphodiesterase with PAS/PAC sensor(s) [Ralstonia pickettii 12D] Length = 980 Score = 242 bits (617), Expect = 2e-61, Method: Composition-based stats. Identities = 148/421 (35%), Positives = 239/421 (56%), Gaps = 20/421 (4%) Query: 61 RSMKKRLDFFWLGFLRKIEIRYRLINSFILVSLVPLVISGLLAYRETTRATQDKVRTYSV 120 R +++ D+ LR++EIR+RL+ +FIL+SL+P+ IS ++Y + A ++ +S Sbjct: 6 RLLQRAFDYLSQDLLRRVEIRHRLVAAFILLSLLPICISASISYVNSIAAIKENAEIFSK 65 Query: 121 QVVKQISQNLMLRMEKIEDTSEELALSDKLQRLLGDYYSGDEATSAAARSGVARVLLDTY 180 +VVKQ+S+N+ LRM +IE S L LS+++Q L SG+ + AR +AR+LL+ Y Sbjct: 66 EVVKQVSRNIELRMRQIEAESNLLVLSNQVQGALARAASGNGKEQSEARQDMARLLLEHY 125 Query: 181 GSLPDVNQKYLLDRKRQVIDPQIFAPLASNITRVAEDAPDLGGRGWWTLYNGGHGQKSVA 240 GS+ +NQKYLLD+ +++D Q A L +TR+ A D+ G +W Y+ G GQ++V Sbjct: 126 GSVDFINQKYLLDKNNRILDTQAAAQLTQGVTRLVSRAQDVHGHTYWGSYDNGVGQQNVG 185 Query: 241 MLREIRFTGNNRGAGVLFIGVRPSYFFSIFEGVDLGYDSSLFIVDASDGTVVVQGRDTSF 300 ++R I +NR G L + VRP+YF +IF V G + +FI+DAS+ V+++ D + Sbjct: 186 VVRAIIDKNSNRQLGNLVLIVRPAYFSTIFNDVATGSGTQIFILDASN-EVIIRAADAAN 244 Query: 301 SSA---DPALLEGITASVGQRRTSDFIAYTRADKTRYYAAIAQLPHTSWWVVSATPSDKL 357 + +P LLE I + F+A RY AA A++P T+W+VVS KL Sbjct: 245 DTGALPEPGLLENIARNATAGEARSFVAIEGKRGGRYLAAYAKIPGTTWFVVSTIAEKKL 304 Query: 358 NADTRSVRDKIIAIGLLCFAASLLLSALIARSISVPLQRLVGAMKEAGSGDTTVRVE--- 414 A+ ++VR++I +G+ S+ L+ I+ SIS PL+ LV + + G D +V+ Sbjct: 305 TAEAQAVRNQIALVGISGVLLSIFLAYFISHSISAPLRELVRKVHDTGD-DAGAQVDEGK 363 Query: 415 --QAGG---DEIAILSRKFNEMAGKLQQNKEE-------LEDQVARRTRELELANRKLEA 462 +AG DE++ L+++F M ++Q E+ LE V RT EL R+ Sbjct: 364 HVEAGARAKDELSRLAQRFERMREAIKQKIEKINEINASLEQTVIERTAELVTRERESRT 423 Query: 463 L 463 L Sbjct: 424 L 424 Score = 92.8 bits (229), Expect = 2e-16, Method: Composition-based stats. Identities = 63/159 (39%), Positives = 89/159 (55%), Gaps = 5/159 (3%) Query: 467 DGLTGVANRRRFDEVLDSELRRSVRSGHALALLMLDVDYFKKYNDRYGHVAGDECLRIVA 526 D LTG+ NR+ F E L E + R G +AL+++D+D FK+ ND GH GD L I A Sbjct: 547 DALTGLPNRQMFHERLAQEASQPGRIGRRMALMLIDLDRFKEVNDSLGHDRGDTLL-IEA 605 Query: 527 RVLQKSSRRATDLVARYGGEEFCVIIAESDTAHALQQ-AEHICQAIFELKLPHADSPFGY 585 + R +D VAR GG+EF VI+ D A ++++ A I + E D F Sbjct: 606 GKRIGACVRQSDTVARLGGDEFTVILPNLDDAESVERIASTIIDKLAEPFKLGTDEAF-- 663 Query: 586 ITASIGVASLQPDEHTSAEQLLRVADQALYHAKYQGRNR 624 ++AS+GV + PD+ + L + ADQA+Y AK GRNR Sbjct: 664 VSASVGV-TFYPDDAHDLDVLFKNADQAMYAAKNAGRNR 701 >ref|ZP_08825478.1| diguanylate cyclase [Thiorhodococcus drewsii AZ1] gb|EGV27913.1| diguanylate cyclase [Thiorhodococcus drewsii AZ1] Length = 630 Score = 234 bits (596), Expect = 5e-59, Method: Composition-based stats. Identities = 151/378 (39%), Positives = 211/378 (55%), Gaps = 25/378 (6%) Query: 260 GVRPSYFFSIFEGVDLGYDSSLFIVDASDGTVVVQGR----DTSFSSADPALLEGITASV 315 G + F + EG + + + ++ SDG ++ +T SA AL G V Sbjct: 266 GAYSTLFLADDEGTLMFHPKHMETIEESDGQASIRSLGLEGETRLLSAGAALAPGQVVLV 325 Query: 316 GQRRTSDFIAYTRADKTRYYAAIAQLPHTSWWVVSATPSDKLNADTRSVRDKIIAIGLLC 375 D A+ ++P T + P + ++A+GLL Sbjct: 326 --------------DTPGAIVAVGRIPETPAILTIHYPRALMRPAILQNLAVVVAVGLLT 371 Query: 376 FAASLLLSALIAR-SISVPLQRLVGAMKEAGSGDTTVRVEQ-----AGGDEIAILSRKFN 429 +++ I R ++ PL++L+ A + GSG T +VE+ DEI L+R F Sbjct: 372 LLVEIVILRNILRFQVARPLEQLIRATRLLGSG-TERKVEEKDLPTGSRDEIGDLARAFA 430 Query: 430 EMAGKLQQNKEELEDQVARRTRELELANRKLEALSATDGLTGVANRRRFDEVLDSELRRS 489 MA ++Q + ELE +V RT ELE ANRKL A+S TD LT +ANRRRFD L+ E RR+ Sbjct: 431 GMAEQVQSARAELESKVLERTLELEAANRKLAAMSTTDSLTDIANRRRFDAALEEEWRRA 490 Query: 490 VRSGHALALLMLDVDYFKKYNDRYGHVAGDECLRIVARVLQKSSRRATDLVARYGGEEFC 549 +RSG +L L M+DVD+FKKYNDRYGH +GD CLR +ARVL+ ++RRA DLVARYGGEEF Sbjct: 491 MRSGSSLTLSMIDVDWFKKYNDRYGHQSGDACLRQIARVLESTARRAGDLVARYGGEEFT 550 Query: 550 VIIAESDTAHALQQAEHICQAIFELKLPHADSPFGYITASIGVASLQPDEHTSAEQLLRV 609 +I + + + I A+ +L+LPHADSPF +T SIGVA P + + LL+ Sbjct: 551 LITCGTTPSCSPGLPHAIRAAVEQLQLPHADSPFHLVTVSIGVACRVPMADQTPDSLLQE 610 Query: 610 ADQALYHAKYQGRNRVVL 627 AD ALY AK +GRNRVV+ Sbjct: 611 ADAALYRAKAEGRNRVVV 628 >ref|YP_002279777.1| diguanylate cyclase [Rhizobium leguminosarum bv. trifolii WSM2304] gb|ACI53551.1| diguanylate cyclase [Rhizobium leguminosarum bv. trifolii WSM2304] Length = 660 Score = 225 bits (574), Expect = 2e-56, Method: Composition-based stats. Identities = 140/371 (37%), Positives = 205/371 (55%), Gaps = 26/371 (7%) Query: 276 GYDSSLFIVDASDGTVVVQGRDTSFSSADPALLEGITASVGQRRTSDFIAYTRA------ 329 G +++F D + GT++ G+ T +A AS+ +D+ +A Sbjct: 285 GARATIFAAD-NQGTLIFDGKYTDAITASAG-----EASISSLEIADYQPLLKASQAIGA 338 Query: 330 ------DKTRYYAAIAQLPHTSWWVVSATPSDKLNADTRSVRDKIIAIGLLC-FAASLLL 382 + T A+ ++P T W + P + + ++A+GLL F +L Sbjct: 339 GSVSLIESTSEITAVGRIPDTPWVLAVHYPKSLMRPAILTNLGIVVAVGLLTLFVELFIL 398 Query: 383 SALIARSISVPLQRLVGAMKEAGSGDTTVR---VEQAGGDEIAILSRKFNEMAGKLQQNK 439 +++ + ++ PL RL+ A + G TV + DEI L+R F MA ++ Sbjct: 399 RSILQKQVAEPLVRLIHATQLVGRSGVTVANDALPTHSDDEIGELARDFASMAARVHTAH 458 Query: 440 EELEDQVARRTRELELANRKLEALSATDGLTGVANRRRFDEVLDSELRRSVRSGHALALL 499 E LE ++ RT ELE N+KL +S TD +TGVANRRRFDEVL SEL + L L Sbjct: 459 EALEGKIRDRTSELERLNQKLLTISQTDEMTGVANRRRFDEVLASELAGLGQGQDLLMLA 518 Query: 500 MLDVDYFKKYNDRYGHVAGDECLRIVARVLQKSSRRATDLVARYGGEEFCVI--IAESDT 557 M+D D+FK YNDRYGH AGD CL+ +ARVL++++R D+VARYGGEEF +I IA + Sbjct: 519 MVDADWFKGYNDRYGHPAGDACLKEIARVLERNTRSKQDVVARYGGEEFAIIARIASASN 578 Query: 558 AHALQQAEHICQAIFELKLPHADSPFGYITASIGVASLQPDEHTSAEQLLRVADQALYHA 617 A + QA +C A+ +KL H SPFG++T S+G+A PD++ S E LL AD+ALY A Sbjct: 579 APVIGQA--LCSAMATVKLAHEGSPFGHVTLSVGIALAAPDQNISPEALLLEADRALYRA 636 Query: 618 KYQGRNRVVLG 628 K GRN+ V+ Sbjct: 637 KQAGRNQAVVA 647