BLASTP 2.2.17 [Aug-26-2007] Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), "Gapped BLAST and PSI-BLAST: a new generation of protein database search programs", Nucleic Acids Res. 25:3389-3402. Reference for composition-based statistics: Schaffer, Alejandro A., L. Aravind, Thomas L. Madden, Sergei Shavirin, John L. Spouge, Yuri I. Wolf, Eugene V. Koonin, and Stephen F. Altschul (2001), "Improving the accuracy of PSI-BLAST protein database searches with composition-based statistics and other refinements", Nucleic Acids Res. 29:2994-3005. Query= 0001.1774.p (304 letters) Database: All non-redundant GenBank CDS translations+PDB+SwissProt+PIR+PRF excluding environmental samples from WGS projects 15,459,386 sequences; 5,307,515,862 total letters Searching..................................................done Score E Sequences producing significant alignments: (bits) Value ref|YP_003778068.1| hydroxymethylglutaryl-CoA lyase [Herbaspiril... 538 e-151 ref|YP_001351814.1| hydroxymethylglutaryl-CoA lyase [Janthinobac... 488 e-136 emb|CAL60339.2| Hydroxymethylglutaryl-CoA lyase (HMG-CoA lyase) ... 471 e-131 ref|YP_004754893.1| hydroxymethylglutaryl-CoA lyase [Collimonas ... 453 e-125 ref|ZP_06843685.1| pyruvate carboxyltransferase [Burkholderia sp... 421 e-116 >ref|YP_003778068.1| hydroxymethylglutaryl-CoA lyase [Herbaspirillum seropedicae SmR1] gb|ADJ66160.1| hydroxymethylglutaryl-CoA lyase protein [Herbaspirillum seropedicae SmR1] Length = 302 Score = 538 bits (1385), Expect = e-151, Method: Composition-based stats. Identities = 277/302 (91%), Positives = 295/302 (97%) Query: 2 MSLPKKVKIVEVGPRDGLQNEKETISAEVKIELVNRLSAAGFPNVEAASFVSPKWVPQMA 61 M+LPKKVKIVEVGPRDGLQNEK+TISAEVKIELVNRL+AAGFPNVEAASFVSPKWVPQMA Sbjct: 1 MNLPKKVKIVEVGPRDGLQNEKDTISAEVKIELVNRLAAAGFPNVEAASFVSPKWVPQMA 60 Query: 62 TSSEVMHGITRKPGVVYSALVPNMKGFEAALEAGVDEVVIFGAASEAFSQKNINCSIAES 121 TS+EVMHGITR+PGVVYSALVPNMKGFEAALEAGVDEVVIFGAASEAFSQKNINCSIAES Sbjct: 61 TSAEVMHGITRRPGVVYSALVPNMKGFEAALEAGVDEVVIFGAASEAFSQKNINCSIAES 120 Query: 122 IERFAEVAKAAKDHRKRLRAAVSCAFGCPYQGEVPLDAVADVVRRFRELGCDEIDIADTI 181 I+RFAEVA+AAK+HRKRLRAAVSCAFGCPYQGEVPL+AVADVVRRFRELGCDEIDIADTI Sbjct: 121 IDRFAEVARAAKEHRKRLRAAVSCAFGCPYQGEVPLEAVADVVRRFRELGCDEIDIADTI 180 Query: 182 GVATPNKVAPVMQAAIREFNIDGLSGHFHDTYGQALANIYASLEVGITIYHSSVAGLGGC 241 GVATP KV PVM+ AIREF+I+GLSGHFHDTYGQALANIYASL+ GI+IYH+SVAGLGGC Sbjct: 181 GVATPGKVRPVMETAIREFHIEGLSGHFHDTYGQALANIYASLQTGISIYHASVAGLGGC 240 Query: 242 PYAKGATGNVATEDVLYMMNGLGIETGIDLDAVAEAGQFISQQLGRKSVSRVGNALAAKR 301 PYAKGATGNVATEDVLYMMNGLGIETG+DLDAV EAGQFISQQLGR+SVSR GNA+AAKR Sbjct: 241 PYAKGATGNVATEDVLYMMNGLGIETGVDLDAVVEAGQFISQQLGRRSVSRAGNAIAAKR 300 Query: 302 AA 303 A Sbjct: 301 AG 302 >ref|YP_001351814.1| hydroxymethylglutaryl-CoA lyase [Janthinobacterium sp. Marseille] gb|ABR88598.1| hydroxymethylglutaryl-CoA lyase [Janthinobacterium sp. Marseille] Length = 309 Score = 488 bits (1256), Expect = e-136, Method: Composition-based stats. Identities = 256/302 (84%), Positives = 272/302 (90%) Query: 3 SLPKKVKIVEVGPRDGLQNEKETISAEVKIELVNRLSAAGFPNVEAASFVSPKWVPQMAT 62 SLP VKI+EVGPRDGLQNE++TISAE KIELVNRLS AGFPNVEAASFVSPKWVPQMAT Sbjct: 6 SLPASVKIIEVGPRDGLQNEQQTISAETKIELVNRLSQAGFPNVEAASFVSPKWVPQMAT 65 Query: 63 SSEVMHGITRKPGVVYSALVPNMKGFEAALEAGVDEVVIFGAASEAFSQKNINCSIAESI 122 SSEVM GITR+PG +YSALVPNMKGFEAAL AGVDEVVIF AASEAFSQKNINCSIAESI Sbjct: 66 SSEVMAGITRRPGTLYSALVPNMKGFEAALAAGVDEVVIFAAASEAFSQKNINCSIAESI 125 Query: 123 ERFAEVAKAAKDHRKRLRAAVSCAFGCPYQGEVPLDAVADVVRRFRELGCDEIDIADTIG 182 RF +VA+AAK H RLR A+SCAFGCPYQGEV D+VADVVR+ RELGCDEIDIADTIG Sbjct: 126 ARFRDVAQAAKQHHLRLRGALSCAFGCPYQGEVTADSVADVVRQLRELGCDEIDIADTIG 185 Query: 183 VATPNKVAPVMQAAIREFNIDGLSGHFHDTYGQALANIYASLEVGITIYHSSVAGLGGCP 242 VATP V VMQ AI EF ID LSGHFHDTYGQALANIYASLEVGI+IYH+SVAGLGGCP Sbjct: 186 VATPRHVQAVMQRAIGEFPIDRLSGHFHDTYGQALANIYASLEVGISIYHASVAGLGGCP 245 Query: 243 YAKGATGNVATEDVLYMMNGLGIETGIDLDAVAEAGQFISQQLGRKSVSRVGNALAAKRA 302 YAKGATGNVATEDVLYMM G GIETGIDLDAV +AGQFIS+QLGRK+VSR GNA+AAKR Sbjct: 246 YAKGATGNVATEDVLYMMQGFGIETGIDLDAVVDAGQFISEQLGRKAVSRAGNAIAAKRG 305 Query: 303 AA 304 AA Sbjct: 306 AA 307 >emb|CAL60339.2| Hydroxymethylglutaryl-CoA lyase (HMG-CoA lyase) (HL) (3-hydroxy-3-methylglutarate-CoA lyase) [Herminiimonas arsenicoxydans] Length = 305 Score = 471 bits (1213), Expect = e-131, Method: Composition-based stats. Identities = 246/300 (82%), Positives = 271/300 (90%) Query: 3 SLPKKVKIVEVGPRDGLQNEKETISAEVKIELVNRLSAAGFPNVEAASFVSPKWVPQMAT 62 SLPK VKI+EVGPRDGLQNE++TISA+VKIELVNRLS AGF N+EAASFVSPKWVPQMAT Sbjct: 5 SLPKAVKIIEVGPRDGLQNEQQTISADVKIELVNRLSQAGFVNIEAASFVSPKWVPQMAT 64 Query: 63 SSEVMHGITRKPGVVYSALVPNMKGFEAALEAGVDEVVIFGAASEAFSQKNINCSIAESI 122 S+EVM GITR+PG +YSALVPNMKGFEAAL AGVDEVVIF AASEAFSQKNINCSIAES+ Sbjct: 65 SAEVMAGITRRPGTLYSALVPNMKGFEAALAAGVDEVVIFAAASEAFSQKNINCSIAESV 124 Query: 123 ERFAEVAKAAKDHRKRLRAAVSCAFGCPYQGEVPLDAVADVVRRFRELGCDEIDIADTIG 182 ERF +VA+AAK+++ RLR A+SCAFGCPYQGEV D+VA VV++ R+LGCDEIDIADTIG Sbjct: 125 ERFRDVARAAKENKLRLRGALSCAFGCPYQGEVSADSVASVVQQLRDLGCDEIDIADTIG 184 Query: 183 VATPNKVAPVMQAAIREFNIDGLSGHFHDTYGQALANIYASLEVGITIYHSSVAGLGGCP 242 VATP V VMQ A +EF I+ LSGHFHDTYGQALANIYASLEVGITIYH+SVAGLGGCP Sbjct: 185 VATPRHVQAVMQRAAQEFPIEKLSGHFHDTYGQALANIYASLEVGITIYHASVAGLGGCP 244 Query: 243 YAKGATGNVATEDVLYMMNGLGIETGIDLDAVAEAGQFISQQLGRKSVSRVGNALAAKRA 302 YAKGATGNVATEDVLYM+ GLGI TGIDLD V +AGQFIS QLGRK+VSR GNALAAKR Sbjct: 245 YAKGATGNVATEDVLYMLRGLGIATGIDLDKVVDAGQFISAQLGRKAVSRAGNALAAKRG 304 >ref|YP_004754893.1| hydroxymethylglutaryl-CoA lyase [Collimonas fungivorans Ter331] gb|AEK64070.1| Hydroxymethylglutaryl-CoA lyase [Collimonas fungivorans Ter331] Length = 307 Score = 453 bits (1165), Expect = e-125, Method: Composition-based stats. Identities = 243/302 (80%), Positives = 267/302 (88%) Query: 2 MSLPKKVKIVEVGPRDGLQNEKETISAEVKIELVNRLSAAGFPNVEAASFVSPKWVPQMA 61 M+ P KVKIVEVGPRDGLQNEKETI A+VKI LV++L+ AGF N+EAASFVSPKWVPQMA Sbjct: 6 MTFPSKVKIVEVGPRDGLQNEKETIPADVKIALVDQLTKAGFVNIEAASFVSPKWVPQMA 65 Query: 62 TSSEVMHGITRKPGVVYSALVPNMKGFEAALEAGVDEVVIFGAASEAFSQKNINCSIAES 121 TSSEVM I RKPGVVYSALVPNMKG EAAL AG DE+VIFGAASEAFSQKNINCSIAES Sbjct: 66 TSSEVMAAIQRKPGVVYSALVPNMKGLEAALAAGADEMVIFGAASEAFSQKNINCSIAES 125 Query: 122 IERFAEVAKAAKDHRKRLRAAVSCAFGCPYQGEVPLDAVADVVRRFRELGCDEIDIADTI 181 IERF EVA+ AK KRLR ++SCAFGCPYQGEV + +V DV+ R R+LGCDEIDIADTI Sbjct: 126 IERFREVAQVAKQEGKRLRGSISCAFGCPYQGEVGIASVVDVLHRLRDLGCDEIDIADTI 185 Query: 182 GVATPNKVAPVMQAAIREFNIDGLSGHFHDTYGQALANIYASLEVGITIYHSSVAGLGGC 241 GVATPNKV VMQ ++EF I+ LSGHFHDTYGQALANIYASLEVGI+IYHSSVAGLGGC Sbjct: 186 GVATPNKVHAVMQRLVQEFPIERLSGHFHDTYGQALANIYASLEVGISIYHSSVAGLGGC 245 Query: 242 PYAKGATGNVATEDVLYMMNGLGIETGIDLDAVAEAGQFISQQLGRKSVSRVGNALAAKR 301 PYAKGATGNV++EDVLY+M GLGIETGIDLDAV +AGQFIS LGRK+VSR GNA+AAKR Sbjct: 246 PYAKGATGNVSSEDVLYLMQGLGIETGIDLDAVVDAGQFISAHLGRKAVSRAGNAIAAKR 305 Query: 302 AA 303 A Sbjct: 306 IA 307 >ref|ZP_06843685.1| pyruvate carboxyltransferase [Burkholderia sp. Ch1-1] gb|EFG68769.1| pyruvate carboxyltransferase [Burkholderia sp. Ch1-1] Length = 308 Score = 421 bits (1083), Expect = e-116, Method: Composition-based stats. Identities = 219/299 (73%), Positives = 245/299 (81%) Query: 2 MSLPKKVKIVEVGPRDGLQNEKETISAEVKIELVNRLSAAGFPNVEAASFVSPKWVPQMA 61 M+LP++VKIVEVGPRDGLQNEKE + KIEL+NRLSAAGF NVEAASFVSPKWVPQMA Sbjct: 1 MALPQQVKIVEVGPRDGLQNEKEFVPTATKIELINRLSAAGFRNVEAASFVSPKWVPQMA 60 Query: 62 TSSEVMHGITRKPGVVYSALVPNMKGFEAALEAGVDEVVIFGAASEAFSQKNINCSIAES 121 ++VM GI R+PG +YS L PN++GFE AL A DE+VIFGAASEAFSQKNINCSIAES Sbjct: 61 DGADVMAGIERRPGTIYSVLTPNLRGFEGALAARADEIVIFGAASEAFSQKNINCSIAES 120 Query: 122 IERFAEVAKAAKDHRKRLRAAVSCAFGCPYQGEVPLDAVADVVRRFRELGCDEIDIADTI 181 I+RFA VA+AAK+H R+R +VSCA GCPYQGEVP+ +VADVV RF LGCDEIDIADTI Sbjct: 121 IDRFAPVAQAAKEHGVRIRGSVSCALGCPYQGEVPVASVADVVERFAALGCDEIDIADTI 180 Query: 182 GVATPNKVAPVMQAAIREFNIDGLSGHFHDTYGQALANIYASLEVGITIYHSSVAGLGGC 241 GV TP + V +A R F LSGHFHDTYGQALANIYA+L GI IYH+SVAGLGGC Sbjct: 181 GVGTPKRTREVFEAVTRVFPRKRLSGHFHDTYGQALANIYAALLEGIEIYHASVAGLGGC 240 Query: 242 PYAKGATGNVATEDVLYMMNGLGIETGIDLDAVAEAGQFISQQLGRKSVSRVGNALAAK 300 PYAKGATGNVATEDVLY+MNGLGIETGIDL V G FIS +GR +VSR G AL AK Sbjct: 241 PYAKGATGNVATEDVLYLMNGLGIETGIDLAQVVAIGDFISTSIGRPNVSRAGKALLAK 299