BLASTP 2.2.17 [Aug-26-2007] Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), "Gapped BLAST and PSI-BLAST: a new generation of protein database search programs", Nucleic Acids Res. 25:3389-3402. Reference for composition-based statistics: Schaffer, Alejandro A., L. Aravind, Thomas L. Madden, Sergei Shavirin, John L. Spouge, Yuri I. Wolf, Eugene V. Koonin, and Stephen F. Altschul (2001), "Improving the accuracy of PSI-BLAST protein database searches with composition-based statistics and other refinements", Nucleic Acids Res. 29:2994-3005. Query= 0001.1663.p (564 letters) Database: All non-redundant GenBank CDS translations+PDB+SwissProt+PIR+PRF excluding environmental samples from WGS projects 15,459,386 sequences; 5,307,515,862 total letters Searching..................................................done Score E Sequences producing significant alignments: (bits) Value ref|YP_003775676.1| pyruvate dehydrogenase [Herbaspirillum serop... 1014 0.0 ref|YP_001424132.2| pyruvate dehydrogenase [cytochrome] [Coxiell... 459 e-127 ref|YP_746170.1| pyruvate dehydrogenase [Granulibacter bethesden... 442 e-122 ref|YP_003114119.1| thiamine pyrophosphate protein TPP binding d... 440 e-121 ref|YP_001990540.1| pyruvate dehydrogenase [Rhodopseudomonas pal... 432 e-118 >ref|YP_003775676.1| pyruvate dehydrogenase [Herbaspirillum seropedicae SmR1] gb|ADJ63768.1| pyruvate dehydrogenase protein [Herbaspirillum seropedicae SmR1] Length = 564 Score = 1014 bits (2623), Expect = 0.0, Method: Composition-based stats. Identities = 512/564 (90%), Positives = 545/564 (96%) Query: 1 MPATVADILIDTLYEIGVRQIFGVVGDALNPLTDAMRRDKRIEWIGVRHEEGAALAAAGQ 60 MPATVADILIDTLYEIGVRQIFGVVGDALNPLTDA+RRDKRIEWIGVRHEEGAALAAAGQ Sbjct: 1 MPATVADILIDTLYEIGVRQIFGVVGDALNPLTDAIRRDKRIEWIGVRHEEGAALAAAGQ 60 Query: 61 AKLTGRLAVCCGTTGPGANHLVAGLYEARKDHAPVLAISGGVPAARRGTDYLQENSPDML 120 AKLTGRLAVCCGTTGPGANHLVAGLYEARKDHAPVLAISGGVPAA RGTDYLQENSP++L Sbjct: 61 AKLTGRLAVCCGTTGPGANHLVAGLYEARKDHAPVLAISGGVPAAHRGTDYLQENSPELL 120 Query: 121 FRDVAAYSQVITSPEQAPAVFHQAIAQAYAQRGVAHLNIPADIIGAKVSGTVPSIHTLRE 180 FRDVAAYSQ+ITSP+QAPAVFHQAIAQAYAQRGVAHLNIPAD+IGAK SG+VPS+HTLRE Sbjct: 121 FRDVAAYSQIITSPDQAPAVFHQAIAQAYAQRGVAHLNIPADVIGAKTSGSVPSLHTLRE 180 Query: 181 CSELAPPAAEIAAAAELINAAGSVAIFAGNGCRGSIDQVLALASKLQAPVMHTFRGKDLV 240 + L+PPAA+I AAA+LINAAGSVAIFAGNGCRG+ID+VLALASKLQAPVMHTFRGKDL Sbjct: 181 RTPLSPPAADIQAAADLINAAGSVAIFAGNGCRGAIDEVLALASKLQAPVMHTFRGKDLA 240 Query: 241 AYDHPHWIGGVGLIGGAPGTDALHGAEVMLMLGSDYPYSEFLPTKAKIIQIDERGFVLGR 300 +YDHPHWIGGVGLIGGAPGTDALH AEVMLMLGSDYPYSEFLPTK+K+IQIDERGFVLGR Sbjct: 241 SYDHPHWIGGVGLIGGAPGTDALHAAEVMLMLGSDYPYSEFLPTKSKVIQIDERGFVLGR 300 Query: 301 RAPVTLGITGSVGPAVQALLEKVDGKTDGSFLQKANADRERWNSKLDSAAEIKRHHKKIK 360 RAPVTLGITGSV PAVQ LLE+V+GKTDG+FLQ+ANA RERWN+KLDSAAEIKRHHKKIK Sbjct: 301 RAPVTLGITGSVAPAVQQLLERVEGKTDGAFLQQANAHRERWNAKLDSAAEIKRHHKKIK 360 Query: 361 PQSVARALSDLADDDARFVIDTGVVTLWCGNWIRQRGQQRLLASFNNAAVGTSLGQANGI 420 PQSVARA+SDLADDDA FV+DTGVVTLWCGNWIRQRG QR+LASFNNAAVGTSLGQANGI Sbjct: 361 PQSVARAISDLADDDAAFVVDTGVVTLWCGNWIRQRGGQRILASFNNAAVGTSLGQANGI 420 Query: 421 QALDRERQVIVGVGDGGFTMLLGEFMTSVEHKLPVKVIVFNNREWGLVHLEMEEAGMPAF 480 QALDRERQV+V VGDGGFTMLLGEFMTSVEH+LPVKV+VFNNREWGLVHLEMEEAGMPAF Sbjct: 421 QALDRERQVVVAVGDGGFTMLLGEFMTSVEHRLPVKVVVFNNREWGLVHLEMEEAGMPAF 480 Query: 481 EGSEFPNADFAAFARACGGQGFTARAPEELQESLQQLLAAPGPAVLDVFIDPSELPVMPH 540 EGSEFPN DFAAFARACGGQGF+ R PEEL+ LQQLLAAPGPAVLDVFIDP ELPVMPH Sbjct: 481 EGSEFPNPDFAAFARACGGQGFSVRTPEELEGGLQQLLAAPGPAVLDVFIDPDELPVMPH 540 Query: 541 IKMEQIWKFGLAKVKESLIAMQGG 564 IKMEQIW+FGLAKV+ESLIAM+GG Sbjct: 541 IKMEQIWRFGLAKVRESLIAMKGG 564 >ref|YP_001424132.2| pyruvate dehydrogenase [cytochrome] [Coxiella burnetii Dugway 5J108-111] gb|ABS76858.2| pyruvate dehydrogenase (cytochrome) [Coxiella burnetii Dugway 5J108-111] Length = 563 Score = 459 bits (1182), Expect = e-127, Method: Composition-based stats. Identities = 238/558 (42%), Positives = 346/558 (62%), Gaps = 4/558 (0%) Query: 1 MPATVADILIDTLYEIGVRQIFGVVGDALNPLTDAMRRDKR--IEWIGVRHEEGAALAAA 58 M V ++L+D L RQIFGV GDA+NPL +A+R DKR EWI VRHEE A AA Sbjct: 2 MKINVWEMLLDILDGCSNRQIFGVFGDAINPLANALRTDKRKRFEWIAVRHEETGAFAAG 61 Query: 59 GQAKLTGRLAVCCGTTGPGANHLVAGLYEARKDHAPVLAISGGVPAARRGTDYLQENSPD 118 QAKLTG+L +C GT GPGA HL+ GLY+A+ DHAPVLA++G VP GTDY QE + D Sbjct: 62 AQAKLTGKLGLCAGTVGPGAIHLLNGLYDAKMDHAPVLALTGQVPRDEIGTDYHQEVNLD 121 Query: 119 MLFRDVAAYSQVITSPEQAPAVFHQAIAQAYAQRGVAHLNIPADIIGAKVSGTVPSIHTL 178 LF DV+AY++ + PEQ P + A+ A A++GVAHL+IP D+ +K Sbjct: 122 RLFDDVSAYNESLIVPEQMPRLGLLAVQTAIARQGVAHLSIPTDVGPSKEINWSLDHPVF 181 Query: 179 RECSELAPPAAEIAAAAELINAAGSVAIFAGNGCRGSIDQVLALASKLQAPVMHTFRGKD 238 ++ + P ++ A +N + V IF G G RG+ ++L LA KL++PV+H +GK Sbjct: 182 QKYQQPVPAPQDLENIATALNRSDKVTIFIGWGARGATQEILDLAQKLKSPVIHALKGKA 241 Query: 239 LVAYDHPHWIGGVGLIGGAPGTDALHGAEVMLMLGSDYPYSEFLPTKAKIIQIDERGFVL 298 ++A ++P+W GGVG++G G +A+ E++LMLG+D+PY +F P IIQID L Sbjct: 242 VIANENPYWAGGVGMLGSTCGMEAMESCELLLMLGTDFPYRQFYPKGKTIIQIDTLPEHL 301 Query: 299 GRRAPVTLGITGSVGPAVQALLEKVDGKTDGSFLQKANADRERWNSKLDSAAEIKRHHKK 358 G+R V +G+ G V +V ALL V K L++ R+ W ++ A I+ Sbjct: 302 GKRCNVKMGVVGDVKASVTALLPMVKEKKSDKHLKRTQRKRKEWEERMLKRA-IRPLKNS 360 Query: 359 IKPQSVARALSDLADDDARFVIDTGVVTLWCGNWIRQRGQQRLLASFNNAAVGTSLGQAN 418 I+PQ+VA ++ A D+A F DTG +W I +G++ +ASFN A++ + QA Sbjct: 361 IRPQAVAHLINHYASDNAVFTADTGETIIWMARQIEMKGERDFIASFNLASMANAFAQAI 420 Query: 419 GIQALDRERQVIVGVGDGGFTMLLGEFMTSVEHKLPVKVIVFNNREWGLVHLEMEEAGMP 478 G+QALDR RQV+ GDGGFTML+G+F+T+V H+LP+K VFNN + GLV +EME +G P Sbjct: 421 GVQALDRSRQVVAMCGDGGFTMLMGDFITAVSHQLPIKAFVFNNGKLGLVKMEMEASGYP 480 Query: 479 AFEGSEFPNADFAAFARACGGQGFTARAPEELQESLQQLLAAPGPAVLDVFIDPSELPVM 538 + G N + A A+A GG+G + ++L+ ++++ GP ++DV +P+EL V Sbjct: 481 EW-GVSLHNPNLADCAKAMGGEGIRVESHDQLKNAVKRAFEIDGPVLVDVLTNPNELIVP 539 Query: 539 PHIKMEQIWKFGLAKVKE 556 P +K + W F ++K+KE Sbjct: 540 PKLKPAEAWGFSISKMKE 557 >ref|YP_746170.1| pyruvate dehydrogenase [Granulibacter bethesdensis CGDNIH1] gb|ABI63247.1| pyruvate oxidase [Granulibacter bethesdensis CGDNIH1] Length = 577 Score = 442 bits (1138), Expect = e-122, Method: Composition-based stats. Identities = 233/551 (42%), Positives = 337/551 (61%), Gaps = 5/551 (0%) Query: 4 TVADILIDTLYEIGVRQIFGVVGDALNPLTDAMRRDKRIEWIGVRHEEGAALAAAGQAKL 63 TVA+IL +TL IGVR+++GVVGD+LN +T+A+RR ++WI VRHEE AA AA ++L Sbjct: 5 TVAEILAETLQVIGVRRVYGVVGDSLNAITEALRRRPDMDWIHVRHEESAAFAAGADSQL 64 Query: 64 TGRLAVCCGTTGPGANHLVAGLYEARKDHAPVLAISGGVPAARRGTDYLQENSPDMLFRD 123 TG++AVC G+ GPG HL+ GLY+A++ P+LAI+ +P A G++Y QE P+ LFR+ Sbjct: 65 TGQIAVCAGSCGPGNLHLINGLYDAQRSRTPMLAIAAHIPTAEIGSNYFQETRPEALFRE 124 Query: 124 VAAYSQVITSPEQAPAVFHQAIAQAYAQRGVAHLNIPADIIGAKVSGTVPSIHTLRECSE 183 + Y + ++ P+Q P + AI A +GVA + IP D+ V V S T C E Sbjct: 125 CSVYCETVSDPDQMPRTLNTAIRAAIGHQGVAVVVIPGDVAMKTVPSPVVSTKTAL-CPE 183 Query: 184 ---LAPPAAEIAAAAELINAAGSVAIFAGNGCRGSIDQVLALASKLQAPVMHTFRGKDLV 240 +P + A L+ AAG V + G GCRG+ D+V+ALA L+AP++H GK+ + Sbjct: 184 PPVTSPSEESLNALTALLEAAGKVTLMCGRGCRGAHDEVVALAEHLKAPIVHALGGKEWI 243 Query: 241 AYDHPHWIGGVGLIGGAPGTDALHGAEVMLMLGSDYPYSEFLPTKAKIIQIDERGFVLGR 300 YD+P+ +G GLIG + G A+ +++LMLG+D+PY +F P +AKI Q+D R LGR Sbjct: 244 EYDNPYDVGMTGLIGFSSGYYAMESCDMLLMLGTDFPYRQFFPEEAKIAQVDLRPENLGR 303 Query: 301 RAPVTLGITGSVGPAVQALLEKVDGKTDGSFLQKANADRERWNSKLDSAAEIKRHHKKIK 360 R + LG+ G V + ALL ++ K D + L + LD A+ K I Sbjct: 304 RTRIDLGVVGDVSATISALLPRLKAKQDTAHLDTCRQHYLKARKGLDDLADGKAGRPPIH 363 Query: 361 PQSVARALSDLADDDARFVIDTGVVTLWCGNWIRQRGQQRLLASFNNAAVGTSLGQANGI 420 PQ VAR +S+ A DDA F D G T+W +++ G++RLL SF + ++ +L QA G Sbjct: 364 PQHVARLISEHASDDAVFACDVGTPTIWAARYLKMNGRRRLLGSFAHGSMANALPQAIGA 423 Query: 421 QALDRERQVIVGVGDGGFTMLLGEFMTSVEHKLPVKVIVFNNREWGLVHLEMEEAGMPAF 480 Q ERQV+ GDGGF ML+G+F+T V+H+LPVK++VFNN G V +EM+ AG+ Sbjct: 424 QVSAPERQVVSMSGDGGFAMLMGDFLTLVQHRLPVKIVVFNNGTLGFVEMEMKAAGLLE- 482 Query: 481 EGSEFPNADFAAFARACGGQGFTARAPEELQESLQQLLAAPGPAVLDVFIDPSELPVMPH 540 G N DFAA ARACG P +L E+++ +L PGPA+LD ++ EL + P Sbjct: 483 SGVALDNPDFAAMARACGVYARRVEDPGKLDEAVRDVLNHPGPALLDAVVNRQELSMPPK 542 Query: 541 IKMEQIWKFGL 551 + +EQ+ F L Sbjct: 543 VSIEQVKGFSL 553 >ref|YP_003114119.1| thiamine pyrophosphate protein TPP binding domain-containing protein [Catenulispora acidiphila DSM 44928] gb|ACU72278.1| thiamine pyrophosphate protein TPP binding domain protein [Catenulispora acidiphila DSM 44928] Length = 576 Score = 440 bits (1132), Expect = e-121, Method: Composition-based stats. Identities = 246/571 (43%), Positives = 351/571 (61%), Gaps = 16/571 (2%) Query: 4 TVADILIDTLYEIGVRQIFGVVGDALNPLTDAMRRDKRIEWIGVRHEEGAALAAAGQAKL 63 TVA+ ++ L ++GVR ++GVVGDALNP+TDA+RR++RIEWIG RHEE AA AA+ QA+L Sbjct: 3 TVAEQIVTALADLGVRTVWGVVGDALNPVTDAIRREERIEWIGTRHEEAAAFAASAQAQL 62 Query: 64 TGRLAVCCGTTGPGANHLVAGLYEARKDHAPVLAISGGVPAARRGTDYLQENSPDMLFRD 123 +G + VC GT GPG+ HL+ GLY+A+K HAPVLAI G VP+A G +Y QE D +FRD Sbjct: 63 SGTIGVCMGTVGPGSLHLLNGLYDAKKSHAPVLAICGQVPSAELGAEYFQEVDNDAVFRD 122 Query: 124 VAAYSQVITSPEQAPAVFHQAIAQAYAQRGVAHLNIPADIIGAKVSGTVPSIHTLRECSE 183 VAA+ +TS Q P V QA+ AYA GV+ L +P DI A+V+ ++H R + Sbjct: 123 VAAFRHTVTSASQMPRVLEQAVQTAYATPGVSVLTLPGDIGSAEVAKD-SAVHITRVPAR 181 Query: 184 LAPPAAEIAAAAELINAAGSVAIFAGNGCRGSIDQVLALASKLQAPVMHTFRGKDLVAYD 243 L P EI A L++ A +V + G G R S VL LA +L AP++ T + K+ + D Sbjct: 182 LTPDDDEITRAVRLLDDAKTVTMLVGAGARESRASVLQLADRLAAPMVLTLKAKEGLEDD 241 Query: 244 HPHWIGGVGLIGGAPGTDALHGAEVMLMLGSDYPYSEFLPTKAKIIQIDERGFVLGRRAP 303 +P IG GLIG +A A +LM+G+D+PY ++LP +QID R +GRR P Sbjct: 242 NPFQIGQSGLIGNPATREAFESAGALLMIGTDFPYPDWLPRSTPTVQIDTRAGHIGRRTP 301 Query: 304 VTLGITGSVGPAVQALLEKVDGKTDGSFLQKANADRERW--------NSKLDSA------ 349 V +G+ G G ++ ALL +V K D S L+KA + E W + + D + Sbjct: 302 VDVGVVGDAGLSIAALLNRVRSKDDRSHLEKARSSYEDWQGHQRRLTDPEFDQSLVGKVR 361 Query: 350 AEIKRHHKKIKPQSVARALSDLADDDARFVIDTGVVTLWCGNWIRQRGQQRLLASFNNAA 409 + + KI+P+++A + A +D F DTG+ T+W + RG +RL+ SFN + Sbjct: 362 SWLDNTEDKIRPEALATLIDTHAAEDTVFTTDTGMSTVWLARCVTMRGSRRLIGSFNLGS 421 Query: 410 VGTSLGQANGIQALDRERQVIVGVGDGGFTMLLGEFMTSVEHKLPVKVIVFNNREWGLVH 469 + +L A G ALDR+RQV+ GDGG TMLLG+ +T+V + LPVK+IVF+N G+V Sbjct: 422 MANALPHALGAAALDRQRQVVAFCGDGGLTMLLGDVLTAVAYDLPVKLIVFDNGRLGMVK 481 Query: 470 LEMEEAGMPAFEGSEFPNADFAAFARACGGQGFTARAPEELQESLQQLLAAPGPAVLDVF 529 LE E+ G+P F G+E N D AA A A G PE L+ ++Q LA+PGP +LDV Sbjct: 482 LEQEQGGLPEF-GTELANPDLAAVATAMGMPAARVTEPEALEAAVQAALASPGPYLLDVV 540 Query: 530 IDPSELPVMPHIKMEQIWKFGLAKVKESLIA 560 +P E+ + P ++Q W F +AK+KE +++ Sbjct: 541 TNPEEIALPPKTSIDQAWGFAIAKMKEGIVS 571 >ref|YP_001990540.1| pyruvate dehydrogenase [Rhodopseudomonas palustris TIE-1] gb|ACF00065.1| thiamine pyrophosphate protein TPP binding domain protein [Rhodopseudomonas palustris TIE-1] Length = 576 Score = 432 bits (1110), Expect = e-118, Method: Composition-based stats. Identities = 242/557 (43%), Positives = 337/557 (60%), Gaps = 4/557 (0%) Query: 1 MPATVADILIDTLYEIGVRQIFGVVGDALNPLTDAMRRDKRIEWIGVRHEEGAALAAAGQ 60 MP VAD +++TL++ GVR+IFGVVGD+LN LT+A+R I+W+ VRHEE AA AAAG+ Sbjct: 1 MP-KVADRIVETLHQAGVRRIFGVVGDSLNGLTEALREHGGIQWVHVRHEEVAAFAAAGE 59 Query: 61 AKLTGRLAVCCGTTGPGANHLVAGLYEARKDHAPVLAISGGVPAARRGTDYLQENSPDML 120 +++TG LAVC G+ GPG HL+ GLY+A++ PVLAI+ +P+A G Y QE P L Sbjct: 60 SQITGELAVCAGSCGPGNLHLINGLYDAQRTRTPVLAIAAQIPSAEIGGGYFQETHPQNL 119 Query: 121 FRDVAAYSQVITSPEQAPAVFHQAIAQAYAQRGVAHLNIPADIIGAKVS--GTVPSIHTL 178 FR+ + Y +++T P Q V AI A +RGVA + IP D+ + S G P L Sbjct: 120 FRECSVYCEMVTDPHQFDYVIENAIRAAIGRRGVAVVVIPGDVALHEASSRGVSPVSGLL 179 Query: 179 RECSELAPPAAEIAAAAELINAAGSVAIFAGNGCRGSIDQVLALASKLQAPVMHTFRGKD 238 + P EI A A L+N AG V +F G GC G+ D+++ALA L++P++H GK+ Sbjct: 180 PPAPVVTPGEPEIEALATLLNDAGKVTLFCGRGCAGAHDELMALAEALKSPIVHALGGKE 239 Query: 239 LVAYDHPHWIGGVGLIGGAPGTDALHGAEVMLMLGSDYPYSEFLPTKAKIIQIDERGFVL 298 V Y +P+ +G G IG + G +A+H +V++MLG+D+PY +FLP KI Q+D R L Sbjct: 240 YVEYGNPYDVGMTGFIGFSSGYEAMHACDVLVMLGTDFPYKQFLPGDVKIAQVDLRAEHL 299 Query: 299 GRRAPVTLGITGSVGPAVQALLEKVDGKTDGSFLQKANADRERWNSKLDSAAEIKRHHKK 358 GRR + LG+ G V ++ALL K+ KTD L A LD A+ HK Sbjct: 300 GRRCKLDLGVVGGVRETIEALLPKLTTKTDRGHLDHCVAHYVSAREGLDDLAKGTPGHKP 359 Query: 359 IKPQSVARALSDLADDDARFVIDTGVVTLWCGNWIRQRGQQRLLASFNNAAVGTSLGQAN 418 I PQ +A+ +SD A +DA F D G T+W +++ G++RL+ S + ++ +L QA Sbjct: 360 IHPQYLAKLISDSAAEDAVFSFDVGTPTIWAARYLKMNGRRRLIGSLAHGSMANALPQAI 419 Query: 419 GIQALDRERQVIVGVGDGGFTMLLGEFMTSVEHKLPVKVIVFNNREWGLVHLEMEEAGMP 478 G+QA RQVI GDGGFTML+G+ +T + KLPVKV++FNN G V LEM+ AG Sbjct: 420 GVQAAQPGRQVISLSGDGGFTMLMGDLITLTQMKLPVKVVIFNNGVLGFVALEMKAAGFV 479 Query: 479 AFEGSEFPNADFAAFARACGGQGFTARAPEELQESLQQLLAAPGPAVLDVFIDPSELPVM 538 G++ N DFAA ARA G G P +L ++ + LA GPAVLDV EL + Sbjct: 480 EL-GTDLQNPDFAAMARAVGIHGVRVEDPGDLPAAVAEFLAHDGPAVLDVVTAKQELSMP 538 Query: 539 PHIKMEQIWKFGLAKVK 555 P I EQ+ F L V+ Sbjct: 539 PTIGAEQVKGFSLWLVR 555