BLASTP 2.2.17 [Aug-26-2007] Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), "Gapped BLAST and PSI-BLAST: a new generation of protein database search programs", Nucleic Acids Res. 25:3389-3402. Reference for composition-based statistics: Schaffer, Alejandro A., L. Aravind, Thomas L. Madden, Sergei Shavirin, John L. Spouge, Yuri I. Wolf, Eugene V. Koonin, and Stephen F. Altschul (2001), "Improving the accuracy of PSI-BLAST protein database searches with composition-based statistics and other refinements", Nucleic Acids Res. 29:2994-3005. Query= 0001.0215.p (590 letters) Database: All non-redundant GenBank CDS translations+PDB+SwissProt+PIR+PRF excluding environmental samples from WGS projects 15,459,386 sequences; 5,307,515,862 total letters Searching..................................................done Score E Sequences producing significant alignments: (bits) Value ref|YP_003775005.1| chloride channel EriC protein [Herbaspirillu... 768 0.0 ref|YP_582739.1| putative CBS:Cl-channel, voltage gated [Cupriav... 640 0.0 ref|YP_296879.1| CBS:Cl- channel, voltage gated [Ralstonia eutro... 619 e-175 ref|YP_004684522.1| voltage gated Cl-channel protein [Cupriavidu... 613 e-173 ref|ZP_02892953.1| Chloride channel core [Burkholderia ambifaria... 603 e-170 >ref|YP_003775005.1| chloride channel EriC protein [Herbaspirillum seropedicae SmR1] gb|ADJ63097.1| chloride channel EriC protein [Herbaspirillum seropedicae SmR1] Length = 572 Score = 768 bits (1984), Expect = 0.0, Method: Composition-based stats. Identities = 490/571 (85%), Positives = 520/571 (91%), Gaps = 1/571 (0%) Query: 20 MKHKRDYTADRRLPLLCAIAAAIGVLSTGAAWLLLKLIALFTNLFYFQRLSFEAISPAAH 79 MKHKRDYTADRRLP LCAIA IG+LSTGAAWLLLKLIALFTNLFYFQRLS A +PA H Sbjct: 1 MKHKRDYTADRRLPYLCAIALPIGLLSTGAAWLLLKLIALFTNLFYFQRLSLAASTPATH 60 Query: 80 TLGWMAALLPVIGGLIVGLMARYGSDKIRGHGIPEAIEAILFGKSRMSPKVALLKPLSSG 139 TLGW+AALLP+ GGLIVGLMARYGSDKIRGHGIPEAIEAILFGKSRMSPKVALLKPLSSG Sbjct: 61 TLGWIAALLPIAGGLIVGLMARYGSDKIRGHGIPEAIEAILFGKSRMSPKVALLKPLSSG 120 Query: 140 IVIGSGGPFGAEGPIIMTGGSLGSLLAQWLHLTAAERKTLLVAGACAGMTAIFGTPLAAL 199 IVIGSGGPFGAEGPIIMTGGS+GSLLAQ LHLTAAERKTLLVAGACAGMTAIFGTPLAA+ Sbjct: 121 IVIGSGGPFGAEGPIIMTGGSIGSLLAQLLHLTAAERKTLLVAGACAGMTAIFGTPLAAV 180 Query: 200 LLAVELLLFELRPRSLLPVALACAIAGFLRPWLIEGGVLFPLEVAPVAPIALLSCLAAGL 259 LLAVELLLFEL+PRSLLPVALACA+AGF+RPWL+E G LFPL+VA P+ALLSCL AGL Sbjct: 181 LLAVELLLFELKPRSLLPVALACAVAGFVRPWLVEAGPLFPLDVAAPTPVALLSCLVAGL 240 Query: 260 ASGVLAALLTLALYRIEDGFHRLPLHWMWWPALGGIAVGLGGLLQPRALGVGYDVIADLL 319 ASGVLAA LTLALYRIEDGFHRL LHWMWWPALGGIAVGLGGLLQPRALGVGYDVI DLL Sbjct: 241 ASGVLAAALTLALYRIEDGFHRLRLHWMWWPALGGIAVGLGGLLQPRALGVGYDVIGDLL 300 Query: 320 NQHMLVSAALALLLVKAVIWLLALGSGTSGGVLAPLLMMGAGLGLVLAPWLPGGSPGLWP 379 +QHML+SAALALLLVKAVIWLLALGSGTSGGVLAPLLM+GAGLGLVL+PWLPGGS GLWP Sbjct: 301 HQHMLLSAALALLLVKAVIWLLALGSGTSGGVLAPLLMLGAGLGLVLSPWLPGGSDGLWP 360 Query: 380 LVCMAGVLGSVLGAPLTAIVFAFGLTHAGNALLPLIATTAVAYGVNVLWMKRSIMTEKIA 439 LVCMAGVLGSVLGAPLTAIVFAFGLTHA ALLPLIATTAVAYGVNVL MKRSIMTEKIA Sbjct: 361 LVCMAGVLGSVLGAPLTAIVFAFGLTHASQALLPLIATTAVAYGVNVLLMKRSIMTEKIA 420 Query: 440 RRGLHVHREYGVDPLERVHVEDLMS-APQAVEAALPAGEALARYYIIERVHRYYPVTAHG 498 RRGLHVHREYGVDPLER+HVE+LM+ APQ + ALPA EALA E VHRYYPVT Sbjct: 421 RRGLHVHREYGVDPLERMHVEELMTAAPQTLAGALPAAEALAWCRAQEHVHRYYPVTDGV 480 Query: 499 RLLGMVALSRLQFADPAEGCGTLMQADAGYLLPHLSARAAAGAMARQGVARLPVVNGPER 558 L+GM+AL L+ AD ++ C TL Q YLLPH+SAR+AAG MAR GVARLPVV GPER Sbjct: 481 HLVGMLALRALEHADASQPCDTLAQGHEHYLLPHMSARSAAGMMARLGVARLPVVAGPER 540 Query: 559 RQLVGVLSLSDLARASASHAEEESVREKLLG 589 R+LVGVLSLSDLARASA+HAEEESVRE+LLG Sbjct: 541 RKLVGVLSLSDLARASAAHAEEESVRERLLG 571 >ref|YP_582739.1| putative CBS:Cl-channel, voltage gated [Cupriavidus metallidurans CH34] gb|ABF07470.1| putative CBS:Cl-channel, voltage gated [Cupriavidus metallidurans CH34] Length = 637 Score = 640 bits (1652), Expect = 0.0, Method: Composition-based stats. Identities = 399/589 (67%), Positives = 457/589 (77%), Gaps = 11/589 (1%) Query: 12 PTLQIRHSMKHKRDYTADRRLPLLCAIAAAIGVLSTGAAWLLLKLIALFTNLFYFQRLSF 71 P + KRDY + RLP+L AIA IG +STGAA++L+ LI FTNLF+FQ LSF Sbjct: 39 PLMHTEVHTVEKRDYAVNGRLPMLAAIALGIGAISTGAAYVLVNLIHFFTNLFFFQTLSF 98 Query: 72 EAISPAAHTLGWMAALLPVIGGLIVGLMARYGSDKIRGHGIPEAIEAILFGKSRMSPKVA 131 SPA HTLG ++P IGGLIVGLMARYGSDKIRGHGIPEAIEA+LFGKS+MSPKVA Sbjct: 99 ADRSPAGHTLGPWVIVVPAIGGLIVGLMARYGSDKIRGHGIPEAIEAVLFGKSKMSPKVA 158 Query: 132 LLKPLSSGIVIGSGGPFGAEGPIIMTGGSLGSLLAQWLHLTAAERKTLLVAGACAGMTAI 191 +LKPLSSGIVIGSGGPFGAEGPIIMTGGS+ SLLAQ+LHLTAAERKTLLV+GACAGMTAI Sbjct: 159 VLKPLSSGIVIGSGGPFGAEGPIIMTGGSIASLLAQYLHLTAAERKTLLVSGACAGMTAI 218 Query: 192 FGTPLAALLLAVELLLFELRPRSLLPVALACAIAGFLRPWLIEGGVLFPLEVAPVAPIAL 251 FGTP+AA+LLA+ELLLFELRPRSLLPVALACA+AGFLRP++ E G LFPL+ AP + +AL Sbjct: 219 FGTPVAAVLLAIELLLFELRPRSLLPVALACAVAGFLRPFVFEAGPLFPLQTAPASTLAL 278 Query: 252 LSCLAAGLASGVLAALLTLALYRIEDGFHRLPLHWMWWPALGGIAVGLGGLLQPRALGVG 311 SC+ AGL G L A LTLALYR ED F L LHWMWWPA+GG+ VG+GG +PRALGVG Sbjct: 279 GSCVLAGLLCGALGAGLTLALYRTEDAFDHLRLHWMWWPAIGGLVVGIGGYFEPRALGVG 338 Query: 312 YDVIADLLNQHMLVSAALALLLVKAVIWLLALGSGTSGGVLAPLLMMGAGLGLVLAPWLP 371 YDVI DLLN +LV AA+ALL VKAVIW+ ALGSGTSGGVLAPLLM+GAGLG+VLAP LP Sbjct: 339 YDVIGDLLNNRLLVEAAVALLAVKAVIWIAALGSGTSGGVLAPLLMLGAGLGVVLAPMLP 398 Query: 372 GGSPGLWPLVCMAGVLGSVLGAPLTAIVFAFGLTHAGNALLPLIATTAVAYGVNVLWMKR 431 GGSPGLW LVCMAGVLGSVLGAPLTAIVFAFGLTH ALLPL+ TTAVAYG +VL MKR Sbjct: 399 GGSPGLWALVCMAGVLGSVLGAPLTAIVFAFGLTHDSEALLPLLLTTAVAYGFSVLTMKR 458 Query: 432 SIMTEKIARRGLHVHREYGVDPLERVHVEDLMSAPQA-VEAALPAGEALARYYIIERVHR 490 SIMTEKIARRGLH++REYGVDPLER HV +LM+ ++A+LP EAL RY+ HR Sbjct: 459 SIMTEKIARRGLHIYREYGVDPLERAHVGELMTRDVVWIDASLPVTEALPRYFGDHAAHR 518 Query: 491 YYPVTAHGRLLGMVALSRLQFA----DPAEGCGTLM------QADAGYLLPHLSARAAAG 540 YPV GR++GM+ + + A D CG L+ A LLP + RAAAG Sbjct: 519 AYPVLRDGRVIGMLQRAAIVAAHAGDDAGLTCGDLLADGANPNAGPAVLLPAQTGRAAAG 578 Query: 541 AMARQGVARLPVVNGPERRQLVGVLSLSDLARASASHAEEESVREKLLG 589 MA VARLPVV +LVG++SL DL S+ EE+ RE+L G Sbjct: 579 RMAELSVARLPVVEDEITMRLVGIVSLRDLMAPSSHVLHEETQRERLRG 627 >ref|YP_296879.1| CBS:Cl- channel, voltage gated [Ralstonia eutropha JMP134] gb|AAZ62035.1| CBS:Cl- channel, voltage gated [Ralstonia eutropha JMP134] Length = 584 Score = 619 bits (1596), Expect = e-175, Method: Composition-based stats. Identities = 395/574 (68%), Positives = 453/574 (78%), Gaps = 6/574 (1%) Query: 23 KRDYTADRRLPLLCAIAAAIGVLSTGAAWLLLKLIALFTNLFYFQRLSFEAISPAAHTLG 82 K DY +RL LLC IA IGV+ST AA +LLKLI FTNLF++Q LS SPA HTLG Sbjct: 5 KSDYAVSQRLLLLCGIALLIGVVSTLAADVLLKLIRFFTNLFFYQTLSLAERSPAHHTLG 64 Query: 83 WMAALLPVIGGLIVGLMARYGSDKIRGHGIPEAIEAILFGKSRMSPKVALLKPLSSGIVI 142 ++PV+GGLIVGLMARYGSDKIRGHGIPEAIEA+LFGKS+MSP+VA+LKPLSSGIVI Sbjct: 65 AWVIVVPVLGGLIVGLMARYGSDKIRGHGIPEAIEAVLFGKSKMSPRVAVLKPLSSGIVI 124 Query: 143 GSGGPFGAEGPIIMTGGSLGSLLAQWLHLTAAERKTLLVAGACAGMTAIFGTPLAALLLA 202 GSGGPFGAEGPIIMTGGSL SLLAQ+LHLTA ERK+LLVAGACAGMTAIFGTP+AA+LLA Sbjct: 125 GSGGPFGAEGPIIMTGGSLASLLAQYLHLTAGERKSLLVAGACAGMTAIFGTPVAAVLLA 184 Query: 203 VELLLFELRPRSLLPVALACAIAGFLRPWLIEGGVLFPLEVAPVAPIALLSCLAAGLASG 262 +ELLLFELRPRSLLPVALACA+AGFLRP+ E G LFPL+ AP P+AL SC+ AGL G Sbjct: 185 IELLLFELRPRSLLPVALACAVAGFLRPFFFEAGPLFPLQTAPAGPVALGSCVVAGLLCG 244 Query: 263 VLAALLTLALYRIEDGFHRLPLHWMWWPALGGIAVGLGGLLQPRALGVGYDVIADLLNQH 322 L A LTLALYR ED F RLPLHWMWWPA+GG+ VG+GG +PRALGVGYDVI DLLN H Sbjct: 245 ALGAALTLALYRTEDAFSRLPLHWMWWPAIGGLLVGIGGYFEPRALGVGYDVIGDLLNNH 304 Query: 323 MLVSAALALLLVKAVIWLLALGSGTSGGVLAPLLMMGAGLGLVLAPWLPGGSPGLWPLVC 382 + +S A+ALL+VKA+IW+ ALGSGTSGGVLAPLLM+GAGLG VLAPWLPGGSP LW LVC Sbjct: 305 LAISVAVALLVVKALIWIAALGSGTSGGVLAPLLMLGAGLGTVLAPWLPGGSPQLWALVC 364 Query: 383 MAGVLGSVLGAPLTAIVFAFGLTHAGNALLPLIATTAVAYGVNVLWMKRSIMTEKIARRG 442 MAGVLGSVLGAPLTAIVFAFGLTH ALLPL+ TTAVAYG +VL MKRSIMTEKIARRG Sbjct: 365 MAGVLGSVLGAPLTAIVFAFGLTHNTEALLPLLLTTAVAYGFSVLTMKRSIMTEKIARRG 424 Query: 443 LHVHREYGVDPLERVHVEDLMSAPQ-AVEAALPAGEALARYYIIERVHRYYPVTAHGRLL 501 LH++REY VDPLER HV +LM+ ++A L EA ARY+ HR YPV + R+L Sbjct: 425 LHIYREYSVDPLERAHVAELMTRDVITIDADLGVSEATARYFGEHAAHRAYPVVSGDRVL 484 Query: 502 GMVALSRLQFADPAEG-----CGTLMQADAGYLLPHLSARAAAGAMARQGVARLPVVNGP 556 GM+ + ++ A C L+ A A L+P +ARAAAG+MA VARLPVV Sbjct: 485 GMLDRATVRGAAAGSAPANLRCRDLLVAQAQVLMPAQTARAAAGSMAASSVARLPVVESL 544 Query: 557 ERRQLVGVLSLSDLARASASHAEEESVREKLLGS 590 + +LVG++SL DL + S EE RE+L GS Sbjct: 545 DTMRLVGIVSLRDLLQPSGQVFHEEFRRERLRGS 578 >ref|YP_004684522.1| voltage gated Cl-channel protein [Cupriavidus necator N-1] gb|AEI76041.1| Cl-channel, voltage gated [Cupriavidus necator N-1] Length = 585 Score = 613 bits (1581), Expect = e-173, Method: Composition-based stats. Identities = 403/573 (70%), Positives = 448/573 (78%), Gaps = 6/573 (1%) Query: 23 KRDYTADRRLPLLCAIAAAIGVLSTGAAWLLLKLIALFTNLFYFQRLSFEAISPAAHTLG 82 KRDY +RRL +L IA IG LST AA +L+ LI FTNLF++Q LS SPA H LG Sbjct: 9 KRDYAVNRRLLMLSVIALGIGALSTVAADVLVNLIRFFTNLFFYQTLSLAERSPANHALG 68 Query: 83 WMAALLPVIGGLIVGLMARYGSDKIRGHGIPEAIEAILFGKSRMSPKVALLKPLSSGIVI 142 +PVIGGLIVGLMARYGSDKIRGHGIPEAIEA+LFGKS MSP+VA+LKPLSSGIVI Sbjct: 69 AWVIAMPVIGGLIVGLMARYGSDKIRGHGIPEAIEAVLFGKSTMSPRVAVLKPLSSGIVI 128 Query: 143 GSGGPFGAEGPIIMTGGSLGSLLAQWLHLTAAERKTLLVAGACAGMTAIFGTPLAALLLA 202 GSGGPFGAEGPIIMTGGSL SLLAQ+LHLTA ERK LLVAGACAGMTAIFGTP+AA+LLA Sbjct: 129 GSGGPFGAEGPIIMTGGSLASLLAQYLHLTAGERKALLVAGACAGMTAIFGTPVAAVLLA 188 Query: 203 VELLLFELRPRSLLPVALACAIAGFLRPWLIEGGVLFPLEVAPVAPIALLSCLAAGLASG 262 VELLLFELRPRSLLPVALACA+AGFLRP E G LFPL+ A ALLSC+ AGL G Sbjct: 189 VELLLFELRPRSLLPVALACAVAGFLRPLFFEAGPLFPLQTAAAGTPALLSCVLAGLLCG 248 Query: 263 VLAALLTLALYRIEDGFHRLPLHWMWWPALGGIAVGLGGLLQPRALGVGYDVIADLLNQH 322 VL A LTLALYR ED F RLPLHWMWWPALGG+ VG+GG +PRALGVGYDVI DLLN Sbjct: 249 VLGAGLTLALYRTEDAFSRLPLHWMWWPALGGLVVGIGGYFEPRALGVGYDVIGDLLNNR 308 Query: 323 MLVSAALALLLVKAVIWLLALGSGTSGGVLAPLLMMGAGLGLVLAPWLPGGSPGLWPLVC 382 + + ALALL VKAVIW+ ALGSGTSGGVLAPLLM+GAGLG+VLAPWLPGGSP LW LVC Sbjct: 309 IAIEIALALLAVKAVIWIAALGSGTSGGVLAPLLMLGAGLGVVLAPWLPGGSPQLWSLVC 368 Query: 383 MAGVLGSVLGAPLTAIVFAFGLTHAGNALLPLIATTAVAYGVNVLWMKRSIMTEKIARRG 442 MAGVLGSVLGAPLTAIVFAFGLTH ALLPL+ TTAVAYG +VL MKRSIMTEKIARRG Sbjct: 369 MAGVLGSVLGAPLTAIVFAFGLTHDTQALLPLLLTTAVAYGFSVLTMKRSIMTEKIARRG 428 Query: 443 LHVHREYGVDPLERVHVEDLMSAP-QAVEAALPAGEALARYYIIERVHRYYPVTAHGRLL 501 LH++REYGVDPLER HV++LM+ A++A LP EA+ RY+ HR YPV A GR+L Sbjct: 429 LHIYREYGVDPLERAHVDELMTREVVAIDAELPVAEAMVRYFGEHAAHRAYPVVAEGRVL 488 Query: 502 GMVALSRLQF-----ADPAEGCGTLMQADAGYLLPHLSARAAAGAMARQGVARLPVVNGP 556 GM+ + ++ P C L+ A A LLP +ARAAAG MA VARLPVV Sbjct: 489 GMLERAAIRGLAAGEIPPGMRCRDLLNAPAHVLLPGQTARAAAGRMAALSVARLPVVESA 548 Query: 557 ERRQLVGVLSLSDLARASASHAEEESVREKLLG 589 E +L G+LSL DL R S S EES RE+L G Sbjct: 549 ETMRLAGILSLRDLLRPSGSVFHEESRRERLRG 581 >ref|ZP_02892953.1| Chloride channel core [Burkholderia ambifaria IOP40-10] gb|EDT01457.1| Chloride channel core [Burkholderia ambifaria IOP40-10] Length = 595 Score = 603 bits (1554), Expect = e-170, Method: Composition-based stats. Identities = 361/574 (62%), Positives = 438/574 (76%), Gaps = 8/574 (1%) Query: 22 HKRDYTADRRLPLLCAIAAAIGVLSTGAAWLLLKLIALFTNLFYFQRLSFEAISPAAHTL 81 HKRD++ + RLP + +AA IG+LST AA++LL LI LFTNLF+FQ+ SF SPA HTL Sbjct: 5 HKRDFSTNERLPRIALLAAGIGLLSTLAAFVLLSLIHLFTNLFFFQQFSFADRSPANHTL 64 Query: 82 GWMAALLPVIGGLIVGLMARYGSDKIRGHGIPEAIEAILFGKSRMSPKVALLKPLSSGIV 141 G ++PVIGGLIVGLMAR+GS+KIRGHGIPEAIEAILFGKSRMSPKVA+LKPLSSG+V Sbjct: 65 GAWVIVVPVIGGLIVGLMARFGSEKIRGHGIPEAIEAILFGKSRMSPKVAILKPLSSGVV 124 Query: 142 IGSGGPFGAEGPIIMTGGSLGSLLAQWLHLTAAERKTLLVAGACAGMTAIFGTPLAALLL 201 IGSGGPFGAEGPIIMTGG+LGSL+AQ +H+TAAERKTLLVAGA AGMTA+FGTP+AA+LL Sbjct: 125 IGSGGPFGAEGPIIMTGGALGSLIAQCVHVTAAERKTLLVAGAAAGMTAVFGTPVAAVLL 184 Query: 202 AVELLLFELRPRSLLPVALACAIAGFLRPWLIEGGVLFPLEVAPVAPIALLSCLAAGLAS 261 AVELLLFE RPRS LPVALACA+AGF R LFPL A P+ALLSC+ AGL S Sbjct: 185 AVELLLFEWRPRSFLPVALACAVAGFARAVFFGVEPLFPLTTASPTPVALLSCIVAGLLS 244 Query: 262 GVLAALLTLALYRIEDGFHRLPLHWMWWPALGGIAVGLGGLLQPRALGVGYDVIADLLNQ 321 G+LA L+ ALYR+ED F +LP+HWMWWPALG +A+G+GG L+PRALGVGYDVI DLL+Q Sbjct: 245 GMLACGLSAALYRVEDTFAKLPVHWMWWPALGAVAIGIGGWLEPRALGVGYDVIGDLLHQ 304 Query: 322 HMLVSAALALLLVKAVIWLLALGSGTSGGVLAPLLMMGAGLGLVLAPWLPGGSPGLWPLV 381 H+ + ALALL+VKAV+W++ALGSGTSGGVLAPLLM+GAGLG VL+P LPGG P LWPLV Sbjct: 305 HIALKIALALLIVKAVMWVIALGSGTSGGVLAPLLMLGAGLGTVLSPVLPGGDPALWPLV 364 Query: 382 CMAGVLGSVLGAPLTAIVFAFGLTHAGNALLPLIATTAVAYGVNVLWMKRSIMTEKIARR 441 CMA LG+ LGAPLTAIVFAFGLTH NALLPL+A T VA+G + MKRSIMTEKIARR Sbjct: 365 CMAATLGATLGAPLTAIVFAFGLTHDANALLPLLAATLVAHGFATIVMKRSIMTEKIARR 424 Query: 442 GLHVHREYGVDPLERVHVEDLMSAPQ---AVEAALPAGEALARYYIIERVHRYYPVTAHG 498 G H++REYGVDPLER V ++M++ A++ A P ++Y+ ++ HR YPV HG Sbjct: 425 GYHIYREYGVDPLERHDVAEVMTSADALVAIDGATPLDAVESQYFGAKQTHRAYPVVQHG 484 Query: 499 RLLGMVALS-----RLQFADPAEGCGTLMQADAGYLLPHLSARAAAGAMARQGVARLPVV 553 RLLG++ + R Q A H + R A +A G+ RLPVV Sbjct: 485 RLLGLIDRATLDAHRAQAGPDASLASAFADRAPAVAQAHETCRVVASRLAMLGLERLPVV 544 Query: 554 NGPERRQLVGVLSLSDLARASASHAEEESVREKL 587 + P+ +L G++S SDL + + H ++E RE+ Sbjct: 545 DDPQSLRLAGIVSRSDLIKPALQHFDDEQKRERF 578