BLASTP 2.2.21 [Jun-14-2009] Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), "Gapped BLAST and PSI-BLAST: a new generation of protein database search programs", Nucleic Acids Res. 25:3389-3402. Reference for compositional score matrix adjustment: Altschul, Stephen F., John C. Wootton, E. Michael Gertz, Richa Agarwala, Aleksandr Morgulis, Alejandro A. Schaffer, and Yi-Kuo Yu (2005) "Protein database searches using compositionally adjusted substitution matrices", FEBS J. 272:5101-5109. Query= 0037.0150.p (302 letters) Database: All non-redundant GenBank CDS translations+PDB+SwissProt+PIR+PRF excluding environmental samples from WGS projects 15,459,386 sequences; 5,307,515,862 total letters Searching..................................................done Score E Sequences producing significant alignments: (bits) Value ref|YP_003778068.1| hydroxymethylglutaryl-CoA lyase [Herbaspiril... 540 e-152 ref|YP_001351814.1| hydroxymethylglutaryl-CoA lyase [Janthinobac... 512 e-143 emb|CAL60339.2| Hydroxymethylglutaryl-CoA lyase (HMG-CoA lyase) ... 510 e-143 ref|YP_004754893.1| hydroxymethylglutaryl-CoA lyase [Collimonas ... 493 e-137 ref|YP_001098468.1| putative hydroxymethylglutaryl-CoA lyase [He... 452 e-125 >ref|YP_003778068.1| hydroxymethylglutaryl-CoA lyase [Herbaspirillum seropedicae SmR1] gb|ADJ66160.1| hydroxymethylglutaryl-CoA lyase protein [Herbaspirillum seropedicae SmR1] Length = 302 Score = 540 bits (1392), Expect = e-152, Method: Compositional matrix adjust. Identities = 259/302 (85%), Positives = 282/302 (93%) Query: 1 MSLPKKVKIVEVGPRDGLQNEKETISAEVKIELVNRLTSAGFVNVEAASFVSPKWVPQMA 60 M+LPKKVKIVEVGPRDGLQNEK+TISAEVKIELVNRL +AGF NVEAASFVSPKWVPQMA Sbjct: 1 MNLPKKVKIVEVGPRDGLQNEKDTISAEVKIELVNRLAAAGFPNVEAASFVSPKWVPQMA 60 Query: 61 TSGEVMRGIARKPGVIYSALTPNMKGFEAALEAGADEVVIFGAASEAFSQKNINCSIAES 120 TS EVM GI R+PGV+YSAL PNMKGFEAALEAG DEVVIFGAASEAFSQKNINCSIAES Sbjct: 61 TSAEVMHGITRRPGVVYSALVPNMKGFEAALEAGVDEVVIFGAASEAFSQKNINCSIAES 120 Query: 121 IERFREVALAAKQHKIRLRAAVSCAFGCPYQGEVPLSSVSDVVGRFRDLGCDEIDIADTI 180 I+RF EVA AAK+H+ RLRAAVSCAFGCPYQGEVPL +V+DVV RFR+LGCDEIDIADTI Sbjct: 121 IDRFAEVARAAKEHRKRLRAAVSCAFGCPYQGEVPLEAVADVVRRFRELGCDEIDIADTI 180 Query: 181 GVATPNKVAPVMQAAIREFNIDGLSGHFHDTYGQALANIYASLEVGITIYHSSVAGLGGC 240 GVATP KV PVM+ AIREF+I+GLSGHFHDTYGQALANIYASL+ GI+IYH+SVAGLGGC Sbjct: 181 GVATPGKVRPVMETAIREFHIEGLSGHFHDTYGQALANIYASLQTGISIYHASVAGLGGC 240 Query: 241 PYAKGATGNVASEDVLYMMQGLGIDTGIDLDIVVDAGQFISQHLGRKAVSRAGNAIAAKR 300 PYAKGATGNVA+EDVLYMM GLGI+TG+DLD VV+AGQFISQ LGR++VSRAGNAIAAKR Sbjct: 241 PYAKGATGNVATEDVLYMMNGLGIETGVDLDAVVEAGQFISQQLGRRSVSRAGNAIAAKR 300 Query: 301 LG 302 G Sbjct: 301 AG 302 >ref|YP_001351814.1| hydroxymethylglutaryl-CoA lyase [Janthinobacterium sp. Marseille] gb|ABR88598.1| hydroxymethylglutaryl-CoA lyase [Janthinobacterium sp. Marseille] Length = 309 Score = 512 bits (1319), Expect = e-143, Method: Compositional matrix adjust. Identities = 249/299 (83%), Positives = 266/299 (88%) Query: 2 SLPKKVKIVEVGPRDGLQNEKETISAEVKIELVNRLTSAGFVNVEAASFVSPKWVPQMAT 61 SLP VKI+EVGPRDGLQNE++TISAE KIELVNRL+ AGF NVEAASFVSPKWVPQMAT Sbjct: 6 SLPASVKIIEVGPRDGLQNEQQTISAETKIELVNRLSQAGFPNVEAASFVSPKWVPQMAT 65 Query: 62 SGEVMRGIARKPGVIYSALTPNMKGFEAALEAGADEVVIFGAASEAFSQKNINCSIAESI 121 S EVM GI R+PG +YSAL PNMKGFEAAL AG DEVVIF AASEAFSQKNINCSIAESI Sbjct: 66 SSEVMAGITRRPGTLYSALVPNMKGFEAALAAGVDEVVIFAAASEAFSQKNINCSIAESI 125 Query: 122 ERFREVALAAKQHKIRLRAAVSCAFGCPYQGEVPLSSVSDVVGRFRDLGCDEIDIADTIG 181 RFR+VA AAKQH +RLR A+SCAFGCPYQGEV SV+DVV + R+LGCDEIDIADTIG Sbjct: 126 ARFRDVAQAAKQHHLRLRGALSCAFGCPYQGEVTADSVADVVRQLRELGCDEIDIADTIG 185 Query: 182 VATPNKVAPVMQAAIREFNIDGLSGHFHDTYGQALANIYASLEVGITIYHSSVAGLGGCP 241 VATP V VMQ AI EF ID LSGHFHDTYGQALANIYASLEVGI+IYH+SVAGLGGCP Sbjct: 186 VATPRHVQAVMQRAIGEFPIDRLSGHFHDTYGQALANIYASLEVGISIYHASVAGLGGCP 245 Query: 242 YAKGATGNVASEDVLYMMQGLGIDTGIDLDIVVDAGQFISQHLGRKAVSRAGNAIAAKR 300 YAKGATGNVA+EDVLYMMQG GI+TGIDLD VVDAGQFIS+ LGRKAVSRAGNAIAAKR Sbjct: 246 YAKGATGNVATEDVLYMMQGFGIETGIDLDAVVDAGQFISEQLGRKAVSRAGNAIAAKR 304 >emb|CAL60339.2| Hydroxymethylglutaryl-CoA lyase (HMG-CoA lyase) (HL) (3-hydroxy-3-methylglutarate-CoA lyase) [Herminiimonas arsenicoxydans] Length = 305 Score = 510 bits (1314), Expect = e-143, Method: Compositional matrix adjust. Identities = 246/299 (82%), Positives = 269/299 (89%) Query: 2 SLPKKVKIVEVGPRDGLQNEKETISAEVKIELVNRLTSAGFVNVEAASFVSPKWVPQMAT 61 SLPK VKI+EVGPRDGLQNE++TISA+VKIELVNRL+ AGFVN+EAASFVSPKWVPQMAT Sbjct: 5 SLPKAVKIIEVGPRDGLQNEQQTISADVKIELVNRLSQAGFVNIEAASFVSPKWVPQMAT 64 Query: 62 SGEVMRGIARKPGVIYSALTPNMKGFEAALEAGADEVVIFGAASEAFSQKNINCSIAESI 121 S EVM GI R+PG +YSAL PNMKGFEAAL AG DEVVIF AASEAFSQKNINCSIAES+ Sbjct: 65 SAEVMAGITRRPGTLYSALVPNMKGFEAALAAGVDEVVIFAAASEAFSQKNINCSIAESV 124 Query: 122 ERFREVALAAKQHKIRLRAAVSCAFGCPYQGEVPLSSVSDVVGRFRDLGCDEIDIADTIG 181 ERFR+VA AAK++K+RLR A+SCAFGCPYQGEV SV+ VV + RDLGCDEIDIADTIG Sbjct: 125 ERFRDVARAAKENKLRLRGALSCAFGCPYQGEVSADSVASVVQQLRDLGCDEIDIADTIG 184 Query: 182 VATPNKVAPVMQAAIREFNIDGLSGHFHDTYGQALANIYASLEVGITIYHSSVAGLGGCP 241 VATP V VMQ A +EF I+ LSGHFHDTYGQALANIYASLEVGITIYH+SVAGLGGCP Sbjct: 185 VATPRHVQAVMQRAAQEFPIEKLSGHFHDTYGQALANIYASLEVGITIYHASVAGLGGCP 244 Query: 242 YAKGATGNVASEDVLYMMQGLGIDTGIDLDIVVDAGQFISQHLGRKAVSRAGNAIAAKR 300 YAKGATGNVA+EDVLYM++GLGI TGIDLD VVDAGQFIS LGRKAVSRAGNA+AAKR Sbjct: 245 YAKGATGNVATEDVLYMLRGLGIATGIDLDKVVDAGQFISAQLGRKAVSRAGNALAAKR 303 >ref|YP_004754893.1| hydroxymethylglutaryl-CoA lyase [Collimonas fungivorans Ter331] gb|AEK64070.1| Hydroxymethylglutaryl-CoA lyase [Collimonas fungivorans Ter331] Length = 307 Score = 493 bits (1270), Expect = e-137, Method: Compositional matrix adjust. Identities = 251/301 (83%), Positives = 271/301 (90%) Query: 1 MSLPKKVKIVEVGPRDGLQNEKETISAEVKIELVNRLTSAGFVNVEAASFVSPKWVPQMA 60 M+ P KVKIVEVGPRDGLQNEKETI A+VKI LV++LT AGFVN+EAASFVSPKWVPQMA Sbjct: 6 MTFPSKVKIVEVGPRDGLQNEKETIPADVKIALVDQLTKAGFVNIEAASFVSPKWVPQMA 65 Query: 61 TSGEVMRGIARKPGVIYSALTPNMKGFEAALEAGADEVVIFGAASEAFSQKNINCSIAES 120 TS EVM I RKPGV+YSAL PNMKG EAAL AGADE+VIFGAASEAFSQKNINCSIAES Sbjct: 66 TSSEVMAAIQRKPGVVYSALVPNMKGLEAALAAGADEMVIFGAASEAFSQKNINCSIAES 125 Query: 121 IERFREVALAAKQHKIRLRAAVSCAFGCPYQGEVPLSSVSDVVGRFRDLGCDEIDIADTI 180 IERFREVA AKQ RLR ++SCAFGCPYQGEV ++SV DV+ R RDLGCDEIDIADTI Sbjct: 126 IERFREVAQVAKQEGKRLRGSISCAFGCPYQGEVGIASVVDVLHRLRDLGCDEIDIADTI 185 Query: 181 GVATPNKVAPVMQAAIREFNIDGLSGHFHDTYGQALANIYASLEVGITIYHSSVAGLGGC 240 GVATPNKV VMQ ++EF I+ LSGHFHDTYGQALANIYASLEVGI+IYHSSVAGLGGC Sbjct: 186 GVATPNKVHAVMQRLVQEFPIERLSGHFHDTYGQALANIYASLEVGISIYHSSVAGLGGC 245 Query: 241 PYAKGATGNVASEDVLYMMQGLGIDTGIDLDIVVDAGQFISQHLGRKAVSRAGNAIAAKR 300 PYAKGATGNV+SEDVLY+MQGLGI+TGIDLD VVDAGQFIS HLGRKAVSRAGNAIAAKR Sbjct: 246 PYAKGATGNVSSEDVLYLMQGLGIETGIDLDAVVDAGQFISAHLGRKAVSRAGNAIAAKR 305 Query: 301 L 301 + Sbjct: 306 I 306 >ref|YP_001098468.1| putative hydroxymethylglutaryl-CoA lyase [Herminiimonas arsenicoxydans] Length = 269 Score = 452 bits (1163), Expect = e-125, Method: Compositional matrix adjust. Identities = 218/267 (81%), Positives = 238/267 (89%) Query: 34 VNRLTSAGFVNVEAASFVSPKWVPQMATSGEVMRGIARKPGVIYSALTPNMKGFEAALEA 93 +NRL+ AGFVN+EAASFVSPKWVPQMATS EVM GI R+PG +YSAL PNMKGFEAAL A Sbjct: 1 MNRLSQAGFVNIEAASFVSPKWVPQMATSAEVMAGITRRPGTLYSALVPNMKGFEAALAA 60 Query: 94 GADEVVIFGAASEAFSQKNINCSIAESIERFREVALAAKQHKIRLRAAVSCAFGCPYQGE 153 G DEVVIF AASEAFSQKNINCSIAES+ERFR+VA AAK++K+RLR A+SCAFGCPYQGE Sbjct: 61 GVDEVVIFAAASEAFSQKNINCSIAESVERFRDVARAAKENKLRLRGALSCAFGCPYQGE 120 Query: 154 VPLSSVSDVVGRFRDLGCDEIDIADTIGVATPNKVAPVMQAAIREFNIDGLSGHFHDTYG 213 V SV+ VV + RDLGCDEIDIADTIGVATP V VMQ A +EF I+ LSGHFHDTYG Sbjct: 121 VSADSVASVVQQLRDLGCDEIDIADTIGVATPRHVQAVMQRAAQEFPIEKLSGHFHDTYG 180 Query: 214 QALANIYASLEVGITIYHSSVAGLGGCPYAKGATGNVASEDVLYMMQGLGIDTGIDLDIV 273 QALANIYASLEVGITIYH+SVAGLGGCPYAKGATGNVA+EDVLYM++GLGI TGIDLD V Sbjct: 181 QALANIYASLEVGITIYHASVAGLGGCPYAKGATGNVATEDVLYMLRGLGIATGIDLDKV 240 Query: 274 VDAGQFISQHLGRKAVSRAGNAIAAKR 300 VDAGQFIS LGRKAVSRAGNA+AAKR Sbjct: 241 VDAGQFISAQLGRKAVSRAGNALAAKR 267