BLASTP 2.2.21 [Jun-14-2009] Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), "Gapped BLAST and PSI-BLAST: a new generation of protein database search programs", Nucleic Acids Res. 25:3389-3402. Reference for compositional score matrix adjustment: Altschul, Stephen F., John C. Wootton, E. Michael Gertz, Richa Agarwala, Aleksandr Morgulis, Alejandro A. Schaffer, and Yi-Kuo Yu (2005) "Protein database searches using compositionally adjusted substitution matrices", FEBS J. 272:5101-5109. Query= 0037.0033.p (496 letters) Database: All non-redundant GenBank CDS translations+PDB+SwissProt+PIR+PRF excluding environmental samples from WGS projects 15,459,386 sequences; 5,307,515,862 total letters Searching..................................................done Score E Sequences producing significant alignments: (bits) Value ref|YP_001817716.1| multi-sensor signal transduction histidine k... 221 3e-55 ref|ZP_04893174.1| response regulator/sensory box histidine kina... 214 4e-53 ref|YP_001062927.1| Signal transduction histidine kinase [Burkho... 214 4e-53 ref|ZP_00439400.1| sensory box histidine kinase/response regulat... 213 4e-53 ref|YP_105597.1| sensory box histidine kinase/response regulator... 213 5e-53 >ref|YP_001817716.1| multi-sensor signal transduction histidine kinase [Opitutus terrae PB90-1] gb|ACB74116.1| multi-sensor signal transduction histidine kinase [Opitutus terrae PB90-1] Length = 644 Score = 221 bits (562), Expect = 3e-55, Method: Compositional matrix adjust. Identities = 145/382 (37%), Positives = 201/382 (52%), Gaps = 19/382 (4%) Query: 127 RHHELEKGIFKRTA-----QLEFTLG----QLKLAVSASNTGLWNWNLRTDQFYFSPEWK 177 RH G+ RT QL LG +LK A+ A GLW+W + T FS WK Sbjct: 261 RHELAVAGLRARTELADRRQLLAALGASDQRLKTALEAGRIGLWSWEVGTGHMEFSARWK 320 Query: 178 RQIGYADHEIDDGMEEWTARLHPDDVERAVTLTRAYLASPQESLEIEYRMRHRDGTFRWM 237 QIGYA++EI + EW +R HPDD+ TLT YLA+P +EYR++H+DG++R Sbjct: 321 AQIGYAENEIGEDAAEWFSRCHPDDLANLHTLTARYLAAPWPDFNVEYRLKHKDGSWRCF 380 Query: 238 LSRSMAMLDENDKAILLQGSHVDITERKQSEENLLALTRELRDVSRELARVEEAERRRFA 297 L + D+ + + G+ +D+T+ KQ + ++ + + L+ +SR L V+E ERR A Sbjct: 381 LLHAALETDDPGEPRRMVGAQIDVTQLKQQQADIASTSARLQQLSRRLLNVQEMERRSLA 440 Query: 298 QELHDTIGSALAALSINMTIMSGEISGTNDHPSAG-MAARLKDSIVLLDDTTDAVRRLMA 356 +ELHD IG L I++ T P G +A RLK+ + LLD VR L Sbjct: 441 RELHDEIGQVLTVAKIHL-------QSTVLLPECGRVAGRLKEPVALLDRLLAQVRSLSL 493 Query: 357 ELRPPVLDDYGLEAALRWQCELFAERS-GFRFTVDVYGIDDRLEPELEISLFRIAQGAIT 415 LRPP+LDD GL AL W + G R + R +P LE + FRIAQ A+T Sbjct: 494 NLRPPLLDDLGLVPALHWLLHQHQSHTGGPRVHLATDPELARFDPTLETACFRIAQEALT 553 Query: 416 NIAKHARATNVEVMLNILPTSVTLTIMDDGVGFVLNKQRDHKLK-PTWGLVSMRERAQAL 474 N +HARA V + L + + L + DDGVGF R + + GL+ M ERA Sbjct: 554 NALRHARAQGVHLTLTVQDQKLRLRVQDDGVGFDATSARGRAERGGSLGLLGMHERALLA 613 Query: 475 GGHLKIISEPGKGTCIEVAVEL 496 GG L ++S PG+GT IE L Sbjct: 614 GGTLTLLSAPGRGTEIEAIFPL 635 >ref|ZP_04893174.1| response regulator/sensory box histidine kinase [Burkholderia pseudomallei Pasteur 52237] ref|ZP_04955703.1| response regulator/sensory box histidine kinase [Burkholderia pseudomallei 1710a] gb|EDO90012.1| response regulator/sensory box histidine kinase [Burkholderia pseudomallei Pasteur 52237] gb|EET05225.1| response regulator/sensory box histidine kinase [Burkholderia pseudomallei 1710a] Length = 492 Score = 214 bits (544), Expect = 4e-53, Method: Compositional matrix adjust. Identities = 139/417 (33%), Positives = 223/417 (53%), Gaps = 22/417 (5%) Query: 90 EVSASPIVVNRGADCIGVVTFLREITE-------RKEAEEALEKRHHELEKGIFKRTAQL 142 +V P++V G D + V L+ I E +K E L R + A L Sbjct: 79 QVPDVPVLVLTGLDDLSV--GLQAIQEGAQDYLLKKRVETPLLSRAIRYAMERHRVAAAL 136 Query: 143 EFTLGQLKLAVSASNTGLWNWNLRTDQFYFSPEWKRQIGYADHEIDDGMEEWTARLHPDD 202 + + +LAVS ++ GLW+WN +T Y SP +K+ +GY DHE+ D + +HPDD Sbjct: 137 AASEERFQLAVSGASAGLWDWNPKTGAMYLSPHFKKIMGYEDHELPDEIPGHRESIHPDD 196 Query: 203 VERAVTLTRAYLASPQESLEIEYRMRHRDGTFRWMLSRSMAMLDENDKAILLQGSHVDIT 262 ++R + +A+L +++ ++EYR+R R G +RW+ SR A+ + + + G +D+T Sbjct: 197 LKRVLDALKAHLEH-RDTYDVEYRVRTRSGDYRWIQSRGQALWNSAGEPYRMVGWIMDVT 255 Query: 263 ERKQSEENLLALTRELRDVSRELARVEEAERRRFAQELHDTIGSALAALSINMTIMSGEI 322 +RK+ E+ L ELR +S + + E E+ R A+ELHD +G L AL + +T++ E+ Sbjct: 256 DRKRDEDALRVSREELRRLSAHIQSIREEEKTRIARELHDDLGQQLTALKMAVTLVDNEL 315 Query: 323 SGTNDHPSAGMAARLKDSIVLLDDTTDAVRRLMAELRPPVLDDYGLEAALRWQCELFAER 382 D A +RL + L+ D+VRR+ A+LRP +LDD GL AA+ W F ER Sbjct: 316 ---KDAGWASRTSRLPNVYALIGQLLDSVRRIAADLRPVMLDDLGLMAAIEWLTHEFVER 372 Query: 383 SGFRFTVDVYGIDDRLEPELEISLFRIAQGAITNIAKHARATNVEVMLNIL---PTSVTL 439 T + D +FRI Q A+TN+A+H+ AT EV L+I+ P + + Sbjct: 373 YRIPVTSRIEADDIAFTRGSATEVFRIVQEALTNVARHSEAT--EVTLDIIRDEPNCI-V 429 Query: 440 TIMDDGVGFVLNKQRDHKLKPTWGLVSMRERAQALGGHLKIISEPGKGTCIEVAVEL 496 I D+G G + + + + + GL+ MRERA LGG ++I + PG+G + + L Sbjct: 430 RIADNGCGTARDTRPN---RHSLGLLGMRERAARLGGEIRIDTAPGRGFALTATLPL 483 >ref|YP_001062927.1| Signal transduction histidine kinase [Burkholderia pseudomallei 668] gb|ABN87128.1| signal transduction histidine kinase [Burkholderia pseudomallei 668] Length = 492 Score = 214 bits (544), Expect = 4e-53, Method: Compositional matrix adjust. Identities = 139/417 (33%), Positives = 223/417 (53%), Gaps = 22/417 (5%) Query: 90 EVSASPIVVNRGADCIGVVTFLREITE-------RKEAEEALEKRHHELEKGIFKRTAQL 142 +V P++V G D + V L+ I E +K E L R + A L Sbjct: 79 QVPDVPVLVLTGLDDLSV--GLQAIQEGAQDYLLKKRVETPLLSRAIRYAMERHRVAAAL 136 Query: 143 EFTLGQLKLAVSASNTGLWNWNLRTDQFYFSPEWKRQIGYADHEIDDGMEEWTARLHPDD 202 + + +LAVS ++ GLW+WN +T Y SP +K+ +GY DHE+ D + +HPDD Sbjct: 137 AASEERFQLAVSGASAGLWDWNPKTGAMYLSPHFKKIMGYEDHELPDEITGHRESIHPDD 196 Query: 203 VERAVTLTRAYLASPQESLEIEYRMRHRDGTFRWMLSRSMAMLDENDKAILLQGSHVDIT 262 ++R + +A+L +++ ++EYR+R R G +RW+ SR A+ + + + G +D+T Sbjct: 197 LKRVLDALKAHLEH-RDTYDVEYRVRTRSGDYRWIQSRGQALWNSAGEPYRMVGWIMDVT 255 Query: 263 ERKQSEENLLALTRELRDVSRELARVEEAERRRFAQELHDTIGSALAALSINMTIMSGEI 322 +RK+ E+ L ELR +S + + E E+ R A+ELHD +G L AL + +T++ E+ Sbjct: 256 DRKRDEDALRVSREELRRLSAHIQSIREEEKTRIARELHDDLGQQLTALKMAVTLVDNEL 315 Query: 323 SGTNDHPSAGMAARLKDSIVLLDDTTDAVRRLMAELRPPVLDDYGLEAALRWQCELFAER 382 D A +RL + L+ D+VRR+ A+LRP +LDD GL AA+ W F ER Sbjct: 316 ---KDAGWASRTSRLPNVYALIGQLLDSVRRIAADLRPVMLDDLGLMAAIEWLTHEFVER 372 Query: 383 SGFRFTVDVYGIDDRLEPELEISLFRIAQGAITNIAKHARATNVEVMLNIL---PTSVTL 439 T + D +FRI Q A+TN+A+H+ AT EV L+I+ P + + Sbjct: 373 YRIPVTSRIEADDIAFTRGSATEVFRIVQEALTNVARHSEAT--EVTLDIIRDEPNCI-V 429 Query: 440 TIMDDGVGFVLNKQRDHKLKPTWGLVSMRERAQALGGHLKIISEPGKGTCIEVAVEL 496 I D+G G + + + + + GL+ MRERA LGG ++I + PG+G + + L Sbjct: 430 RIADNGCGTARDTRPN---RHSLGLLGMRERAARLGGEIRIDTAPGRGFALTATLPL 483 >ref|ZP_00439400.1| sensory box histidine kinase/response regulator [Burkholderia mallei GB8 horse 4] ref|YP_990082.1| sensory box histidine kinase/response regulator [Burkholderia mallei SAVP1] ref|YP_001024001.1| sensory box histidine kinase/response regulator [Burkholderia mallei NCTC 10229] ref|YP_001078617.1| sensory box histidine kinase/response regulator [Burkholderia mallei NCTC 10247] ref|YP_001075876.1| response regulator/sensory box histidine kinase [Burkholderia pseudomallei 1106a] ref|ZP_01769342.1| response regulator/sensory box histidine kinase [Burkholderia pseudomallei 305] ref|ZP_02265375.1| sensory box histidine kinase/response regulator [Burkholderia mallei PRL-20] ref|ZP_02415691.1| response regulator/sensory box histidine kinase [Burkholderia pseudomallei 14] ref|ZP_02459939.1| response regulator/sensory box histidine kinase [Burkholderia pseudomallei 9] ref|ZP_02475431.1| response regulator/sensory box histidine kinase [Burkholderia pseudomallei B7210] ref|ZP_02485928.1| response regulator/sensory box histidine kinase [Burkholderia pseudomallei 7894] ref|ZP_02494080.1| response regulator/sensory box histidine kinase [Burkholderia pseudomallei NCTC 13177] ref|ZP_02502326.1| response regulator/sensory box histidine kinase [Burkholderia pseudomallei 112] ref|ZP_02510156.1| response regulator/sensory box histidine kinase [Burkholderia pseudomallei BCC215] ref|ZP_03794587.1| response regulator/sensory box histidine kinase [Burkholderia pseudomallei Pakistan 9] ref|ZP_04520465.1| sensory box histidine kinase/response regulator [Burkholderia pseudomallei MSHR346] ref|ZP_04811663.1| response regulator/sensory box histidine kinase [Burkholderia pseudomallei 1106b] ref|ZP_04882982.1| sensory box histidine kinase/response regulator [Burkholderia mallei ATCC 10399] ref|ZP_04890336.1| response regulator/sensory box histidine kinase [Burkholderia pseudomallei 1655] ref|ZP_04900332.1| response regulator/sensory box histidine kinase [Burkholderia pseudomallei S13] ref|ZP_04906755.1| sensory box histidine kinase/response regulator [Burkholderia mallei FMH] ref|ZP_04910767.1| sensory box histidine kinase/response regulator [Burkholderia mallei JHU] ref|ZP_04969101.1| response regulator/sensory box histidine kinase [Burkholderia pseudomallei 406e] ref|ZP_04972916.1| sensory box histidine kinase/response regulator [Burkholderia mallei 2002721280] gb|ABM47794.1| sensory box histidine kinase/response regulator [Burkholderia mallei SAVP1] gb|ABM99626.1| sensory box histidine kinase/response regulator [Burkholderia mallei NCTC 10229] gb|ABN95319.1| response regulator/sensory box histidine kinase [Burkholderia pseudomallei 1106a] gb|ABO02259.1| sensory box histidine kinase/response regulator [Burkholderia mallei NCTC 10247] gb|EBA46285.1| response regulator/sensory box histidine kinase [Burkholderia pseudomallei 305] gb|EDK55077.1| sensory box histidine kinase/response regulator [Burkholderia mallei FMH] gb|EDK61064.1| sensory box histidine kinase/response regulator [Burkholderia mallei JHU] gb|EDK83791.1| sensory box histidine kinase/response regulator [Burkholderia mallei 2002721280] gb|EDO88098.1| response regulator/sensory box histidine kinase [Burkholderia pseudomallei 406e] gb|EDP87336.1| sensory box histidine kinase/response regulator [Burkholderia mallei ATCC 10399] gb|EDS83344.1| response regulator/sensory box histidine kinase [Burkholderia pseudomallei S13] gb|EDU11320.1| response regulator/sensory box histidine kinase [Burkholderia pseudomallei 1655] gb|EEH24825.1| response regulator/sensory box histidine kinase [Burkholderia pseudomallei Pakistan 9] gb|EEP49379.1| sensory box histidine kinase/response regulator [Burkholderia pseudomallei MSHR346] gb|EEP84805.1| sensory box histidine kinase/response regulator [Burkholderia mallei GB8 horse 4] gb|EES22288.1| response regulator/sensory box histidine kinase [Burkholderia pseudomallei 1106b] gb|EES46560.1| sensory box histidine kinase/response regulator [Burkholderia mallei PRL-20] Length = 492 Score = 213 bits (543), Expect = 4e-53, Method: Compositional matrix adjust. Identities = 139/417 (33%), Positives = 223/417 (53%), Gaps = 22/417 (5%) Query: 90 EVSASPIVVNRGADCIGVVTFLREITE-------RKEAEEALEKRHHELEKGIFKRTAQL 142 +V P++V G D + V L+ I E +K E L R + A L Sbjct: 79 QVPDVPVLVLTGLDDLSV--GLQAIQEGAQDYLLKKRVETPLLSRAIRYAMERHRVAAAL 136 Query: 143 EFTLGQLKLAVSASNTGLWNWNLRTDQFYFSPEWKRQIGYADHEIDDGMEEWTARLHPDD 202 + + +LAVS ++ GLW+WN +T Y SP +K+ +GY DHE+ D + +HPDD Sbjct: 137 AASEERFQLAVSGASAGLWDWNPKTGAMYLSPHFKKIMGYEDHELPDEITGHRESIHPDD 196 Query: 203 VERAVTLTRAYLASPQESLEIEYRMRHRDGTFRWMLSRSMAMLDENDKAILLQGSHVDIT 262 ++R + +A+L +++ ++EYR+R R G +RW+ SR A+ + + + G +D+T Sbjct: 197 LKRVLDALKAHLEH-RDTYDVEYRVRTRSGDYRWIQSRGQALWNSAGEPYRMVGWIMDVT 255 Query: 263 ERKQSEENLLALTRELRDVSRELARVEEAERRRFAQELHDTIGSALAALSINMTIMSGEI 322 +RK+ E+ L ELR +S + + E E+ R A+ELHD +G L AL + +T++ E+ Sbjct: 256 DRKRDEDALRVSREELRRLSAHIQSIREEEKTRIARELHDDLGQQLTALKMAVTLVDNEL 315 Query: 323 SGTNDHPSAGMAARLKDSIVLLDDTTDAVRRLMAELRPPVLDDYGLEAALRWQCELFAER 382 D A +RL + L+ D+VRR+ A+LRP +LDD GL AA+ W F ER Sbjct: 316 ---KDAGWASRTSRLPNVYALIGQLLDSVRRIAADLRPVMLDDLGLMAAIEWLTHEFVER 372 Query: 383 SGFRFTVDVYGIDDRLEPELEISLFRIAQGAITNIAKHARATNVEVMLNIL---PTSVTL 439 T + D +FRI Q A+TN+A+H+ AT EV L+I+ P + + Sbjct: 373 YRIPVTSRIEADDIAFTRGSATEVFRIVQEALTNVARHSEAT--EVTLDIIRDEPNCI-V 429 Query: 440 TIMDDGVGFVLNKQRDHKLKPTWGLVSMRERAQALGGHLKIISEPGKGTCIEVAVEL 496 I D+G G + + + + + GL+ MRERA LGG ++I + PG+G + + L Sbjct: 430 RIADNGCGTARDTRPN---RHSLGLLGMRERAARLGGEIRIDTAPGRGFALTATLPL 483 >ref|YP_105597.1| sensory box histidine kinase/response regulator [Burkholderia mallei ATCC 23344] gb|AAU46707.1| sensory box histidine kinase/response regulator [Burkholderia mallei ATCC 23344] Length = 463 Score = 213 bits (543), Expect = 5e-53, Method: Compositional matrix adjust. Identities = 139/417 (33%), Positives = 223/417 (53%), Gaps = 22/417 (5%) Query: 90 EVSASPIVVNRGADCIGVVTFLREITE-------RKEAEEALEKRHHELEKGIFKRTAQL 142 +V P++V G D + V L+ I E +K E L R + A L Sbjct: 50 QVPDVPVLVLTGLDDLSV--GLQAIQEGAQDYLLKKRVETPLLSRAIRYAMERHRVAAAL 107 Query: 143 EFTLGQLKLAVSASNTGLWNWNLRTDQFYFSPEWKRQIGYADHEIDDGMEEWTARLHPDD 202 + + +LAVS ++ GLW+WN +T Y SP +K+ +GY DHE+ D + +HPDD Sbjct: 108 AASEERFQLAVSGASAGLWDWNPKTGAMYLSPHFKKIMGYEDHELPDEITGHRESIHPDD 167 Query: 203 VERAVTLTRAYLASPQESLEIEYRMRHRDGTFRWMLSRSMAMLDENDKAILLQGSHVDIT 262 ++R + +A+L +++ ++EYR+R R G +RW+ SR A+ + + + G +D+T Sbjct: 168 LKRVLDALKAHLEH-RDTYDVEYRVRTRSGDYRWIQSRGQALWNSAGEPYRMVGWIMDVT 226 Query: 263 ERKQSEENLLALTRELRDVSRELARVEEAERRRFAQELHDTIGSALAALSINMTIMSGEI 322 +RK+ E+ L ELR +S + + E E+ R A+ELHD +G L AL + +T++ E+ Sbjct: 227 DRKRDEDALRVSREELRRLSAHIQSIREEEKTRIARELHDDLGQQLTALKMAVTLVDNEL 286 Query: 323 SGTNDHPSAGMAARLKDSIVLLDDTTDAVRRLMAELRPPVLDDYGLEAALRWQCELFAER 382 D A +RL + L+ D+VRR+ A+LRP +LDD GL AA+ W F ER Sbjct: 287 ---KDAGWASRTSRLPNVYALIGQLLDSVRRIAADLRPVMLDDLGLMAAIEWLTHEFVER 343 Query: 383 SGFRFTVDVYGIDDRLEPELEISLFRIAQGAITNIAKHARATNVEVMLNIL---PTSVTL 439 T + D +FRI Q A+TN+A+H+ AT EV L+I+ P + + Sbjct: 344 YRIPVTSRIEADDIAFTRGSATEVFRIVQEALTNVARHSEAT--EVTLDIIRDEPNCI-V 400 Query: 440 TIMDDGVGFVLNKQRDHKLKPTWGLVSMRERAQALGGHLKIISEPGKGTCIEVAVEL 496 I D+G G + + + + + GL+ MRERA LGG ++I + PG+G + + L Sbjct: 401 RIADNGCGTARDTRPN---RHSLGLLGMRERAARLGGEIRIDTAPGRGFALTATLPL 454