BLASTP 2.2.21 [Jun-14-2009] Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), "Gapped BLAST and PSI-BLAST: a new generation of protein database search programs", Nucleic Acids Res. 25:3389-3402. Reference for compositional score matrix adjustment: Altschul, Stephen F., John C. Wootton, E. Michael Gertz, Richa Agarwala, Aleksandr Morgulis, Alejandro A. Schaffer, and Yi-Kuo Yu (2005) "Protein database searches using compositionally adjusted substitution matrices", FEBS J. 272:5101-5109. Query= 0034.0119.p (294 letters) Database: All non-redundant GenBank CDS translations+PDB+SwissProt+PIR+PRF excluding environmental samples from WGS projects 15,459,386 sequences; 5,307,515,862 total letters Searching..................................................done Score E Sequences producing significant alignments: (bits) Value ref|ZP_05638266.1| 3-hydroxyisobutyrate dehydrogenase [Pseudomon... 310 1e-82 ref|ZP_02886199.1| 3-hydroxyisobutyrate dehydrogenase [Burkholde... 310 2e-82 ref|YP_001755917.1| 3-hydroxyisobutyrate dehydrogenase [Methylob... 304 9e-81 ref|NP_667562.1| oxidoreductase [Yersinia pestis KIM 10] >gi|454... 300 2e-79 ref|YP_072064.1| 2-hydroxy-3-oxopropionate reductase [Yersinia p... 298 7e-79 >ref|ZP_05638266.1| 3-hydroxyisobutyrate dehydrogenase [Pseudomonas syringae pv. tabaci ATCC 11528] Length = 289 Score = 310 bits (795), Expect = 1e-82, Method: Compositional matrix adjust. Identities = 157/287 (54%), Positives = 212/287 (73%), Gaps = 5/287 (1%) Query: 4 KICFIGLGMMGYPMAALLTKAGHTVHVADADPARAAQFAAEYQAQAFDAAAAQLPPADIV 63 K+ FIGLGMMG PMA + KAG+ + V+D + + AE A + + + L D++ Sbjct: 3 KVLFIGLGMMGRPMAGHIAKAGYPLVVSDTNAEAVKELCAEVGAVSIQSLES-LSDIDVI 61 Query: 64 ITMLPNSDIVESVVLGKNKDGLAFRLSTATF-IDMSSSEPMRSRQLAADLAEIGHHYIDA 122 ITMLPNS IVE+V+LG +G+A R+ T IDMSSSEP+R+R+LAADL ++ +DA Sbjct: 62 ITMLPNSSIVEAVLLGD--EGIAKRVKAGTVVIDMSSSEPLRTRELAADLDKLSVGLLDA 119 Query: 123 PVSGGVKKAIEGTLAIMVGGAATTYAACTEVLQCMGKTLFHVGGPGAGHAMKALNNFVSA 182 PVSGGVK+A+ GTLAIM+GG + ++ MGK + HVG GAGHA+KALNN+VSA Sbjct: 120 PVSGGVKRAVSGTLAIMLGGEGALVEKHSALISTMGK-ITHVGPIGAGHAIKALNNYVSA 178 Query: 183 AGLVAAVEALHVGQIFGLDPAVMTDVLNTSTGRNNTTEAKVKQFMLSGSFGSGFSLQLMT 242 AGL+A VEALH+G+ FGLDP++MTDVLNT++G N T+ KVKQFMLSG++ SGF+LQLM Sbjct: 179 AGLLATVEALHIGEKFGLDPSIMTDVLNTASGSNFATQNKVKQFMLSGTYASGFALQLMV 238 Query: 243 KDLGVAMKLGQELNYPMQLGNECLKIWKDAAQSLDRVADHTEMYRLL 289 KDL +A+ LG++++ PM+LG+ECL +WK+AA D DHTEMYR++ Sbjct: 239 KDLKIAVALGEQMDQPMKLGHECLDVWKEAAGESDARTDHTEMYRIV 285 >ref|ZP_02886199.1| 3-hydroxyisobutyrate dehydrogenase [Burkholderia graminis C4D1M] gb|EDT08327.1| 3-hydroxyisobutyrate dehydrogenase [Burkholderia graminis C4D1M] Length = 295 Score = 310 bits (793), Expect = 2e-82, Method: Compositional matrix adjust. Identities = 174/288 (60%), Positives = 202/288 (70%), Gaps = 3/288 (1%) Query: 3 KKICFIGLGMMGYPMAALLTKAGHTVHVADADPARAAQFAAEYQAQAFDAAAAQLPPADI 62 K+I FIGLGMMG PM L AG + V DAD ARA AA+ Q A D Sbjct: 5 KRIGFIGLGMMGAPMVQCLANAGFELFVDDADTARADTLAAQIGGQRLSKDNA--VSLDA 62 Query: 63 VITMLPNSDIVESVVLGKNKDGLAFRLS-TATFIDMSSSEPMRSRQLAADLAEIGHHYID 121 +ITMLPNS +VE+V+LG DG A L+ A IDMSSSEP RS++L A L E G Y+D Sbjct: 63 LITMLPNSAVVETVLLGGGADGWASALARNAVVIDMSSSEPQRSQKLGAVLEERGLAYLD 122 Query: 122 APVSGGVKKAIEGTLAIMVGGAATTYAACTEVLQCMGKTLFHVGGPGAGHAMKALNNFVS 181 APVSGGVKKA EGTLAI+VGG A A C VL+ MGK++ H+GG GAGHA KALNN+VS Sbjct: 123 APVSGGVKKAKEGTLAILVGGRAEVLARCQSVLEAMGKSILHIGGAGAGHAAKALNNYVS 182 Query: 182 AAGLVAAVEALHVGQIFGLDPAVMTDVLNTSTGRNNTTEAKVKQFMLSGSFGSGFSLQLM 241 AAGL A VEALHV Q FG++P VMTDVLN STGR+NT+E KVKQFMLSG+F SGF+LQLM Sbjct: 183 AAGLAATVEALHVAQRFGIEPGVMTDVLNASTGRSNTSENKVKQFMLSGTFASGFALQLM 242 Query: 242 TKDLGVAMKLGQELNYPMQLGNECLKIWKDAAQSLDRVADHTEMYRLL 289 KDL +A L Q ++YPM LG C +W +AAQ DHTEMYRLL Sbjct: 243 NKDLKIARALAQSVDYPMTLGVTCTTMWDEAAQRSTPATDHTEMYRLL 290 >ref|YP_001755917.1| 3-hydroxyisobutyrate dehydrogenase [Methylobacterium radiotolerans JCM 2831] gb|ACB25234.1| 3-hydroxyisobutyrate dehydrogenase [Methylobacterium radiotolerans JCM 2831] Length = 290 Score = 304 bits (779), Expect = 9e-81, Method: Compositional matrix adjust. Identities = 167/290 (57%), Positives = 201/290 (69%), Gaps = 8/290 (2%) Query: 3 KKICFIGLGMMGYPMAALLTKAGHTVHVADADPARAAQFAAEYQAQAFDAA-AAQLPPAD 61 + I IGLGMMG PM+ L KAGH + + DAD R A + A A AA L D Sbjct: 4 RTIGVIGLGMMGDPMSRCLAKAGHVLRLLDADVGRTDALARDLGATALTRENAAGL---D 60 Query: 62 IVITMLPNSDIVESVVLGKNKDGLAFRL-STATFIDMSSSEPMRSRQLAADLAEIGHHYI 120 ++ITMLPNS IVE+V+L DG A L + AT IDMSSSEP+RSR L LA G Y+ Sbjct: 61 LLITMLPNSAIVEAVLL---DDGWADALPAGATVIDMSSSEPVRSRALGETLAGKGLGYL 117 Query: 121 DAPVSGGVKKAIEGTLAIMVGGAATTYAACTEVLQCMGKTLFHVGGPGAGHAMKALNNFV 180 DAPVSGGVK+A+ GTLAI+VGGAA A VL+ MG ++ H+G G+GHA KALNNFV Sbjct: 118 DAPVSGGVKRAVNGTLAILVGGAADLLARWRPVLEAMGTSVLHIGPAGSGHAAKALNNFV 177 Query: 181 SAAGLVAAVEALHVGQIFGLDPAVMTDVLNTSTGRNNTTEAKVKQFMLSGSFGSGFSLQL 240 SAAGL+A VEALHV Q FG+ P MTDVLN S+GR+NT+E KVKQFMLSGSF SGFSL+L Sbjct: 178 SAAGLLATVEALHVAQRFGIAPEAMTDVLNASSGRSNTSENKVKQFMLSGSFASGFSLKL 237 Query: 241 MTKDLGVAMKLGQELNYPMQLGNECLKIWKDAAQSLDRVADHTEMYRLLA 290 M KDLG+A L + ++YP+ G C++ W A + ADHTEMYRLLA Sbjct: 238 MDKDLGIAGALAESVDYPLGFGRHCIETWHAIAGEVGPAADHTEMYRLLA 287 >ref|NP_667562.1| oxidoreductase [Yersinia pestis KIM 10] ref|NP_995167.1| putative 2-hydroxy-3-oxopropionate reductase [Yersinia pestis biovar Microtus str. 91001] ref|YP_653568.1| putative 2-hydroxy-3-oxopropionate reductase [Yersinia pestis Antiqua] ref|YP_649450.1| 2-hydroxy-3-oxopropionate reductase [Yersinia pestis Nepal516] ref|YP_001161647.1| 2-hydroxy-3-oxopropionate reductase [Yersinia pestis Pestoides F] ref|ZP_02022514.1| putative 2-hydroxy-3-oxopropionate reductase [Yersinia pestis CA88-4125] ref|YP_001605758.1| 6-phosphogluconate dehydrogenase [Yersinia pestis Angola] ref|ZP_02223441.1| 6-phosphogluconate dehydrogenase NAD-binding domain protein [Yersinia pestis biovar Orientalis str. F1991016] ref|ZP_02226109.1| 6-phosphogluconate dehydrogenase NAD-binding domain protein [Yersinia pestis biovar Orientalis str. IP275] ref|ZP_02233133.1| 6-phosphogluconate dehydrogenase NAD-binding domain protein [Yersinia pestis biovar Antiqua str. E1979001] ref|ZP_02240199.1| 6-phosphogluconate dehydrogenase NAD-binding domain protein [Yersinia pestis biovar Antiqua str. B42003004] ref|ZP_02307516.1| 6-phosphogluconate dehydrogenase NAD-binding domain protein [Yersinia pestis biovar Antiqua str. UG05-0454] ref|ZP_02312410.1| 6-phosphogluconate dehydrogenase NAD-binding domain protein [Yersinia pestis biovar Orientalis str. MG05-1020] ref|ZP_02317258.1| 6-phosphogluconate dehydrogenase NAD-binding domain protein [Yersinia pestis biovar Mediaevalis str. K1973002] ref|ZP_02335032.1| 6-phosphogluconate dehydrogenase NAD-binding domain protein [Yersinia pestis FV-1] ref|YP_002348533.1| putative 2-hydroxy-3-oxopropionate reductase [Yersinia pestis CO92] ref|ZP_04456956.1| putative 2-hydroxy-3-oxopropionate reductase [Yersinia pestis Pestoides A] ref|ZP_04459468.1| putative 2-hydroxy-3-oxopropionate reductase [Yersinia pestis biovar Orientalis str. PEXU2] ref|ZP_04515014.1| putative 2-hydroxy-3-oxopropionate reductase [Yersinia pestis biovar Orientalis str. India 195] ref|ZP_04519295.1| putative 2-hydroxy-3-oxopropionate reductase [Yersinia pestis Nepal516] ref|ZP_06205698.1| NAD binding domain of 6-phosphogluconate dehydrogenase [Yersinia pestis KIM D27] ref|YP_003569305.1| putative 2-hydroxy-3-oxopropionate reductase [Yersinia pestis Z176003] gb|AAM83813.1|AE013622_2 putative oxidoreductase [Yersinia pestis KIM 10] gb|AAS64044.1| putative 2-hydroxy-3-oxopropionate reductase [Yersinia pestis biovar Microtus str. 91001] gb|ABG19850.1| 2-hydroxy-3-oxopropionate reductase [Yersinia pestis Nepal516] gb|ABG15623.1| putative 2-hydroxy-3-oxopropionate reductase [Yersinia pestis Antiqua] emb|CAL22236.1| putative 2-hydroxy-3-oxopropionate reductase [Yersinia pestis CO92] gb|ABP38674.1| 2-hydroxy-3-oxopropionate reductase [Yersinia pestis Pestoides F] gb|EDM39131.1| putative 2-hydroxy-3-oxopropionate reductase [Yersinia pestis CA88-4125] gb|ABX87400.1| 6-phosphogluconate dehydrogenase NAD-binding domain protein [Yersinia pestis Angola] gb|EDR33265.1| 6-phosphogluconate dehydrogenase NAD-binding domain protein [Yersinia pestis biovar Orientalis str. IP275] gb|EDR37780.1| 6-phosphogluconate dehydrogenase NAD-binding domain protein [Yersinia pestis biovar Orientalis str. F1991016] gb|EDR41155.1| 6-phosphogluconate dehydrogenase NAD-binding domain protein [Yersinia pestis biovar Antiqua str. E1979001] gb|EDR49131.1| 6-phosphogluconate dehydrogenase NAD-binding domain protein [Yersinia pestis biovar Antiqua str. B42003004] gb|EDR57484.1| 6-phosphogluconate dehydrogenase NAD-binding domain protein [Yersinia pestis biovar Orientalis str. MG05-1020] gb|EDR60027.1| 6-phosphogluconate dehydrogenase NAD-binding domain protein [Yersinia pestis biovar Antiqua str. UG05-0454] gb|EDR65312.1| 6-phosphogluconate dehydrogenase NAD-binding domain protein [Yersinia pestis biovar Mediaevalis str. K1973002] gb|EEO74407.1| putative 2-hydroxy-3-oxopropionate reductase [Yersinia pestis Nepal516] gb|EEO79440.1| putative 2-hydroxy-3-oxopropionate reductase [Yersinia pestis biovar Orientalis str. India 195] gb|EEO85722.1| putative 2-hydroxy-3-oxopropionate reductase [Yersinia pestis biovar Orientalis str. PEXU2] gb|EEO91743.1| putative 2-hydroxy-3-oxopropionate reductase [Yersinia pestis Pestoides A] gb|ACY60026.1| putative 2-hydroxy-3-oxopropionate reductase [Yersinia pestis D106004] gb|ACY63873.1| putative 2-hydroxy-3-oxopropionate reductase [Yersinia pestis D182038] gb|EFA47905.1| NAD binding domain of 6-phosphogluconate dehydrogenase [Yersinia pestis KIM D27] gb|ADE66043.1| putative 2-hydroxy-3-oxopropionate reductase [Yersinia pestis Z176003] gb|ADW00761.1| putative 2-hydroxy-3-oxopropionate reductase [Yersinia pestis biovar Medievalis str. Harbin 35] gb|AEL72187.1| putative 2-hydroxy-3-oxopropionate reductase [Yersinia pestis A1122] Length = 296 Score = 300 bits (767), Expect = 2e-79, Method: Compositional matrix adjust. Identities = 157/293 (53%), Positives = 201/293 (68%), Gaps = 8/293 (2%) Query: 3 KKICFIGLGMMGYPMAALLTKAGHTVHVADADPARAAQFAAEYQAQAF--DAAAAQLPPA 60 ++I FIGLG MG PM L KAG +++ DAD + AE A++ D AA+ Sbjct: 5 QRIGFIGLGKMGTPMVQRLVKAGFELYLCDADITKVQILTAELNAESLTVDNAAS----L 60 Query: 61 DIVITMLPNSDIVESVVLGKNK-DGLAFRLS-TATFIDMSSSEPMRSRQLAADLAEIGHH 118 D +ITMLPNS+ VE V+LG + G +LS A IDMSSS+P RSR+LA LA Sbjct: 61 DALITMLPNSEAVEQVLLGSDGISGWVAQLSQAAVVIDMSSSDPERSRRLAILLAVWELD 120 Query: 119 YIDAPVSGGVKKAIEGTLAIMVGGAATTYAACTEVLQCMGKTLFHVGGPGAGHAMKALNN 178 Y+DAPVSGGVKKA GTL+I++GG +C L MG+ + VG G+GHA KALNN Sbjct: 121 YLDAPVSGGVKKAQNGTLSILIGGEDRVLKSCYTALAAMGEQILFVGPAGSGHAAKALNN 180 Query: 179 FVSAAGLVAAVEALHVGQIFGLDPAVMTDVLNTSTGRNNTTEAKVKQFMLSGSFGSGFSL 238 +VSA GL+A +EALHV Q FG++P VMT+VLNTSTGR+NT+E KV+QFML+GS+ SGF+L Sbjct: 181 YVSATGLLATIEALHVAQRFGIEPEVMTEVLNTSTGRSNTSENKVRQFMLNGSYASGFTL 240 Query: 239 QLMTKDLGVAMKLGQELNYPMQLGNECLKIWKDAAQSLDRVADHTEMYRLLAD 291 QLM KDL +A L Q LNYPM+LG C+ +W + ++ +ADHTEMYRLL D Sbjct: 241 QLMNKDLHIARNLAQRLNYPMRLGMHCVDVWDEVSRRATPMADHTEMYRLLID 293 >ref|YP_072064.1| 2-hydroxy-3-oxopropionate reductase [Yersinia pseudotuberculosis IP 32953] ref|YP_001399373.1| 6-phosphogluconate dehydrogenase [Yersinia pseudotuberculosis IP 31758] ref|YP_001719203.1| 3-hydroxyisobutyrate dehydrogenase [Yersinia pseudotuberculosis YPIII] ref|YP_001874180.1| 6-phosphogluconate dehydrogenase [Yersinia pseudotuberculosis PB1/+] emb|CAH22820.1| putative 2-hydroxy-3-oxopropionate reductase [Yersinia pseudotuberculosis IP 32953] gb|ABS47357.1| 6-phosphogluconate dehydrogenase NAD-binding domain protein [Yersinia pseudotuberculosis IP 31758] gb|ACA66750.1| 3-hydroxyisobutyrate dehydrogenase [Yersinia pseudotuberculosis YPIII] gb|ACC90723.1| 6-phosphogluconate dehydrogenase NAD-binding [Yersinia pseudotuberculosis PB1/+] Length = 296 Score = 298 bits (763), Expect = 7e-79, Method: Compositional matrix adjust. Identities = 156/293 (53%), Positives = 200/293 (68%), Gaps = 8/293 (2%) Query: 3 KKICFIGLGMMGYPMAALLTKAGHTVHVADADPARAAQFAAEYQAQAF--DAAAAQLPPA 60 ++I FIGLG MG PM L KAG +++ DAD + AE A++ D AA+ Sbjct: 5 QRIGFIGLGKMGTPMVQRLVKAGFELYLCDADITKVQILTAELNAESLTVDNAAS----L 60 Query: 61 DIVITMLPNSDIVESVVLGKNK-DGLAFRLS-TATFIDMSSSEPMRSRQLAADLAEIGHH 118 D +ITMLPNS+ VE +LG + G +LS A IDMSSS+P RSR+LA LA Sbjct: 61 DALITMLPNSEAVEQALLGSDGISGWVAQLSQAAVVIDMSSSDPERSRRLAILLAVWELD 120 Query: 119 YIDAPVSGGVKKAIEGTLAIMVGGAATTYAACTEVLQCMGKTLFHVGGPGAGHAMKALNN 178 Y+DAPVSGGVKKA GTL+I++GG +C L MG+ + VG G+GHA KALNN Sbjct: 121 YLDAPVSGGVKKAQNGTLSILIGGEDRVLKSCYTALAAMGEQILFVGPAGSGHAAKALNN 180 Query: 179 FVSAAGLVAAVEALHVGQIFGLDPAVMTDVLNTSTGRNNTTEAKVKQFMLSGSFGSGFSL 238 +VSA GL+A +EALHV Q FG++P VMT+VLNTSTGR+NT+E KV+QFML+GS+ SGF+L Sbjct: 181 YVSATGLLATIEALHVAQRFGIEPEVMTEVLNTSTGRSNTSENKVRQFMLNGSYASGFTL 240 Query: 239 QLMTKDLGVAMKLGQELNYPMQLGNECLKIWKDAAQSLDRVADHTEMYRLLAD 291 QLM KDL +A L Q LNYPM+LG C+ +W + ++ +ADHTEMYRLL D Sbjct: 241 QLMNKDLHIARNLAQRLNYPMRLGMHCVDVWDEVSRRATPMADHTEMYRLLID 293