BLASTP 2.2.21 [Jun-14-2009] Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), "Gapped BLAST and PSI-BLAST: a new generation of protein database search programs", Nucleic Acids Res. 25:3389-3402. Reference for compositional score matrix adjustment: Altschul, Stephen F., John C. Wootton, E. Michael Gertz, Richa Agarwala, Aleksandr Morgulis, Alejandro A. Schaffer, and Yi-Kuo Yu (2005) "Protein database searches using compositionally adjusted substitution matrices", FEBS J. 272:5101-5109. Query= 0026.0093.p (294 letters) Database: All non-redundant GenBank CDS translations+PDB+SwissProt+PIR+PRF excluding environmental samples from WGS projects 15,459,386 sequences; 5,307,515,862 total letters Searching..................................................done Score E Sequences producing significant alignments: (bits) Value ref|YP_003774875.1| bifunctional methylenetetrahydrofolate dehyd... 546 e-153 ref|YP_004751563.1| methenyltetrahydrofolate cyclohydrolase [Col... 541 e-152 ref|YP_295513.1| methenyltetrahydrofolate cyclohydrolase [Ralsto... 473 e-131 ref|YP_002005316.1| bifunctional 5,10-methylene-tetrahydrofolate... 469 e-130 ref|YP_725874.1| 5,10-methylene-tetrahydrofolate dehydrogenase [... 468 e-130 >ref|YP_003774875.1| bifunctional methylenetetrahydrofolate dehydrogenase/methenyltetrahydrofolate cyclohydrolase [Herbaspirillum seropedicae SmR1] gb|ADJ62967.1| bifunctional enzyme: methylenetetrahydrofolate dehydrogenase/methenyltetrahydrofolate cyclohydrolase protein [Herbaspirillum seropedicae SmR1] Length = 281 Score = 546 bits (1406), Expect = e-153, Method: Compositional matrix adjust. Identities = 268/280 (95%), Positives = 278/280 (99%) Query: 14 MPAQLIDGNLLSQQLRADVAKRAAALTAKGKQPGLAVILVGDSPASQVYVRNKVKACEDN 73 MPAQLIDGNLLSQQLRA+VAKRAAALTA+GKQPGLAVILVGDSPASQVYVRNKVKAC+DN Sbjct: 1 MPAQLIDGNLLSQQLRAEVAKRAAALTAQGKQPGLAVILVGDSPASQVYVRNKVKACQDN 60 Query: 74 GLHSVLEKYDAALTEAELLARIDALNKDPKINGILVQLPLPAHIDANKVIEAIAADKDVD 133 GLHSVLEKY+A++TEAELLARIDALN DPKINGILVQLPLPAHIDA+KVIEAIA +KDVD Sbjct: 61 GLHSVLEKYEASMTEAELLARIDALNSDPKINGILVQLPLPAHIDAHKVIEAIAPEKDVD 120 Query: 134 GFHVSNAGLLMTGQPLFRPCTPYGVMKMLESIDYPVRGANAVVVGASNIVGKPQAMLLLQ 193 GFHVSNAGLLMTGQPLFRPCTPYGVMKMLESIDYPVRGANAVVVGASNIVGKPQAMLLLQ Sbjct: 121 GFHVSNAGLLMTGQPLFRPCTPYGVMKMLESIDYPVRGANAVVVGASNIVGKPQAMLLLQ 180 Query: 194 AGATVTICNSKTRDLGHHTRQADILVVATGKRNIVTADMVKPGAVVIDVGMNRDDNGKLC 253 AGATVTICNSKTRDLGHHTRQADILVVATGKRNIVTADMVKPGAVVIDVGMNRDDNGKLC Sbjct: 181 AGATVTICNSKTRDLGHHTRQADILVVATGKRNIVTADMVKPGAVVIDVGMNRDDNGKLC 240 Query: 254 GDVDFANAKEVAGYITPVPGGVGPMTITMLLVNTIEAAER 293 GDVDFANAK+VAG+ITPVPGGVGPMTITMLLVNTIEAAER Sbjct: 241 GDVDFANAKDVAGWITPVPGGVGPMTITMLLVNTIEAAER 280 >ref|YP_004751563.1| methenyltetrahydrofolate cyclohydrolase [Collimonas fungivorans Ter331] gb|AEK60740.1| Methenyltetrahydrofolate cyclohydrolase [Collimonas fungivorans Ter331] Length = 290 Score = 541 bits (1395), Expect = e-152, Method: Compositional matrix adjust. Identities = 267/287 (93%), Positives = 278/287 (96%) Query: 7 SFPVPATMPAQLIDGNLLSQQLRADVAKRAAALTAKGKQPGLAVILVGDSPASQVYVRNK 66 S + +TMPAQLIDGNLLSQQLRADVAKRAAALTA+GKQPGLAVILVGDSPASQVYVRNK Sbjct: 3 SIFIASTMPAQLIDGNLLSQQLRADVAKRAAALTAQGKQPGLAVILVGDSPASQVYVRNK 62 Query: 67 VKACEDNGLHSVLEKYDAALTEAELLARIDALNKDPKINGILVQLPLPAHIDANKVIEAI 126 VKACEDNGLHSVLEKYDA LTEA LLARIDALN DPKINGILVQLPLPAHIDA+KVIEAI Sbjct: 63 VKACEDNGLHSVLEKYDADLTEAALLARIDALNHDPKINGILVQLPLPAHIDAHKVIEAI 122 Query: 127 AADKDVDGFHVSNAGLLMTGQPLFRPCTPYGVMKMLESIDYPVRGANAVVVGASNIVGKP 186 AA+KDVDGFH+SNAGLLMTGQPLFRPCTPYGVMKMLES+++PVRGA+AV+VGASNIVGKP Sbjct: 123 AAEKDVDGFHISNAGLLMTGQPLFRPCTPYGVMKMLESVNFPVRGAHAVIVGASNIVGKP 182 Query: 187 QAMLLLQAGATVTICNSKTRDLGHHTRQADILVVATGKRNIVTADMVKPGAVVIDVGMNR 246 QAMLLLQAGATVTICNSKTRDLG HTR ADILVVATGKRNIVTADMVKPGA VIDVGMNR Sbjct: 183 QAMLLLQAGATVTICNSKTRDLGLHTRMADILVVATGKRNIVTADMVKPGAAVIDVGMNR 242 Query: 247 DDNGKLCGDVDFANAKEVAGYITPVPGGVGPMTITMLLVNTIEAAER 293 DDNGKLCGDVDFANAKEVAGYITPVPGGVGPMTITMLLVNTIEAAER Sbjct: 243 DDNGKLCGDVDFANAKEVAGYITPVPGGVGPMTITMLLVNTIEAAER 289 >ref|YP_295513.1| methenyltetrahydrofolate cyclohydrolase [Ralstonia eutropha JMP134] sp|Q472L4.1|FOLD_CUPPJ RecName: Full=Bifunctional protein FolD; Includes: RecName: Full=Methylenetetrahydrofolate dehydrogenase; Includes: RecName: Full=Methenyltetrahydrofolate cyclohydrolase gb|AAZ60669.1| 5,10-methylenetetrahydrofolate dehydrogenase (NADP+) / methenyltetrahydrofolate cyclohydrolase [Ralstonia eutropha JMP134] Length = 283 Score = 473 bits (1216), Expect = e-131, Method: Compositional matrix adjust. Identities = 227/280 (81%), Positives = 253/280 (90%) Query: 14 MPAQLIDGNLLSQQLRADVAKRAAALTAKGKQPGLAVILVGDSPASQVYVRNKVKACEDN 73 M AQLIDGN L++Q+R++ A RAA LT +G QPGLAV+LVG+ PASQVYVRNKVKACEDN Sbjct: 1 MSAQLIDGNALAKQIRSEAAVRAARLTERGHQPGLAVVLVGEDPASQVYVRNKVKACEDN 60 Query: 74 GLHSVLEKYDAALTEAELLARIDALNKDPKINGILVQLPLPAHIDANKVIEAIAADKDVD 133 G HS L++Y A L+EAELLARIDALN DPKI+GILVQLPLP HID++KV+EAIA +KDVD Sbjct: 61 GFHSSLDRYPADLSEAELLARIDALNNDPKIHGILVQLPLPKHIDSHKVLEAIAPEKDVD 120 Query: 134 GFHVSNAGLLMTGQPLFRPCTPYGVMKMLESIDYPVRGANAVVVGASNIVGKPQAMLLLQ 193 GFHV+NAG LMTG PLFRPCTPYG MKMLESI YP+RGA AVVVGASNIVGKP AMLLLQ Sbjct: 121 GFHVANAGALMTGAPLFRPCTPYGCMKMLESISYPLRGARAVVVGASNIVGKPMAMLLLQ 180 Query: 194 AGATVTICNSKTRDLGHHTRQADILVVATGKRNIVTADMVKPGAVVIDVGMNRDDNGKLC 253 AGATVTICNSKTRD+G HTR AD++V A GKRN++TADMVKPGAVVIDVGMNRDDNGKLC Sbjct: 181 AGATVTICNSKTRDIGAHTRDADVIVAAVGKRNLITADMVKPGAVVIDVGMNRDDNGKLC 240 Query: 254 GDVDFANAKEVAGYITPVPGGVGPMTITMLLVNTIEAAER 293 GDVDFA +EVAGYITPVPGGVGPMTITMLL+NT+EAAER Sbjct: 241 GDVDFAGVREVAGYITPVPGGVGPMTITMLLINTLEAAER 280 >ref|YP_002005316.1| bifunctional 5,10-methylene-tetrahydrofolate dehydrogenase/ 5,10-methylene-tetrahydrofolate cyclohydrolase [Cupriavidus taiwanensis LMG 19424] sp|B3R4L6.1|FOLD_CUPTR RecName: Full=Bifunctional protein FolD; Includes: RecName: Full=Methylenetetrahydrofolate dehydrogenase; Includes: RecName: Full=Methenyltetrahydrofolate cyclohydrolase emb|CAQ69249.1| bifunctional: 5,10-methylene-tetrahydrofolate dehydrogenase; 5,10-methylene-tetrahydrofolate cyclohydrolase [Cupriavidus taiwanensis LMG 19424] Length = 283 Score = 469 bits (1208), Expect = e-130, Method: Compositional matrix adjust. Identities = 223/280 (79%), Positives = 254/280 (90%) Query: 14 MPAQLIDGNLLSQQLRADVAKRAAALTAKGKQPGLAVILVGDSPASQVYVRNKVKACEDN 73 MPAQLIDGN L++Q+R++ A+RAA LT +G QPGLAV+LVG+ PASQVYVRNKVKACEDN Sbjct: 1 MPAQLIDGNALAKQIRSEAAQRAARLTERGHQPGLAVVLVGEDPASQVYVRNKVKACEDN 60 Query: 74 GLHSVLEKYDAALTEAELLARIDALNKDPKINGILVQLPLPAHIDANKVIEAIAADKDVD 133 G HS L++Y A L+EA+LLARID LN+DP+I+GILVQLPLP HID++KV+EAIA +KDVD Sbjct: 61 GFHSSLDRYPADLSEADLLARIDELNRDPRIHGILVQLPLPKHIDSHKVLEAIAPEKDVD 120 Query: 134 GFHVSNAGLLMTGQPLFRPCTPYGVMKMLESIDYPVRGANAVVVGASNIVGKPQAMLLLQ 193 GFHV+NAG LMTG PLFRPCTPYG MKMLESI YP+RGA AVVVGASNIVGKP AMLLLQ Sbjct: 121 GFHVANAGALMTGAPLFRPCTPYGCMKMLESIQYPLRGARAVVVGASNIVGKPMAMLLLQ 180 Query: 194 AGATVTICNSKTRDLGHHTRQADILVVATGKRNIVTADMVKPGAVVIDVGMNRDDNGKLC 253 GATVTICNSKTRD+G HTR AD++V A GKRN++TADMVKPGAVVIDVGMNRDD+GKLC Sbjct: 181 GGATVTICNSKTRDIGAHTRDADVVVAAVGKRNLITADMVKPGAVVIDVGMNRDDHGKLC 240 Query: 254 GDVDFANAKEVAGYITPVPGGVGPMTITMLLVNTIEAAER 293 GDVDFA +EVAGYITPVPGGVGPMTITMLL+NT+EAAER Sbjct: 241 GDVDFAGVREVAGYITPVPGGVGPMTITMLLINTLEAAER 280 >ref|YP_725874.1| 5,10-methylene-tetrahydrofolate dehydrogenase [Ralstonia eutropha H16] sp|Q0KBW5.1|FOLD_CUPNH RecName: Full=Bifunctional protein FolD; Includes: RecName: Full=Methylenetetrahydrofolate dehydrogenase; Includes: RecName: Full=Methenyltetrahydrofolate cyclohydrolase emb|CAJ92506.1| 5,10-Methylene-tetrahydrofolate dehydrogenase [Ralstonia eutropha H16] Length = 283 Score = 468 bits (1204), Expect = e-130, Method: Compositional matrix adjust. Identities = 224/280 (80%), Positives = 254/280 (90%) Query: 14 MPAQLIDGNLLSQQLRADVAKRAAALTAKGKQPGLAVILVGDSPASQVYVRNKVKACEDN 73 MPAQLIDGN L++Q+R++ A RAA LT +G +PGLAVILVG+ PASQVYVRNKVKAC+DN Sbjct: 1 MPAQLIDGNALAKQIRSEAALRAARLTERGHRPGLAVILVGEDPASQVYVRNKVKACQDN 60 Query: 74 GLHSVLEKYDAALTEAELLARIDALNKDPKINGILVQLPLPAHIDANKVIEAIAADKDVD 133 G HS L++Y A L+EAELLARI+ALN+DP I+GILVQLPLP HID++KV+EAIA +KDVD Sbjct: 61 GFHSSLDRYPADLSEAELLARIEALNQDPNIHGILVQLPLPKHIDSHKVLEAIAPEKDVD 120 Query: 134 GFHVSNAGLLMTGQPLFRPCTPYGVMKMLESIDYPVRGANAVVVGASNIVGKPQAMLLLQ 193 GFHV+NAG LMTG PLFRPCTPYG MKMLES+ +P+RGA AVVVGASNIVGKP AMLLLQ Sbjct: 121 GFHVANAGALMTGAPLFRPCTPYGCMKMLESVQFPLRGARAVVVGASNIVGKPMAMLLLQ 180 Query: 194 AGATVTICNSKTRDLGHHTRQADILVVATGKRNIVTADMVKPGAVVIDVGMNRDDNGKLC 253 AGATVTICNSKTRD+G HTR AD++V A GKRN++TADMVKPGAVVIDVGMNRDDNGKLC Sbjct: 181 AGATVTICNSKTRDIGAHTRDADVVVAAVGKRNLITADMVKPGAVVIDVGMNRDDNGKLC 240 Query: 254 GDVDFANAKEVAGYITPVPGGVGPMTITMLLVNTIEAAER 293 GDVDFA +EVAGYITPVPGGVGPMTITMLLVNT+EAAER Sbjct: 241 GDVDFAGVREVAGYITPVPGGVGPMTITMLLVNTLEAAER 280