BLASTP 2.2.21 [Jun-14-2009] Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), "Gapped BLAST and PSI-BLAST: a new generation of protein database search programs", Nucleic Acids Res. 25:3389-3402. Reference for compositional score matrix adjustment: Altschul, Stephen F., John C. Wootton, E. Michael Gertz, Richa Agarwala, Aleksandr Morgulis, Alejandro A. Schaffer, and Yi-Kuo Yu (2005) "Protein database searches using compositionally adjusted substitution matrices", FEBS J. 272:5101-5109. Query= 0025.0187.p (278 letters) Database: All non-redundant GenBank CDS translations+PDB+SwissProt+PIR+PRF excluding environmental samples from WGS projects 15,459,386 sequences; 5,307,515,862 total letters Searching..................................................done Score E Sequences producing significant alignments: (bits) Value ref|YP_001099265.1| putative cobalamin synthase [Herminiimonas a... 324 9e-87 ref|YP_001352778.1| cobalamin (5'-phosphate) synthase [Janthinob... 296 2e-78 ref|YP_003775371.1| cobalamin-5-phosphate synthase [Herbaspirill... 267 1e-69 ref|YP_283378.1| cobalamin synthase [Dechloromonas aromatica RCB... 229 4e-58 ref|YP_003168259.1| cobalamin synthase [Candidatus Accumulibacte... 210 2e-52 >ref|YP_001099265.1| putative cobalamin synthase [Herminiimonas arsenicoxydans] emb|CAL61138.1| putative cobalamin synthase cobS [Herminiimonas arsenicoxydans] Length = 270 Score = 324 bits (831), Expect = 9e-87, Method: Compositional matrix adjust. Identities = 161/251 (64%), Positives = 192/251 (76%) Query: 15 YQLQLFFTALQFFTRLPAPGWVGFDAAWLQHAARYFPAVGIIVSLACAVVYWLAALWLPQ 74 +QL+LFF ALQFFTR+P P WVGFD WLQHA+RYFPAVGI+V+L CA+VY L +L+ Q Sbjct: 17 HQLRLFFVALQFFTRIPIPRWVGFDERWLQHASRYFPAVGIVVALVCALVYLLGSLFWNQ 76 Query: 75 VVAVLLSTAAGIYLTGAFHEDGFADVCDGFGGGMQPSRVLEIMRDSRVGAYGVIGIVLLL 134 VAVLLS +AGIYLTGAFHEDGFAD CDGFGGGM RVLEIM DSR+GAYG IGI ++L Sbjct: 77 SVAVLLSMSAGIYLTGAFHEDGFADTCDGFGGGMTEERVLEIMTDSRIGAYGAIGIGMML 136 Query: 135 ATKIAGLVSLPALQVIPALLIAHPLSRCFAAALIWRMPYVREEGKVKPLAQSMSNGEFAV 194 A K L S+P+ V+ ALLI HP SR A +L+WRM YV+ GK KP+ Q MSNGEF + Sbjct: 137 ALKWVVLSSMPSPAVVAALLIVHPFSRLAAISLVWRMNYVKANGKAKPIGQQMSNGEFCI 196 Query: 195 AVVTAALPLVVCVAAGWLALQALLLAMLLGGAATWFLARKFQRRIGGYTGDCLGAVQQFS 254 A TA LP+V+ GW+ +A+ +LL + +LAR FQRRIGGYTGDCLGAVQQ + Sbjct: 197 ASATALLPMVLFSLTGWMPWEAIAAGVLLAAIVSLWLARMFQRRIGGYTGDCLGAVQQAA 256 Query: 255 EVAIYLGLLAA 265 EVA YLG+LAA Sbjct: 257 EVACYLGILAA 267 >ref|YP_001352778.1| cobalamin (5'-phosphate) synthase [Janthinobacterium sp. Marseille] gb|ABR89122.1| cobalamin (5'-phosphate) synthase [Janthinobacterium sp. Marseille] Length = 270 Score = 296 bits (758), Expect = 2e-78, Method: Compositional matrix adjust. Identities = 156/253 (61%), Positives = 184/253 (72%) Query: 15 YQLQLFFTALQFFTRLPAPGWVGFDAAWLQHAARYFPAVGIIVSLACAVVYWLAALWLPQ 74 +QL+LFF ALQFFTR+P P WVGFD WLQHA+RYFPAVGI+V+LA VVY +A+L Q Sbjct: 17 HQLRLFFIALQFFTRIPVPRWVGFDVQWLQHASRYFPAVGIVVALASIVVYIIASLLWTQ 76 Query: 75 VVAVLLSTAAGIYLTGAFHEDGFADVCDGFGGGMQPSRVLEIMRDSRVGAYGVIGIVLLL 134 +AVLLST AGIYLTGAFHEDGFAD CDG GGG P RVLEIM+DSR+GAYG IGI L+L Sbjct: 77 SIAVLLSTIAGIYLTGAFHEDGFADTCDGLGGGGTPERVLEIMKDSRIGAYGAIGIGLML 136 Query: 135 ATKIAGLVSLPALQVIPALLIAHPLSRCFAAALIWRMPYVREEGKVKPLAQSMSNGEFAV 194 A K L SLP+ V+ ALLIAHPLSR A +L+WRM Y + GK KP+AQ MSN EF + Sbjct: 137 ALKWMALSSLPSPAVVSALLIAHPLSRLAAISLVWRMEYAKANGKAKPIAQQMSNREFGI 196 Query: 195 AVVTAALPLVVCVAAGWLALQALLLAMLLGGAATWFLARKFQRRIGGYTGDCLGAVQQFS 254 A T LP+ + G L + + + A ++LAR FQRRI GYTGD LGAVQQ + Sbjct: 197 AAGTTFLPIALLCLTGLLPVSGVACGIFFAALAAFWLARLFQRRIAGYTGDTLGAVQQVA 256 Query: 255 EVAIYLGLLAAAS 267 EVA YLG+L S Sbjct: 257 EVAFYLGVLTVIS 269 >ref|YP_003775371.1| cobalamin-5-phosphate synthase [Herbaspirillum seropedicae SmR1] gb|ADJ63463.1| cobalamin-5-phosphate synthase protein [Herbaspirillum seropedicae SmR1] Length = 274 Score = 267 bits (682), Expect = 1e-69, Method: Compositional matrix adjust. Identities = 161/266 (60%), Positives = 191/266 (71%), Gaps = 3/266 (1%) Query: 3 VAPTPTPSG---GLRYQLQLFFTALQFFTRLPAPGWVGFDAAWLQHAARYFPAVGIIVSL 59 PT +PS GL YQL+LFFTALQFFTRLP P WVGF WL H+ RYFP VG IV+ Sbjct: 2 TEPTSSPSAPGRGLLYQLRLFFTALQFFTRLPIPRWVGFHPDWLAHSTRYFPLVGWIVAW 61 Query: 60 ACAVVYWLAALWLPQVVAVLLSTAAGIYLTGAFHEDGFADVCDGFGGGMQPSRVLEIMRD 119 A A+VY LA + PQ VAVLL TAAGI+LTGAFHEDGFAD+CDG GG + R LEIMRD Sbjct: 62 ATALVYLLAVQFWPQPVAVLLGTAAGIWLTGAFHEDGFADLCDGLGGAVSRERALEIMRD 121 Query: 120 SRVGAYGVIGIVLLLATKIAGLVSLPALQVIPALLIAHPLSRCFAAALIWRMPYVREEGK 179 SR+G+YGVIG+VLL+ T++A L +L Q++ AL IAHPLSR A LIWRM YVREEGK Sbjct: 122 SRLGSYGVIGLVLLMLTRLAALAALQPWQILAALGIAHPLSRWLATCLIWRMDYVREEGK 181 Query: 180 VKPLAQSMSNGEFAVAVVTAALPLVVCVAAGWLALQALLLAMLLGGAATWFLARKFQRRI 239 K LAQ MS GEF VA V +P++ VA G ++ Q + + L A +LA + QRR+ Sbjct: 182 SKLLAQRMSTGEFLVATVWVVVPVIGTVALGLMSWQHIAMGCGLAALAALWLAYRLQRRL 241 Query: 240 GGYTGDCLGAVQQFSEVAIYLGLLAA 265 GGYTGD LGAVQQ SE YLG+LA+ Sbjct: 242 GGYTGDGLGAVQQLSETVFYLGVLAS 267 >ref|YP_283378.1| cobalamin synthase [Dechloromonas aromatica RCB] gb|AAZ44908.1| cobalamin-5'-phosphate synthase [Dechloromonas aromatica RCB] Length = 256 Score = 229 bits (583), Expect = 4e-58, Method: Compositional matrix adjust. Identities = 135/254 (53%), Positives = 163/254 (64%), Gaps = 8/254 (3%) Query: 13 LRYQLQLFFTALQFFTRLPAPGWVGFDAAWLQHAARYFPAVGIIVSLACAVVYWLAALWL 72 +R +L+ FF A++FFTRLP PGWVG A L H+ARYFPAVG++V A+VYWLA Sbjct: 2 IRRELEYFFGAIRFFTRLPVPGWVGHSAEALNHSARYFPAVGLLVGGIGALVYWLALYLW 61 Query: 73 PQVVAVLLSTAAGIYLTGAFHEDGFADVCDGFGGGMQPSRVLEIMRDSRVGAYGVIGIVL 132 PQ VAVLLS AA IY TGAFHEDG +D DG GGG + +R+L+IM+DSRVG+YGV+ +VL Sbjct: 62 PQPVAVLLSMAATIYATGAFHEDGLSDTVDGLGGGWEKARILDIMKDSRVGSYGVVAMVL 121 Query: 133 LLATKIAGLVSLPALQVIPALLIAHPLSRCFAAALIWRMPYVREE--GKVKPLAQSMSNG 190 L K L SL V ALL H +SR A L+ M YVR++ K KPLA MS G Sbjct: 122 ALLGKFVLLSSLAPALVPFALLAGHAVSRFCATVLLATMDYVRDDQLSKAKPLANRMSAG 181 Query: 191 EFAVAVVTAALPLVVCVAAGWLALQALLLAMLLGGAATWFLARKFQRRIGGYTGDCLGAV 250 VA+ A PL +A W A L L ARKFQR +GGYTGDCLGA Sbjct: 182 AIVVALCFAVAPL---LALPWFKAAAGLALAALATLWL---ARKFQRWLGGYTGDCLGAT 235 Query: 251 QQFSEVAIYLGLLA 264 QQF+E+ YLGL+A Sbjct: 236 QQFAEIVFYLGLMA 249 >ref|YP_003168259.1| cobalamin synthase [Candidatus Accumulibacter phosphatis clade IIA str. UW-1] gb|ACV36330.1| cobalamin 5'-phosphate synthase [Candidatus Accumulibacter phosphatis clade IIA str. UW-1] Length = 250 Score = 210 bits (535), Expect = 2e-52, Method: Compositional matrix adjust. Identities = 126/251 (50%), Positives = 164/251 (65%), Gaps = 6/251 (2%) Query: 13 LRYQLQLFFTALQFFTRLPAPGWVGFDAAWLQHAARYFPAVGIIVSLACAVVYWLAALWL 72 LR +++ FF A++FFTRLP P WVG + L AARYFPAVG++V A+V+ L A Sbjct: 2 LRREIEYFFGAIRFFTRLPVPAWVGHSSEALNRAARYFPAVGLLVGAIAALVFVLTAQVW 61 Query: 73 PQVVAVLLSTAAGIYLTGAFHEDGFADVCDGFGGGMQPSRVLEIMRDSRVGAYGVIGIVL 132 P +AVL S ++ +Y+TGAFHEDG++D+ DGFGGG + +++L IM+DSR+G++G I +V+ Sbjct: 62 PTTLAVLASMSSALYVTGAFHEDGWSDMVDGFGGGWEKAQILAIMKDSRIGSFGAIALVI 121 Query: 133 LLATKIAGLVSLPALQVIPALLIAHPLSRCFAAALIWRMPYVREEGKVKPLAQSMSNGEF 192 LL + L+ L V ALL H +SR A L+ + YVR+EGK KPLA + GE Sbjct: 122 LLLARFCALIELDPAVVAAALLAGHTISRFAATTLLRGLAYVRDEGKSKPLATRIGWGEL 181 Query: 193 AVAVVTAALPLVVCVAAGWLALQALLLAMLLGGAATWFLARKFQRRIGGYTGDCLGAVQQ 252 A VTA LPL++ L LL L AT +LAR F RRIGGYTGDCLGA QQ Sbjct: 182 LFAGVTAVLPLLL------LPATEALLGCLFAALATLWLARLFGRRIGGYTGDCLGATQQ 235 Query: 253 FSEVAIYLGLL 263 SEVA Y GLL Sbjct: 236 LSEVAFYCGLL 246