BLASTP 2.2.21 [Jun-14-2009] Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), "Gapped BLAST and PSI-BLAST: a new generation of protein database search programs", Nucleic Acids Res. 25:3389-3402. Reference for compositional score matrix adjustment: Altschul, Stephen F., John C. Wootton, E. Michael Gertz, Richa Agarwala, Aleksandr Morgulis, Alejandro A. Schaffer, and Yi-Kuo Yu (2005) "Protein database searches using compositionally adjusted substitution matrices", FEBS J. 272:5101-5109. Query= 0025.0118.p (343 letters) Database: All non-redundant GenBank CDS translations+PDB+SwissProt+PIR+PRF excluding environmental samples from WGS projects 15,459,386 sequences; 5,307,515,862 total letters Searching..................................................done Score E Sequences producing significant alignments: (bits) Value ref|YP_004752065.1| porphobilinogen deaminase [Collimonas fungiv... 464 e-129 ref|YP_001099316.1| porphobilinogen deaminase [Herminiimonas ars... 463 e-128 ref|YP_001352832.1| hydroxymethylbilane synthase [Janthinobacter... 460 e-127 ref|YP_003776321.1| porphobilinogen deaminase [Herbaspirillum se... 444 e-122 ref|ZP_08273542.1| Porphobilinogen deaminase [Oxalobacteraceae b... 411 e-113 >ref|YP_004752065.1| porphobilinogen deaminase [Collimonas fungivorans Ter331] gb|AEK61242.1| Porphobilinogen deaminase [Collimonas fungivorans Ter331] Length = 313 Score = 464 bits (1195), Expect = e-129, Method: Compositional matrix adjust. Identities = 242/306 (79%), Positives = 267/306 (87%) Query: 31 PPSSLVIASRESRLAMWQAEHVRDRLAALYPQCSITILGMTTRGDQILDRTLSKVGGKGL 90 PPS LVIASRES LAMWQAEHVR+RL+ALYP C+I ILGMTTRGDQILDRTLSKVGGKGL Sbjct: 6 PPSKLVIASRESPLAMWQAEHVRERLSALYPDCNIEILGMTTRGDQILDRTLSKVGGKGL 65 Query: 91 FVKELEVAMAEGRADFAVHSLKDVPMELPGGFVLGAILEREDPRDAFVSNDYAGLDELPA 150 FVKELEVAMAEGRAD AVHSLKD+PMELP GFVL A+LEREDPRDAFVSNDYA L++LPA Sbjct: 66 FVKELEVAMAEGRADLAVHSLKDMPMELPPGFVLSAVLEREDPRDAFVSNDYASLEQLPA 125 Query: 151 GAVVGTSSLRRQALIAARYPHLVIKPLRGNLDTRLGKLDRGDYAAIILAVAGLKRLGLES 210 GA+VGTSSLRRQALIAAR+P L IKPLRGNL TRL KLDRG+YAAIILA AGLKRLGL Sbjct: 126 GAIVGTSSLRRQALIAARFPLLQIKPLRGNLGTRLAKLDRGEYAAIILAAAGLKRLGLAD 185 Query: 211 RIRSAIAPEQSLPAPGQGAMAIEILAERTDLQRVLAPINHLATDRAVTAERTLSRTFGGS 270 RI + I PEQSLPAPGQGAMAIEI A+R DLQ +LAP+NHL T+ AVTAERTLSR FGGS Sbjct: 186 RITAPIEPEQSLPAPGQGAMAIEIRADRADLQEILAPLNHLPTELAVTAERTLSRAFGGS 245 Query: 271 CQIPLAAFATIAGDRMHMRALVATPDGKQVAAAEAEGPADAPAALGKQIADLLQTQGAEA 330 CQ+PLAAFATI GD+M +RA++ATPDG +VA A+A G ADAP LG+ IA L+ Q A A Sbjct: 246 CQVPLAAFATIDGDQMRLRAMIATPDGLRVAVADASGAADAPEVLGETIAAALEAQDAGA 305 Query: 331 ILAACR 336 ILA C+ Sbjct: 306 ILALCK 311 >ref|YP_001099316.1| porphobilinogen deaminase [Herminiimonas arsenicoxydans] emb|CAL61189.1| Porphobilinogen deaminase (PBG) (Hydroxymethylbilane synthase) (HMBS) (Pre-uroporphyrinogen synthase) [Herminiimonas arsenicoxydans] Length = 317 Score = 463 bits (1191), Expect = e-128, Method: Compositional matrix adjust. Identities = 240/312 (76%), Positives = 266/312 (85%) Query: 27 LKEFPPSSLVIASRESRLAMWQAEHVRDRLAALYPQCSITILGMTTRGDQILDRTLSKVG 86 +K PP LVIASRESRLAMWQAEHVR++LA LYPQC+I ILGMTTRGDQILDRTLSKVG Sbjct: 1 MKFPPPKKLVIASRESRLAMWQAEHVREKLALLYPQCAIEILGMTTRGDQILDRTLSKVG 60 Query: 87 GKGLFVKELEVAMAEGRADFAVHSLKDVPMELPGGFVLGAILEREDPRDAFVSNDYAGLD 146 GKGLFVKELEVA+AE RAD AVHSLKDVPM LP GF L A+LEREDPRDAFVSNDYA LD Sbjct: 61 GKGLFVKELEVAIAERRADLAVHSLKDVPMSLPEGFALAAVLEREDPRDAFVSNDYASLD 120 Query: 147 ELPAGAVVGTSSLRRQALIAARYPHLVIKPLRGNLDTRLGKLDRGDYAAIILAVAGLKRL 206 +LP GA+VGTSSLRRQALIAARYP LVI+PLRGNLDTRLGKLD+G+YAAIILA AGLKRL Sbjct: 121 DLPDGAIVGTSSLRRQALIAARYPKLVIRPLRGNLDTRLGKLDKGEYAAIILAAAGLKRL 180 Query: 207 GLESRIRSAIAPEQSLPAPGQGAMAIEILAERTDLQRVLAPINHLATDRAVTAERTLSRT 266 G+ RIR+ + PEQSLPAPGQGAM IEI A+R DLQ LAP+NH AT +AVTAERT+SR Sbjct: 181 GMPQRIRAVLDPEQSLPAPGQGAMGIEIHADRADLQEWLAPLNHEATAQAVTAERTVSRN 240 Query: 267 FGGSCQIPLAAFATIAGDRMHMRALVATPDGKQVAAAEAEGPADAPAALGKQIADLLQTQ 326 FGGSCQIPLAAFATI M +RA++ATPDGK+VA A+ G A AP ALG QIA+LL Q Sbjct: 241 FGGSCQIPLAAFATIENGTMRLRAMIATPDGKRVARADLNGAAHAPEALGGQIAELLHQQ 300 Query: 327 GAEAILAACRAE 338 A AIL +C+ E Sbjct: 301 EANAILESCKTE 312 >ref|YP_001352832.1| hydroxymethylbilane synthase [Janthinobacterium sp. Marseille] gb|ABR88938.1| hydroxymethylbilane synthase [Janthinobacterium sp. Marseille] Length = 317 Score = 460 bits (1183), Expect = e-127, Method: Compositional matrix adjust. Identities = 240/314 (76%), Positives = 268/314 (85%) Query: 27 LKEFPPSSLVIASRESRLAMWQAEHVRDRLAALYPQCSITILGMTTRGDQILDRTLSKVG 86 +K PP LVIASRESRLAMWQAEHVR++LA LYPQCSI ILGMTTRGDQILDRTLSKVG Sbjct: 1 MKFPPPKKLVIASRESRLAMWQAEHVREKLAILYPQCSIEILGMTTRGDQILDRTLSKVG 60 Query: 87 GKGLFVKELEVAMAEGRADFAVHSLKDVPMELPGGFVLGAILEREDPRDAFVSNDYAGLD 146 GKGLFVKELEVA+AE RAD AVHSLKDV M LP GF L A+LEREDPRDAFVSN++ L+ Sbjct: 61 GKGLFVKELEVAIAEQRADLAVHSLKDVAMTLPDGFELAAVLEREDPRDAFVSNEFDTLE 120 Query: 147 ELPAGAVVGTSSLRRQALIAARYPHLVIKPLRGNLDTRLGKLDRGDYAAIILAVAGLKRL 206 LPAGA+VGTSSLRRQALIAARYP LVI+PLRGNLD RLGKLD G+YAAIILA AGLKRL Sbjct: 121 ALPAGAIVGTSSLRRQALIAARYPQLVIRPLRGNLDRRLGKLDNGEYAAIILAAAGLKRL 180 Query: 207 GLESRIRSAIAPEQSLPAPGQGAMAIEILAERTDLQRVLAPINHLATDRAVTAERTLSRT 266 GL +RIRS + PEQSLPAPGQGAMAIEIL+ER DL+ LAP+NH T AVTAERT+SR Sbjct: 181 GLTARIRSYLPPEQSLPAPGQGAMAIEILSERADLKEWLAPLNHTETALAVTAERTVSRN 240 Query: 267 FGGSCQIPLAAFATIAGDRMHMRALVATPDGKQVAAAEAEGPADAPAALGKQIADLLQTQ 326 FGGSCQIPLAAFATI G M +RA++ATPDG ++A+A+ G A+AP ALG+QIAD LQ Q Sbjct: 241 FGGSCQIPLAAFATIDGVNMRLRAIIATPDGSKMASADLSGAANAPEALGRQIADALQQQ 300 Query: 327 GAEAILAACRAEAD 340 A AILA C+ +AD Sbjct: 301 DAAAILALCKTDAD 314 >ref|YP_003776321.1| porphobilinogen deaminase [Herbaspirillum seropedicae SmR1] gb|ADJ64413.1| porphobilinogen deaminase protein [Herbaspirillum seropedicae SmR1] Length = 318 Score = 444 bits (1141), Expect = e-122, Method: Compositional matrix adjust. Identities = 232/306 (75%), Positives = 264/306 (86%) Query: 27 LKEFPPSSLVIASRESRLAMWQAEHVRDRLAALYPQCSITILGMTTRGDQILDRTLSKVG 86 +KEFPPS++VI SRESRLAMWQAE+VRDRLAALYPQCSI+ILG TTRGDQILDR LSKVG Sbjct: 1 MKEFPPSNIVIVSRESRLAMWQAEYVRDRLAALYPQCSISILGTTTRGDQILDRALSKVG 60 Query: 87 GKGLFVKELEVAMAEGRADFAVHSLKDVPMELPGGFVLGAILEREDPRDAFVSNDYAGLD 146 GKGLFVKELEVAMAEGRAD AVH LKD+PM+LP GF L AILEREDPRDAFVSNDYA LD Sbjct: 61 GKGLFVKELEVAMAEGRADLAVHCLKDMPMDLPEGFELAAILEREDPRDAFVSNDYAALD 120 Query: 147 ELPAGAVVGTSSLRRQALIAARYPHLVIKPLRGNLDTRLGKLDRGDYAAIILAVAGLKRL 206 ELP GAVVGTSSLRRQA+IAARYP LV+KPLRGNLDTRL KLDRGDYAAIILAVAGL RL Sbjct: 121 ELPDGAVVGTSSLRRQAMIAARYPQLVVKPLRGNLDTRLAKLDRGDYAAIILAVAGLNRL 180 Query: 207 GLESRIRSAIAPEQSLPAPGQGAMAIEILAERTDLQRVLAPINHLATDRAVTAERTLSRT 266 GL++RIRS + P QSLP+PGQG +AIEI R D++R+LAP++ AER++SR Sbjct: 181 GLKARIRSFLDPAQSLPSPGQGTLAIEIPEGREDIKRLLAPLHDEPAAVVSAAERSVSRI 240 Query: 267 FGGSCQIPLAAFATIAGDRMHMRALVATPDGKQVAAAEAEGPADAPAALGKQIADLLQTQ 326 FG SCQIPLAA+AT+ G R+H+RA++ATPDG AAAEAEGPA AP ALG Q+A+LL+ + Sbjct: 241 FGASCQIPLAAYATLDGQRLHLRAMIATPDGLHAAAAEAEGPAAAPEALGAQVAELLKAR 300 Query: 327 GAEAIL 332 GA+ IL Sbjct: 301 GADDIL 306 >ref|ZP_08273542.1| Porphobilinogen deaminase [Oxalobacteraceae bacterium IMCC9480] gb|EGF32978.1| Porphobilinogen deaminase [Oxalobacteraceae bacterium IMCC9480] Length = 280 Score = 411 bits (1057), Expect = e-113, Method: Compositional matrix adjust. Identities = 216/270 (80%), Positives = 240/270 (88%) Query: 70 MTTRGDQILDRTLSKVGGKGLFVKELEVAMAEGRADFAVHSLKDVPMELPGGFVLGAILE 129 MTTRGDQILDRTLSKVGGKGLFVKELEVA+AEGRAD AVHSLKDVPMELP GF+L A LE Sbjct: 1 MTTRGDQILDRTLSKVGGKGLFVKELEVAIAEGRADLAVHSLKDVPMELPDGFMLAAFLE 60 Query: 130 REDPRDAFVSNDYAGLDELPAGAVVGTSSLRRQALIAARYPHLVIKPLRGNLDTRLGKLD 189 REDPRDAFVSN+YA L+ LPAGAVVGTSSLRRQALIAAR+PHLVI+PLRGNLDTRLGKLD Sbjct: 61 REDPRDAFVSNEYASLEALPAGAVVGTSSLRRQALIAARFPHLVIRPLRGNLDTRLGKLD 120 Query: 190 RGDYAAIILAVAGLKRLGLESRIRSAIAPEQSLPAPGQGAMAIEILAERTDLQRVLAPIN 249 RG+YAAIILA AGLKRLG+ RIR A+ PE SLPAPGQGAMAIEI A RTDL +LAP++ Sbjct: 121 RGEYAAIILAAAGLKRLGVPERIRMALEPEHSLPAPGQGAMAIEIKAGRTDLAALLAPLD 180 Query: 250 HLATDRAVTAERTLSRTFGGSCQIPLAAFATIAGDRMHMRALVATPDGKQVAAAEAEGPA 309 HLAT RAV AERTLSR FGGSCQIPLAAFA + GD++H+RA+VATPDG +VA+AEA GPA Sbjct: 181 HLATARAVQAERTLSRAFGGSCQIPLAAFAVVDGDQLHLRAMVATPDGVRVASAEARGPA 240 Query: 310 DAPAALGKQIADLLQTQGAEAILAACRAEA 339 D P A+G+Q+AD L+ Q AE ILA C+AEA Sbjct: 241 DNPEAVGQQVADALRGQDAEIILAICKAEA 270