BLASTP 2.2.21 [Jun-14-2009] Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), "Gapped BLAST and PSI-BLAST: a new generation of protein database search programs", Nucleic Acids Res. 25:3389-3402. Reference for compositional score matrix adjustment: Altschul, Stephen F., John C. Wootton, E. Michael Gertz, Richa Agarwala, Aleksandr Morgulis, Alejandro A. Schaffer, and Yi-Kuo Yu (2005) "Protein database searches using compositionally adjusted substitution matrices", FEBS J. 272:5101-5109. Query= 0025.0052.p (204 letters) Database: All non-redundant GenBank CDS translations+PDB+SwissProt+PIR+PRF excluding environmental samples from WGS projects 15,459,386 sequences; 5,307,515,862 total letters Searching..................................................done Score E Sequences producing significant alignments: (bits) Value ref|YP_003776678.1| bifunctional folylpolyglutamate synthase/dih... 268 4e-70 ref|YP_004752531.1| folylpolyglutamate synthase [Collimonas fung... 259 1e-67 ref|YP_001099529.1| bifunctional folylpolyglutamate synthase/dih... 226 2e-57 ref|YP_001353851.1| bifunctional folylpolyglutamate synthase / d... 224 6e-57 ref|ZP_08273835.1| Dihydrofolate synthase [Oxalobacteraceae bact... 216 2e-54 >ref|YP_003776678.1| bifunctional folylpolyglutamate synthase/dihydrofolate synthase [Herbaspirillum seropedicae SmR1] gb|ADJ64770.1| bifunctional folylpolyglutamate synthase/dihydrofolate synthase protein [Herbaspirillum seropedicae SmR1] Length = 437 Score = 268 bits (684), Expect = 4e-70, Method: Compositional matrix adjust. Identities = 129/154 (83%), Positives = 138/154 (89%) Query: 2 QAQAKPSTLAEWLTLLETRHTKSIDMGLERVGKVKEQLGIHFDCPVIMVAGTNGKGSTCA 61 QA P+TL EWL LLE RH K IDMGLERV +VK++L IHFDCPVIMVAGTNGKGSTCA Sbjct: 4 QASPTPTTLNEWLALLEQRHFKQIDMGLERVMQVKQKLDIHFDCPVIMVAGTNGKGSTCA 63 Query: 62 MLESILMRAGYRVGLYIKPHFLHFNERARIEGIPASDAALIAAFEAVEEKRGDISLTYFE 121 MLESIL+RAGYRVGLY+KPHFLHFNERAR+ G ASDA LIAAFEAVE +RGDISLTYFE Sbjct: 64 MLESILLRAGYRVGLYMKPHFLHFNERARLSGDMASDAQLIAAFEAVEAQRGDISLTYFE 123 Query: 122 FTTLAIMKLLADAKMDVVILEVGLGGRLDAVNVI 155 FTTLAIMKLLADA+ DVVILEVGLGGRLDAVNVI Sbjct: 124 FTTLAIMKLLADARQDVVILEVGLGGRLDAVNVI 157 >ref|YP_004752531.1| folylpolyglutamate synthase [Collimonas fungivorans Ter331] gb|AEK61708.1| Folylpolyglutamate synthase [Collimonas fungivorans Ter331] Length = 440 Score = 259 bits (663), Expect = 1e-67, Method: Compositional matrix adjust. Identities = 124/151 (82%), Positives = 139/151 (92%) Query: 5 AKPSTLAEWLTLLETRHTKSIDMGLERVGKVKEQLGIHFDCPVIMVAGTNGKGSTCAMLE 64 AKP TLA+WL+LLE+RH K+IDMGL+RV +VKE+L + FDCPVIMVAGTNGKGSTCAMLE Sbjct: 10 AKPVTLADWLSLLESRHFKTIDMGLDRVVQVKERLQLQFDCPVIMVAGTNGKGSTCAMLE 69 Query: 65 SILMRAGYRVGLYIKPHFLHFNERARIEGIPASDAALIAAFEAVEEKRGDISLTYFEFTT 124 SIL+RAGY+VGLYIKPHFL FNERARI G ASDAALIA+FEAVE +RGDISLTYFEFTT Sbjct: 70 SILLRAGYKVGLYIKPHFLDFNERARIGGESASDAALIASFEAVEAQRGDISLTYFEFTT 129 Query: 125 LAIMKLLADAKMDVVILEVGLGGRLDAVNVI 155 LAIM LLA AK+DVVILEVGLGGRLDAVN++ Sbjct: 130 LAIMHLLAQAKLDVVILEVGLGGRLDAVNIV 160 >ref|YP_001099529.1| bifunctional folylpolyglutamate synthase/dihydrofolate synthase [Herminiimonas arsenicoxydans] emb|CAL61402.1| FolC bifunctional protein [Includes: Folylpolyglutamate synthase (Folylpoly-gamma-glutamate synthetase) (FPGS) (Tetrahydrofolate synthase) (Tetrahydrofolylpolyglutamate synthase); Dihydrofolate synthase ] [Herminiimonas arsenicoxydans] Length = 433 Score = 226 bits (575), Expect = 2e-57, Method: Compositional matrix adjust. Identities = 105/149 (70%), Positives = 123/149 (82%) Query: 7 PSTLAEWLTLLETRHTKSIDMGLERVGKVKEQLGIHFDCPVIMVAGTNGKGSTCAMLESI 66 PS LAEWL LET H K+IDMGL+RV +VK+ + + F CPVI+V GTNGKGSTCAMLESI Sbjct: 5 PSNLAEWLAHLETMHPKAIDMGLDRVRQVKQAMTVEFTCPVIIVGGTNGKGSTCAMLESI 64 Query: 67 LMRAGYRVGLYIKPHFLHFNERARIEGIPASDAALIAAFEAVEEKRGDISLTYFEFTTLA 126 L+RAGYRVGLY PH LHFNER RI G ASDA L+AAF+ +E RGD+SL+YFEFTTLA Sbjct: 65 LLRAGYRVGLYTSPHLLHFNERMRINGESASDAELLAAFDKLEAVRGDVSLSYFEFTTLA 124 Query: 127 IMKLLADAKMDVVILEVGLGGRLDAVNVI 155 ++L +DAK+D VI EVGLGGRLDAVNV+ Sbjct: 125 AIQLFSDAKLDAVIFEVGLGGRLDAVNVL 153 >ref|YP_001353851.1| bifunctional folylpolyglutamate synthase / dihydrofolate synthase [Janthinobacterium sp. Marseille] gb|ABR89349.1| bifunctional folylpolyglutamate synthase / dihydrofolate synthase [Janthinobacterium sp. Marseille] Length = 432 Score = 224 bits (571), Expect = 6e-57, Method: Compositional matrix adjust. Identities = 102/150 (68%), Positives = 122/150 (81%) Query: 6 KPSTLAEWLTLLETRHTKSIDMGLERVGKVKEQLGIHFDCPVIMVAGTNGKGSTCAMLES 65 P TLA+WLT LE H K+IDMGL+RV +VK+ + + F CPVI+V GTNGKGSTCAMLES Sbjct: 3 NPKTLADWLTRLEALHPKAIDMGLDRVREVKQAMDVQFACPVIIVGGTNGKGSTCAMLES 62 Query: 66 ILMRAGYRVGLYIKPHFLHFNERARIEGIPASDAALIAAFEAVEEKRGDISLTYFEFTTL 125 IL+RAGYRVGLY PH LHFNER R+ G+ +D LIAAF+ +E RGD+SL+YFEFTTL Sbjct: 63 ILLRAGYRVGLYTSPHLLHFNERMRVNGVSCTDQELIAAFDKLEAVRGDVSLSYFEFTTL 122 Query: 126 AIMKLLADAKMDVVILEVGLGGRLDAVNVI 155 A ++L ADAK+D VI EVGLGGRLDAVNV+ Sbjct: 123 AAIQLFADAKLDAVIFEVGLGGRLDAVNVL 152 >ref|ZP_08273835.1| Dihydrofolate synthase [Oxalobacteraceae bacterium IMCC9480] gb|EGF32699.1| Dihydrofolate synthase [Oxalobacteraceae bacterium IMCC9480] Length = 433 Score = 216 bits (549), Expect = 2e-54, Method: Compositional matrix adjust. Identities = 101/149 (67%), Positives = 121/149 (81%) Query: 7 PSTLAEWLTLLETRHTKSIDMGLERVGKVKEQLGIHFDCPVIMVAGTNGKGSTCAMLESI 66 P TLA WLT LE++H +IDMGL+RV V ++GI FDCPVI V GTNGKGSTCAMLE+I Sbjct: 5 PDTLAGWLTRLESQHPITIDMGLDRVSAVAVRMGIRFDCPVITVGGTNGKGSTCAMLEAI 64 Query: 67 LMRAGYRVGLYIKPHFLHFNERARIEGIPASDAALIAAFEAVEEKRGDISLTYFEFTTLA 126 L++AGYRVGL PH + FNERAR+ G ASDA L+ F VE+ RGDISL+YFEFTTLA Sbjct: 65 LLQAGYRVGLSTSPHLIDFNERARVAGESASDAELVRYFGVVEQARGDISLSYFEFTTLA 124 Query: 127 IMKLLADAKMDVVILEVGLGGRLDAVNVI 155 I++L DA++DVVILEVGLGGRLDA+N+I Sbjct: 125 ILQLFVDARLDVVILEVGLGGRLDAMNII 153