BLASTP 2.2.21 [Jun-14-2009] Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), "Gapped BLAST and PSI-BLAST: a new generation of protein database search programs", Nucleic Acids Res. 25:3389-3402. Reference for compositional score matrix adjustment: Altschul, Stephen F., John C. Wootton, E. Michael Gertz, Richa Agarwala, Aleksandr Morgulis, Alejandro A. Schaffer, and Yi-Kuo Yu (2005) "Protein database searches using compositionally adjusted substitution matrices", FEBS J. 272:5101-5109. Query= 0015.0126.p (476 letters) Database: All non-redundant GenBank CDS translations+PDB+SwissProt+PIR+PRF excluding environmental samples from WGS projects 15,459,386 sequences; 5,307,515,862 total letters Searching..................................................done Score E Sequences producing significant alignments: (bits) Value ref|YP_002513318.1| isopropylmalate isomerase large subunit [Thi... 623 e-176 ref|YP_004294053.1| 3-isopropylmalate dehydratase, large subunit... 620 e-175 ref|YP_004695648.1| 3-isopropylmalate dehydratase large subunit ... 619 e-175 ref|YP_001898955.1| 3-isopropylmalate dehydratase large subunit ... 618 e-175 ref|YP_412608.1| isopropylmalate isomerase large subunit [Nitros... 616 e-174 >ref|YP_002513318.1| isopropylmalate isomerase large subunit [Thioalkalivibrio sulfidophilus HL-EbGr7] sp|B8GQD6.1|LEUC_THISH RecName: Full=3-isopropylmalate dehydratase large subunit; AltName: Full=Alpha-IPM isomerase; Short=IPMI; AltName: Full=Isopropylmalate isomerase gb|ACL72331.1| 3-isopropylmalate dehydratase, large subunit [Thioalkalivibrio sulfidophilus HL-EbGr7] Length = 470 Score = 623 bits (1607), Expect = e-176, Method: Compositional matrix adjust. Identities = 303/461 (65%), Positives = 372/461 (80%) Query: 11 TLFEKLWQAHVVSSDDEGNALVYIDRQYVYEVTSPQAFEGLREKKRKVRRPGTVLATVDH 70 TL++KLW AHVV ++ +G AL+YIDR V+EVTSPQAFEGLR RK R TVLA DH Sbjct: 5 TLYDKLWDAHVVRTEPDGTALLYIDRHLVHEVTSPQAFEGLRLAGRKPWRTDTVLAVPDH 64 Query: 71 NVPTTARDVPMRDRLAQLQVDTLTSNCADFGIPYFDIRDVRQGIVHVVGPEQGATLPGST 130 NVPTT RD + D ++++QV+TL +N +FGI +F + DVRQGIVHV+GPEQGATLPG T Sbjct: 65 NVPTTHRDQGISDPVSRIQVETLDANVHEFGITFFPMNDVRQGIVHVIGPEQGATLPGMT 124 Query: 131 VICGDSHTSTHGAFGALAWGVGTTEVEHALATHCLWLVRPLTTRITVKGTLAPGVGAKDL 190 V+CGDSHTSTHGAFGALA+G+GT+EVEH LAT CL + ++V G + PGV AKD+ Sbjct: 125 VVCGDSHTSTHGAFGALAFGIGTSEVEHVLATQCLLQKKMKNMLVSVDGRVGPGVTAKDI 184 Query: 191 ALYLIGFLGTQGGIGHAIEFAGDAIAALSMEGRMTLCNMAVEAGARFGLVAVDDTTIDYL 250 L +IG +GT GG G+AIEF G+AI LSMEGRMT+CNMA+EAGAR G+VAVD+TTI+Y+ Sbjct: 185 VLAIIGEIGTAGGTGYAIEFGGEAIRDLSMEGRMTVCNMAIEAGARAGMVAVDETTIEYV 244 Query: 251 QGRPLVPSGAQWDAANAYWRQLRSDSGAQFYRELEIDAGTVKPMVTWGTSPDMCVGVDGV 310 +GR P+G QW++A A WR+L SD+ A+F R + +DA + P V+WGTSP+M V V G Sbjct: 245 KGRTYAPTGEQWESAVAAWRELNSDADARFDRVVRLDATAIAPQVSWGTSPEMVVPVTGR 304 Query: 311 VPDPSQEENITRQSGMRKALAYMDISAGTPMEQLALDKVFIGSCTNARIEDLRAAAAVVR 370 VPDP++ + + SGM++AL YM ++A TP+EQ+A+DKVFIGSCTN+RIEDLRAAAAVVR Sbjct: 305 VPDPAEATDPVKASGMKRALEYMGLAANTPIEQIAIDKVFIGSCTNSRIEDLRAAAAVVR 364 Query: 371 GYTVSQTIRQALVVPGSGLVKRQAEQEGLDKVFLAAGFEWREPGCSMCLGMNDDRLAPGE 430 G V+ ++ A+VVPGSGLVK+QAEQEGLD+VFL AGFEWREPGCSMCL MN DRL PGE Sbjct: 365 GRKVAGNVKLAMVVPGSGLVKQQAEQEGLDQVFLEAGFEWREPGCSMCLAMNADRLEPGE 424 Query: 431 RCASTSNRNFEGRQGPGGRSHLVSPATAAAAAICGHFTDVR 471 RCASTSNRNFEGRQG GGR+HLVSPA AAAAA+ GHFTDVR Sbjct: 425 RCASTSNRNFEGRQGQGGRTHLVSPAMAAAAAVTGHFTDVR 465 >ref|YP_004294053.1| 3-isopropylmalate dehydratase, large subunit [Nitrosomonas sp. AL212] gb|ADZ25891.1| 3-isopropylmalate dehydratase, large subunit [Nitrosomonas sp. AL212] Length = 472 Score = 620 bits (1600), Expect = e-175, Method: Compositional matrix adjust. Identities = 301/467 (64%), Positives = 367/467 (78%), Gaps = 3/467 (0%) Query: 11 TLFEKLWQAHVV--SSDDEGN-ALVYIDRQYVYEVTSPQAFEGLREKKRKVRRPGTVLAT 67 TL++KLW H+V SDD G+ AL+YIDR V+EVTSPQAFE L+ RK R ++LA Sbjct: 3 TLYDKLWNQHIVHTESDDPGSMALIYIDRHLVHEVTSPQAFESLKLAGRKPWRLNSILAV 62 Query: 68 VDHNVPTTARDVPMRDRLAQLQVDTLTSNCADFGIPYFDIRDVRQGIVHVVGPEQGATLP 127 DHNVPTT R + D +++LQVDTL NC + GI F + D+RQGIVHV+GPEQGATLP Sbjct: 63 ADHNVPTTDRSQGIHDPISRLQVDTLDQNCDELGITEFKMNDLRQGIVHVIGPEQGATLP 122 Query: 128 GSTVICGDSHTSTHGAFGALAWGVGTTEVEHALATHCLWLVRPLTTRITVKGTLAPGVGA 187 G TV+CGDSHTSTHGAFG LA+G+GT+EVEH LAT CL + + RI+V+G L GV A Sbjct: 123 GMTVVCGDSHTSTHGAFGCLAFGIGTSEVEHVLATQCLLMKKSKAMRISVEGELGLGVTA 182 Query: 188 KDLALYLIGFLGTQGGIGHAIEFAGDAIAALSMEGRMTLCNMAVEAGARFGLVAVDDTTI 247 KD+AL +IG +GT GG G+AIEF G AI ALSMEGRMTLCNMA+EAGAR G+VAVDDTTI Sbjct: 183 KDIALAIIGKIGTAGGTGYAIEFTGSAIRALSMEGRMTLCNMAIEAGARAGMVAVDDTTI 242 Query: 248 DYLQGRPLVPSGAQWDAANAYWRQLRSDSGAQFYRELEIDAGTVKPMVTWGTSPDMCVGV 307 DY++GRP P WD+A +WR L SD+ A F R + +DA ++P VTWGTSP+M + Sbjct: 243 DYIKGRPFAPKNELWDSAVEFWRTLHSDADAVFDRTVALDAAQIEPQVTWGTSPEMVTTI 302 Query: 308 DGVVPDPSQEENITRQSGMRKALAYMDISAGTPMEQLALDKVFIGSCTNARIEDLRAAAA 367 DGVVPDP+ + ++ M++AL YM +SA TP++Q+ LDK+FIGSCTN+RIEDLRAAA Sbjct: 303 DGVVPDPAHVSDEVKRHDMQQALNYMGLSANTPIQQINLDKIFIGSCTNSRIEDLRAAAE 362 Query: 368 VVRGYTVSQTIRQALVVPGSGLVKRQAEQEGLDKVFLAAGFEWREPGCSMCLGMNDDRLA 427 +V+G ++ I+ ALVVPGSGLVK+QAEQEGLD++FL+AGFEWREPGCSMCL MNDDRL Sbjct: 363 IVKGKHIAVNIKLALVVPGSGLVKKQAEQEGLDQIFLSAGFEWREPGCSMCLAMNDDRLT 422 Query: 428 PGERCASTSNRNFEGRQGPGGRSHLVSPATAAAAAICGHFTDVRTWS 474 GERCASTSNRNFEGRQGPGGR+HLVSPA AAAAAI GHF DVR ++ Sbjct: 423 AGERCASTSNRNFEGRQGPGGRTHLVSPAMAAAAAIAGHFVDVRKFN 469 >ref|YP_004695648.1| 3-isopropylmalate dehydratase large subunit [Nitrosomonas sp. Is79A3] gb|AEJ02249.1| 3-isopropylmalate dehydratase large subunit [Nitrosomonas sp. Is79A3] Length = 469 Score = 619 bits (1597), Expect = e-175, Method: Compositional matrix adjust. Identities = 302/464 (65%), Positives = 364/464 (78%), Gaps = 3/464 (0%) Query: 11 TLFEKLWQAHVV---SSDDEGNALVYIDRQYVYEVTSPQAFEGLREKKRKVRRPGTVLAT 67 TL++KLW HVV SS+ + AL+YIDR V+EVTSPQAFE L+ RK R ++LA Sbjct: 3 TLYDKLWNQHVVHTESSEPDSMALIYIDRHLVHEVTSPQAFESLKLAGRKPWRLDSILAV 62 Query: 68 VDHNVPTTARDVPMRDRLAQLQVDTLTSNCADFGIPYFDIRDVRQGIVHVVGPEQGATLP 127 DHNVPTT R + D +++LQVDTL NC + GI F ++D+RQGIVHV+GPEQGATLP Sbjct: 63 ADHNVPTTDRSHGIHDPISRLQVDTLDQNCDELGITEFKMQDLRQGIVHVIGPEQGATLP 122 Query: 128 GSTVICGDSHTSTHGAFGALAWGVGTTEVEHALATHCLWLVRPLTTRITVKGTLAPGVGA 187 G TV+CGDSHTSTHGAFG LA+G+GT+EVEH LAT CL + + RI+V+G L+ GV A Sbjct: 123 GMTVVCGDSHTSTHGAFGCLAFGIGTSEVEHVLATQCLLMKKAKAMRISVEGKLSLGVTA 182 Query: 188 KDLALYLIGFLGTQGGIGHAIEFAGDAIAALSMEGRMTLCNMAVEAGARFGLVAVDDTTI 247 KD+AL +IG +GT GG G+AIEF G AI LSMEGRMTLCNMA+EAGAR G+VAVDDTTI Sbjct: 183 KDIALAVIGEIGTAGGTGYAIEFTGSAIRTLSMEGRMTLCNMAIEAGARAGMVAVDDTTI 242 Query: 248 DYLQGRPLVPSGAQWDAANAYWRQLRSDSGAQFYRELEIDAGTVKPMVTWGTSPDMCVGV 307 +Y+QGRP P G WD A AYWR L+SD+ A F R + +DA +KP VTWGTSP+M + Sbjct: 243 NYIQGRPFAPKGELWDRAVAYWRTLQSDADAVFDRTVALDAAQIKPQVTWGTSPEMVTTI 302 Query: 308 DGVVPDPSQEENITRQSGMRKALAYMDISAGTPMEQLALDKVFIGSCTNARIEDLRAAAA 367 DG VPDPS + ++ +++AL YM + A TP+ Q+ LDK+FIGSCTN+RIEDLRAAA Sbjct: 303 DGTVPDPSLVTDEVKRHDLQQALNYMGLVANTPIRQITLDKIFIGSCTNSRIEDLRAAAQ 362 Query: 368 VVRGYTVSQTIRQALVVPGSGLVKRQAEQEGLDKVFLAAGFEWREPGCSMCLGMNDDRLA 427 +V+G ++ I+ ALVVPGSGLVK+QAEQEGLD++FLAAGFEWREPGCSMCL MNDDRL Sbjct: 363 IVKGKRIAANIKLALVVPGSGLVKKQAEQEGLDRIFLAAGFEWREPGCSMCLAMNDDRLT 422 Query: 428 PGERCASTSNRNFEGRQGPGGRSHLVSPATAAAAAICGHFTDVR 471 GERCASTSNRNFEGRQGPGGR+HLVSPA AAAAAI GHF DVR Sbjct: 423 AGERCASTSNRNFEGRQGPGGRTHLVSPAMAAAAAIAGHFVDVR 466 >ref|YP_001898955.1| 3-isopropylmalate dehydratase large subunit [Ralstonia pickettii 12J] ref|YP_002981404.1| 3-isopropylmalate dehydratase large subunit [Ralstonia pickettii 12D] ref|ZP_07676766.1| 3-isopropylmalate dehydratase, large subunit [Ralstonia sp. 5_7_47FAA] gb|ACD26523.1| 3-isopropylmalate dehydratase, large subunit [Ralstonia pickettii 12J] gb|ACS62732.1| 3-isopropylmalate dehydratase, large subunit [Ralstonia pickettii 12D] gb|EFP64769.1| 3-isopropylmalate dehydratase, large subunit [Ralstonia sp. 5_7_47FAA] Length = 480 Score = 618 bits (1593), Expect = e-175, Method: Compositional matrix adjust. Identities = 301/460 (65%), Positives = 361/460 (78%) Query: 11 TLFEKLWQAHVVSSDDEGNALVYIDRQYVYEVTSPQAFEGLREKKRKVRRPGTVLATVDH 70 TLF KLWQ H V D+G+ L+YID V EVTSPQAFEGLR + RP +VLAT DH Sbjct: 5 TLFAKLWQRHAVRDTDDGHTLLYIDLHLVNEVTSPQAFEGLRISRLHPWRPASVLATEDH 64 Query: 71 NVPTTARDVPMRDRLAQLQVDTLTSNCADFGIPYFDIRDVRQGIVHVVGPEQGATLPGST 130 NVPT R + D +A+ QV+ L SNCA FGI + ++D RQGI+HV+GPEQGATLPG T Sbjct: 65 NVPTANRAAGITDDIARRQVEALRSNCARFGITEYPMQDARQGILHVIGPEQGATLPGMT 124 Query: 131 VICGDSHTSTHGAFGALAWGVGTTEVEHALATHCLWLVRPLTTRITVKGTLAPGVGAKDL 190 ++CGDSHT+THGAF LA+G+GT+E+EH LAT CL + + T R+ V+G L+PGV +KD+ Sbjct: 125 IVCGDSHTTTHGAFATLAFGIGTSEIEHVLATQCLIVKKMKTMRVLVEGDLSPGVTSKDV 184 Query: 191 ALYLIGFLGTQGGIGHAIEFAGDAIAALSMEGRMTLCNMAVEAGARFGLVAVDDTTIDYL 250 AL LIG +GT G G+AIEFAG AI+A+SM+ RMTLCNM +EAGAR G+VAVDD TI+YL Sbjct: 185 ALALIGRIGTAGATGYAIEFAGSAISAMSMDARMTLCNMVIEAGARCGMVAVDDKTINYL 244 Query: 251 QGRPLVPSGAQWDAANAYWRQLRSDSGAQFYRELEIDAGTVKPMVTWGTSPDMCVGVDGV 310 +GR P GAQWDAA AYWR LRSD GAQF R + +DA T++P VTWGTSP+M V +DG Sbjct: 245 RGRARAPQGAQWDAAQAYWRTLRSDEGAQFDRTIALDATTIRPHVTWGTSPEMVVTIDGR 304 Query: 311 VPDPSQEENITRQSGMRKALAYMDISAGTPMEQLALDKVFIGSCTNARIEDLRAAAAVVR 370 VPDP++E + ++ G+ +AL YM + GTP+ +ALDK+FIGSCTNARIEDLRAAA VV Sbjct: 305 VPDPAEESDPIKRQGITRALTYMGLEPGTPLRDIALDKIFIGSCTNARIEDLRAAARVVA 364 Query: 371 GYTVSQTIRQALVVPGSGLVKRQAEQEGLDKVFLAAGFEWREPGCSMCLGMNDDRLAPGE 430 G V+ I QALVVPGSGLVKRQAE EGLD++F+ AGFEWR+PGCSMCLGMNDDRL PGE Sbjct: 365 GKHVAANIVQALVVPGSGLVKRQAEAEGLDRIFVDAGFEWRDPGCSMCLGMNDDRLQPGE 424 Query: 431 RCASTSNRNFEGRQGPGGRSHLVSPATAAAAAICGHFTDV 470 RCASTSNRNFEGRQG GGR+HLVSP AAAAAI GHF V Sbjct: 425 RCASTSNRNFEGRQGAGGRTHLVSPPMAAAAAIAGHFVAV 464 >ref|YP_412608.1| isopropylmalate isomerase large subunit [Nitrosospira multiformis ATCC 25196] gb|ABB75216.1| 3-isopropylmalate dehydratase, large subunit [Nitrosospira multiformis ATCC 25196] Length = 469 Score = 616 bits (1589), Expect = e-174, Method: Compositional matrix adjust. Identities = 300/464 (64%), Positives = 363/464 (78%), Gaps = 3/464 (0%) Query: 11 TLFEKLWQAHVV---SSDDEGNALVYIDRQYVYEVTSPQAFEGLREKKRKVRRPGTVLAT 67 TL++KLWQ+HVV S D EG AL+YIDR V+EVTSPQAFEGL+ RK R ++LA Sbjct: 3 TLYDKLWQSHVVHEESDDAEGMALLYIDRHLVHEVTSPQAFEGLKLAGRKPWRLNSILAV 62 Query: 68 VDHNVPTTARDVPMRDRLAQLQVDTLTSNCADFGIPYFDIRDVRQGIVHVVGPEQGATLP 127 DHNVPTT RD + D +++LQV+TL NC + GI F + D RQGIVHV+GPEQGATLP Sbjct: 63 ADHNVPTTGRDHGISDPVSRLQVETLDQNCEELGITEFRMNDQRQGIVHVIGPEQGATLP 122 Query: 128 GSTVICGDSHTSTHGAFGALAWGVGTTEVEHALATHCLWLVRPLTTRITVKGTLAPGVGA 187 G TV+CGDSHTSTHGAFG LA+G+GT+EVEH LAT CL + T +I V G L G+ A Sbjct: 123 GMTVVCGDSHTSTHGAFGCLAFGIGTSEVEHVLATQCLLAKKSRTMQIVVDGNLGNGITA 182 Query: 188 KDLALYLIGFLGTQGGIGHAIEFAGDAIAALSMEGRMTLCNMAVEAGARFGLVAVDDTTI 247 KD+AL ++G +GT GG G+AIEFAG AI LSMEGRMTLCNMA+EAGAR G+VAVDD TI Sbjct: 183 KDVALAVVGRIGTAGGTGYAIEFAGSAIRGLSMEGRMTLCNMAIEAGARAGMVAVDDVTI 242 Query: 248 DYLQGRPLVPSGAQWDAANAYWRQLRSDSGAQFYRELEIDAGTVKPMVTWGTSPDMCVGV 307 +YL+GRP P G W+ A AYWR L+SD GA F + +++DA ++KP VTWGTSP+M V Sbjct: 243 EYLRGRPFAPKGDLWEKAVAYWRTLKSDEGASFDKGVQLDAASIKPQVTWGTSPEMVATV 302 Query: 308 DGVVPDPSQEENITRQSGMRKALAYMDISAGTPMEQLALDKVFIGSCTNARIEDLRAAAA 367 DG VPDP++ + ++ M +AL YM ++ TP+ ++ DK+FIGSCTNARIEDLRAAA Sbjct: 303 DGKVPDPTEIADAVKRHDMERALKYMALAPNTPISEIRPDKIFIGSCTNARIEDLRAAAE 362 Query: 368 VVRGYTVSQTIRQALVVPGSGLVKRQAEQEGLDKVFLAAGFEWREPGCSMCLGMNDDRLA 427 VVRG ++++I+ A+VVPGSGLVK QAEQEGLD++F AGFEWREPGCSMCL MNDDRL Sbjct: 363 VVRGRRIAKSIKLAMVVPGSGLVKHQAEQEGLDRIFRDAGFEWREPGCSMCLAMNDDRLE 422 Query: 428 PGERCASTSNRNFEGRQGPGGRSHLVSPATAAAAAICGHFTDVR 471 PGERCASTSNRNFEGRQGP GR+HLVSPA AAAAA+ GHF DVR Sbjct: 423 PGERCASTSNRNFEGRQGPAGRTHLVSPAMAAAAAVAGHFVDVR 466