BLASTP 2.2.21 [Jun-14-2009] Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), "Gapped BLAST and PSI-BLAST: a new generation of protein database search programs", Nucleic Acids Res. 25:3389-3402. Reference for compositional score matrix adjustment: Altschul, Stephen F., John C. Wootton, E. Michael Gertz, Richa Agarwala, Aleksandr Morgulis, Alejandro A. Schaffer, and Yi-Kuo Yu (2005) "Protein database searches using compositionally adjusted substitution matrices", FEBS J. 272:5101-5109. Query= 0005.0187.p (390 letters) Database: All non-redundant GenBank CDS translations+PDB+SwissProt+PIR+PRF excluding environmental samples from WGS projects 15,459,386 sequences; 5,307,515,862 total letters Searching..................................................done Score E Sequences producing significant alignments: (bits) Value ref|YP_003776430.1| 3-hydroxy-3-methylglutaryl-coenzyme A reduct... 600 e-169 ref|YP_004416465.1| HMG-CoA reductase [Pusillimonas sp. T7-7] >g... 586 e-165 ref|ZP_08275680.1| Hydroxymethylglutaryl-CoA reductase [Oxalobac... 581 e-164 ref|YP_001777654.1| hydroxymethylglutaryl-CoA reductase, degrada... 574 e-162 ref|YP_837137.1| hydroxymethylglutaryl-CoA reductase, degradativ... 573 e-161 >ref|YP_003776430.1| 3-hydroxy-3-methylglutaryl-coenzyme A reductase [Herbaspirillum seropedicae SmR1] gb|ADJ64522.1| 3-hydroxy-3-methylglutaryl-coenzyme A reductase protein [Herbaspirillum seropedicae SmR1] Length = 436 Score = 600 bits (1548), Expect = e-169, Method: Compositional matrix adjust. Identities = 304/425 (71%), Positives = 337/425 (79%), Gaps = 38/425 (8%) Query: 2 TVDSRLPQFRSLNPQQRLEQIAQRANLTADEVALLANPAALPLEVANGMIENVIGTFQIP 61 T DSRLP FR+ P QRL ++ + A L E ALL P ALPL A+GMIENV+G+FQ+P Sbjct: 10 TPDSRLPGFRTYTPAQRLAEVGRLAQLDQAEQALLGQPGALPLGTADGMIENVVGSFQLP 69 Query: 62 MGVAGYFQLNGKDVLVPMAVEEPSVVAAASFMAKLIRDCGGFHTSSSAPLMRAQVQVIGV 121 +GVAGYFQLNG+DVLVPMAVEEPSVVAAASFMAKL+R CGGF TSSS PLMRAQ+Q+ G+ Sbjct: 70 LGVAGYFQLNGRDVLVPMAVEEPSVVAAASFMAKLVRTCGGFQTSSSLPLMRAQIQLTGI 129 Query: 122 SDPYGARVL--------------------------------------AGAMVIVHLIVDV 143 SDP+GAR+ GAMV+ HLIVDV Sbjct: 130 SDPHGARLAILKERQAIIDIANSRDQLLQQLGGGCRDIEVQVFPDTRRGAMVVTHLIVDV 189 Query: 144 RDAMGANTVNTMAEAVAGHIEQITGGKVRLRILSNLADLRLARAHVRVSPEALTTADYDG 203 RDAMGANTVNTMAEAVA HIE++TGGKVRLRILSNLADLRLARA V+VS + L+TA Y G Sbjct: 190 RDAMGANTVNTMAEAVASHIERVTGGKVRLRILSNLADLRLARARVKVSADVLSTAQYRG 249 Query: 204 ADVINRIVDAYTFAAVDPYRAATHNKGIMNGIDPVIVATGNDWRAVEAGAHAYACRNGHY 263 +VIN IVDAY AAVDPYRAATHNKGIMNGIDPVIVATGNDWRAVEAGAHAYACR+G Y Sbjct: 250 EEVINGIVDAYELAAVDPYRAATHNKGIMNGIDPVIVATGNDWRAVEAGAHAYACRHGRY 309 Query: 264 TSLSTWEIGNDGHLVGTLEIPMPVGLVGGATKTHPLARLALKMMDVKSAQELAEIAVAVG 323 TSL+ WEI DG LVGTLEIPMPVGLVGGATKTHP AR+ALK++ V+SAQ LAE+AVAVG Sbjct: 310 TSLTHWEIAADGDLVGTLEIPMPVGLVGGATKTHPAARVALKILGVQSAQALAEVAVAVG 369 Query: 324 LAQNMAALRALATEGIQRGHMALHARNIGLAAGASAEEMDWVVQQMVAAKDVRVDFAVKL 383 LAQNMAALRALATEGIQRGHMALHARNI LAAGA A EMDW+VQQMVA DVRVD+A L Sbjct: 370 LAQNMAALRALATEGIQRGHMALHARNIALAAGAEASEMDWLVQQMVARHDVRVDYAKAL 429 Query: 384 LAQRR 388 LA+RR Sbjct: 430 LAERR 434 >ref|YP_004416465.1| HMG-CoA reductase [Pusillimonas sp. T7-7] gb|AEC19841.1| HMG-CoA reductase [Pusillimonas sp. T7-7] Length = 433 Score = 586 bits (1510), Expect = e-165, Method: Compositional matrix adjust. Identities = 289/425 (68%), Positives = 338/425 (79%), Gaps = 38/425 (8%) Query: 1 MTVDSRLPQFRSLNPQQRLEQIAQRANLTADEVALLANPAALPLEVANGMIENVIGTFQI 60 M +DS LPQFR+L+P +RLE +A++ L+ ++ LLA P ALPLE A+ MIENVIG F++ Sbjct: 1 MNLDSSLPQFRTLSPDERLEHLAKKLQLSQEDRRLLAGPGALPLETADSMIENVIGKFEL 60 Query: 61 PMGVAGYFQLNGKDVLVPMAVEEPSVVAAASFMAKLIRDCGGFHTSSSAPLMRAQVQVIG 120 P VAGYFQ+NGKDVLVPMAVEEPSVVAAAS+MAKL+R GGFHTSSS P+MRAQVQ++ Sbjct: 61 PYAVAGYFQVNGKDVLVPMAVEEPSVVAAASYMAKLVRANGGFHTSSSGPIMRAQVQIVN 120 Query: 121 VSDPYGAR--------------------------------------VLAGAMVIVHLIVD 142 + DPYGAR GAMV+VHLIVD Sbjct: 121 LGDPYGARHAILQQRQDIIDIANSRDQVLMGLGGGCKDIEVHVFPDTARGAMVVVHLIVD 180 Query: 143 VRDAMGANTVNTMAEAVAGHIEQITGGKVRLRILSNLADLRLARAHVRVSPEALTTADYD 202 VRDAMGANTVNTMAEAVA +EQITGG+VRLRILSNLADLRLARAH+R++PE L T++Y Sbjct: 181 VRDAMGANTVNTMAEAVAPRMEQITGGRVRLRILSNLADLRLARAHLRLTPELLQTSEYS 240 Query: 203 GADVINRIVDAYTFAAVDPYRAATHNKGIMNGIDPVIVATGNDWRAVEAGAHAYACRNGH 262 G DVI+ IVDAY FAAVDPYRAATHNKGIMNGIDP+IVATGNDWRAVEAGAHAYACR+G Sbjct: 241 GVDVIDGIVDAYEFAAVDPYRAATHNKGIMNGIDPIIVATGNDWRAVEAGAHAYACRHGR 300 Query: 263 YTSLSTWEIGNDGHLVGTLEIPMPVGLVGGATKTHPLARLALKMMDVKSAQELAEIAVAV 322 YTSLSTWE+ ++G LVGTLE+PMPVGLVGGATKTHPLA+L+LK+++V SAQELAEIA AV Sbjct: 301 YTSLSTWEVASNGELVGTLEMPMPVGLVGGATKTHPLAQLSLKILNVASAQELAEIAAAV 360 Query: 323 GLAQNMAALRALATEGIQRGHMALHARNIGLAAGASAEEMDWVVQQMVAAKDVRVDFAVK 382 GLAQN+AALRAL+TEGIQRGHMALHARNI L AGA +++ WV Q+MV A+DVR D A + Sbjct: 361 GLAQNLAALRALSTEGIQRGHMALHARNIALLAGAKGDDIAWVAQKMVEARDVRADLATE 420 Query: 383 LLAQR 387 LL + Sbjct: 421 LLQNK 425 >ref|ZP_08275680.1| Hydroxymethylglutaryl-CoA reductase [Oxalobacteraceae bacterium IMCC9480] gb|EGF30846.1| Hydroxymethylglutaryl-CoA reductase [Oxalobacteraceae bacterium IMCC9480] Length = 426 Score = 581 bits (1498), Expect = e-164, Method: Compositional matrix adjust. Identities = 291/424 (68%), Positives = 337/424 (79%), Gaps = 38/424 (8%) Query: 1 MTVDSRLPQFRSLNPQQRLEQIAQRANLTADEVALLANPAALPLEVANGMIENVIGTFQI 60 MT+DSRLP FR+L+P RL+ I A LT +E AL+A P +LPLEVANGM+ENVIG F++ Sbjct: 1 MTIDSRLPNFRALDPAARLDHIVAVAGLTPEERALIAEPGSLPLEVANGMVENVIGKFEL 60 Query: 61 PMGVAGYFQLNGKDVLVPMAVEEPSVVAAASFMAKLIRDCGGFHTSSSAPLMRAQVQVIG 120 P VAGYFQ+NG+DVLVPM VEEPSVVAAASFMAK+IR+ GGF TSS+ PLMRAQVQV+ Sbjct: 61 PYSVAGYFQINGRDVLVPMVVEEPSVVAAASFMAKIIRESGGFQTSSTGPLMRAQVQVME 120 Query: 121 VSDPYGAR--VLA------------------------------------GAMVIVHLIVD 142 ++DP+GAR VL+ G MVIVHLIVD Sbjct: 121 LADPFGARHAVLSHKQELITLANSRDKVLIGLGGGCKDIEVHVFADTARGPMVIVHLIVD 180 Query: 143 VRDAMGANTVNTMAEAVAGHIEQITGGKVRLRILSNLADLRLARAHVRVSPEALTTADYD 202 VRDAMGANTVNTMAEAVAG IE ITGGKVRLRILSNLADLRLARA V++ PE L +ADY Sbjct: 181 VRDAMGANTVNTMAEAVAGRIEAITGGKVRLRILSNLADLRLARARVQIRPELLKSADYT 240 Query: 203 GADVINRIVDAYTFAAVDPYRAATHNKGIMNGIDPVIVATGNDWRAVEAGAHAYACRNGH 262 VIN I+DAYTFAA+DPYRAATHNKGIMNGIDPVIVATGNDWRAVEAGAHAYACR+G Sbjct: 241 ADQVINGIIDAYTFAAIDPYRAATHNKGIMNGIDPVIVATGNDWRAVEAGAHAYACRDGR 300 Query: 263 YTSLSTWEIGNDGHLVGTLEIPMPVGLVGGATKTHPLARLALKMMDVKSAQELAEIAVAV 322 YTSL+TWE+ G LVGT+E+PMPVGLVGGATKTHP+ARL+LK+M ++SAQELAEIAVAV Sbjct: 301 YTSLTTWEVSATGDLVGTIEMPMPVGLVGGATKTHPMARLSLKIMQLRSAQELAEIAVAV 360 Query: 323 GLAQNMAALRALATEGIQRGHMALHARNIGLAAGASAEEMDWVVQQMVAAKDVRVDFAVK 382 GLAQN+ ALRAL+TEGIQRGHMALHARNI + AGA+ ++D + ++MVAA DVR DFA + Sbjct: 361 GLAQNLGALRALSTEGIQRGHMALHARNIAIVAGATGADVDRIAREMVAAGDVRADFAAE 420 Query: 383 LLAQ 386 LL + Sbjct: 421 LLGK 424 >ref|YP_001777654.1| hydroxymethylglutaryl-CoA reductase, degradative [Burkholderia cenocepacia MC0-3] gb|ACA93164.1| hydroxymethylglutaryl-CoA reductase, degradative [Burkholderia cenocepacia MC0-3] Length = 428 Score = 574 bits (1480), Expect = e-162, Method: Compositional matrix adjust. Identities = 295/427 (69%), Positives = 331/427 (77%), Gaps = 38/427 (8%) Query: 1 MTVDSRLPQFRSLNPQQRLEQIAQRANLTADEVALLANPAALPLEVANGMIENVIGTFQI 60 M +DS LP FRSL P+QRL +++ L E ALLA P ALPL+ ANGMIENVIGTF++ Sbjct: 1 MPIDSALPNFRSLTPEQRLSHLSRIVGLDDAEHALLAQPGALPLDTANGMIENVIGTFEL 60 Query: 61 PMGVAGYFQLNGKDVLVPMAVEEPSVVAAASFMAKLIRDCGGFHTSSSAPLMRAQVQVIG 120 PM VAGYF++N +DV+VPMAVEEPS+VAAAS+MAKL R GGF TSSS PLMRAQVQVIG Sbjct: 61 PMAVAGYFRINDRDVIVPMAVEEPSIVAAASYMAKLSRAAGGFRTSSSGPLMRAQVQVIG 120 Query: 121 VSDPYGARV-----------LA---------------------------GAMVIVHLIVD 142 V DPYGAR+ LA GAM++ HLIVD Sbjct: 121 VDDPYGARLAILRHAAELIALANSRDKVLVGLGGGCRDIEVHVFPDTPRGAMIVAHLIVD 180 Query: 143 VRDAMGANTVNTMAEAVAGHIEQITGGKVRLRILSNLADLRLARAHVRVSPEALTTADYD 202 VRDAMGANTVNTMAE VA IE ITGG+VRLRILSNLADLRLARA VR S L T DY Sbjct: 181 VRDAMGANTVNTMAETVATRIEAITGGQVRLRILSNLADLRLARAEVRYSAATLATDDYA 240 Query: 203 GADVINRIVDAYTFAAVDPYRAATHNKGIMNGIDPVIVATGNDWRAVEAGAHAYACRNGH 262 G VI+R++DAY FAA DPYRAATHNKGIMNGIDPV+VATGNDWRAVEAGAHAYA R+G Sbjct: 241 GEAVIDRVIDAYVFAATDPYRAATHNKGIMNGIDPVVVATGNDWRAVEAGAHAYASRSGR 300 Query: 263 YTSLSTWEIGNDGHLVGTLEIPMPVGLVGGATKTHPLARLALKMMDVKSAQELAEIAVAV 322 YTSL+TWE +G LVGT+E+PMPVGLVGGATKTHPLARLALK+M+V SAQEL EIAVAV Sbjct: 301 YTSLTTWEKAANGDLVGTIEMPMPVGLVGGATKTHPLARLALKIMNVTSAQELGEIAVAV 360 Query: 323 GLAQNMAALRALATEGIQRGHMALHARNIGLAAGASAEEMDWVVQQMVAAKDVRVDFAVK 382 GLAQN+ ALRALATEGIQRGHMALHARNI +AAGA+ ++D + QQMVAAKDVR DFAV+ Sbjct: 361 GLAQNLGALRALATEGIQRGHMALHARNIAVAAGATGADIDRIAQQMVAAKDVRTDFAVE 420 Query: 383 LLAQRRG 389 LLA R G Sbjct: 421 LLAGRSG 427 >ref|YP_837137.1| hydroxymethylglutaryl-CoA reductase, degradative [Burkholderia cenocepacia HI2424] gb|ABK10244.1| hydroxymethylglutaryl-CoA reductase, degradative [Burkholderia cenocepacia HI2424] Length = 428 Score = 573 bits (1477), Expect = e-161, Method: Compositional matrix adjust. Identities = 294/427 (68%), Positives = 331/427 (77%), Gaps = 38/427 (8%) Query: 1 MTVDSRLPQFRSLNPQQRLEQIAQRANLTADEVALLANPAALPLEVANGMIENVIGTFQI 60 M +DS LP FRSL P+QRL +++ L E ALLA P ALPL+ ANGMIENVIGTF++ Sbjct: 1 MPIDSALPNFRSLTPEQRLSHLSRAVGLDDAEHALLAQPGALPLDTANGMIENVIGTFEL 60 Query: 61 PMGVAGYFQLNGKDVLVPMAVEEPSVVAAASFMAKLIRDCGGFHTSSSAPLMRAQVQVIG 120 PM VAGYF++N +DV+VPMAVEEPS+VAAAS+MAKL R GGF TSSS PLMRAQVQVIG Sbjct: 61 PMAVAGYFRINDRDVIVPMAVEEPSIVAAASYMAKLSRAAGGFRTSSSGPLMRAQVQVIG 120 Query: 121 VSDPYGARV-----------LA---------------------------GAMVIVHLIVD 142 V DPYGAR+ LA GAM++ HLIVD Sbjct: 121 VDDPYGARLAILRHAAELIALANSRDKVLVGLGGGCRDIEVHVFPDTPRGAMIVAHLIVD 180 Query: 143 VRDAMGANTVNTMAEAVAGHIEQITGGKVRLRILSNLADLRLARAHVRVSPEALTTADYD 202 VRDAMGANTVNTMAE VA IE ITGG+VRLRILSNLADLRLARA VR S L T DY Sbjct: 181 VRDAMGANTVNTMAETVATRIEAITGGQVRLRILSNLADLRLARAEVRYSAATLATDDYA 240 Query: 203 GADVINRIVDAYTFAAVDPYRAATHNKGIMNGIDPVIVATGNDWRAVEAGAHAYACRNGH 262 G VI+R++DAY FAA DPYRAATHNKGIMNGIDPV+VATGNDWRAVEAGAHAYA R+G Sbjct: 241 GEAVIDRVIDAYVFAATDPYRAATHNKGIMNGIDPVVVATGNDWRAVEAGAHAYASRSGR 300 Query: 263 YTSLSTWEIGNDGHLVGTLEIPMPVGLVGGATKTHPLARLALKMMDVKSAQELAEIAVAV 322 YTSL+TWE +G LVGT+E+PMPVGLVGGATKTHPLARLALK+M+V SAQEL EIAVAV Sbjct: 301 YTSLTTWEKAANGDLVGTIEMPMPVGLVGGATKTHPLARLALKIMNVTSAQELGEIAVAV 360 Query: 323 GLAQNMAALRALATEGIQRGHMALHARNIGLAAGASAEEMDWVVQQMVAAKDVRVDFAVK 382 GLAQN+ ALRALATEGIQRGHMALHARNI +AAGA+ ++D + Q+MVAAKDVR DFAV+ Sbjct: 361 GLAQNLGALRALATEGIQRGHMALHARNIAVAAGATGADIDRIAQRMVAAKDVRADFAVE 420 Query: 383 LLAQRRG 389 LLA R G Sbjct: 421 LLAGRSG 427