BLASTP 2.2.21 [Jun-14-2009] Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), "Gapped BLAST and PSI-BLAST: a new generation of protein database search programs", Nucleic Acids Res. 25:3389-3402. Reference for compositional score matrix adjustment: Altschul, Stephen F., John C. Wootton, E. Michael Gertz, Richa Agarwala, Aleksandr Morgulis, Alejandro A. Schaffer, and Yi-Kuo Yu (2005) "Protein database searches using compositionally adjusted substitution matrices", FEBS J. 272:5101-5109. Query= 0004.0146.p (410 letters) Database: All non-redundant GenBank CDS translations+PDB+SwissProt+PIR+PRF excluding environmental samples from WGS projects 15,459,386 sequences; 5,307,515,862 total letters Searching..................................................done Score E Sequences producing significant alignments: (bits) Value gb|EGW62939.1| diguanylate cyclase/phosphodiesterase with PAS/PA... 276 6e-72 ref|ZP_05131533.1| diguanylate cyclase/phosphodiesterase domain ... 244 2e-62 ref|YP_003048652.1| diguanylate cyclase/phosphodiesterase [Methy... 241 1e-61 ref|YP_004226904.1| PAS/PAC sensor-containing diguanylate cyclas... 238 2e-60 ref|ZP_08571338.1| PAS domain S-box/diguanylate cyclase (GGDEF) ... 233 4e-59 >gb|EGW62939.1| diguanylate cyclase/phosphodiesterase with PAS/PAC sensor(s) [Dechlorosoma suillum PS] Length = 766 Score = 276 bits (705), Expect = 6e-72, Method: Compositional matrix adjust. Identities = 160/384 (41%), Positives = 237/384 (61%), Gaps = 15/384 (3%) Query: 32 NDAHGSAAGDALIVAFADALRRLLPDGSLIARLRSVVFSF--TIETSHASRDAIPQIEHI 89 ND G A GDAL+ A+ AL LP + +AR V F+ +E A + + Sbjct: 374 NDRLGPAIGDALLRAYGQALAEHLPADAFLARTAGVTFALLLPLEPGEAPEA---RARGL 430 Query: 90 RRSLPEELLV--GGQRHPVQVSMAIAFSRPGETSGDELIQRGKLALDSARRSGTQDITVF 147 + LP EL + G PV V++ + +R E + DE +QR + AL+ AR + V Sbjct: 431 LQQLPRELALPDSGLAVPVPVAVGVTAARLDEGA-DEALQRVQTALELARNLPEGSVAVL 489 Query: 148 DDEAAALIRRRLNIEQSILMALRE---NELRLVYQPKVTQDGEIVGLEALIRWRSPTLGD 204 D E R+L++E +ALRE + L LVYQPK DG+++G EAL+RW+ P LG Sbjct: 490 DQEMEQRHHRQLDLE----LALRELDDSGLELVYQPKCLADGKVLGFEALLRWQHPRLGA 545 Query: 205 VSPAEFIPVAETSGAIHFITAFVVDKVCAYIRQTLDSERRCLPIAINLSAIDIVRADLLD 264 VSPAEFIP+AE +G +H +T FV+++VC +++ R LP+AINLSA+DIVR D++ Sbjct: 546 VSPAEFIPLAERTGLMHRLTDFVLEQVCRQLQRWQGEGCRLLPVAINLSALDIVRPDIVH 605 Query: 265 LVNASCQKYGVSSDHLEFEITETGLVGNENLAISHLEALNAKGYGITIDDFGTGYSSLQK 324 + + ++ + +E EITETGL+ +E LA+ + +AL +G+ + IDDFGTGYSSL K Sbjct: 606 RLGETLARHHIPPALVEIEITETGLIRDERLAVENAQALRERGFALLIDDFGTGYSSLSK 665 Query: 325 LSRFPTKSIKIDQSFVAQIGISEKSELIIRAVVSLAKILSCTTVAEGVETLVQEKFLKAI 384 L+ FP +IKID+SF+A + EK LI+++++SL+++L C TVAEGVET Q FL A+ Sbjct: 666 LNEFPVSAIKIDRSFIADLPGQEKKALIVKSILSLSRVLGCATVAEGVETREQLDFLTAL 725 Query: 385 GCQFFQGFYYYPPMEFQQVNQLLK 408 GC +QG+Y++ P+ LL+ Sbjct: 726 GCTAYQGYYFHRPLPATTAGGLLE 749 >ref|ZP_05131533.1| diguanylate cyclase/phosphodiesterase domain 2 [Clostridium sp. 7_2_43FAA] gb|EEH98427.1| diguanylate cyclase/phosphodiesterase domain 2 [Clostridium sp. 7_2_43FAA] Length = 743 Score = 244 bits (623), Expect = 2e-62, Method: Compositional matrix adjust. Identities = 137/388 (35%), Positives = 226/388 (58%), Gaps = 7/388 (1%) Query: 19 ALVVIRLDSIKYANDAHGSAAGDALIVAFADALRRLLPDGSLIARLRSVVFSFTIETSHA 78 A + I LD+ KY ND +G AGD L++ FA ++ + SL AR F ++ + Sbjct: 352 AFIFIDLDNFKYVNDTYGHDAGDLLLIEFAKIIKNMKIKDSLFARYGGDEF-IIVQYNIQ 410 Query: 79 SRDAIPQI-EHIRRSLPEELLVGGQRHPVQVSMAIAFSRPGETSGDE--LIQRGKLALDS 135 ++ I I ++I + L +++ + + +++I S GD L++R +A+ Sbjct: 411 EKNQIKYILDNIIKKLSNPIIINDK--EIFCTLSIGVSVYPIDGGDMPILLKRADMAMYL 468 Query: 136 ARRSGTQDITVFDDEAAALIRRRLNIEQSILMALRENELRLVYQPKVTQDGE-IVGLEAL 194 A+ +G FD + ++ R +IE+ + +A+ ++E++++YQPK+ D E ++G E+L Sbjct: 469 AKVNGKNRYEFFDIKILEILNREFDIEKGLRVAVDKSEIKMLYQPKIKVDTEEVIGFESL 528 Query: 195 IRWRSPTLGDVSPAEFIPVAETSGAIHFITAFVVDKVCAYIRQTLDSERRCLPIAINLSA 254 +RW S +LG VSP+EFIP+AE+SG I I +++++ ++ + +AINLS Sbjct: 529 VRWNSKSLGIVSPSEFIPIAESSGLIIPIGKYIINESFRRCKELTLKNNKKFKMAINLSE 588 Query: 255 IDIVRADLLDLVNASCQKYGVSSDHLEFEITETGLVGNENLAISHLEALNAKGYGITIDD 314 + I D++ ++ S + Y +S++++EFEITE+ ++ + IS LE L G + +DD Sbjct: 589 VQIRDEDIVSFISESLKFYDLSAEYIEFEITESIIMKSAERNISTLEKLKKLGVSLALDD 648 Query: 315 FGTGYSSLQKLSRFPTKSIKIDQSFVAQIGISEKSELIIRAVVSLAKILSCTTVAEGVET 374 FGTGYSSL L P +KID+SF+ I I EKSE II ++V L+ LS VAEGVET Sbjct: 649 FGTGYSSLSYLRTLPIDVLKIDKSFIDGIVIEEKSEYIINSIVELSHYLSLLVVAEGVET 708 Query: 375 LVQEKFLKAIGCQFFQGFYYYPPMEFQQ 402 Q FLK I C QG+Y+ P+EF + Sbjct: 709 KEQLDFLKRISCDVIQGYYFSRPVEFDE 736 >ref|YP_003048652.1| diguanylate cyclase/phosphodiesterase [Methylotenera mobilis JLW8] gb|ACT48125.1| diguanylate cyclase/phosphodiesterase [Methylotenera mobilis JLW8] Length = 447 Score = 241 bits (616), Expect = 1e-61, Method: Compositional matrix adjust. Identities = 139/401 (34%), Positives = 215/401 (53%), Gaps = 6/401 (1%) Query: 14 SMPTAALVVIRLDSIKYANDAHGSAAGDALIVAFADALRRLLPDGSLIARLRSVVFSFTI 73 S AL+ I LD+ K ND+ G A GD L++ A+ L + +G +ARL F T+ Sbjct: 46 SQNKGALLFIDLDNFKNLNDSLGHAVGDMLLLQVAERLNNCVREGDTVARLGGDEFVVTL 105 Query: 74 ETSHASRDAIPQI-----EHIRRSLPEELLVGGQRHPVQVSMAIAFSRPGETSGDELIQR 128 E D E I + + +GG H + S+ +A E S DEL+++ Sbjct: 106 EDLSLQLDEAASKTKLIGEKILHQVSQPYNLGGHEHQITCSIGVALFHHHEQSQDELLKQ 165 Query: 129 GKLALDSARRSGTQDITVFDDEAAALIRRRLNIEQSILMALRENELRLVYQPKVTQDGEI 188 +A+ A++ G I FD I R+ +E+ + +A+ E + L YQ ++ G+ Sbjct: 166 ADIAMYQAKKVGRNAICFFDPGMQTSINARVELERDLNIAINEQQFELFYQIQLDIHGQA 225 Query: 189 VGLEALIRWRSPTLGDVSPAEFIPVAETSGAIHFITAFVVDKVCAYIRQ-TLDSERRCLP 247 +G EALIRW P LG +SPA+FIP+AE + I I ++V+D CA ++Q D+ + L Sbjct: 226 IGAEALIRWPHPELGLISPAKFIPLAEETDLIIPIGSWVLDTACAQLKQWQKDTSTQGLV 285 Query: 248 IAINLSAIDIVRADLLDLVNASCQKYGVSSDHLEFEITETGLVGNENLAISHLEALNAKG 307 +++N+SA + + D V + KY ++ + L+ EITE+ L+ + I+ + L G Sbjct: 286 LSVNVSAKQLHQVDFTSTVQNTINKYAINPNLLKLEITESMLLNSIEDTINIMSRLQTIG 345 Query: 308 YGITIDDFGTGYSSLQKLSRFPTKSIKIDQSFVAQIGISEKSELIIRAVVSLAKILSCTT 367 ++DDFGTGYSSLQ L R P +KIDQSFV I + E + +IIR ++++A+ L T Sbjct: 346 VRFSLDDFGTGYSSLQYLKRLPLNQLKIDQSFVRDITVDESNRVIIRTIIAMAQSLGLET 405 Query: 368 VAEGVETLVQEKFLKAIGCQFFQGFYYYPPMEFQQVNQLLK 408 +AEGVET Q +L GC FQG+ P+ LK Sbjct: 406 IAEGVETEAQRTYLLTNGCTHFQGYLLGKPLPIHDFESALK 446 >ref|YP_004226904.1| PAS/PAC sensor-containing diguanylate cyclase/phosphodiesterase [Burkholderia sp. CCGE1001] gb|ADX53844.1| diguanylate cyclase/phosphodiesterase with PAS/PAC sensor(s) [Burkholderia sp. CCGE1001] Length = 1036 Score = 238 bits (607), Expect = 2e-60, Method: Compositional matrix adjust. Identities = 147/396 (37%), Positives = 216/396 (54%), Gaps = 9/396 (2%) Query: 19 ALVVIRLDSIKYANDAHGSAAGDALIVAFADALRRLLPDGSLIARLRSVVFSFTIETSHA 78 A+V + LD K ND+ G + GD L+ A+ L R +AR F + + Sbjct: 636 AVVFMDLDGFKNVNDSLGHSVGDRLLGVVAERLARCTRTSDTVARHGGDEFVIVMTDTVD 695 Query: 79 SRDAIPQIEHIRRSLPEELLVGGQRHPVQVSMAIA-FSRPGETSGDELIQRGKLALDSAR 137 + I +E +R S+ E + + G V SM + F + G+ + + L+++ LA+ A+ Sbjct: 696 EQSLIAWMERVRVSISEPVWLDGTELYVGCSMGASLFPQDGDDA-ETLMKKADLAMYRAK 754 Query: 138 RSGTQDITVFDDEAAALIRRRLNIEQSILMALRENELRLVYQPKVT-QDGEIVGLEALIR 196 G + E A RL +EQ + ALR+N+ L YQP+V G+IVG EAL+R Sbjct: 755 DMGRNTFQFYQPEMNASAGARLALEQRLRRALRDNQFLLHYQPQVDIHTGQIVGTEALVR 814 Query: 197 WRSPTLGDVSPAEFIPVAETSGAIHFITAFVVDKVCAYIRQTLDSERRCLP---IAINLS 253 W P G V P+ FIPVAE SG I ++ +V+ + C RQ + LP +++NLS Sbjct: 815 WSDPEAGLVPPSSFIPVAEESGLIGPLSEWVLREAC---RQNKAWQNLGLPPARVSVNLS 871 Query: 254 AIDIVRADLLDLVNASCQKYGVSSDHLEFEITETGLVGNENLAISHLEALNAKGYGITID 313 A + D+ LV + G+ +LE E+TE+ ++ N A+S L L+A G G+ ID Sbjct: 872 ARVFQQRDIAKLVMQVLDETGLEPQYLELELTESAIMRNAEEAVSMLNELSALGIGLAID 931 Query: 314 DFGTGYSSLQKLSRFPTKSIKIDQSFVAQIGISEKSELIIRAVVSLAKILSCTTVAEGVE 373 DFGTGYSSL L RFP +KID+SFV+ IGIS E I A+++LA L +AEGVE Sbjct: 932 DFGTGYSSLSYLKRFPVDRLKIDRSFVSDIGISGDDETITSAIIALAHSLKLQVIAEGVE 991 Query: 374 TLVQEKFLKAIGCQFFQGFYYYPPMEFQQVNQLLKG 409 T Q FLK C QGFY+ P+ + +++L+KG Sbjct: 992 TSAQLDFLKERACDEMQGFYFAKPLSTEAISELMKG 1027 >ref|ZP_08571338.1| PAS domain S-box/diguanylate cyclase (GGDEF) domain-containing protein [Rheinheimera sp. A13L] gb|EGM77208.1| PAS domain S-box/diguanylate cyclase (GGDEF) domain-containing protein [Rheinheimera sp. A13L] Length = 1294 Score = 233 bits (594), Expect = 4e-59, Method: Composition-based stats. Identities = 140/407 (34%), Positives = 214/407 (52%), Gaps = 15/407 (3%) Query: 11 CSASMPTAALVVIRLDSIKYANDAHGSAAGDALIVAFADALRRLLPDGSLIARLRSVVFS 70 CS+ P A++++ LD ND+ G +G+ L+ A+ L++ LP G ++A+L F+ Sbjct: 885 CSSRFPHFAVLLVDLDRFAKINDSLGHDSGNMLLQMVAERLQKQLPAGYILAKLGVDEFA 944 Query: 71 FTIETSHASRDAIPQIE---------HIRRSLPEELLVGGQRHPVQVSMAIAFSRPGETS 121 + SH S + + HIR + LL+G + S+ IA S Sbjct: 945 VLV-PSHFSVEQFDLLLNRLSLQLLLHIR----QPLLLGDLEITLTASIGIAVYPDDGRS 999 Query: 122 GDELIQRGKLALDSARRSGTQDITVFDDEAAALIRRRLNIEQSILMALRENELRLVYQPK 181 D L++ AL A++ G + F+D+ L +E + + + E ++VYQPK Sbjct: 1000 SDILLRSADTALHHAKQMGRNNAQFFNDKMLQRTPEYLALESDLWRGISQGEFKVVYQPK 1059 Query: 182 VT-QDGEIVGLEALIRWRSPTLGDVSPAEFIPVAETSGAIHFITAFVVDKVCAYIRQTLD 240 IVG EAL RW +P+ G VSPA FIP+AE +G I + V +VCA IRQ Sbjct: 1060 YNVSTNTIVGYEALCRWHNPSRGMVSPAMFIPIAEENGVIIQLDRLVFSQVCAQIRQWQQ 1119 Query: 241 SERRCLPIAINLSAIDIVRADLLDLVNASCQKYGVSSDHLEFEITETGLVGNENLAISHL 300 R +A+NLS + + DLLD + Q Y + + LE EITET ++ + + + Sbjct: 1120 QGRMRGRVAVNLSVQQLQQPDLLDFLQQELQHYQLDASLLELEITETAMMRDAEHCLEVM 1179 Query: 301 EALNAKGYGITIDDFGTGYSSLQKLSRFPTKSIKIDQSFVAQIGISEKSELIIRAVVSLA 360 L A G+ + +DDFGTGYSSL L RFP ++KID++F+ + SE+ I ++ LA Sbjct: 1180 HQLKALGFTLALDDFGTGYSSLGYLKRFPIDTLKIDRAFIKDMDSSEQDRNITSTIIRLA 1239 Query: 361 KILSCTTVAEGVETLVQEKFLKAIGCQFFQGFYYYPPMEFQQVNQLL 407 L VAEGVET +Q L +GCQ QG+ + PP++ +Q+ LL Sbjct: 1240 SYLKIAVVAEGVETEMQAYLLHVMGCQVVQGYLFSPPVQPEQIALLL 1286