BLASTP 2.2.21 [Jun-14-2009] Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), "Gapped BLAST and PSI-BLAST: a new generation of protein database search programs", Nucleic Acids Res. 25:3389-3402. Reference for compositional score matrix adjustment: Altschul, Stephen F., John C. Wootton, E. Michael Gertz, Richa Agarwala, Aleksandr Morgulis, Alejandro A. Schaffer, and Yi-Kuo Yu (2005) "Protein database searches using compositionally adjusted substitution matrices", FEBS J. 272:5101-5109. Query= 0002.0681.p (280 letters) Database: All non-redundant GenBank CDS translations+PDB+SwissProt+PIR+PRF excluding environmental samples from WGS projects 15,459,386 sequences; 5,307,515,862 total letters Searching..................................................done Score E Sequences producing significant alignments: (bits) Value ref|YP_004754671.1| 5,10-methylenetetrahydrofolate reductase [Co... 493 e-137 ref|YP_003777664.1| 5,10-methylenetetrahydrofolate reductase oxi... 486 e-135 ref|YP_001101181.1| 5,10-methylenetetrahydrofolate reductase [He... 476 e-132 ref|ZP_08273864.1| 5,10-methylenetetrahydrofolate reductase [Oxa... 471 e-131 ref|YP_001354884.1| 5,10-methylenetetrahydrofolate reductase (FA... 469 e-130 >ref|YP_004754671.1| 5,10-methylenetetrahydrofolate reductase [Collimonas fungivorans Ter331] gb|AAT42397.1| 5,10-methylenetetrahydrofolate reductase [Collimonas fungivorans Ter331] gb|AEK63848.1| 5,10-methylenetetrahydrofolate reductase [Collimonas fungivorans Ter331] Length = 284 Score = 493 bits (1268), Expect = e-137, Method: Compositional matrix adjust. Identities = 229/276 (82%), Positives = 249/276 (90%) Query: 3 QHNFSIEFFPPKTPEGTEKLRATRAKLAALQPKYFSVTFGAGGSTQQGTLDTVLEIMREG 62 Q NFSIEFFPPKTPEG EKLR TRAKLA L P+YFSVTFGAGGSTQ+GTLDTVL+I EG Sbjct: 7 QKNFSIEFFPPKTPEGAEKLRVTRAKLAELHPRYFSVTFGAGGSTQKGTLDTVLDIRSEG 66 Query: 63 HVAAPHLSCIGSSRDALRDILTEYKSHGIKKLVALRGDLPSGFGAADFSSGEFRYANELV 122 H AAPHLSC+GSSR++LR IL +YK HGIK+LVALRGDLPSG+GA D SSGEFRYANELV Sbjct: 67 HEAAPHLSCLGSSRESLRTILAQYKDHGIKRLVALRGDLPSGYGAMDISSGEFRYANELV 126 Query: 123 EFIRAETGDWFHIEVGAYPEMHPQAKSPQDDVRNFARKIEAGADAAITQYFYNPDAYFNF 182 EFIRAETGDWFHIEV AYPEMHPQAKSPQDDV+ F K++AGA+ AITQYFYN DAYF F Sbjct: 127 EFIRAETGDWFHIEVAAYPEMHPQAKSPQDDVQRFVSKVKAGANGAITQYFYNADAYFRF 186 Query: 183 VDDAQKLGVNVPIVPGIMPITNYTQLMRFSDMCGTEIPRWIRLKLASYGDDADSIRAFGL 242 VD+AQKLG VP++ GIMPITNY+QLMRFSDMCGTEIPRWIRLKLASYGDD+DSIRAFGL Sbjct: 187 VDEAQKLGAAVPVIAGIMPITNYSQLMRFSDMCGTEIPRWIRLKLASYGDDSDSIRAFGL 246 Query: 243 DVVTQLCEQLLEGGAPGLHFYTLNQPAATMEIWQRL 278 DVVTQLCE+LL GGAPGLHFYTLNQ AT+ IWQRL Sbjct: 247 DVVTQLCERLLAGGAPGLHFYTLNQSPATIAIWQRL 282 >ref|YP_003777664.1| 5,10-methylenetetrahydrofolate reductase oxidoreductase [Herbaspirillum seropedicae SmR1] gb|ADJ65756.1| 5,10-methylenetetrahydrofolate reductase oxidoreductase protein [Herbaspirillum seropedicae SmR1] Length = 282 Score = 486 bits (1251), Expect = e-135, Method: Compositional matrix adjust. Identities = 224/278 (80%), Positives = 251/278 (90%) Query: 2 TQHNFSIEFFPPKTPEGTEKLRATRAKLAALQPKYFSVTFGAGGSTQQGTLDTVLEIMRE 61 + HNFSIEFFPPKT EG EKLRATRA+LAALQPKYFSVTFGAGGSTQQGT DTVLEI+ E Sbjct: 4 STHNFSIEFFPPKTAEGAEKLRATRARLAALQPKYFSVTFGAGGSTQQGTRDTVLEIVSE 63 Query: 62 GHVAAPHLSCIGSSRDALRDILTEYKSHGIKKLVALRGDLPSGFGAADFSSGEFRYANEL 121 GH AAPHLSCIGSSR +LR IL +Y+++GIK+LVALRGDLPSG+GA D +S EFRYANEL Sbjct: 64 GHEAAPHLSCIGSSRASLRAILEDYRANGIKRLVALRGDLPSGYGAMDQASSEFRYANEL 123 Query: 122 VEFIRAETGDWFHIEVGAYPEMHPQAKSPQDDVRNFARKIEAGADAAITQYFYNPDAYFN 181 VEF+RAETGDWFHIEV AYPEMHPQA+SPQDD +NFARK++AGA++AITQYFYN DAYF Sbjct: 124 VEFVRAETGDWFHIEVAAYPEMHPQARSPQDDAQNFARKVKAGANSAITQYFYNADAYFR 183 Query: 182 FVDDAQKLGVNVPIVPGIMPITNYTQLMRFSDMCGTEIPRWIRLKLASYGDDADSIRAFG 241 FVD+A +LG VP++ GIMPITNY+QLMRFSDMCGTEIPRWIRLKLASYGDD +SIRAFG Sbjct: 184 FVDEAARLGATVPVIAGIMPITNYSQLMRFSDMCGTEIPRWIRLKLASYGDDTESIRAFG 243 Query: 242 LDVVTQLCEQLLEGGAPGLHFYTLNQPAATMEIWQRLV 279 LDVVTQLCE+LL GGAPGLHFY+LNQ T IWQ+LV Sbjct: 244 LDVVTQLCERLLAGGAPGLHFYSLNQAGPTQAIWQQLV 281 >ref|YP_001101181.1| 5,10-methylenetetrahydrofolate reductase [Herminiimonas arsenicoxydans] emb|CAL63060.1| 5,10-methylenetetrahydrofolate reductase [Herminiimonas arsenicoxydans] Length = 283 Score = 476 bits (1224), Expect = e-132, Method: Compositional matrix adjust. Identities = 223/278 (80%), Positives = 240/278 (86%) Query: 1 MTQHNFSIEFFPPKTPEGTEKLRATRAKLAALQPKYFSVTFGAGGSTQQGTLDTVLEIMR 60 MTQ NFSIEFFPPKTP G EKLR T AKLA L PKYFSVTFGAGGSTQ GTLDTVLEI Sbjct: 1 MTQQNFSIEFFPPKTPLGVEKLRVTCAKLAELNPKYFSVTFGAGGSTQHGTLDTVLEIRS 60 Query: 61 EGHVAAPHLSCIGSSRDALRDILTEYKSHGIKKLVALRGDLPSGFGAADFSSGEFRYANE 120 GH AAPHLSC+GSSR+ LR IL EYKSHGIK++VALRGDLPSG+GA D SS EF YANE Sbjct: 61 AGHDAAPHLSCLGSSRENLRAILQEYKSHGIKRIVALRGDLPSGYGAMDASSSEFHYANE 120 Query: 121 LVEFIRAETGDWFHIEVGAYPEMHPQAKSPQDDVRNFARKIEAGADAAITQYFYNPDAYF 180 LVEFIRAETGDWFHIEV AYPEMHPQAKSP DD+ ++ RK++AGAD+AITQYFYN DAYF Sbjct: 121 LVEFIRAETGDWFHIEVAAYPEMHPQAKSPSDDIASYVRKVKAGADSAITQYFYNADAYF 180 Query: 181 NFVDDAQKLGVNVPIVPGIMPITNYTQLMRFSDMCGTEIPRWIRLKLASYGDDADSIRAF 240 FVDDA+K G +VP+ G+MPITNY+QLMRFSDMCG EIPRWIRLKLASY DD DSIRAF Sbjct: 181 RFVDDARKAGADVPVTAGVMPITNYSQLMRFSDMCGAEIPRWIRLKLASYNDDTDSIRAF 240 Query: 241 GLDVVTQLCEQLLEGGAPGLHFYTLNQPAATMEIWQRL 278 GLDVVT LCE+LL GGAPGLHFYTLNQ AAT IW RL Sbjct: 241 GLDVVTDLCERLLAGGAPGLHFYTLNQAAATHAIWSRL 278 >ref|ZP_08273864.1| 5,10-methylenetetrahydrofolate reductase [Oxalobacteraceae bacterium IMCC9480] gb|EGF32668.1| 5,10-methylenetetrahydrofolate reductase [Oxalobacteraceae bacterium IMCC9480] Length = 283 Score = 471 bits (1212), Expect = e-131, Method: Compositional matrix adjust. Identities = 219/278 (78%), Positives = 247/278 (88%) Query: 1 MTQHNFSIEFFPPKTPEGTEKLRATRAKLAALQPKYFSVTFGAGGSTQQGTLDTVLEIMR 60 MT +FSIEFFPPK EG +KLRATRA++A L PKYFSVTFGAGGSTQQGTLDTVL+I Sbjct: 1 MTSPDFSIEFFPPKPAEGADKLRATRARMAVLNPKYFSVTFGAGGSTQQGTLDTVLDIRS 60 Query: 61 EGHVAAPHLSCIGSSRDALRDILTEYKSHGIKKLVALRGDLPSGFGAADFSSGEFRYANE 120 EGH AAPH+SC+GSSR LR+IL EY+SHGI++LVALRGDLPSG+GA D +SGEFRYANE Sbjct: 61 EGHQAAPHISCLGSSRARLREILAEYRSHGIERLVALRGDLPSGYGAMDAASGEFRYANE 120 Query: 121 LVEFIRAETGDWFHIEVGAYPEMHPQAKSPQDDVRNFARKIEAGADAAITQYFYNPDAYF 180 LVEFIRAE+GDWFH+EVGAYPEMHPQA+SP DD+++F RK++AGADAAITQYFYN DAYF Sbjct: 121 LVEFIRAESGDWFHVEVGAYPEMHPQARSPSDDMQHFVRKVQAGADAAITQYFYNADAYF 180 Query: 181 NFVDDAQKLGVNVPIVPGIMPITNYTQLMRFSDMCGTEIPRWIRLKLASYGDDADSIRAF 240 FVD A+K GV VPIV G+MPITNYTQLMRFSDMCG EIPRWIRL LASYGDD++SIRAF Sbjct: 181 RFVDSARKHGVQVPIVAGVMPITNYTQLMRFSDMCGAEIPRWIRLALASYGDDSESIRAF 240 Query: 241 GLDVVTQLCEQLLEGGAPGLHFYTLNQPAATMEIWQRL 278 GLDVVT +CE+LL GGAPGLHFY+LNQ A TM I QRL Sbjct: 241 GLDVVTAMCERLLVGGAPGLHFYSLNQAAPTMAICQRL 278 >ref|YP_001354884.1| 5,10-methylenetetrahydrofolate reductase (FADH2) [Janthinobacterium sp. Marseille] gb|ABR88310.1| 5,10-methylenetetrahydrofolate reductase (FADH2) [Janthinobacterium sp. Marseille] Length = 283 Score = 469 bits (1207), Expect = e-130, Method: Compositional matrix adjust. Identities = 220/278 (79%), Positives = 240/278 (86%) Query: 1 MTQHNFSIEFFPPKTPEGTEKLRATRAKLAALQPKYFSVTFGAGGSTQQGTLDTVLEIMR 60 M NFSIEFFPPKTP G EKLR T AKLA L PKYFSVTFGAGGSTQQGTL+TVLEI Sbjct: 1 MKDQNFSIEFFPPKTPAGVEKLRVTCAKLAELNPKYFSVTFGAGGSTQQGTLETVLEIRG 60 Query: 61 EGHVAAPHLSCIGSSRDALRDILTEYKSHGIKKLVALRGDLPSGFGAADFSSGEFRYANE 120 G AAPHLSC+GSSRD+LR IL EYKSHGIK++VALRGDLPSG+GA D SS EF +ANE Sbjct: 61 AGQDAAPHLSCLGSSRDSLRAILAEYKSHGIKRIVALRGDLPSGYGAMDMSSSEFHHANE 120 Query: 121 LVEFIRAETGDWFHIEVGAYPEMHPQAKSPQDDVRNFARKIEAGADAAITQYFYNPDAYF 180 LVEFIRAETGDWFHIEV AYPEMHPQAKSPQDD+ +F RK +AGAD+AITQYFYN DAYF Sbjct: 121 LVEFIRAETGDWFHIEVAAYPEMHPQAKSPQDDIASFVRKAKAGADSAITQYFYNADAYF 180 Query: 181 NFVDDAQKLGVNVPIVPGIMPITNYTQLMRFSDMCGTEIPRWIRLKLASYGDDADSIRAF 240 FVDDA+K G ++P+ GIMPITNY+QLMRFSDMCG EIPRWIRLKLAS+GDD++SIRAF Sbjct: 181 RFVDDARKAGTDIPVTAGIMPITNYSQLMRFSDMCGAEIPRWIRLKLASFGDDSESIRAF 240 Query: 241 GLDVVTQLCEQLLEGGAPGLHFYTLNQPAATMEIWQRL 278 GLDVVT LCE+LL GGAPGLHFYTLNQ AT IW RL Sbjct: 241 GLDVVTDLCERLLAGGAPGLHFYTLNQAVATHTIWTRL 278