BLASTP 2.2.21 [Jun-14-2009] Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), "Gapped BLAST and PSI-BLAST: a new generation of protein database search programs", Nucleic Acids Res. 25:3389-3402. Reference for compositional score matrix adjustment: Altschul, Stephen F., John C. Wootton, E. Michael Gertz, Richa Agarwala, Aleksandr Morgulis, Alejandro A. Schaffer, and Yi-Kuo Yu (2005) "Protein database searches using compositionally adjusted substitution matrices", FEBS J. 272:5101-5109. Query= 0037.0225.p (579 letters) Database: pfamseq 15,929,002 sequences; 5,169,768,107 total letters Searching..................................................done Score E Sequences producing significant alignments: (bits) Value A4G5T3.1 A4G5T3_HERAR Putative Clc chloride channel 865 0.0 A6SYC8.1 A6SYC8_JANMA EriC chloride channel protein 839 0.0 E6V8I8.1 E6V8I8_VARPD Cl-channel voltage-gated family protein 741 0.0 B5SHJ4.1 B5SHJ4_RALSO Chloride channel protein 736 0.0 A3RRR8.1 A3RRR8_RALSO Chloride channel protein 736 0.0 >A4G5T3.1 A4G5T3_HERAR Putative Clc chloride channel Length = 578 Score = 865 bits (2234), Expect = 0.0, Method: Compositional matrix adjust. Identities = 446/579 (77%), Positives = 504/579 (87%), Gaps = 1/579 (0%) Query: 1 MRRHQRDFGLDRRVLFLAGIAVIIGGISTVAAFVLLNLIHFFTNLFFFQTFSLADRSPAT 60 MR HQRDF DRR++FL IAV+IG +STVAAFVLLNLIHFFTNLFFFQTFS ADRSPAT Sbjct: 1 MRSHQRDFAPDRRIIFLCLIAVVIGAVSTVAAFVLLNLIHFFTNLFFFQTFSFADRSPAT 60 Query: 61 HTMGIVVVIVPVIGGLIVGLMARFGSDKIRGHGIPEAIEAILFGKSKMSGKVAVLKPLAS 120 HT+G+ V+ VPV GGLI GL+AR+GSDK+RGHGIPEAIEAILF KS+MS KVA+LKPL S Sbjct: 61 HTLGLWVIAVPVAGGLIAGLIARYGSDKVRGHGIPEAIEAILFRKSQMSPKVALLKPLTS 120 Query: 121 GIVIGSGGPFGAEGPIIMTGGAIGSLIAQHFHVSAAERKTLLVAGATAGMTAVFGTPVAA 180 GIVIGSGGPFGAEGPIIMTGGAIGSLIAQ+F +SAAERKTLLVAGATAGMTAVFGTPVAA Sbjct: 121 GIVIGSGGPFGAEGPIIMTGGAIGSLIAQNFSMSAAERKTLLVAGATAGMTAVFGTPVAA 180 Query: 181 VLLAVELLLFEWRPRSLLPVILACAVAGFARPLLLEPGPLFPLHTDPVGLSALLVCIVAG 240 VLLAVELLLFEWRPRSLLPVILACAVA F RPLLLE GPLFP+HT PVGL+A +CIVAG Sbjct: 181 VLLAVELLLFEWRPRSLLPVILACAVAAFCRPLLLESGPLFPIHTAPVGLAAFAICIVAG 240 Query: 241 LLSGALSSAMSMALYWIEDRFHALPLHWMWWPALGAVAVGIGGYFEPRALGVGYDVIADL 300 LLSG LS+ MS++LY +ED F LPLHWMWWPA+G +AVGIG YFEPRALGVGYDVIADL Sbjct: 241 LLSGMLSAVMSLSLYRVEDWFGKLPLHWMWWPAIGGLAVGIGAYFEPRALGVGYDVIADL 300 Query: 301 LNHHLAMSAVLALLVVKAIIWVIALGSGTSGGVLAPLLMLGAGLGTAIAYVVPGSDPALW 360 LNH + +SA L+LL+VKAIIWV+ALGSGTSGGVLAPLLMLGAGLG IA +VPGSDP LW Sbjct: 301 LNHRMILSAALSLLLVKAIIWVVALGSGTSGGVLAPLLMLGAGLGAVIASLVPGSDPTLW 360 Query: 361 PLVCMAAVLSGVLGAPLTAAVFALGLTGDFNAFLPLLLATGISYGFTVLVMRRSIMTEKI 420 PLVCMAAVL+GVLGAPLTAA+FALGLTGDFNA LPLLLATG+SYGFTVLVMRRSIMTEKI Sbjct: 361 PLVCMAAVLAGVLGAPLTAAIFALGLTGDFNALLPLLLATGVSYGFTVLVMRRSIMTEKI 420 Query: 421 ARRGLHIYREYSVDPQERMFVEEVMTREPVTISASLSLEEIATVYFGATQQHRAFPVCDN 480 ARRGLHIYREYSVDPQER+FV++VM + I A+LSL++++ YFGA Q+HR+FPV + Sbjct: 421 ARRGLHIYREYSVDPQERVFVQDVMATDIAHIDAALSLQQVSRDYFGAGQKHRSFPVVNA 480 Query: 481 KGKLIGMLDRHALLGHLDKHAAATPVGELLTSSTSLLAFSTETCQSIARRMAAHHVERLP 540 + KL+GMLDR L+ + KH A +G L S +AF+TETCQ + RRMA H ERLP Sbjct: 481 QQKLLGMLDRELLMQWMGKHDGARQIGSLFEKIPS-VAFATETCQVVGRRMAIQHAERLP 539 Query: 541 VVADASSLQLIGIVSRSDLVKPAHTVFHEEHVRERLAQR 579 VVAD +S+ LIGIVSRSDL+KP+HT F+EEH+RERL R Sbjct: 540 VVADRASMSLIGIVSRSDLLKPSHTAFYEEHIRERLFSR 578 >A6SYC8.1 A6SYC8_JANMA EriC chloride channel protein Length = 580 Score = 839 bits (2167), Expect = 0.0, Method: Compositional matrix adjust. Identities = 439/576 (76%), Positives = 498/576 (86%) Query: 1 MRRHQRDFGLDRRVLFLAGIAVIIGGISTVAAFVLLNLIHFFTNLFFFQTFSLADRSPAT 60 MR HQRDF LD+R+L L IA++IG ISTVAA++LLN IHFFTNLFFFQTFS AD SPAT Sbjct: 1 MRAHQRDFSLDKRILLLCAIAIVIGAISTVAAYLLLNSIHFFTNLFFFQTFSFADSSPAT 60 Query: 61 HTMGIVVVIVPVIGGLIVGLMARFGSDKIRGHGIPEAIEAILFGKSKMSGKVAVLKPLAS 120 HT+G+ V+ +PV+GGLI GL+AR+GSDK+RGHGIPEAIEAILF KS+MS KVAVLKPL S Sbjct: 61 HTLGVWVIALPVLGGLIAGLIARYGSDKVRGHGIPEAIEAILFRKSQMSPKVAVLKPLTS 120 Query: 121 GIVIGSGGPFGAEGPIIMTGGAIGSLIAQHFHVSAAERKTLLVAGATAGMTAVFGTPVAA 180 GIVIGSGGPFGAEGPIIMTGGAIGSLIAQ+F VSAAERKTLLVAGATAGMTAVFGTPVAA Sbjct: 121 GIVIGSGGPFGAEGPIIMTGGAIGSLIAQNFSVSAAERKTLLVAGATAGMTAVFGTPVAA 180 Query: 181 VLLAVELLLFEWRPRSLLPVILACAVAGFARPLLLEPGPLFPLHTDPVGLSALLVCIVAG 240 VLLAVELLLFEWRPRSLLPVILACAVA F RPLLLE GPLFPLHT PVG++A +CIVAG Sbjct: 181 VLLAVELLLFEWRPRSLLPVILACAVAAFCRPLLLESGPLFPLHTAPVGMAAFAICIVAG 240 Query: 241 LLSGALSSAMSMALYWIEDRFHALPLHWMWWPALGAVAVGIGGYFEPRALGVGYDVIADL 300 L SG LS+ MS+ALY +ED F LPLHWMWWPA+G + VGIGGYF+PRALGVGYDVI+DL Sbjct: 241 LASGMLSAGMSLALYRVEDWFGKLPLHWMWWPAIGGLVVGIGGYFQPRALGVGYDVISDL 300 Query: 301 LNHHLAMSAVLALLVVKAIIWVIALGSGTSGGVLAPLLMLGAGLGTAIAYVVPGSDPALW 360 LN+H+A+S L+LL+VKA+IWV+ALGSGTSGGVLAPLLMLGAGLG IA++VPGSDP LW Sbjct: 301 LNNHIALSVALSLLLVKAVIWVVALGSGTSGGVLAPLLMLGAGLGAVIAHLVPGSDPTLW 360 Query: 361 PLVCMAAVLSGVLGAPLTAAVFALGLTGDFNAFLPLLLATGISYGFTVLVMRRSIMTEKI 420 PLVCMAAVL+GVLGAPLTAA+FALGLTGDFNA LPLLLATG+SYGFTVL+MRRSIMTEKI Sbjct: 361 PLVCMAAVLAGVLGAPLTAAIFALGLTGDFNALLPLLLATGVSYGFTVLLMRRSIMTEKI 420 Query: 421 ARRGLHIYREYSVDPQERMFVEEVMTREPVTISASLSLEEIATVYFGATQQHRAFPVCDN 480 ARRGLHIYREYSVDPQER FV +VMT + V+I+A L+L E A YFG+ Q+HR+FPV D Sbjct: 421 ARRGLHIYREYSVDPQERAFVGDVMTTDIVSIAAGLTLHETAQQYFGSEQRHRSFPVIDQ 480 Query: 481 KGKLIGMLDRHALLGHLDKHAAATPVGELLTSSTSLLAFSTETCQSIARRMAAHHVERLP 540 G L+GML+R +LL H+ H + +L S+ LA TETCQ + RRMA H ERL Sbjct: 481 HGALLGMLERESLLHHIALHGGDQQLASILDSAHMQLALPTETCQVVGRRMAIQHAERLA 540 Query: 541 VVADASSLQLIGIVSRSDLVKPAHTVFHEEHVRERL 576 VVAD S +L+GI+SRSDL+KPAHT FHEEHVRERL Sbjct: 541 VVADKESRRLLGIISRSDLLKPAHTAFHEEHVRERL 576 >E6V8I8.1 E6V8I8_VARPD Cl-channel voltage-gated family protein Length = 581 Score = 741 bits (1914), Expect = 0.0, Method: Compositional matrix adjust. Identities = 394/570 (69%), Positives = 459/570 (80%), Gaps = 6/570 (1%) Query: 7 DFGLDRRVLFLAGIAVIIGGISTVAAFVLLNLIHFFTNLFFFQTFSLADRSPATHTMGIV 66 DF L+ R+L + +A++IG ISTVAA VLL+LI FFTNLFFFQTFSLADRSPA HT+G Sbjct: 11 DFALNARLLRITAMAIVIGAISTVAARVLLDLIRFFTNLFFFQTFSLADRSPAEHTLGAW 70 Query: 67 VVIVPVIGGLIVGLMARFGSDKIRGHGIPEAIEAILFGKSKMSGKVAVLKPLASGIVIGS 126 V++VPVIGGLIVGL+AR+GSDKIRGHGIPEAIEAILFGKSKMS KVAVLKPL+SGIVIGS Sbjct: 71 VIVVPVIGGLIVGLVARYGSDKIRGHGIPEAIEAILFGKSKMSPKVAVLKPLSSGIVIGS 130 Query: 127 GGPFGAEGPIIMTGGAIGSLIAQHFHVSAAERKTLLVAGATAGMTAVFGTPVAAVLLAVE 186 GGPFGAEGPIIMTGGAIGSLIAQ+FH++AAERK LLVAGATAGMTAVFGTPVAAVLLAVE Sbjct: 131 GGPFGAEGPIIMTGGAIGSLIAQYFHLTAAERKALLVAGATAGMTAVFGTPVAAVLLAVE 190 Query: 187 LLLFEWRPRSLLPVILACAVAGFARPLLLEPGPLFPLHTDPVGLSALLVCIVAGLLSGAL 246 LLLFE RPRSLLPV +ACAVAGF RPLL++ GPLFPL T G A+L CIVAGLL G L Sbjct: 191 LLLFELRPRSLLPVAVACAVAGFTRPLLMDAGPLFPLQTAVPGPLAMLSCIVAGLLCGVL 250 Query: 247 SSAMSMALYWIEDRFHALPLHWMWWPALGAVAVGIGGYFEPRALGVGYDVIADLLNHHLA 306 S+++S++LY +ED F LP+HWMWWPA+G +AVGIGGYFEPRALGVGYDVI DLL++HLA Sbjct: 251 SASLSISLYKVEDLFGKLPIHWMWWPAIGGLAVGIGGYFEPRALGVGYDVIGDLLHNHLA 310 Query: 307 MSAVLALLVVKAIIWVIALGSGTSGGVLAPLLMLGAGLGTAIAYVVPGSDPALWPLVCMA 366 + V ALL VKAIIW+I+LGSGTSGGVLAPLLM+GAGLG +++V+PG+DP LWPLVCMA Sbjct: 311 LGVVAALLAVKAIIWIISLGSGTSGGVLAPLLMMGAGLGVVLSHVLPGNDPILWPLVCMA 370 Query: 367 AVLSGVLGAPLTAAVFALGLTGDFNAFLPLLLATGISYGFTVLVMRRSIMTEKIARRGLH 426 A L GV+ APLTA +FA GLT D NA LPLL + ++YGFTVL MRRSI+TEKIARRG H Sbjct: 371 ATLGGVMRAPLTATIFAFGLTHDSNALLPLLTTSAVAYGFTVLTMRRSILTEKIARRGYH 430 Query: 427 IYREYSVDPQERMFVEEVMTREPVTISASLSLEEIATVYFGATQQHRAFPVCDNKGKLIG 486 IYREY +DP ER VEEVMTRE +I A+L + E YFG Q HRA+PV +IG Sbjct: 431 IYREYGIDPLERHSVEEVMTREVRSIDAALPVAEALAQYFGEGQMHRAYPVLRGNA-VIG 489 Query: 487 MLDRHALLGHLDKHAAATPVGELLTSSTSLLAFSTETCQSIARRMAAHHVERLPVVADAS 546 M DR L + VG+ S L A + E C+ +A R+A H +ERLPVV DA Sbjct: 490 MADRAMLAAF-----SVGTVGDACEGSAPLFALAGENCRVVATRLARHRLERLPVVKDAQ 544 Query: 547 SLQLIGIVSRSDLVKPAHTVFHEEHVRERL 576 SL L+G+V+RSDL+KP+ F EE RER+ Sbjct: 545 SLALVGLVARSDLIKPSLAHFDEEEKRERM 574 >B5SHJ4.1 B5SHJ4_RALSO Chloride channel protein Length = 600 Score = 736 bits (1899), Expect = 0.0, Method: Compositional matrix adjust. Identities = 401/571 (70%), Positives = 458/571 (80%), Gaps = 7/571 (1%) Query: 1 MRRH--QRDFGLDRRVLFLAGIAVIIGGISTVAAFVLLNLIHFFTNLFFFQTFSLADRSP 58 M+ H +RDF D + A +AV+I +T+AA VLL+LI FFTNLFFFQT SLADRSP Sbjct: 1 MQAHTLRRDFATDTTLFRTAALAVVIAAFATLAAVVLLDLIRFFTNLFFFQTLSLADRSP 60 Query: 59 ATHTMGIVVVIVPVIGGLIVGLMARFGSDKIRGHGIPEAIEAILFGKSKMSGKVAVLKPL 118 A +T+G+ V+ VPV+GGLIVGLMARFGSDKIRGHGIPEAIEAILFGKS+MS KVAVLKPL Sbjct: 61 AGNTLGLWVIAVPVLGGLIVGLMARFGSDKIRGHGIPEAIEAILFGKSRMSPKVAVLKPL 120 Query: 119 ASGIVIGSGGPFGAEGPIIMTGGAIGSLIAQHFHVSAAERKTLLVAGATAGMTAVFGTPV 178 +SGIVIGSGGPFGAEGPIIMTGGAIGSL+AQ F ++AAERKTLLVAGA AGMTAVFGTPV Sbjct: 121 SSGIVIGSGGPFGAEGPIIMTGGAIGSLLAQCFKLTAAERKTLLVAGAAAGMTAVFGTPV 180 Query: 179 AAVLLAVELLLFEWRPRSLLPVILACAVAGFARPLLLEPGPLFPLHTDPVGLSALLVCIV 238 AA+LLAVELLLFEWRPRS+LPV +ACAVAGF R L+LEPGPLFPL T P L AL C+V Sbjct: 181 AALLLAVELLLFEWRPRSMLPVAIACAVAGFLRVLVLEPGPLFPLATAPATLPALGSCLV 240 Query: 239 AGLLSGALSSAMSMALYWIEDRFHALPLHWMWWPALGAVAVGIGGYFEPRALGVGYDVIA 298 AGLL GALS ++SMALY ED F LP+HWMWWPALG +AVGIGGYFEP ALGVGYDVI Sbjct: 241 AGLLCGALSRSLSMALYKTEDLFARLPIHWMWWPALGGLAVGIGGYFEPHALGVGYDVIG 300 Query: 299 DLLNHHLAMSAVLALLVVKAIIWVIALGSGTSGGVLAPLLMLGAGLGTAIAYVVPGSDPA 358 DLL++HLA+ LALLVVKA+IWVIALGSGTSGGVLAPLLM+GAGLG + V+PG DP Sbjct: 301 DLLHNHLAIRVALALLVVKALIWVIALGSGTSGGVLAPLLMMGAGLGVMLGPVLPGGDPG 360 Query: 359 LWPLVCMAAVLSGVLGAPLTAAVFALGLTGDFNAFLPLLLATGISYGFTVLVMRRSIMTE 418 LWPLVCMAA L+GVLGAPLTA VFA GLT D NA LP+LLA ++YGF VL M RSIMTE Sbjct: 361 LWPLVCMAATLAGVLGAPLTAIVFAFGLTHDVNAILPVLLAVSVAYGFVVLTMPRSIMTE 420 Query: 419 KIARRGLHIYREYSVDPQERMFVEEVMTREPVTISASLSLEEIATVYFGATQQHRAFPVC 478 KIARRG HIYREY+VDP ER V+EVMTR TI A S+ I FG TQ HRAFPV Sbjct: 421 KIARRGFHIYREYAVDPLERHAVDEVMTRAVQTIDAHASVAGILAERFGPTQTHRAFPVV 480 Query: 479 DNKGKLIGMLDRHALL-GHLDKHAAATPVGELLTSSTSLLAFSTETCQSIARRMAAHHVE 537 + G L+GML+R ALL GH AAT + +L ++ ++A ETC+ +A R+A H +E Sbjct: 481 RD-GVLVGMLERDALLAGH--ARGAAT-IADLFGANAPVMALPGETCRIVATRLAVHGLE 536 Query: 538 RLPVVADASSLQLIGIVSRSDLVKPAHTVFH 568 RLPVVAD S +L+GIVSRSDLVKP+ F Sbjct: 537 RLPVVADTQSRRLVGIVSRSDLVKPSLAFFD 567 >A3RRR8.1 A3RRR8_RALSO Chloride channel protein Length = 600 Score = 736 bits (1899), Expect = 0.0, Method: Compositional matrix adjust. Identities = 401/571 (70%), Positives = 458/571 (80%), Gaps = 7/571 (1%) Query: 1 MRRH--QRDFGLDRRVLFLAGIAVIIGGISTVAAFVLLNLIHFFTNLFFFQTFSLADRSP 58 M+ H +RDF D + A +AV+I +T+AA VLL+LI FFTNLFFFQT SLADRSP Sbjct: 1 MQAHTLRRDFATDTTLFRTAALAVVIAAFATLAAVVLLDLIRFFTNLFFFQTLSLADRSP 60 Query: 59 ATHTMGIVVVIVPVIGGLIVGLMARFGSDKIRGHGIPEAIEAILFGKSKMSGKVAVLKPL 118 A +T+G+ V+ VPV+GGLIVGLMARFGSDKIRGHGIPEAIEAILFGKS+MS KVAVLKPL Sbjct: 61 AGNTLGLWVIAVPVLGGLIVGLMARFGSDKIRGHGIPEAIEAILFGKSRMSPKVAVLKPL 120 Query: 119 ASGIVIGSGGPFGAEGPIIMTGGAIGSLIAQHFHVSAAERKTLLVAGATAGMTAVFGTPV 178 +SGIVIGSGGPFGAEGPIIMTGGAIGSL+AQ F ++AAERKTLLVAGA AGMTAVFGTPV Sbjct: 121 SSGIVIGSGGPFGAEGPIIMTGGAIGSLLAQCFKLTAAERKTLLVAGAAAGMTAVFGTPV 180 Query: 179 AAVLLAVELLLFEWRPRSLLPVILACAVAGFARPLLLEPGPLFPLHTDPVGLSALLVCIV 238 AA+LLAVELLLFEWRPRS+LPV +ACAVAGF R L+LEPGPLFPL T P L AL C+V Sbjct: 181 AALLLAVELLLFEWRPRSMLPVAIACAVAGFLRVLVLEPGPLFPLATAPATLPALGSCLV 240 Query: 239 AGLLSGALSSAMSMALYWIEDRFHALPLHWMWWPALGAVAVGIGGYFEPRALGVGYDVIA 298 AGLL GALS ++SMALY ED F LP+HWMWWPALG +AVGIGGYFEP ALGVGYDVI Sbjct: 241 AGLLCGALSRSLSMALYKTEDLFARLPIHWMWWPALGGLAVGIGGYFEPHALGVGYDVIG 300 Query: 299 DLLNHHLAMSAVLALLVVKAIIWVIALGSGTSGGVLAPLLMLGAGLGTAIAYVVPGSDPA 358 DLL++HLA+ LALLVVKA+IWVIALGSGTSGGVLAPLLM+GAGLG + V+PG DP Sbjct: 301 DLLHNHLAIRVALALLVVKALIWVIALGSGTSGGVLAPLLMMGAGLGVMLGPVLPGGDPG 360 Query: 359 LWPLVCMAAVLSGVLGAPLTAAVFALGLTGDFNAFLPLLLATGISYGFTVLVMRRSIMTE 418 LWPLVCMAA L+GVLGAPLTA VFA GLT D NA LP+LLA ++YGF VL M RSIMTE Sbjct: 361 LWPLVCMAATLAGVLGAPLTAIVFAFGLTHDVNAILPVLLAVSVAYGFVVLTMPRSIMTE 420 Query: 419 KIARRGLHIYREYSVDPQERMFVEEVMTREPVTISASLSLEEIATVYFGATQQHRAFPVC 478 KIARRG HIYREY+VDP ER V+EVMTR TI A S+ I FG TQ HRAFPV Sbjct: 421 KIARRGFHIYREYAVDPLERHAVDEVMTRAVQTIDAHASVAGILAERFGPTQTHRAFPVV 480 Query: 479 DNKGKLIGMLDRHALL-GHLDKHAAATPVGELLTSSTSLLAFSTETCQSIARRMAAHHVE 537 + G L+GML+R ALL GH AAT + +L ++ ++A ETC+ +A R+A H +E Sbjct: 481 RD-GVLVGMLERDALLAGH--ARGAAT-IADLFGANAPVMALPGETCRIVATRLAVHGLE 536 Query: 538 RLPVVADASSLQLIGIVSRSDLVKPAHTVFH 568 RLPVVAD S +L+GIVSRSDLVKP+ F Sbjct: 537 RLPVVADTQSRRLVGIVSRSDLVKPSLAFFD 567