BLASTP 2.2.21 [Jun-14-2009] Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), "Gapped BLAST and PSI-BLAST: a new generation of protein database search programs", Nucleic Acids Res. 25:3389-3402. Reference for compositional score matrix adjustment: Altschul, Stephen F., John C. Wootton, E. Michael Gertz, Richa Agarwala, Aleksandr Morgulis, Alejandro A. Schaffer, and Yi-Kuo Yu (2005) "Protein database searches using compositionally adjusted substitution matrices", FEBS J. 272:5101-5109. Query= 0037.0213.p (271 letters) Database: pfamseq 15,929,002 sequences; 5,169,768,107 total letters Searching..................................................done Score E Sequences producing significant alignments: (bits) Value D8IXZ2.1 D8IXZ2_HERSS Methylmalonate-semialdehyde dehydrogenase ... 432 e-119 B2TEV7.1 B2TEV7_BURPP Methylmalonate-semialdehyde dehydrogenase 375 e-102 E8YTJ6.1 E8YTJ6_9BURK Methylmalonate-semialdehyde dehydrogenase 370 e-100 B1G0G1.1 B1G0G1_9BURK Methylmalonate-semialdehyde dehydrogenase 368 e-100 D5NCK8.1 D5NCK8_9BURK Methylmalonate-semialdehyde dehydrogenase 367 e-100 >D8IXZ2.1 D8IXZ2_HERSS Methylmalonate-semialdehyde dehydrogenase protein EC=1.2.1.27 Length = 497 Score = 432 bits (1112), Expect = e-119, Method: Compositional matrix adjust. Identities = 215/265 (81%), Positives = 235/265 (88%), Gaps = 17/265 (6%) Query: 1 VAVARVALGTAEEVNDAVATAVAAFPAWSNTPPLXVAAFPAWSNTP---RARVLFKFLNL 57 V VA+VALGT++EV+ AV VAAFPAW SNTP RARVLF+FL+L Sbjct: 30 VPVAQVALGTSDEVDAAVKAGVAAFPAW--------------SNTPPLTRARVLFRFLHL 75 Query: 58 IQQHADDFAAILTREHGKTFSDAQGEVARGIEVVEYAVGIPQMLKGEYTDQIARGIDAWS 117 IQQ ADDFA I+ REHGKTFSDAQGEVARGIE+VE+A GIPQMLKGEYTDQIARGIDAWS Sbjct: 76 IQQRADDFARIIVREHGKTFSDAQGEVARGIEIVEFAAGIPQMLKGEYTDQIARGIDAWS 135 Query: 118 MRQPLGVVAGITPFNFPAMVPMWMFPIALACGNCFILKPSERDPSASLLIAELLQQAGLP 177 MRQ LGVVAGITPFNFPAMVPMWMFPIA+ACGNCF+LKPSERDPSASLLIA+LL++AGLP Sbjct: 136 MRQALGVVAGITPFNFPAMVPMWMFPIAIACGNCFVLKPSERDPSASLLIADLLKEAGLP 195 Query: 178 DGVFSVIQGDKVTVDALLDHPKVKAISFVGSTPIAEYIYARGSAKGKRVQALGGAKNHMV 237 DGVF+V+QGDKVTVDALLDHP+VKAISFVGSTPIAEYIYARGSAKGKRVQALGGAKNHMV Sbjct: 196 DGVFNVVQGDKVTVDALLDHPQVKAISFVGSTPIAEYIYARGSAKGKRVQALGGAKNHMV 255 Query: 238 VMPDADMQVAVDALIGAAYXCSGRR 262 VMPDADMQ+AVDAL+GAAY +G R Sbjct: 256 VMPDADMQLAVDALMGAAYGSAGER 280 >B2TEV7.1 B2TEV7_BURPP Methylmalonate-semialdehyde dehydrogenase Length = 501 Score = 375 bits (962), Expect = e-102, Method: Compositional matrix adjust. Identities = 190/261 (72%), Positives = 221/261 (84%), Gaps = 11/261 (4%) Query: 2 AVARVALGTAEEVNDAVATAVAAFPAWSNTPPLXVAAFPAWSNTPRARVLFKFLNLIQQH 61 AVA+VA+G+AE+++ AV A AAFPAWS PPL RAR+L K+L L+QQH Sbjct: 35 AVAQVAMGSAEDIHAAVGAAAAAFPAWSARPPLA-----------RARILAKYLQLMQQH 83 Query: 62 ADDFAAILTREHGKTFSDAQGEVARGIEVVEYAVGIPQMLKGEYTDQIARGIDAWSMRQP 121 D A +LTREHGKT DA+GEVARG+EVVE+AVGIP +LKGE++DQI+RGIDAWS+RQP Sbjct: 84 TDTLAQMLTREHGKTLDDARGEVARGLEVVEFAVGIPHLLKGEFSDQISRGIDAWSIRQP 143 Query: 122 LGVVAGITPFNFPAMVPMWMFPIALACGNCFILKPSERDPSASLLIAELLQQAGLPDGVF 181 LGVVAGITPFNFPAMVPMWMFPIALACGN F+LKPSERDPS SLL AELL++AGLPDGVF Sbjct: 144 LGVVAGITPFNFPAMVPMWMFPIALACGNTFVLKPSERDPSCSLLHAELLKEAGLPDGVF 203 Query: 182 SVIQGDKVTVDALLDHPKVKAISFVGSTPIAEYIYARGSAKGKRVQALGGAKNHMVVMPD 241 +V+QGDK VDALLDHP+V+A+SFVGSTPIAEY+YAR SA GKR QALGGAKNH+VVMPD Sbjct: 204 NVVQGDKAVVDALLDHPEVQAVSFVGSTPIAEYVYARASANGKRAQALGGAKNHLVVMPD 263 Query: 242 ADMQVAVDALIGAAYXCSGRR 262 ADM +A DALIGAA+ +G R Sbjct: 264 ADMAMATDALIGAAFGSAGER 284 >E8YTJ6.1 E8YTJ6_9BURK Methylmalonate-semialdehyde dehydrogenase Length = 507 Score = 370 bits (950), Expect = e-100, Method: Compositional matrix adjust. Identities = 177/257 (68%), Positives = 207/257 (80%), Gaps = 11/257 (4%) Query: 6 VALGTAEEVNDAVATAVAAFPAWSNTPPLXVAAFPAWSNTPRARVLFKFLNLIQQHADDF 65 VAL + EEV+ AV +A AAFPAWS T P+ RAR+LFKF L+ +H D+ Sbjct: 46 VALASVEEVDAAVKSAKAAFPAWSETAPIK-----------RARILFKFKELLNRHHDEL 94 Query: 66 AAILTREHGKTFSDAQGEVARGIEVVEYAVGIPQMLKGEYTDQIARGIDAWSMRQPLGVV 125 A ++TREHGK F+DAQGEV RGIEVVE+A GIP +LK ++TDQI GID W++RQ LGVV Sbjct: 95 AMLITREHGKVFTDAQGEVVRGIEVVEFACGIPNLLKTDFTDQIGGGIDNWNLRQALGVV 154 Query: 126 AGITPFNFPAMVPMWMFPIALACGNCFILKPSERDPSASLLIAELLQQAGLPDGVFSVIQ 185 AGITPFNFP MVPMWMFP+ALACGN F+LKPSERDPSASL IAELL++AGLPDGVF+V+ Sbjct: 155 AGITPFNFPVMVPMWMFPVALACGNTFVLKPSERDPSASLRIAELLKEAGLPDGVFNVVN 214 Query: 186 GDKVTVDALLDHPKVKAISFVGSTPIAEYIYARGSAKGKRVQALGGAKNHMVVMPDADMQ 245 GDKV VDAL+DHP V A+SFVGSTPIAEYI+ S +GKRVQALGGAKNH+VVMPDAD+ Sbjct: 215 GDKVAVDALIDHPDVAALSFVGSTPIAEYIHTEASKRGKRVQALGGAKNHLVVMPDADLD 274 Query: 246 VAVDALIGAAYXCSGRR 262 AVDALIGAAY +G R Sbjct: 275 QAVDALIGAAYGSAGER 291 >B1G0G1.1 B1G0G1_9BURK Methylmalonate-semialdehyde dehydrogenase Length = 507 Score = 368 bits (945), Expect = e-100, Method: Compositional matrix adjust. Identities = 176/257 (68%), Positives = 207/257 (80%), Gaps = 11/257 (4%) Query: 6 VALGTAEEVNDAVATAVAAFPAWSNTPPLXVAAFPAWSNTPRARVLFKFLNLIQQHADDF 65 VAL + EEV+ AV +A AAF AWS T PL RAR+LF+F L+ +H D+ Sbjct: 46 VALASVEEVDAAVKSAKAAFAAWSETAPLK-----------RARILFRFKELLNRHHDEL 94 Query: 66 AAILTREHGKTFSDAQGEVARGIEVVEYAVGIPQMLKGEYTDQIARGIDAWSMRQPLGVV 125 A ++TREHGK F+DAQGEV RGIEVVE+A GIP +LK ++TDQI GID W++RQPLGVV Sbjct: 95 AMLITREHGKVFTDAQGEVVRGIEVVEFACGIPNLLKTDFTDQIGGGIDNWNLRQPLGVV 154 Query: 126 AGITPFNFPAMVPMWMFPIALACGNCFILKPSERDPSASLLIAELLQQAGLPDGVFSVIQ 185 AGITPFNFP MVPMWMFP+ALACGN F+LKPSERDPSASL IAELL++AGLPDGVF+V+ Sbjct: 155 AGITPFNFPVMVPMWMFPVALACGNTFVLKPSERDPSASLRIAELLKEAGLPDGVFNVVN 214 Query: 186 GDKVTVDALLDHPKVKAISFVGSTPIAEYIYARGSAKGKRVQALGGAKNHMVVMPDADMQ 245 GDKV VDAL++HP V A+SFVGSTPIAEYI+ S +GKRVQALGGAKNH+VVMPDAD+ Sbjct: 215 GDKVAVDALIEHPDVAALSFVGSTPIAEYIHGEASKRGKRVQALGGAKNHLVVMPDADLD 274 Query: 246 VAVDALIGAAYXCSGRR 262 AVDALIGAAY +G R Sbjct: 275 QAVDALIGAAYGSAGER 291 >D5NCK8.1 D5NCK8_9BURK Methylmalonate-semialdehyde dehydrogenase Length = 507 Score = 367 bits (943), Expect = e-100, Method: Compositional matrix adjust. Identities = 177/257 (68%), Positives = 205/257 (79%), Gaps = 11/257 (4%) Query: 6 VALGTAEEVNDAVATAVAAFPAWSNTPPLXVAAFPAWSNTPRARVLFKFLNLIQQHADDF 65 VAL + EEV+ AV A AAF AWS T PL RAR+LF+F L+ QH D+ Sbjct: 46 VALASVEEVDAAVQVAKAAFSAWSETAPLK-----------RARILFRFKELLNQHHDEL 94 Query: 66 AAILTREHGKTFSDAQGEVARGIEVVEYAVGIPQMLKGEYTDQIARGIDAWSMRQPLGVV 125 A ++TREHGK F+DAQGEV RGIEVVE+A GIP +LK ++TDQI GID W++RQ LGVV Sbjct: 95 AMLITREHGKVFTDAQGEVVRGIEVVEFACGIPNLLKTDFTDQIGGGIDNWNLRQALGVV 154 Query: 126 AGITPFNFPAMVPMWMFPIALACGNCFILKPSERDPSASLLIAELLQQAGLPDGVFSVIQ 185 AGITPFNFP MVPMWMFP+ALACGN F+LKPSERDPSASL IAELL++AGLPDGVF+V+ Sbjct: 155 AGITPFNFPVMVPMWMFPVALACGNTFVLKPSERDPSASLRIAELLKEAGLPDGVFNVVN 214 Query: 186 GDKVTVDALLDHPKVKAISFVGSTPIAEYIYARGSAKGKRVQALGGAKNHMVVMPDADMQ 245 GDKV VDAL+DHP V A+SFVGSTPIAEYI+ S +GKRVQALGGAKNH+VVMPDAD+ Sbjct: 215 GDKVAVDALIDHPDVAALSFVGSTPIAEYIHTEASKRGKRVQALGGAKNHLVVMPDADLD 274 Query: 246 VAVDALIGAAYXCSGRR 262 AVDALIGAAY +G R Sbjct: 275 QAVDALIGAAYGSAGER 291