BLASTP 2.2.21 [Jun-14-2009] Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), "Gapped BLAST and PSI-BLAST: a new generation of protein database search programs", Nucleic Acids Res. 25:3389-3402. Reference for compositional score matrix adjustment: Altschul, Stephen F., John C. Wootton, E. Michael Gertz, Richa Agarwala, Aleksandr Morgulis, Alejandro A. Schaffer, and Yi-Kuo Yu (2005) "Protein database searches using compositionally adjusted substitution matrices", FEBS J. 272:5101-5109. Query= 0037.0160.p (394 letters) Database: pfamseq 15,929,002 sequences; 5,169,768,107 total letters Searching..................................................done Score E Sequences producing significant alignments: (bits) Value D8IY31.1 D8IY31_HERSS Isovaleryl-CoA dehydrogenase protein EC=1.... 766 0.0 F1VUJ4.1 F1VUJ4_9BURK Isovaleryl-CoA dehydrogenase 738 0.0 A6GLN0.1 A6GLN0_9BURK Acyl-CoA dehydrogenase domain protein 676 0.0 D3NZC5.1 D3NZC5_AZOS1 Isovaleryl-CoA dehydrogenase EC=1.3.99.10 663 0.0 Q1BQT2.1 Q1BQT2_BURCA Isovaleryl-CoA dehydrogenase EC=1.3.99.10 661 0.0 >D8IY31.1 D8IY31_HERSS Isovaleryl-CoA dehydrogenase protein EC=1.3.99.10 Length = 394 Score = 766 bits (1977), Expect = 0.0, Method: Compositional matrix adjust. Identities = 366/394 (92%), Positives = 384/394 (97%) Query: 1 MIHLPGLTFDHGEDIAALRESVAAFAQAEIAPRAAEIDRSDQFPMDLWKKMGDLGVLGIT 60 MIHLPGL+FDHGEDIAALRE+VAAFA +EIAPRAAEIDRSDQFPMDLWKK+GDLGVLGIT Sbjct: 1 MIHLPGLSFDHGEDIAALREAVAAFAHSEIAPRAAEIDRSDQFPMDLWKKLGDLGVLGIT 60 Query: 61 ADEEYGGAAMGYLAHIVALEEISRASASVGLSYGAHSNLCVNQIKRNGSTEQKNKYLPKL 120 EEYGGA +GYLAHI+A+EEISRASASVGLSYGAHSNLCVNQIKRNG+ EQK KYLP+L Sbjct: 61 VSEEYGGAGLGYLAHIIAMEEISRASASVGLSYGAHSNLCVNQIKRNGNEEQKRKYLPRL 120 Query: 121 ISGDFIGALAMSEPNAGSDVVSMKLRADKKGDRYVLNGSKMWITNGPDADVLVVYAKTDL 180 ISGDFIGALAMSEPNAGSDVVSMKLRADKKGDRYVLNGSKMWITNGPDADVLVVYAKTDL Sbjct: 121 ISGDFIGALAMSEPNAGSDVVSMKLRADKKGDRYVLNGSKMWITNGPDADVLVVYAKTDL 180 Query: 181 EAGARGMTAFLVEKGFKGFSVAQKLDKLGMRGSHTGELVFQDCEVPAENVLGGIGRGVNV 240 EAGARGMTAFLVEKG+KGFSVAQKLDKLGMRGSHTGELVFQDCEVP ENVLGG+GRGVNV Sbjct: 181 EAGARGMTAFLVEKGYKGFSVAQKLDKLGMRGSHTGELVFQDCEVPEENVLGGVGRGVNV 240 Query: 241 LMSGLDFERTVLSGGPLGIMQACMDVVVPYVHDRKQFGQSIGEFQLMQGKIADMYSTMMA 300 LMSGLDFER+VLSGGPLGIMQACMDVVVPYVHDRKQFGQ+IGEFQLMQGK+ADMYSTMMA Sbjct: 241 LMSGLDFERSVLSGGPLGIMQACMDVVVPYVHDRKQFGQAIGEFQLMQGKLADMYSTMMA 300 Query: 301 CKAYVYAVGQACDRAKTPDAVRALRKDAAGAILYSAEKATWMAGEAIQALGGNGYINEYP 360 CKAYVYAVGQACDRA + D VRALRKDAAGAILYSAEKATWMAGEAIQ+LGGNGYINEYP Sbjct: 301 CKAYVYAVGQACDRADSADKVRALRKDAAGAILYSAEKATWMAGEAIQSLGGNGYINEYP 360 Query: 361 VGRLWRDAKLYEIGAGTSEIRRMLIGRELFAETM 394 VGRLWRDAKLYEIGAGTSEIRRMLIGRELFA+T+ Sbjct: 361 VGRLWRDAKLYEIGAGTSEIRRMLIGRELFADTL 394 >F1VUJ4.1 F1VUJ4_9BURK Isovaleryl-CoA dehydrogenase Length = 394 Score = 738 bits (1906), Expect = 0.0, Method: Compositional matrix adjust. Identities = 351/393 (89%), Positives = 374/393 (95%) Query: 1 MIHLPGLTFDHGEDIAALRESVAAFAQAEIAPRAAEIDRSDQFPMDLWKKMGDLGVLGIT 60 M+HLPGLTFDHG+DIAALR++++ FA AEIAPRA EIDR+DQFPMDLW+KMGDLGVLGIT Sbjct: 1 MLHLPGLTFDHGDDIAALRDTISQFAAAEIAPRAGEIDRTDQFPMDLWRKMGDLGVLGIT 60 Query: 61 ADEEYGGAAMGYLAHIVALEEISRASASVGLSYGAHSNLCVNQIKRNGSTEQKNKYLPKL 120 EEYGG MGYLAHI+A+EEISRASASVGLSYGAHSNLCVNQIKRNGS EQK KYLPKL Sbjct: 61 VGEEYGGTGMGYLAHIIAMEEISRASASVGLSYGAHSNLCVNQIKRNGSAEQKAKYLPKL 120 Query: 121 ISGDFIGALAMSEPNAGSDVVSMKLRADKKGDRYVLNGSKMWITNGPDADVLVVYAKTDL 180 +SG++IGALAMSEPNAGSDVVSMKLRAD KGDR+VLNG+KMWITNGPDADVLVVYAK DL Sbjct: 121 VSGEYIGALAMSEPNAGSDVVSMKLRADWKGDRWVLNGTKMWITNGPDADVLVVYAKNDL 180 Query: 181 EAGARGMTAFLVEKGFKGFSVAQKLDKLGMRGSHTGELVFQDCEVPAENVLGGIGRGVNV 240 EAGARGMTAFL+EK FKGFSVAQKLDKLGMRGSHTGELVF+DCEVPAENVLGG+G+GVNV Sbjct: 181 EAGARGMTAFLIEKDFKGFSVAQKLDKLGMRGSHTGELVFRDCEVPAENVLGGLGKGVNV 240 Query: 241 LMSGLDFERTVLSGGPLGIMQACMDVVVPYVHDRKQFGQSIGEFQLMQGKIADMYSTMMA 300 LMSGLD+ER VLSGGPLGIMQACMDV VPYVHDRKQFGQ IGEFQLMQGK+ADMYSTMMA Sbjct: 241 LMSGLDYERAVLSGGPLGIMQACMDVAVPYVHDRKQFGQPIGEFQLMQGKLADMYSTMMA 300 Query: 301 CKAYVYAVGQACDRAKTPDAVRALRKDAAGAILYSAEKATWMAGEAIQALGGNGYINEYP 360 CKAYVYAVGQACDRA +P+AVRALRKDAAGAILYSAEKATWMAGE IQALGGNGYINEYP Sbjct: 301 CKAYVYAVGQACDRAASPEAVRALRKDAAGAILYSAEKATWMAGETIQALGGNGYINEYP 360 Query: 361 VGRLWRDAKLYEIGAGTSEIRRMLIGRELFAET 393 GRLWRDAKLYEIGAGTSEIRRMLIGRELF ET Sbjct: 361 AGRLWRDAKLYEIGAGTSEIRRMLIGRELFNET 393 >A6GLN0.1 A6GLN0_9BURK Acyl-CoA dehydrogenase domain protein Length = 393 Score = 676 bits (1743), Expect = 0.0, Method: Compositional matrix adjust. Identities = 323/394 (81%), Positives = 359/394 (91%), Gaps = 1/394 (0%) Query: 1 MIHLPGLTFDHGEDIAALRESVAAFAQAEIAPRAAEIDRSDQFPMDLWKKMGDLGVLGIT 60 M++LPGL FD GEDI ALR++V FAQAEIAP AAE+D++DQFPM LW+KMGD+G+LG+T Sbjct: 1 MLNLPGLQFDLGEDIDALRDAVQTFAQAEIAPLAAEMDKTDQFPMHLWRKMGDMGLLGLT 60 Query: 61 ADEEYGGAAMGYLAHIVALEEISRASASVGLSYGAHSNLCVNQIKRNGSTEQKNKYLPKL 120 +EE GG+ MGYLAHIVA+EEISRASASV LSYGAHSNLCVNQI+RNG+ Q+ +LPKL Sbjct: 61 VEEELGGSGMGYLAHIVAMEEISRASASVALSYGAHSNLCVNQIRRNGTDWQRKTFLPKL 120 Query: 121 ISGDFIGALAMSEPNAGSDVVSMKLRADKKGDRYVLNGSKMWITNGPDADVLVVYAKTDL 180 ISG+ IGALAMSEP AGSDVVSM+LRADKKGD+YVLNG+KMWITNGPDADVLVVYAKTDL Sbjct: 121 ISGEHIGALAMSEPGAGSDVVSMQLRADKKGDKYVLNGNKMWITNGPDADVLVVYAKTDL 180 Query: 181 EAGARGMTAFLVEKGFKGFSVAQKLDKLGMRGSHTGELVFQDCEVPAENVLGGIGRGVNV 240 AG G+TAFL+EK FKGFS+AQKLDKLGMRGSHTGELVF+DCEVP +VLG +GRGVNV Sbjct: 181 AAGPHGITAFLIEKNFKGFSIAQKLDKLGMRGSHTGELVFEDCEVPETHVLGKVGRGVNV 240 Query: 241 LMSGLDFERTVLSGGPLGIMQACMDVVVPYVHDRKQFGQSIGEFQLMQGKIADMYSTMMA 300 LMSGLDFER VLSGGPLGIM A MDVVVPYVHDRKQFGQSIGEFQL+QGK+ADMYSTMMA Sbjct: 241 LMSGLDFERAVLSGGPLGIMAAAMDVVVPYVHDRKQFGQSIGEFQLIQGKLADMYSTMMA 300 Query: 301 CKAYVYAVGQACDRAKTPDAVRALRKDAAGAILYSAEKATWMAGEAIQALGGNGYINEYP 360 +AYVY VG+ACD+A TP+ VR LRKD AGAILYSAEKATWMAGE+IQ LGGNGYINEYP Sbjct: 301 TRAYVYQVGKACDKA-TPETVRKLRKDCAGAILYSAEKATWMAGESIQILGGNGYINEYP 359 Query: 361 VGRLWRDAKLYEIGAGTSEIRRMLIGRELFAETM 394 GRLWRDAKLYEIGAGTSEIRRMLIGRELF+ETM Sbjct: 360 CGRLWRDAKLYEIGAGTSEIRRMLIGRELFSETM 393 >D3NZC5.1 D3NZC5_AZOS1 Isovaleryl-CoA dehydrogenase EC=1.3.99.10 Length = 390 Score = 663 bits (1711), Expect = 0.0, Method: Compositional matrix adjust. Identities = 317/391 (81%), Positives = 349/391 (89%), Gaps = 6/391 (1%) Query: 3 HLPGLTFDHGEDIAALRESVAAFAQAEIAPRAAEIDRSDQFPMDLWKKMGDLGVLGITAD 62 PGL FD GE LR+SV AFA AEIAPRAAEIDRS++FP +LW++MGDLG+LG+T + Sbjct: 5 QYPGLNFDLGEAADMLRDSVRAFADAEIAPRAAEIDRSNEFPNELWRRMGDLGILGVTVE 64 Query: 63 EEYGGAAMGYLAHIVALEEISRASASVGLSYGAHSNLCVNQIKRNGSTEQKNKYLPKLIS 122 EEYGGA MGYL H+VA+EE+SRASASVGLSYGAHSNLCVNQI++NG+ EQK +YLPKLIS Sbjct: 65 EEYGGAGMGYLEHVVAMEEVSRASASVGLSYGAHSNLCVNQIRKNGNEEQKRRYLPKLIS 124 Query: 123 GDFIGALAMSEPNAGSDVVSMKLRADKKGDRYVLNGSKMWITNGPDADVLVVYAKTDLEA 182 G+ IGALAMSEPNAGSDVVSMKLRA+K+GDRYVLNG+KMWITNGPDAD LV+YAKTDL A Sbjct: 125 GEHIGALAMSEPNAGSDVVSMKLRAEKRGDRYVLNGTKMWITNGPDADTLVIYAKTDLAA 184 Query: 183 GARGMTAFLVEKGFKGFSVAQKLDKLGMRGSHTGELVFQDCEVPAENVLGGIGRGVNVLM 242 G RG+TAFLVEKGFKGFSVAQKLDKLGMRGS+TGELVF+DCEVP EN+LGG+GRGVNVLM Sbjct: 185 GPRGITAFLVEKGFKGFSVAQKLDKLGMRGSNTGELVFEDCEVPEENILGGVGRGVNVLM 244 Query: 243 SGLDFERTVLSGGPLGIMQACMDVVVPYVHDRKQFGQSIGEFQLMQGKIADMYSTMMACK 302 SGLD+ER VL+GGPLGIMQACMDVV+PYVHDRKQFGQ IGEFQLMQGKIADMY+ M A K Sbjct: 245 SGLDYERAVLAGGPLGIMQACMDVVIPYVHDRKQFGQPIGEFQLMQGKIADMYTVMNAAK 304 Query: 303 AYVYAVGQACDRAKTPDAVRALRKDAAGAILYSAEKATWMAGEAIQALGGNGYINEYPVG 362 AYVY V +ACDR +T RKDAA AILYSAEKATWMA EAIQ LGGNGYINEYP G Sbjct: 305 AYVYTVAKACDRGETT------RKDAAAAILYSAEKATWMALEAIQTLGGNGYINEYPTG 358 Query: 363 RLWRDAKLYEIGAGTSEIRRMLIGRELFAET 393 RL RDAKLYEIGAGTSEIRRMLIGRELF ET Sbjct: 359 RLLRDAKLYEIGAGTSEIRRMLIGRELFKET 389 >Q1BQT2.1 Q1BQT2_BURCA Isovaleryl-CoA dehydrogenase EC=1.3.99.10 Length = 393 Score = 661 bits (1706), Expect = 0.0, Method: Compositional matrix adjust. Identities = 315/394 (79%), Positives = 349/394 (88%), Gaps = 1/394 (0%) Query: 1 MIHLPGLTFDHGEDIAALRESVAAFAQAEIAPRAAEIDRSDQFPMDLWKKMGDLGVLGIT 60 MI+LPG+ F GEDI LR++VA FA EI PRAAE+DR+DQFPMDLWKK GDLGVLG+T Sbjct: 1 MINLPGVQFMLGEDIEMLRDAVATFAAKEITPRAAEVDRTDQFPMDLWKKFGDLGVLGMT 60 Query: 61 ADEEYGGAAMGYLAHIVALEEISRASASVGLSYGAHSNLCVNQIKRNGSTEQKNKYLPKL 120 EEYGGA MGY AH+VA+EEISRASAS+GLSYGAHSNLCVNQI RNG+ QK KYLPKL Sbjct: 61 VSEEYGGANMGYTAHMVAMEEISRASASIGLSYGAHSNLCVNQIHRNGTEAQKQKYLPKL 120 Query: 121 ISGDFIGALAMSEPNAGSDVVSMKLRADKKGDRYVLNGSKMWITNGPDADVLVVYAKTDL 180 +SG+ IGALAMSEPNAGSDVVSMKLRADK+GDRYVLNG+KMWITNGPD D LVVYAKTD+ Sbjct: 121 VSGEHIGALAMSEPNAGSDVVSMKLRADKRGDRYVLNGTKMWITNGPDCDTLVVYAKTDI 180 Query: 181 EAGARGMTAFLVEKGFKGFSVAQKLDKLGMRGSHTGELVFQDCEVPAENVLGGIGRGVNV 240 EAG RG+TAF+VEKG KGFSVAQKLDKLGMRGSHTGELVFQD EVP EN+LG + GV V Sbjct: 181 EAGPRGITAFIVEKGMKGFSVAQKLDKLGMRGSHTGELVFQDVEVPEENILGQLNGGVKV 240 Query: 241 LMSGLDFERTVLSGGPLGIMQACMDVVVPYVHDRKQFGQSIGEFQLMQGKIADMYSTMMA 300 LMSGLD+ER VLSGGP GIM AC+D VVPY+HDRKQFGQ+IGEFQL+QGK+ADMY+T A Sbjct: 241 LMSGLDYERAVLSGGPTGIMAACLDAVVPYIHDRKQFGQAIGEFQLIQGKVADMYTTFQA 300 Query: 301 CKAYVYAVGQACDRAKTPDAVRALRKDAAGAILYSAEKATWMAGEAIQALGGNGYINEYP 360 C+AY+YAVG+ D A + D +R +RKD AG ILY+AEKATWMAGEAIQ LGGNGYINEYP Sbjct: 301 CRAYLYAVGRHLDSAGS-DHIRQVRKDCAGVILYTAEKATWMAGEAIQILGGNGYINEYP 359 Query: 361 VGRLWRDAKLYEIGAGTSEIRRMLIGRELFAETM 394 VGRLWRDAKLYEIGAGTSEIRRMLIGRELFAETM Sbjct: 360 VGRLWRDAKLYEIGAGTSEIRRMLIGRELFAETM 393