BLASTP 2.2.21 [Jun-14-2009] Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), "Gapped BLAST and PSI-BLAST: a new generation of protein database search programs", Nucleic Acids Res. 25:3389-3402. Reference for compositional score matrix adjustment: Altschul, Stephen F., John C. Wootton, E. Michael Gertz, Richa Agarwala, Aleksandr Morgulis, Alejandro A. Schaffer, and Yi-Kuo Yu (2005) "Protein database searches using compositionally adjusted substitution matrices", FEBS J. 272:5101-5109. Query= 0037.0150.p (302 letters) Database: pfamseq 15,929,002 sequences; 5,169,768,107 total letters Searching..................................................done Score E Sequences producing significant alignments: (bits) Value D8IY38.1 D8IY38_HERSS Hydroxymethylglutaryl-CoA lyase protein EC... 540 e-152 A6SU67.1 A6SU67_JANMA Hydroxymethylglutaryl-CoA lyase EC=4.1.3.4 512 e-143 A4G1F2.2 A4G1F2_HERAR Hydroxymethylglutaryl-CoA lyase (HMG-CoA l... 510 e-143 A9IFQ7.1 A9IFQ7_BORPD Hydroxymethylglutaryl-CoA lyase EC=4.1.3.4 446 e-123 D5NKM8.1 D5NKM8_9BURK Pyruvate carboxyltransferase 446 e-123 >D8IY38.1 D8IY38_HERSS Hydroxymethylglutaryl-CoA lyase protein EC=4.1.3.4 Length = 302 Score = 540 bits (1392), Expect = e-152, Method: Compositional matrix adjust. Identities = 259/302 (85%), Positives = 282/302 (93%) Query: 1 MSLPKKVKIVEVGPRDGLQNEKETISAEVKIELVNRLTSAGFVNVEAASFVSPKWVPQMA 60 M+LPKKVKIVEVGPRDGLQNEK+TISAEVKIELVNRL +AGF NVEAASFVSPKWVPQMA Sbjct: 1 MNLPKKVKIVEVGPRDGLQNEKDTISAEVKIELVNRLAAAGFPNVEAASFVSPKWVPQMA 60 Query: 61 TSGEVMRGIARKPGVIYSALTPNMKGFEAALEAGADEVVIFGAASEAFSQKNINCSIAES 120 TS EVM GI R+PGV+YSAL PNMKGFEAALEAG DEVVIFGAASEAFSQKNINCSIAES Sbjct: 61 TSAEVMHGITRRPGVVYSALVPNMKGFEAALEAGVDEVVIFGAASEAFSQKNINCSIAES 120 Query: 121 IERFREVALAAKQHKIRLRAAVSCAFGCPYQGEVPLSSVSDVVGRFRDLGCDEIDIADTI 180 I+RF EVA AAK+H+ RLRAAVSCAFGCPYQGEVPL +V+DVV RFR+LGCDEIDIADTI Sbjct: 121 IDRFAEVARAAKEHRKRLRAAVSCAFGCPYQGEVPLEAVADVVRRFRELGCDEIDIADTI 180 Query: 181 GVATPNKVAPVMQAAIREFNIDGLSGHFHDTYGQALANIYASLEVGITIYHSSVAGLGGC 240 GVATP KV PVM+ AIREF+I+GLSGHFHDTYGQALANIYASL+ GI+IYH+SVAGLGGC Sbjct: 181 GVATPGKVRPVMETAIREFHIEGLSGHFHDTYGQALANIYASLQTGISIYHASVAGLGGC 240 Query: 241 PYAKGATGNVASEDVLYMMQGLGIDTGIDLDIVVDAGQFISQHLGRKAVSRAGNAIAAKR 300 PYAKGATGNVA+EDVLYMM GLGI+TG+DLD VV+AGQFISQ LGR++VSRAGNAIAAKR Sbjct: 241 PYAKGATGNVATEDVLYMMNGLGIETGVDLDAVVEAGQFISQQLGRRSVSRAGNAIAAKR 300 Query: 301 LG 302 G Sbjct: 301 AG 302 >A6SU67.1 A6SU67_JANMA Hydroxymethylglutaryl-CoA lyase EC=4.1.3.4 Length = 309 Score = 512 bits (1319), Expect = e-143, Method: Compositional matrix adjust. Identities = 249/299 (83%), Positives = 266/299 (88%) Query: 2 SLPKKVKIVEVGPRDGLQNEKETISAEVKIELVNRLTSAGFVNVEAASFVSPKWVPQMAT 61 SLP VKI+EVGPRDGLQNE++TISAE KIELVNRL+ AGF NVEAASFVSPKWVPQMAT Sbjct: 6 SLPASVKIIEVGPRDGLQNEQQTISAETKIELVNRLSQAGFPNVEAASFVSPKWVPQMAT 65 Query: 62 SGEVMRGIARKPGVIYSALTPNMKGFEAALEAGADEVVIFGAASEAFSQKNINCSIAESI 121 S EVM GI R+PG +YSAL PNMKGFEAAL AG DEVVIF AASEAFSQKNINCSIAESI Sbjct: 66 SSEVMAGITRRPGTLYSALVPNMKGFEAALAAGVDEVVIFAAASEAFSQKNINCSIAESI 125 Query: 122 ERFREVALAAKQHKIRLRAAVSCAFGCPYQGEVPLSSVSDVVGRFRDLGCDEIDIADTIG 181 RFR+VA AAKQH +RLR A+SCAFGCPYQGEV SV+DVV + R+LGCDEIDIADTIG Sbjct: 126 ARFRDVAQAAKQHHLRLRGALSCAFGCPYQGEVTADSVADVVRQLRELGCDEIDIADTIG 185 Query: 182 VATPNKVAPVMQAAIREFNIDGLSGHFHDTYGQALANIYASLEVGITIYHSSVAGLGGCP 241 VATP V VMQ AI EF ID LSGHFHDTYGQALANIYASLEVGI+IYH+SVAGLGGCP Sbjct: 186 VATPRHVQAVMQRAIGEFPIDRLSGHFHDTYGQALANIYASLEVGISIYHASVAGLGGCP 245 Query: 242 YAKGATGNVASEDVLYMMQGLGIDTGIDLDIVVDAGQFISQHLGRKAVSRAGNAIAAKR 300 YAKGATGNVA+EDVLYMMQG GI+TGIDLD VVDAGQFIS+ LGRKAVSRAGNAIAAKR Sbjct: 246 YAKGATGNVATEDVLYMMQGFGIETGIDLDAVVDAGQFISEQLGRKAVSRAGNAIAAKR 304 >A4G1F2.2 A4G1F2_HERAR Hydroxymethylglutaryl-CoA lyase (HMG-CoA lyase) (HL) (3-hydroxy-3-methylglutarate-CoA lyase) EC=4.1.3.4 Length = 305 Score = 510 bits (1314), Expect = e-143, Method: Compositional matrix adjust. Identities = 246/299 (82%), Positives = 269/299 (89%) Query: 2 SLPKKVKIVEVGPRDGLQNEKETISAEVKIELVNRLTSAGFVNVEAASFVSPKWVPQMAT 61 SLPK VKI+EVGPRDGLQNE++TISA+VKIELVNRL+ AGFVN+EAASFVSPKWVPQMAT Sbjct: 5 SLPKAVKIIEVGPRDGLQNEQQTISADVKIELVNRLSQAGFVNIEAASFVSPKWVPQMAT 64 Query: 62 SGEVMRGIARKPGVIYSALTPNMKGFEAALEAGADEVVIFGAASEAFSQKNINCSIAESI 121 S EVM GI R+PG +YSAL PNMKGFEAAL AG DEVVIF AASEAFSQKNINCSIAES+ Sbjct: 65 SAEVMAGITRRPGTLYSALVPNMKGFEAALAAGVDEVVIFAAASEAFSQKNINCSIAESV 124 Query: 122 ERFREVALAAKQHKIRLRAAVSCAFGCPYQGEVPLSSVSDVVGRFRDLGCDEIDIADTIG 181 ERFR+VA AAK++K+RLR A+SCAFGCPYQGEV SV+ VV + RDLGCDEIDIADTIG Sbjct: 125 ERFRDVARAAKENKLRLRGALSCAFGCPYQGEVSADSVASVVQQLRDLGCDEIDIADTIG 184 Query: 182 VATPNKVAPVMQAAIREFNIDGLSGHFHDTYGQALANIYASLEVGITIYHSSVAGLGGCP 241 VATP V VMQ A +EF I+ LSGHFHDTYGQALANIYASLEVGITIYH+SVAGLGGCP Sbjct: 185 VATPRHVQAVMQRAAQEFPIEKLSGHFHDTYGQALANIYASLEVGITIYHASVAGLGGCP 244 Query: 242 YAKGATGNVASEDVLYMMQGLGIDTGIDLDIVVDAGQFISQHLGRKAVSRAGNAIAAKR 300 YAKGATGNVA+EDVLYM++GLGI TGIDLD VVDAGQFIS LGRKAVSRAGNA+AAKR Sbjct: 245 YAKGATGNVATEDVLYMLRGLGIATGIDLDKVVDAGQFISAQLGRKAVSRAGNALAAKR 303 >A9IFQ7.1 A9IFQ7_BORPD Hydroxymethylglutaryl-CoA lyase EC=4.1.3.4 Length = 302 Score = 446 bits (1147), Expect = e-123, Method: Compositional matrix adjust. Identities = 215/300 (71%), Positives = 247/300 (82%) Query: 1 MSLPKKVKIVEVGPRDGLQNEKETISAEVKIELVNRLTSAGFVNVEAASFVSPKWVPQMA 60 M LP +VKIVEV PRDGLQNEKE IS ++K+ELV+RLT+AGF N+EA SFVSPKWVPQMA Sbjct: 1 MPLPSRVKIVEVSPRDGLQNEKELISTDIKVELVDRLTAAGFPNIEATSFVSPKWVPQMA 60 Query: 61 TSGEVMRGIARKPGVIYSALTPNMKGFEAALEAGADEVVIFGAASEAFSQKNINCSIAES 120 + +VM I RKPGVIYS LTPNMKG E AL A ADEVVIFGAASEAFSQKNINCSIAES Sbjct: 61 DATDVMARIQRKPGVIYSVLTPNMKGLEGALAAKADEVVIFGAASEAFSQKNINCSIAES 120 Query: 121 IERFREVALAAKQHKIRLRAAVSCAFGCPYQGEVPLSSVSDVVGRFRDLGCDEIDIADTI 180 I RF VA AA+ +RLR ++SCA GCPYQGEVP+ +V DV R+ LGCDEID+ADTI Sbjct: 121 ITRFEPVAEAARAAGVRLRGSISCALGCPYQGEVPIEAVVDVARRYVALGCDEIDVADTI 180 Query: 181 GVATPNKVAPVMQAAIREFNIDGLSGHFHDTYGQALANIYASLEVGITIYHSSVAGLGGC 240 GV TP +V VM A + + +SGHFHDTYGQALANI A+LE GI+I+H+SVAGLGGC Sbjct: 181 GVGTPQRVRDVMTAVTQVVDPGRVSGHFHDTYGQALANILAALETGISIFHTSVAGLGGC 240 Query: 241 PYAKGATGNVASEDVLYMMQGLGIDTGIDLDIVVDAGQFISQHLGRKAVSRAGNAIAAKR 300 PYAKGATGNVA+EDVLYM++GLGI+TGID D VVD GQ++S HL RK SRAGNA+AAKR Sbjct: 241 PYAKGATGNVATEDVLYMLRGLGINTGIDFDAVVDIGQWMSAHLNRKGGSRAGNAVAAKR 300 >D5NKM8.1 D5NKM8_9BURK Pyruvate carboxyltransferase Length = 308 Score = 446 bits (1146), Expect = e-123, Method: Compositional matrix adjust. Identities = 217/299 (72%), Positives = 246/299 (82%) Query: 1 MSLPKKVKIVEVGPRDGLQNEKETISAEVKIELVNRLTSAGFVNVEAASFVSPKWVPQMA 60 M+LP++VKIVEVGPRDGLQNEKE + KIEL+NRL++AGF NVEAASFVSPKWVPQMA Sbjct: 1 MALPQQVKIVEVGPRDGLQNEKEFVPTATKIELINRLSAAGFRNVEAASFVSPKWVPQMA 60 Query: 61 TSGEVMRGIARKPGVIYSALTPNMKGFEAALEAGADEVVIFGAASEAFSQKNINCSIAES 120 +VM GI R+PG IYS LTPN++GFE AL A ADE+VIFGAASEAFSQKNINCSIAES Sbjct: 61 DGADVMAGIERRPGTIYSVLTPNLRGFEGALAARADEIVIFGAASEAFSQKNINCSIAES 120 Query: 121 IERFREVALAAKQHKIRLRAAVSCAFGCPYQGEVPLSSVSDVVGRFRDLGCDEIDIADTI 180 I+RF VA AAK+H +R+R +VSCA GCPYQGEVP++SV+DVV RF LGCDEIDIADTI Sbjct: 121 IDRFAPVAQAAKEHGVRIRGSVSCALGCPYQGEVPVASVADVVERFAALGCDEIDIADTI 180 Query: 181 GVATPNKVAPVMQAAIREFNIDGLSGHFHDTYGQALANIYASLEVGITIYHSSVAGLGGC 240 GV TP + V +A R F LSGHFHDTYGQALANIYA+L GI IYH+SVAGLGGC Sbjct: 181 GVGTPKRTREVFEAVTRVFPRKRLSGHFHDTYGQALANIYAALLEGIEIYHASVAGLGGC 240 Query: 241 PYAKGATGNVASEDVLYMMQGLGIDTGIDLDIVVDAGQFISQHLGRKAVSRAGNAIAAK 299 PYAKGATGNVA+EDVLY+M GLGI+TGIDL VV G FIS +GR VSRAG A+ AK Sbjct: 241 PYAKGATGNVATEDVLYLMNGLGIETGIDLAQVVAIGDFISTSIGRPNVSRAGKALLAK 299