BLASTP 2.2.21 [Jun-14-2009] Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), "Gapped BLAST and PSI-BLAST: a new generation of protein database search programs", Nucleic Acids Res. 25:3389-3402. Reference for compositional score matrix adjustment: Altschul, Stephen F., John C. Wootton, E. Michael Gertz, Richa Agarwala, Aleksandr Morgulis, Alejandro A. Schaffer, and Yi-Kuo Yu (2005) "Protein database searches using compositionally adjusted substitution matrices", FEBS J. 272:5101-5109. Query= 0034.0346.p (431 letters) Database: pfamseq 15,929,002 sequences; 5,169,768,107 total letters Searching..................................................done Score E Sequences producing significant alignments: (bits) Value D8ITX5.1 D8ITX5_HERSS Glutamate-cysteine ligase protein EC=6.3.2.2 799 0.0 F1W229.1 F1W229_9BURK Glutamate-cysteine ligase 750 0.0 A4G1J3.1 A4G1J3_HERAR Glutamate--cysteine ligase 747 0.0 A6SUB4.1 A6SUB4_JANMA Glutamate--cysteine ligase EC=6.3.2.2 746 0.0 C3XBU4.1 C3XBU4_OXAFO Glutathione synthetase 707 0.0 >D8ITX5.1 D8ITX5_HERSS Glutamate-cysteine ligase protein EC=6.3.2.2 Length = 433 Score = 799 bits (2063), Expect = 0.0, Method: Compositional matrix adjust. Identities = 380/433 (87%), Positives = 411/433 (94%), Gaps = 2/433 (0%) Query: 1 MVPHLVTALNGPLLDLEKKILGATPAIERWFRMEWQEHTPPFYCSVDLRNAGFKLAPVDT 60 MVPHLVTALNGPLL+LEKKILGATPAIERWFRMEWQEHTPPFYCSVDLRNAGFKLAPVDT Sbjct: 1 MVPHLVTALNGPLLELEKKILGATPAIERWFRMEWQEHTPPFYCSVDLRNAGFKLAPVDT 60 Query: 61 NLFPGGFNNLSPEMLPLAVQAAMAAIEKYCPDAKNLLLIPENHIRNSFYLQNVARLMQIF 120 NLFPGGFNNLSPEMLPLAVQAAMAAIEKYCPDA+NLLLIPENH N+FYLQN+ARLMQIF Sbjct: 61 NLFPGGFNNLSPEMLPLAVQAAMAAIEKYCPDARNLLLIPENHTGNTFYLQNIARLMQIF 120 Query: 121 RQTGLNVRLGTLE-DIKKPKLIDLPDGSTITLEPLERSKNGRRLGLKNFDPCTVLLNNDL 179 RQTGLNVRLG+L + KPK I+LPDG+TITLEPLERS NGRRLGLKNFDPCTVLLNNDL Sbjct: 121 RQTGLNVRLGSLAPGVNKPKPIELPDGTTITLEPLERSANGRRLGLKNFDPCTVLLNNDL 180 Query: 180 SIGIPSVLENLDEQNVLPPLHAGWAVRRKSNHFSAYDDVVKKFAKLVDVDPWMLNPLYAK 239 SIGIPSVLE L EQ+VLPPLHAGWA+RRKSNHF+AYD+VVKKFAK+V+VDPWMLNPL+AK Sbjct: 181 SIGIPSVLEGLHEQSVLPPLHAGWAMRRKSNHFAAYDEVVKKFAKMVEVDPWMLNPLFAK 240 Query: 240 CGELNLQEDAGSDCLADNVSSLLSKIRKKYKEYGIKEQPFVIVKANAGTYGMGIMTVKDA 299 +++ QE G+D LAD+VSSLLSKIRKKYKEYGIKEQPFV VKANAGTYGMGIMTVKDA Sbjct: 241 VSDIDFQESTGTDALADSVSSLLSKIRKKYKEYGIKEQPFVFVKANAGTYGMGIMTVKDA 300 Query: 300 SEVKDLNRQQRSK-LAVGKEGLEVNELVIQEGVHSFERINEAVAEPVVYMIDRYVVGGFY 358 SE+KDLNR+QR+ LA GKEGLEV+E+++QEGVHSFERIN+AVAEPVVYMIDRYVVGGFY Sbjct: 301 SEIKDLNRKQRTGMLAAGKEGLEVSEVIVQEGVHSFERINQAVAEPVVYMIDRYVVGGFY 360 Query: 359 RVHADRDINENLNAPGAHFVPLAFQQQHALPDLQAKPGTAAPNRFYMYGVVARLALLAAS 418 RVHADRD+NENLNAPGAHFVPLAF QQHALPD+ AKPGTAAPNRFYMYGVVARLALLAAS Sbjct: 361 RVHADRDVNENLNAPGAHFVPLAFAQQHALPDMHAKPGTAAPNRFYMYGVVARLALLAAS 420 Query: 419 LEMEKTDPNPEVY 431 +EMEKTDPNPEVY Sbjct: 421 VEMEKTDPNPEVY 433 >F1W229.1 F1W229_9BURK Glutamate-cysteine ligase Length = 432 Score = 750 bits (1937), Expect = 0.0, Method: Compositional matrix adjust. Identities = 348/432 (80%), Positives = 397/432 (91%), Gaps = 1/432 (0%) Query: 1 MVPHLVTALNGPLLDLEKKILGATPAIERWFRMEWQEHTPPFYCSVDLRNAGFKLAPVDT 60 MVPHLVTALNGPLLDLEKKIL TPAIERWFR+EWQEHTPPFYCSVDLRNAGFKLAPVDT Sbjct: 1 MVPHLVTALNGPLLDLEKKILNNTPAIERWFRLEWQEHTPPFYCSVDLRNAGFKLAPVDT 60 Query: 61 NLFPGGFNNLSPEMLPLAVQAAMAAIEKYCPDAKNLLLIPENHIRNSFYLQNVARLMQIF 120 NL+PGGFNNL+PEMLPLAVQAAMAAIEKYCPDA+NLLLIPE + RNSFYLQN+ARLMQIF Sbjct: 61 NLYPGGFNNLAPEMLPLAVQAAMAAIEKYCPDARNLLLIPEGNTRNSFYLQNIARLMQIF 120 Query: 121 RQTGLNVRLGTLE-DIKKPKLIDLPDGSTITLEPLERSKNGRRLGLKNFDPCTVLLNNDL 179 RQTGLNVRLG+ DI P IDLPDG+T+TLEPLERS NGRRLGLKNFDPCT+LLNNDL Sbjct: 121 RQTGLNVRLGSFSPDITGPTPIDLPDGTTLTLEPLERSANGRRLGLKNFDPCTILLNNDL 180 Query: 180 SIGIPSVLENLDEQNVLPPLHAGWAVRRKSNHFSAYDDVVKKFAKLVDVDPWMLNPLYAK 239 S GIP + +NL+EQ +LPPLHAGWAVRRKSNHFSAYD+VVKKFAK+ D+DPWMLNP +AK Sbjct: 181 SAGIPEIFDNLNEQTLLPPLHAGWAVRRKSNHFSAYDEVVKKFAKMNDIDPWMLNPYFAK 240 Query: 240 CGELNLQEDAGSDCLADNVSSLLSKIRKKYKEYGIKEQPFVIVKANAGTYGMGIMTVKDA 299 CG+++ + +G D L V +LL+KIRKKY+EYGIKE PFVI+KA+AGTYGMGIMTVK+ Sbjct: 241 CGQVDFNDHSGEDALIVQVDALLTKIRKKYREYGIKETPFVIIKADAGTYGMGIMTVKEG 300 Query: 300 SEVKDLNRQQRSKLAVGKEGLEVNELVIQEGVHSFERINEAVAEPVVYMIDRYVVGGFYR 359 SEV+ ++R+QRS++AV K+GLEV ++++QEGVH+FERIN++VAEPVV MIDRYVVGG+YR Sbjct: 301 SEVRSMDRKQRSRMAVVKDGLEVTDVILQEGVHTFERINDSVAEPVVMMIDRYVVGGYYR 360 Query: 360 VHADRDINENLNAPGAHFVPLAFQQQHALPDLQAKPGTAAPNRFYMYGVVARLALLAASL 419 VHADRDINENLNAPGAHFVPLAF QQH+LPD+ AKPGTAAPNRFY+YGVVARLALLAAS+ Sbjct: 361 VHADRDINENLNAPGAHFVPLAFAQQHSLPDMHAKPGTAAPNRFYLYGVVARLALLAASI 420 Query: 420 EMEKTDPNPEVY 431 E+EKTDPNPEVY Sbjct: 421 ELEKTDPNPEVY 432 >A4G1J3.1 A4G1J3_HERAR Glutamate--cysteine ligase Length = 432 Score = 747 bits (1929), Expect = 0.0, Method: Compositional matrix adjust. Identities = 363/432 (84%), Positives = 400/432 (92%), Gaps = 1/432 (0%) Query: 1 MVPHLVTALNGPLLDLEKKILGATPAIERWFRMEWQEHTPPFYCSVDLRNAGFKLAPVDT 60 MVPHLVTALNGPLLDLEKKIL ATPAIERWFR+EWQEHTPPFYCSVDLRNAGFKLAPVDT Sbjct: 1 MVPHLVTALNGPLLDLEKKILTATPAIERWFRLEWQEHTPPFYCSVDLRNAGFKLAPVDT 60 Query: 61 NLFPGGFNNLSPEMLPLAVQAAMAAIEKYCPDAKNLLLIPENHIRNSFYLQNVARLMQIF 120 NLFPGGFNNLSPEMLPLAVQAAMAAIEKYCPDAKNLLLIPE H RN+FYLQN+ARL+QIF Sbjct: 61 NLFPGGFNNLSPEMLPLAVQAAMAAIEKYCPDAKNLLLIPEAHTRNTFYLQNIARLIQIF 120 Query: 121 RQTGLNVRLGTLE-DIKKPKLIDLPDGSTITLEPLERSKNGRRLGLKNFDPCTVLLNNDL 179 RQTGLNVRLG+L DI P I+LPDG+T+TLEPLERS NGRRLGLKNFDPCT+LLNNDL Sbjct: 121 RQTGLNVRLGSLSPDITAPTPIELPDGTTLTLEPLERSHNGRRLGLKNFDPCTILLNNDL 180 Query: 180 SIGIPSVLENLDEQNVLPPLHAGWAVRRKSNHFSAYDDVVKKFAKLVDVDPWMLNPLYAK 239 S G+P++LENL EQN+LPPLHAGWAVRRK+NHF+AYD+VVKKFAK++DVDPWMLNP + K Sbjct: 181 SSGLPAILENLHEQNLLPPLHAGWAVRRKTNHFAAYDEVVKKFAKMIDVDPWMLNPYFMK 240 Query: 240 CGELNLQEDAGSDCLADNVSSLLSKIRKKYKEYGIKEQPFVIVKANAGTYGMGIMTVKDA 299 C +N E+ G DCLA NV +LL+K+RKKYKEYGIKE+PFVIVKA+AGTYGMGIMTV DA Sbjct: 241 CDNVNFNENTGEDCLASNVDTLLAKMRKKYKEYGIKEKPFVIVKADAGTYGMGIMTVHDA 300 Query: 300 SEVKDLNRQQRSKLAVGKEGLEVNELVIQEGVHSFERINEAVAEPVVYMIDRYVVGGFYR 359 SEVKDLNR+QR+K+AV K+GLEV +++IQEGV +FE INE+VAEPVVYMIDRYVVGGFYR Sbjct: 301 SEVKDLNRKQRNKMAVIKDGLEVTDVIIQEGVPTFEHINESVAEPVVYMIDRYVVGGFYR 360 Query: 360 VHADRDINENLNAPGAHFVPLAFQQQHALPDLQAKPGTAAPNRFYMYGVVARLALLAASL 419 VHADR +ENLNAPGAHFVPLAF QHALPD QAKPGTAAPNRFY+YGVVARLALLAASL Sbjct: 361 VHADRGNDENLNAPGAHFVPLAFAHQHALPDYQAKPGTAAPNRFYIYGVVARLALLAASL 420 Query: 420 EMEKTDPNPEVY 431 EMEKTDPNPEVY Sbjct: 421 EMEKTDPNPEVY 432 >A6SUB4.1 A6SUB4_JANMA Glutamate--cysteine ligase EC=6.3.2.2 Length = 432 Score = 746 bits (1926), Expect = 0.0, Method: Compositional matrix adjust. Identities = 358/432 (82%), Positives = 401/432 (92%), Gaps = 1/432 (0%) Query: 1 MVPHLVTALNGPLLDLEKKILGATPAIERWFRMEWQEHTPPFYCSVDLRNAGFKLAPVDT 60 MVPHLVTALNGPLLDLEKKIL ATPAIERWFR+EWQEHTPPFYCSVDLRNAGFKLAPVDT Sbjct: 1 MVPHLVTALNGPLLDLEKKILTATPAIERWFRLEWQEHTPPFYCSVDLRNAGFKLAPVDT 60 Query: 61 NLFPGGFNNLSPEMLPLAVQAAMAAIEKYCPDAKNLLLIPENHIRNSFYLQNVARLMQIF 120 NLFPGGFNNLSPEMLPLAVQAAMAAIEKYCPDAKNLLL+PE H RN+FYLQNVARLMQIF Sbjct: 61 NLFPGGFNNLSPEMLPLAVQAAMAAIEKYCPDAKNLLLVPEGHTRNTFYLQNVARLMQIF 120 Query: 121 RQTGLNVRLGTLE-DIKKPKLIDLPDGSTITLEPLERSKNGRRLGLKNFDPCTVLLNNDL 179 RQTGLNVRLG+L D+ P IDLPDG+T+TLEPLERS+NGRR+GLKNFDPCT+LLNNDL Sbjct: 121 RQTGLNVRLGSLSPDVTGPTPIDLPDGTTLTLEPLERSQNGRRVGLKNFDPCTILLNNDL 180 Query: 180 SIGIPSVLENLDEQNVLPPLHAGWAVRRKSNHFSAYDDVVKKFAKLVDVDPWMLNPLYAK 239 S G+PS+L+N++EQN+LPPLHAGWAVRRK+NHF+AYD+VVKKFAKL+DVDPWMLNP + K Sbjct: 181 SSGLPSILQNVNEQNLLPPLHAGWAVRRKTNHFAAYDEVVKKFAKLIDVDPWMLNPFFMK 240 Query: 240 CGELNLQEDAGSDCLADNVSSLLSKIRKKYKEYGIKEQPFVIVKANAGTYGMGIMTVKDA 299 C +N + G DCLA NV +LL+K+RKKYKEYGIKE+PFVI+KA+AGTYGMGIMTV DA Sbjct: 241 CEGINFNDSTGEDCLASNVDTLLAKMRKKYKEYGIKEKPFVIIKADAGTYGMGIMTVHDA 300 Query: 300 SEVKDLNRQQRSKLAVGKEGLEVNELVIQEGVHSFERINEAVAEPVVYMIDRYVVGGFYR 359 SEVKDLNR+QR+K++V K+GLEV ++++QEGV +FERINE+VAEPVVYMIDRYVVGGFYR Sbjct: 301 SEVKDLNRKQRNKMSVVKDGLEVTDVILQEGVPTFERINESVAEPVVYMIDRYVVGGFYR 360 Query: 360 VHADRDINENLNAPGAHFVPLAFQQQHALPDLQAKPGTAAPNRFYMYGVVARLALLAASL 419 VH++R +ENLNAPGAHFVPLAF QHALPD QAKPGT APNRFYMYGVVARLALLAASL Sbjct: 361 VHSERGNHENLNAPGAHFVPLAFAHQHALPDYQAKPGTVAPNRFYMYGVVARLALLAASL 420 Query: 420 EMEKTDPNPEVY 431 EMEKTDPNPEVY Sbjct: 421 EMEKTDPNPEVY 432 >C3XBU4.1 C3XBU4_OXAFO Glutathione synthetase Length = 431 Score = 707 bits (1826), Expect = 0.0, Method: Compositional matrix adjust. Identities = 322/428 (75%), Positives = 386/428 (90%), Gaps = 1/428 (0%) Query: 1 MVPHLVTALNGPLLDLEKKILGATPAIERWFRMEWQEHTPPFYCSVDLRNAGFKLAPVDT 60 MVPHLVTALNGPLL+LEK I+ +TPAIERWFR+EWQ+HTPPFYCSVDLRNAGFKLAPVDT Sbjct: 1 MVPHLVTALNGPLLELEKTIIDSTPAIERWFRLEWQDHTPPFYCSVDLRNAGFKLAPVDT 60 Query: 61 NLFPGGFNNLSPEMLPLAVQAAMAAIEKYCPDAKNLLLIPENHIRNSFYLQNVARLMQIF 120 NLFPGGFNNLS EMLPLAVQA MAAIEKYCPDAKNLLL+PE+H RN++YLQN+ARL++I Sbjct: 61 NLFPGGFNNLSVEMLPLAVQATMAAIEKYCPDAKNLLLVPESHTRNTYYLQNIARLIKIL 120 Query: 121 RQTGLNVRLGTL-EDIKKPKLIDLPDGSTITLEPLERSKNGRRLGLKNFDPCTVLLNNDL 179 RQTGL+VR+G+L EDIK+P + LPDG+T+ +EPL+R NGRR+G+ +F+PCT+LLNNDL Sbjct: 121 RQTGLDVRIGSLSEDIKEPTPLILPDGTTLMMEPLKRINNGRRVGVDDFNPCTILLNNDL 180 Query: 180 SIGIPSVLENLDEQNVLPPLHAGWAVRRKSNHFSAYDDVVKKFAKLVDVDPWMLNPLYAK 239 S G P +L N+ EQ++ PPLHAGW VRRKSNHF+AYDDV K+F+K++ +DPW+LNP ++K Sbjct: 181 SSGTPEILRNVYEQSLFPPLHAGWTVRRKSNHFAAYDDVAKRFSKMLGIDPWLLNPFFSK 240 Query: 240 CGELNLQEDAGSDCLADNVSSLLSKIRKKYKEYGIKEQPFVIVKANAGTYGMGIMTVKDA 299 C +N E G +CLA +V S+L+KIR+KYK+YGIKE+PFVIVKA+AGTYGMGIMTV DA Sbjct: 241 CSHVNFSEHEGEECLAASVHSVLTKIRRKYKQYGIKEKPFVIVKADAGTYGMGIMTVTDA 300 Query: 300 SEVKDLNRQQRSKLAVGKEGLEVNELVIQEGVHSFERINEAVAEPVVYMIDRYVVGGFYR 359 SEVKDLNR+QR+K++VGKEGL V +++IQEGVHSFER++EAVAEPVVYMIDRYVVGGFYR Sbjct: 301 SEVKDLNRKQRNKMSVGKEGLPVRDVIIQEGVHSFERVDEAVAEPVVYMIDRYVVGGFYR 360 Query: 360 VHADRDINENLNAPGAHFVPLAFQQQHALPDLQAKPGTAAPNRFYMYGVVARLALLAASL 419 V+ RDINENLNAPGAHFVPLAF QQH +PD A+PGTAAPNRFYMYGVVARLALLAAS+ Sbjct: 361 VNEKRDINENLNAPGAHFVPLAFAQQHTIPDRSAEPGTAAPNRFYMYGVVARLALLAASI 420 Query: 420 EMEKTDPN 427 E+E+TDP+ Sbjct: 421 ELERTDPD 428