BLASTP 2.2.21 [Jun-14-2009]

Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Reference for compositional score matrix adjustment: Altschul, Stephen F., 
John C. Wootton, E. Michael Gertz, Richa Agarwala, Aleksandr Morgulis,
Alejandro A. Schaffer, and Yi-Kuo Yu (2005) "Protein database searches
using compositionally adjusted substitution matrices", FEBS J. 272:5101-5109.

Query= 0034.0284.p         (211 letters)

Database: pfamseq 
           15,929,002 sequences; 5,169,768,107 total letters

Searching..................................................done



                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

D8IUV3.1 D8IUV3_HERSS 4-hydroxybutyrate dehydrogenase protein EC...   166   1e-39
D0J4S8.1 D0J4S8_COMT2 Iron-containing alcohol dehydrogenase           126   3e-27
D8D307.1 D8D307_COMTE Iron-containing alcohol dehydrogenase           125   5e-27
Q7W8P8.1 Q7W8P8_BORPA NAD-dependent 4-hydroxybutyrate dehydrogen...   122   2e-26
Q7WMB2.1 Q7WMB2_BORBR NAD-dependent 4-hydroxybutyrate dehydrogen...   122   3e-26

>D8IUV3.1 D8IUV3_HERSS 4-hydroxybutyrate dehydrogenase protein EC=1.1.1.61
          Length = 379

 Score =  166 bits (421), Expect = 1e-39,   Method: Compositional matrix adjust.
 Identities = 80/116 (68%), Positives = 92/116 (79%), Gaps = 4/116 (3%)

Query: 1   MALINYITQVQFDFGALALLQQECDRIGIRKPLIVTDMGIRNAGILDKVVAQLKDGAQVA 60
           MALINYITQVQFD+GALALLQQECDR+GI+KPL+VTDMGIRNAG+LDKV+ QLK+G    
Sbjct: 1   MALINYITQVQFDYGALALLQQECDRLGIKKPLVVTDMGIRNAGLLDKVLGQLKEGVGAV 60

Query: 61  VFDQTPPNPNEAAVRAAVKLFRDSACDGIMTRVALGLIAKIHAARRVHHICGIHRS 116
           V+DQTPPNPNE AVRAAV LFR   CDGI   VA+G  + I  A+ V  +CG H  
Sbjct: 61  VYDQTPPNPNEGAVRAAVALFRQHGCDGI---VAVGGGSSIDLAKGV-AVCGTHEG 112


>D0J4S8.1 D0J4S8_COMT2 Iron-containing alcohol dehydrogenase
          Length = 378

 Score =  126 bits (316), Expect = 3e-27,   Method: Compositional matrix adjust.
 Identities = 72/178 (40%), Positives = 102/178 (57%), Gaps = 14/178 (7%)

Query: 1   MALINYITQVQFDFGALALLQQECDRIGIRKPLIVTDMGIRNAGILDKVVAQLKDGAQVA 60
           MA INY+TQ+QFDFGA+ +L+QEC+R+GI KPLIVTD G++ AGIL K +  L  G   A
Sbjct: 1   MAFINYVTQIQFDFGAVQMLRQECERVGISKPLIVTDPGVKAAGILQKAINALG-GLPHA 59

Query: 61  VFDQTPPNPNEAAVRAAVKLFRDSACDGIMTRVALGLIAKIHAARRVHHICGIHRSRRMS 120
           VFDQTP NP EAAVRAA +++R   CDG+   +A+G  + I  A+ V  I   H      
Sbjct: 60  VFDQTPSNPTEAAVRAAAEIYRSQNCDGL---IAVGGGSAIDCAKGV-AIAATHEGPLSY 115

Query: 121 QANMRSSTNRRDQLIRTVL---------QEIAYAQLRLGDDADRAGRQRLHRHPRATL 169
            A +   + R  + +  ++          E+A   + + DD  + G    H  P+A +
Sbjct: 116 YATIEGGSPRITERVAPLIAVPTTSGTGSEVARGAIIIVDDHRKLGFHSWHLVPKAAI 173


>D8D307.1 D8D307_COMTE Iron-containing alcohol dehydrogenase
          Length = 378

 Score =  125 bits (313), Expect = 5e-27,   Method: Compositional matrix adjust.
 Identities = 71/178 (39%), Positives = 102/178 (57%), Gaps = 14/178 (7%)

Query: 1   MALINYITQVQFDFGALALLQQECDRIGIRKPLIVTDMGIRNAGILDKVVAQLKDGAQVA 60
           MA INY+TQ+QFDFGA+ +L+QEC+R+GI KPLIVTD G++ AGIL K +  L  G   A
Sbjct: 1   MAFINYVTQIQFDFGAVQMLRQECERVGISKPLIVTDPGVKAAGILQKAINALG-GLPHA 59

Query: 61  VFDQTPPNPNEAAVRAAVKLFRDSACDGIMTRVALGLIAKIHAARRVHHICGIHRSRRMS 120
           VFDQTP NP EAAVRAA ++++   CDG+   +A+G  + I  A+ V  I   H      
Sbjct: 60  VFDQTPSNPTEAAVRAAAEIYKSQNCDGL---IAVGGGSAIDCAKGV-AIAATHEGPLSY 115

Query: 121 QANMRSSTNRRDQLIRTVL---------QEIAYAQLRLGDDADRAGRQRLHRHPRATL 169
            A +   + R  + +  ++          E+A   + + DD  + G    H  P+A +
Sbjct: 116 YATIEGGSPRITERVAPLIAVPTTSGTGSEVARGAIIIVDDHRKLGFHSWHLVPKAAI 173


>Q7W8P8.1 Q7W8P8_BORPA NAD-dependent 4-hydroxybutyrate dehydrogenase
           EC=1.1.1.61
          Length = 379

 Score =  122 bits (307), Expect = 2e-26,   Method: Compositional matrix adjust.
 Identities = 62/116 (53%), Positives = 79/116 (68%), Gaps = 4/116 (3%)

Query: 1   MALINYITQVQFDFGALALLQQECDRIGIRKPLIVTDMGIRNAGILDKVVAQLKDGAQVA 60
           MALI Y+T +QFDFGA+ LLQ ECDRIGI++P++VTD GI+ AGILD  ++ L     V 
Sbjct: 1   MALIQYLTHIQFDFGAVRLLQAECDRIGIKRPMVVTDQGIQAAGILDAALSHLDRPDAVP 60

Query: 61  VFDQTPPNPNEAAVRAAVKLFRDSACDGIMTRVALGLIAKIHAARRVHHICGIHRS 116
           VFD TPPNPNE AVR AV ++  + CDGI   +ALG  + I  A+ V  +C  H  
Sbjct: 61  VFDATPPNPNEEAVRQAVAVYAANDCDGI---IALGGGSSIDLAKGV-AVCATHEG 112


>Q7WMB2.1 Q7WMB2_BORBR NAD-dependent 4-hydroxybutyrate dehydrogenase
           EC=1.1.1.61
          Length = 379

 Score =  122 bits (306), Expect = 3e-26,   Method: Compositional matrix adjust.
 Identities = 62/116 (53%), Positives = 79/116 (68%), Gaps = 4/116 (3%)

Query: 1   MALINYITQVQFDFGALALLQQECDRIGIRKPLIVTDMGIRNAGILDKVVAQLKDGAQVA 60
           MALI Y+T +QFDFGA+ LLQ ECDRIGI++P++VTD GI+ AGILD  ++ L     V 
Sbjct: 1   MALIQYLTHIQFDFGAVRLLQAECDRIGIKRPMVVTDQGIQAAGILDAALSHLDRPDVVP 60

Query: 61  VFDQTPPNPNEAAVRAAVKLFRDSACDGIMTRVALGLIAKIHAARRVHHICGIHRS 116
           VFD TPPNPNE AVR AV ++  + CDGI   +ALG  + I  A+ V  +C  H  
Sbjct: 61  VFDATPPNPNEEAVRQAVAVYAANDCDGI---IALGGGSSIDLAKGV-AVCATHEG 112