BLASTP 2.2.21 [Jun-14-2009] Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), "Gapped BLAST and PSI-BLAST: a new generation of protein database search programs", Nucleic Acids Res. 25:3389-3402. Reference for compositional score matrix adjustment: Altschul, Stephen F., John C. Wootton, E. Michael Gertz, Richa Agarwala, Aleksandr Morgulis, Alejandro A. Schaffer, and Yi-Kuo Yu (2005) "Protein database searches using compositionally adjusted substitution matrices", FEBS J. 272:5101-5109. Query= 0034.0143.p (294 letters) Database: pfamseq 15,929,002 sequences; 5,169,768,107 total letters Searching..................................................done Score E Sequences producing significant alignments: (bits) Value Q21ZN3.1 Q21ZN3_RHOFD 6-phosphogluconate dehydrogenase, NAD-binding 273 1e-71 A8TQ65.1 A8TQ65_9PROT 6-phosphogluconate dehydrogenase, NAD-bind... 272 5e-71 Q98K09.1 Q98K09_RHILO 3-hydroxyisobutyrate dehydrogenase 254 1e-65 E8TE02.1 E8TE02_MESCW 2-hydroxy-3-oxopropionate reductase EC=1.1... 254 1e-65 Q12H32.1 Q12H32_POLSJ 6-phosphogluconate dehydrogenase, NAD-bind... 253 2e-65 >Q21ZN3.1 Q21ZN3_RHOFD 6-phosphogluconate dehydrogenase, NAD-binding Length = 292 Score = 273 bits (699), Expect = 1e-71, Method: Compositional matrix adjust. Identities = 136/249 (54%), Positives = 170/249 (68%) Query: 4 IGFIGVGMMGQGMAHNLVIKGFNVTVMGNRNRKPVEELVAEGAREASSLQDLVANVNAII 63 IG IG+G+MG G+ NL+ GF +TVMGN NR PV+ LV+ GA E+ S+ +LV + ++ Sbjct: 9 IGLIGLGLMGHGIGRNLLKNGFALTVMGNVNRAPVDSLVSLGANESKSVAELVDASDVVM 68 Query: 64 LCVTGSPQVEDLIFRAGGILENCRSGQILIDCSTSEPMSSARIAAQLATKGVSFVDAPLA 123 LCVTGSPQVE L+ R GIL++ R GQI+IDCSTS+P SSA I A L G FVDAPL Sbjct: 69 LCVTGSPQVESLMNRDQGILQSIRPGQIVIDCSTSQPSSSAIINAALLEAGALFVDAPLG 128 Query: 124 RTPVEAMQGRLNTMVGADDATFAKVKPILEAFCENIFHIGGTTSAQKLKLLNNFIAIGTA 183 RTP EA G+LN MVGA ++P+L+AFCENI H+G SAQKLKL+NNF +GTA Sbjct: 129 RTPAEAEAGKLNVMVGATPQLLEHIRPVLQAFCENIIHVGEVISAQKLKLINNFAVVGTA 188 Query: 184 TLATEALAMCDAVGVDQRKFFDVISKGGANSGIFQMIAGGILEGRSDGMKFSIANAGKDL 243 L TEAL CD VGV ++ +D++SKG G+ Q IL GMKFSI NA KD+ Sbjct: 189 ALLTEALRACDQVGVSRQAMYDLMSKGPLQGGLLQATVAEILRENYAGMKFSINNAYKDI 248 Query: 244 SYYNNMTAA 252 Y+NNM A Sbjct: 249 GYFNNMLGA 257 >A8TQ65.1 A8TQ65_9PROT 6-phosphogluconate dehydrogenase, NAD-binding protein Length = 306 Score = 272 bits (695), Expect = 5e-71, Method: Compositional matrix adjust. Identities = 148/285 (51%), Positives = 188/285 (65%) Query: 3 NIGFIGVGMMGQGMAHNLVIKGFNVTVMGNRNRKPVEELVAEGAREASSLQDLVANVNAI 62 +G IG+GMMGQGM NL+ KGF +TV +R+R + L EGA + + + + Sbjct: 8 KVGLIGLGMMGQGMGSNLLRKGFPLTVTAHRDRTGADRLSKEGATVVDTPRAVAEMSEVV 67 Query: 63 ILCVTGSPQVEDLIFRAGGILENCRSGQILIDCSTSEPMSSARIAAQLATKGVSFVDAPL 122 ILCV GSPQVE ++ G+L RSG LIDCSTSEP S+ R++A + G FVDAPL Sbjct: 68 ILCVPGSPQVESVVMGTDGLLSAGRSGLTLIDCSTSEPSSTERVSAAIIGAGGRFVDAPL 127 Query: 123 ARTPVEAMQGRLNTMVGADDATFAKVKPILEAFCENIFHIGGTTSAQKLKLLNNFIAIGT 182 ARTPVEA GRLNTMVGAD TFA ++P+LEAFCENIFH+G + KLKL+NNF+A+G Sbjct: 128 ARTPVEAEAGRLNTMVGADPQTFAAIRPVLEAFCENIFHVGPIGAGHKLKLVNNFLAMGQ 187 Query: 183 ATLATEALAMCDAVGVDQRKFFDVISKGGANSGIFQMIAGGILEGRSDGMKFSIANAGKD 242 A+L EA C AVGV + F+VIS GGANSGIFQM+AG +G DGM+F IANA KD Sbjct: 188 ASLIAEAFEACSAVGVPLDRLFEVISAGGANSGIFQMVAGSAKDGNLDGMRFGIANAAKD 247 Query: 243 LSYYNNMTAAFANPSMIGPHVAATLQQSAKEGYGEQMLGAMVQAH 287 L YY MT A +G V L ++ G+GE ++G ++ A Sbjct: 248 LGYYTRMTDAVPLTGGLGHAVRRALVEARNLGFGEALVGHLIAAQ 292 >Q98K09.1 Q98K09_RHILO 3-hydroxyisobutyrate dehydrogenase Length = 312 Score = 254 bits (649), Expect = 1e-65, Method: Compositional matrix adjust. Identities = 121/257 (47%), Positives = 174/257 (67%), Gaps = 2/257 (0%) Query: 2 KNIGFIGVGMMGQGMAHNLVIKGFNVTVMGNRNRKPVEELVAEGAREASSLQDLVANVNA 61 + IGFIG+G+MG G+A N+V KG+ +T +G +NRKP E+L+ GAREAS+ +D+ + Sbjct: 8 EKIGFIGLGLMGHGIAKNIVDKGYPLTFLGRKNRKPAEDLLGRGAREASTSRDVAVASDI 67 Query: 62 IILCVTGSPQVEDLIFRAGGILENCRSGQILIDCSTSEPMSSARIAAQLATKGVSFVDAP 121 + +CVTGS +VE +I GG+ E + G +++DCSTS+P+S+ +AA+L G+ +VDAP Sbjct: 68 VFICVTGSREVEAIIRGPGGLKEGLKKGSVVVDCSTSDPVSTVALAAELKALGIDYVDAP 127 Query: 122 LARTPVEAMQGRLNTMVGADDATFAKVKPILEAFCENIFHIGGTTSAQKLKLLNNFIAIG 181 L+RTP EA +G L+ MVGA DA FA+VKP++E + I HIG T ++KLLNNFI++G Sbjct: 128 LSRTPKEAWEGTLDAMVGAPDAVFARVKPVIETWAGRIVHIGDTGDGHRMKLLNNFISLG 187 Query: 182 TATLATEALAMCDAVGVDQRKFFDVISKGGANSGIFQMIAGGILEGRSDGMKFSIANAGK 241 A + +EALA+ + VG+ +F VI G + G +Q LEG D KF+IANA K Sbjct: 188 YAAIYSEALALAEKVGISPPRFDSVIRNGRMDCGFYQTFMRWTLEGDRDAHKFTIANAFK 247 Query: 242 DLSYYNNM--TAAFANP 256 DL+Y +M A ANP Sbjct: 248 DLTYLESMAGAAGIANP 264 >E8TE02.1 E8TE02_MESCW 2-hydroxy-3-oxopropionate reductase EC=1.1.1.60 Length = 312 Score = 254 bits (648), Expect = 1e-65, Method: Compositional matrix adjust. Identities = 122/257 (47%), Positives = 174/257 (67%), Gaps = 2/257 (0%) Query: 2 KNIGFIGVGMMGQGMAHNLVIKGFNVTVMGNRNRKPVEELVAEGAREASSLQDLVANVNA 61 + IGFIG+G+MG G+A N+V KG+++T +G +NRKP E+L+ GA EAS+ +D+ A Sbjct: 8 EKIGFIGLGLMGHGIAKNIVDKGYSLTFLGRKNRKPAEDLLGRGATEASTSRDVAAASTI 67 Query: 62 IILCVTGSPQVEDLIFRAGGILENCRSGQILIDCSTSEPMSSARIAAQLATKGVSFVDAP 121 + +CVTGS +VE +I GG+ E + G +++DCSTS+P+S+ +AA+L G+ FVDAP Sbjct: 68 VFICVTGSREVEAIIRGPGGLKEGLKKGSVVVDCSTSDPVSTIALAAELKALGIDFVDAP 127 Query: 122 LARTPVEAMQGRLNTMVGADDATFAKVKPILEAFCENIFHIGGTTSAQKLKLLNNFIAIG 181 L+RTP EA +G L+ MVGA DA FA+VKP++E + I HIG T ++KLLNNFI++G Sbjct: 128 LSRTPKEAWEGTLDAMVGAPDALFARVKPVIETWAGRIVHIGDTGDGHRMKLLNNFISLG 187 Query: 182 TATLATEALAMCDAVGVDQRKFFDVISKGGANSGIFQMIAGGILEGRSDGMKFSIANAGK 241 A + +EALA+ + VG+ +F VI G + G +Q LEG D KF+IANA K Sbjct: 188 YAAIYSEALALAEKVGISPPRFDSVIRNGRMDCGFYQTFMRWTLEGDRDAHKFTIANAFK 247 Query: 242 DLSYYNNM--TAAFANP 256 DL+Y +M A ANP Sbjct: 248 DLTYLESMAGAAGIANP 264 >Q12H32.1 Q12H32_POLSJ 6-phosphogluconate dehydrogenase, NAD-binding protein Length = 297 Score = 253 bits (646), Expect = 2e-65, Method: Compositional matrix adjust. Identities = 134/290 (46%), Positives = 190/290 (65%), Gaps = 3/290 (1%) Query: 1 MKNIGFIGV-GMMGQGMAHNLVIKGFNVTVMGNRNRKPVEELVAEGAREASSLQDLVANV 59 MK+IG IG G+MG G+A NL KGF++++ +RN + V +L+A GA++ +S L + Sbjct: 1 MKHIGMIGASGLMGHGIARNLQAKGFDLSLTVHRNTERVADLLAAGAKQVASPAGL-GDC 59 Query: 60 NAIILCVTGSPQVEDLIFRAGGILENCRSGQILIDCSTSEPMSSARIAAQLATKGVSFVD 119 +A+I+CVTGSPQVE + G+L +G I+ID STSEP S+ R+AA A +GV+ VD Sbjct: 60 DAVIICVTGSPQVEQTLSGPDGVLSRALAGLIVIDTSTSEPESTRRLAALCAERGVTLVD 119 Query: 120 APLARTPVEAMQGRLNTMVGADDATFAKVKPILEAFCENIFHIGGTTSAQKLKLLNNFIA 179 APLARTPVEA GRLNTMVGA+ A F K++P+L A+CENIFH+GG + +KLLNNFI Sbjct: 120 APLARTPVEAELGRLNTMVGAEQAVFDKIRPVLAAYCENIFHVGGPGAGHVIKLLNNFIG 179 Query: 180 IGTATLATEALAMCDAVGVDQRKFFDVISKGGANSGIFQMIAGGILEGRSDGMKFSIANA 239 T EA A+ G++ +K +VIS G NSG+FQ +A L G G+KF + NA Sbjct: 180 QAICTATAEAFAVGALAGINPQKLVEVISAGAVNSGLFQAMA-KTLNGDFTGLKFELDNA 238 Query: 240 GKDLSYYNNMTAAFANPSMIGPHVAATLQQSAKEGYGEQMLGAMVQAHKE 289 KDL YY ++ PS++G V +L ++ G G++ + A+V A ++ Sbjct: 239 RKDLRYYTHLAEMVNVPSLVGEAVHQSLATASALGQGKKFVPALVTAQEK 288