BLASTP 2.2.21 [Jun-14-2009] Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), "Gapped BLAST and PSI-BLAST: a new generation of protein database search programs", Nucleic Acids Res. 25:3389-3402. Reference for compositional score matrix adjustment: Altschul, Stephen F., John C. Wootton, E. Michael Gertz, Richa Agarwala, Aleksandr Morgulis, Alejandro A. Schaffer, and Yi-Kuo Yu (2005) "Protein database searches using compositionally adjusted substitution matrices", FEBS J. 272:5101-5109. Query= 0034.0045.p (481 letters) Database: pfamseq 15,929,002 sequences; 5,169,768,107 total letters Searching..................................................done Score E Sequences producing significant alignments: (bits) Value D8IXY0.1 D8IXY0_HERSS Transmembrane protein 486 e-135 D8ISU7.1 D8ISU7_HERSS Transmembrane protein 469 e-130 D8IWS9.1 D8IWS9_HERSS Transmembrane protein 383 e-104 Q395Z9.1 Q395Z9_BURS3 Diguanylate cyclase 373 e-101 Q0BGZ3.1 Q0BGZ3_BURCM Diguanylate cyclase 372 e-100 >D8IXY0.1 D8IXY0_HERSS Transmembrane protein Length = 515 Score = 486 bits (1252), Expect = e-135, Method: Compositional matrix adjust. Identities = 243/476 (51%), Positives = 328/476 (68%), Gaps = 4/476 (0%) Query: 3 MVFGLFGWMLYKSHEEASQYAVETSQNITLMAQRDIVRNIEILSLSLDALANRYQDPL-F 61 MV + LY+S+++ Q AV + N+TL++QR I RN+E+LSLSLD LA R+Q PL Sbjct: 39 MVMAISASTLYQSYQQTRQSAVSNASNVTLVSQRAISRNLEMLSLSLDTLAYRFQHPLSA 98 Query: 62 RQLTHNQQYSYLFGSVAAAKHVMVMAVLDAAGKVAVSSL--PGTPANTYGDRLYFTVQRD 119 R+L Q+Y+YLFGS H+ VMAVLDA G+V VSS G A Y DR YF RD Sbjct: 99 RRLNDAQRYAYLFGSTTNVSHIAVMAVLDADGRVQVSSRLGRGNGAPHYADRAYFIAHRD 158 Query: 120 RPETGLYISPPITAKFDRELQVVVLSKRLSNQDGSFAGVVVMALDLSYFRELFSGIALGE 179 P GLY+S P+ A ELQVVVLSKRLSN+DGSFAGVVVMALDL+YFRELF G+ALG+ Sbjct: 159 SPTVGLYVSRPMQASLGNELQVVVLSKRLSNEDGSFAGVVVMALDLAYFRELFEGLALGD 218 Query: 180 DGVMSLYARSGVVYMRLPYAASMIGRDISSSDNFLRIKSLIQQESGSFFARAVTDGVKRL 239 +G++SLY+ G+ YMR+PY ++IGRDIS + NF R+++++ +E GSFFA A DGV+RL Sbjct: 219 EGIISLYSDEGIAYMRVPYRETIIGRDISQTGNFQRLRAMLSEEEGSFFAHATNDGVRRL 278 Query: 240 YAFRNVPGTQLVVFVGRSEKHIFSHWTESLYALGGAMLVFTVVCMALFYILRNELKKRRR 299 Y FR +PG+ L+VFVG +E+ IF W ++ YA+ ++ +F ++ L +R EL++R Sbjct: 279 YTFRRIPGSPLIVFVGYAEEAIFKTWRKTFYAVLVSLAIFGLLTAWLLLHVRQELRRRVT 338 Query: 300 AEDRLQELVSVDDLTKLLNRRALDNALGDLWSRSRRSRGI-FSILFIDVDYFKFYNDTYG 358 AE +L+ L D LT LLNRRALD AL W R +R+ G FS+LFIDVDYFK YNDTYG Sbjct: 339 AERQLEALARTDGLTDLLNRRALDEALQATWERCQRNLGASFSVLFIDVDYFKAYNDTYG 398 Query: 359 HQKGDDVLVSVSRAISTQLPRSSDLAARYGGEEFIVVLAETDADGALHVGEKIRDAIEAL 418 H+ GD VL V+ ++ +LPR +D A RYGGEEF+V+L +TD GA + +++ DA+ Sbjct: 399 HKLGDTVLKEVAATLTARLPRHTDCAGRYGGEEFVVLLEQTDLQGAQMMAQRLCDAVRER 458 Query: 419 NIPHAKSQIGHISASIGAAMYDSTVHDSINAVLNAADGALYAAKGNGRNNVQISAK 474 +I H S + ++ S+G A + H + VLNAAD ALY AK GR+ V +S++ Sbjct: 459 HIAHTSSPLAVVTISVGVATLERDHHRRVEDVLNAADAALYRAKQAGRDRVHLSSQ 514 >D8ISU7.1 D8ISU7_HERSS Transmembrane protein Length = 501 Score = 469 bits (1208), Expect = e-130, Method: Compositional matrix adjust. Identities = 245/480 (51%), Positives = 326/480 (67%), Gaps = 11/480 (2%) Query: 1 MAMVFGLFGWMLYKSHEEASQYAVETSQNITLMAQRDIVRNIEILSLSLDALANRYQDPL 60 + MV + G LY+ + + A+ + N+TL+ QR I RN+EILSL++D LA RYQ PL Sbjct: 16 IMMVLSICGASLYEGYRQTRISAITEANNVTLIVQRAISRNMEILSLAMDTLAYRYQHPL 75 Query: 61 FRQLTH---NQQYSYLFGSVAAAKHVMVMAVLDAAGKVAVSSL----PGTPANTYGDRLY 113 LTH ++Y+YLFGS AAA H+ +A+LDA G V V+S P N Y +R Y Sbjct: 76 --DLTHASDEERYNYLFGSTAAAHHITALAILDADGYVRVTSRRSASPSVVVN-YSERTY 132 Query: 114 FTVQRDRPETGLYISPPITAKFDRELQVVVLSKRLSNQDGSFAGVVVMALDLSYFRELFS 173 FTV RD + GL+IS PI A EL VVVLSKRLS +DGSF GVV+MALD+SYFR+LF+ Sbjct: 133 FTVHRDSADAGLFISRPIKANLGNELPVVVLSKRLSRKDGSFDGVVLMALDMSYFRDLFT 192 Query: 174 GIALGEDGVMSLYARSGVVYMRLPYAASMIGRDISSSDNFLRIKSLIQQESGSFFARAVT 233 G+ LGEDG+MSLY+ GV YMR+PY S IGR+I+++ NF R+++++ G+FFARA T Sbjct: 193 GLTLGEDGIMSLYSDDGVTYMRVPYHPSSIGREITNNPNFQRLRAMLVDNDGNFFARAHT 252 Query: 234 DGVKRLYAFRNVPGTQLVVFVGRSEKHIFSHWTESLYALGGAMLVFTVVCMALFYILRNE 293 DGV+RLY FR +P L+V +GRSE+ IF W ++LY++ +++FT + L ++R E Sbjct: 253 DGVERLYTFRRIPDAPLIVLLGRSERFIFKTWYDTLYSVLLLLIIFTALAGVLLMLVRRE 312 Query: 294 LKKRRRAEDRLQELVSVDDLTKLLNRRALDNALGDLWSRSRRSRGI-FSILFIDVDYFKF 352 L KR AE +L++L D LT LLNRR+LD AL +W RS+RS FS LFIDVDYFK Sbjct: 313 LLKRVAAEKQLEDLARTDGLTGLLNRRSLDEALLAVWQRSQRSPTAGFSTLFIDVDYFKR 372 Query: 353 YNDTYGHQKGDDVLVSVSRAISTQLPRSSDLAARYGGEEFIVVLAETDADGALHVGEKIR 412 YNDTYGH+ GD VL +V+ + L R +DLA RYGGEEF+V+L +TD GAL + +++ Sbjct: 373 YNDTYGHEMGDTVLQAVAAVLREHLQRQNDLAGRYGGEEFVVLLEQTDEHGALRMAQQLC 432 Query: 413 DAIEALNIPHAKSQIGHISASIGAAMYDSTVHDSINAVLNAADGALYAAKGNGRNNVQIS 472 +AI IPH+ S +G IS SIG A + H + VLNAAD ALY AK GRN V ++ Sbjct: 433 EAIYNRGIPHSGSPLGVISVSIGVATMNRAPHQRMEDVLNAADHALYIAKREGRNRVCVA 492 >D8IWS9.1 D8IWS9_HERSS Transmembrane protein Length = 475 Score = 383 bits (984), Expect = e-104, Method: Compositional matrix adjust. Identities = 206/468 (44%), Positives = 285/468 (60%), Gaps = 14/468 (2%) Query: 11 MLYKSHEEASQYAVETSQNITLMAQRDIVRNIEILSLSLDALANRYQDPLFRQLTHNQQY 70 +LY+SH + + A+E NI +AQR I RN+E+L+L+LD+L RY+ ++ Q+ Sbjct: 9 VLYQSHRQVERAAIEHGANIARIAQRSISRNVELLTLALDSLTWRYRHTQLHEMPLQQKM 68 Query: 71 SYLFGSVAAAKHVMVMAVLDAAGKVAVSS------LPGTPANTYGDRLYFTVQRD---RP 121 +L G A++V + ++D G++ V S LPG Y +FT + + Sbjct: 69 EFLLGENIEARYVAALGIVDTDGELVVGSAALSQILPGP----YAQSDFFTAHQTHHAQG 124 Query: 122 ETGLYISPPITAKFDRELQVVVLSKRLSNQDGSFAGVVVMALDLSYFRELFSGIALGEDG 181 +TGLYIS P+T + +R +QVVVLSKRL+ DGSFAG+ +M L L YFR+LF G+ L DG Sbjct: 125 DTGLYISAPLTVRLERRMQVVVLSKRLAQPDGSFAGISLMVLYLDYFRDLFQGLTLENDG 184 Query: 182 VMSLYARSGVVYMRLPYAASMIGRDISSSDNFLRIKSLIQQESGSFFARAVTDGVKRLYA 241 V+SLY+ G+ YMR+PY + IG ++ S++ RI S GS+FARA DG + LY Sbjct: 185 VISLYSADGLAYMRIPYNEAFIGSRLNISEDLERIFSPSGPAQGSYFARAQQDGPRWLYT 244 Query: 242 FRNVPGTQLVVFVGRSEKHIFSHWTESLYALGGAMLVFTVVCMALFYILRNELKKRRRAE 301 F VPGT VF+GR+ IF W LYA+ M F + + L +R EL++R + Sbjct: 245 FARVPGTGWTVFIGRTGARIFREWYNMLYAVLFLMASFCIASIYLIRRVRVELQRRSALD 304 Query: 302 DRLQELVSVDDLTKLLNRRALDNALGDLWSRSRRSR-GIFSILFIDVDYFKFYNDTYGHQ 360 +L+EL D LT LLNRRALD AL W R+ + IFS+LF+DVD+FK YNDTYGH+ Sbjct: 305 QQLEELARTDKLTSLLNRRALDEALARAWKRAEENPDAIFSLLFVDVDFFKLYNDTYGHK 364 Query: 361 KGDDVLVSVSRAISTQLPRSSDLAARYGGEEFIVVLAETDADGALHVGEKIRDAIEALNI 420 GD L++VSR I + R SD + RYGGEEF+V+L TD GA HV ++I AI++L I Sbjct: 365 AGDYALMAVSRCIVAAVSRLSDQSGRYGGEEFVVLLNGTDTVGATHVAKRIISAIQSLKI 424 Query: 421 PHAKSQIGHISASIGAAMYDSTVHDSINAVLNAADGALYAAKGNGRNN 468 PH +S ++ SIG H SI V+ AD ALY AK +GRN Sbjct: 425 PHERSPFDILTVSIGVTSLLREHHSSIEDVVKDADAALYRAKQDGRNK 472 >Q395Z9.1 Q395Z9_BURS3 Diguanylate cyclase Length = 492 Score = 373 bits (958), Expect = e-101, Method: Compositional matrix adjust. Identities = 196/467 (41%), Positives = 278/467 (59%), Gaps = 4/467 (0%) Query: 4 VFGLFGWMLYKSHEEASQYAVETSQNITLMAQRDIVRNIEILSLSLDALANRYQDPLFRQ 63 + GL L++S +A A +TS+N+ L+A+RDI RNIE+ LSL+A+ Q P Sbjct: 22 LMGLCILQLFQSRHDALDRARDTSRNLALVAERDIERNIELYGLSLEAVIQGLQRPDVMA 81 Query: 64 LTHNQQYSYLFGSVAAAKHVMVMAVLDAAGKVAVSSLPGTP-ANTYGDRLYFTVQRDRPE 122 + + LF AK + M VLD+AG + + S P +GDR YFTV RD P+ Sbjct: 82 ASPALRRGILFDHAMTAKFLGSMLVLDSAGNIILDSANDVPRQGNFGDRKYFTVHRDNPD 141 Query: 123 TGLYISPPITAKFDRELQVVVLSKRLSNQDGSFAGVVVMALDLSYFRELFSGIALGEDGV 182 GLYIS P ++ V L++R+SN DGSF G+V++A++L YF LF+G+ALG G Sbjct: 142 AGLYISDPYASRLRGGSLSVALTRRVSNPDGSFGGIVMIAVNLEYFHTLFAGLALGSHGA 201 Query: 183 MSLYARSGVVYMRLPYAASMIGRDISSSDNFLRIKSLIQQESGSFFARAVTDGVKRLYAF 242 +SL G+++MR PY IGRDIS + F + + GSF + D V+RLY F Sbjct: 202 ISLVGTDGIMFMRQPYDVHTIGRDISKAATF---RHFLTAPEGSFLDTSTIDNVRRLYYF 258 Query: 243 RNVPGTQLVVFVGRSEKHIFSHWTESLYALGGAMLVFTVVCMALFYILRNELKKRRRAED 302 + +P L++ V +E+ I++ W +G + F + L ++L +L++R RAE Sbjct: 259 KTLPHLPLIIMVAEAEQDIYAAWRHRAITIGALVATFGAAFIVLSFMLGTQLRRRMRAES 318 Query: 303 RLQELVSVDDLTKLLNRRALDNALGDLWSRSRRSRGIFSILFIDVDYFKFYNDTYGHQKG 362 L L D LT L NRR+ L W R+RR+R +FS+LF+DVD FK +NDTYGHQ G Sbjct: 319 ELVMLARTDGLTGLNNRRSFGEVLDLEWRRARRARSVFSLLFVDVDRFKAFNDTYGHQAG 378 Query: 363 DDVLVSVSRAISTQLPRSSDLAARYGGEEFIVVLAETDADGALHVGEKIRDAIEALNIPH 422 DD L +V+R I + R +D AARYGGEEF+V+L +T A GA + E+IR AI+ L I H Sbjct: 379 DDALTAVARCIGDNIRRPADTAARYGGEEFVVILPDTPATGATEIAERIRAAIDGLAIEH 438 Query: 423 AKSQIGHISASIGAAMYDSTVHDSINAVLNAADGALYAAKGNGRNNV 469 A+S+ G ++ASIG A + + +V+ AAD ALY AK GRN V Sbjct: 439 AESEFGRVTASIGVASWAPEQEGEVESVIKAADEALYHAKETGRNKV 485 >Q0BGZ3.1 Q0BGZ3_BURCM Diguanylate cyclase Length = 492 Score = 372 bits (954), Expect = e-100, Method: Compositional matrix adjust. Identities = 196/467 (41%), Positives = 278/467 (59%), Gaps = 4/467 (0%) Query: 4 VFGLFGWMLYKSHEEASQYAVETSQNITLMAQRDIVRNIEILSLSLDALANRYQDPLFRQ 63 + GL L++S +A + A ETS+N+ LMA+RDI RN E+ LSL A+ + Q P Sbjct: 22 LMGLCVLQLFQSRNDALERASETSRNLGLMAERDIERNFELYDLSLQAVIHGLQRPDVMS 81 Query: 64 LTHNQQYSYLFGSVAAAKHVMVMAVLDAAGKVAVSSLPGTP-ANTYGDRLYFTVQRDRPE 122 + LF +A + VLDA G + + S P + DR YFTV RD P+ Sbjct: 82 AAPALRRGVLFDHAMSAPFIGSQLVLDANGDIVLDSSNDVPRKGNFADRKYFTVHRDNPD 141 Query: 123 TGLYISPPITAKFDRELQVVVLSKRLSNQDGSFAGVVVMALDLSYFRELFSGIALGEDGV 182 GLY+S P ++ + +VLS+R+SN DGSF GV ++A++L YF LF+G++LG+ G Sbjct: 142 VGLYVSDPFVSRLRAGMLCIVLSRRISNPDGSFGGVALIAINLEYFHHLFAGLSLGQHGS 201 Query: 183 MSLYARSGVVYMRLPYAASMIGRDISSSDNFLRIKSLIQQESGSFFARAVTDGVKRLYAF 242 MSL + G++ MR PY S++GRDIS + F R + + G F A DGV+RLY F Sbjct: 202 MSLIGKDGIMVMRQPYNVSIVGRDISKATTFRRFQ---RASEGVFSETASIDGVRRLYYF 258 Query: 243 RNVPGTQLVVFVGRSEKHIFSHWTESLYALGGAMLVFTVVCMALFYILRNELKKRRRAED 302 +++P L++ V E+ +++ W +G + F V +AL ++L +L++R RAE Sbjct: 259 KHLPKLPLIIMVAEGEQDVYAAWRHRAVTIGALVATFGVAFIALSFLLSGQLRRRMRAES 318 Query: 303 RLQELVSVDDLTKLLNRRALDNALGDLWSRSRRSRGIFSILFIDVDYFKFYNDTYGHQKG 362 L L D LT L NRR+ L W R+RR+ +FS+LF+DVD FK YNDTYGHQ G Sbjct: 319 ELVLLARTDGLTGLNNRRSFGEVLDREWRRARRTHSVFSLLFVDVDRFKAYNDTYGHQAG 378 Query: 363 DDVLVSVSRAISTQLPRSSDLAARYGGEEFIVVLAETDADGALHVGEKIRDAIEALNIPH 422 DD L +V+R I + R D AARYGGEEF+V+L +T GA + E+IR AI+ L + H Sbjct: 379 DDALAAVARCIGENIRRPVDTAARYGGEEFVVLLPDTPPAGAAQIAERIRAAIDELALEH 438 Query: 423 AKSQIGHISASIGAAMYDSTVHDSINAVLNAADGALYAAKGNGRNNV 469 A S+ G ++ASIG A + + +AV+ AAD ALY AK GRN V Sbjct: 439 AGSEYGRVTASIGLASWTPEQDNEPDAVIKAADEALYYAKTIGRNRV 485