BLASTP 2.2.21 [Jun-14-2009] Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), "Gapped BLAST and PSI-BLAST: a new generation of protein database search programs", Nucleic Acids Res. 25:3389-3402. Reference for compositional score matrix adjustment: Altschul, Stephen F., John C. Wootton, E. Michael Gertz, Richa Agarwala, Aleksandr Morgulis, Alejandro A. Schaffer, and Yi-Kuo Yu (2005) "Protein database searches using compositionally adjusted substitution matrices", FEBS J. 272:5101-5109. Query= 0032.0050.p (545 letters) Database: pfamseq 15,929,002 sequences; 5,169,768,107 total letters Searching..................................................done Score E Sequences producing significant alignments: (bits) Value D8IVU2.1 D8IVU2_HERSS Cobalt-zinc-cadmium resistance cation effl... 752 0.0 A6SYY5.1 A6SYY5_JANMA Heavy metal efflux pump, CzcA family 739 0.0 A4G5I5.1 A4G5I5_HERAR Cobalt-zinc-cadmium resistance protein Czc... 724 0.0 F1VV25.1 F1VV25_9BURK Heavy metal efflux pump, CzcA family 712 0.0 E5U976.1 E5U976_ALCXX Cobalt-zinc-cadmium resistance protein czcA 699 0.0 >D8IVU2.1 D8IVU2_HERSS Cobalt-zinc-cadmium resistance cation efflux system transmembrane protein Length = 1073 Score = 752 bits (1942), Expect = 0.0, Method: Compositional matrix adjust. Identities = 358/463 (77%), Positives = 413/463 (89%), Gaps = 2/463 (0%) Query: 1 MIVYLPMFALTGVEGKMFQPMAFTVVAALLGAMILSVTFIPAAIALFIGDKVDEKENALM 60 MIVYLPMFALTGVEGKMF PMAFTVVAAL+GAMILSVTFIPAAIALFIG+KV EKEN LM Sbjct: 460 MIVYLPMFALTGVEGKMFTPMAFTVVAALIGAMILSVTFIPAAIALFIGEKVAEKENILM 519 Query: 61 RAAKRAYAPLLQASLRNKLVVLSLAAAVIVLCTLLGTRLGSEFVPSLNEGDLAIQSLRIP 120 AKR Y P+L+ + NK VVL+ A A+I++C ++ +RLGSEFVPSLNEGD+AIQ+LRIP Sbjct: 520 LWAKRLYEPMLKTIMENKPVVLTFAGALILVCGVVASRLGSEFVPSLNEGDMAIQALRIP 579 Query: 121 GTSLTQSVEMQQQLERTLKDNFPEIERVFARTGTAEVASDPMPPNISDGYIMLKPQDQWP 180 GTSL+QS+EMQ+Q+E+TLK FPE+ERVFARTGTAEVASDPMPPNISDGYIMLKPQ+QWP Sbjct: 580 GTSLSQSLEMQKQIEKTLKQKFPEVERVFARTGTAEVASDPMPPNISDGYIMLKPQEQWP 639 Query: 181 KPRKTRDELIAAIQETVAALPGNSYEFSQPIQLRFNELISGVRSDVAVKVFGDDMDVLND 240 +P+K+R+EL+ AIQ+ VA +PGNSYEFSQPIQLRFNELISGVRSDVAVKVFGDDM VLND Sbjct: 640 EPKKSREELLEAIQDEVAKIPGNSYEFSQPIQLRFNELISGVRSDVAVKVFGDDMKVLND 699 Query: 241 TAAKIAGTLGKVPGATEVKVEQSTGLPMLTVRIDREKTARYGLNIGDVQDTVAMAIGGKE 300 TA+KI+ L K+PGATEVK+EQ+TGLPMLTV IDREKTARYGLN+ D+QDTVA AIGGKE Sbjct: 700 TASKISAVLEKIPGATEVKIEQTTGLPMLTVEIDREKTARYGLNVSDIQDTVATAIGGKE 759 Query: 301 AGALFQGDRRFDIIVRLPENERNDLDAIKRLPIPLPHNDG--KLSYIPLGEVADFDIAPG 358 AG +FQGDRRF I+VRLP+ R DL+AI+RLPI LP +G ++SY+PLGEVA IAPG Sbjct: 760 AGTMFQGDRRFGIVVRLPDQARTDLEAIRRLPIALPPQEGATRVSYVPLGEVASLTIAPG 819 Query: 359 PNQVSRENGKRRVVVSANVRGRDLGSFVDDAAAGIAAQVKIPTGYWIAWGGQFENLQSAT 418 PNQ+SRE+GKRR+VVSANVRGRDLG FV +A + + VK+P GYW WGGQFENLQSAT Sbjct: 820 PNQISREDGKRRIVVSANVRGRDLGGFVAEAERQLQSAVKVPAGYWTTWGGQFENLQSAT 879 Query: 419 QRLQIVVPVALLLVFVLLFAMFNNVKDGLLVFTGIPFALTGGV 461 QRLQIV+PVALL+VFVLLFAMF+NVKDGLLVFTGIPFALTGG+ Sbjct: 880 QRLQIVIPVALLMVFVLLFAMFSNVKDGLLVFTGIPFALTGGI 922 >A6SYY5.1 A6SYY5_JANMA Heavy metal efflux pump, CzcA family Length = 1051 Score = 739 bits (1908), Expect = 0.0, Method: Compositional matrix adjust. Identities = 355/464 (76%), Positives = 406/464 (87%), Gaps = 3/464 (0%) Query: 1 MIVYLPMFALTGVEGKMFQPMAFTVVAALLGAMILSVTFIPAAIALFIGDKVDEKENALM 60 M+VYLP+FAL+GVEG+MF PMAFTVV AL+GAMILS+TFIPAA+ALFIGDKV EKEN LM Sbjct: 460 MVVYLPIFALSGVEGRMFHPMAFTVVIALVGAMILSITFIPAAVALFIGDKVAEKENVLM 519 Query: 61 RAAKRAYAPLLQASLRNKLVVLSLAAAVIVLCTLLGTRLGSEFVPSLNEGDLAIQSLRIP 120 +AAKR YAP L + NK VVL+ A +++L LL TR+GSEFVP+LNEGD+AIQSLRIP Sbjct: 520 QAAKRWYAPALDYVMANKPVVLTFAFVLVLLSGLLATRMGSEFVPNLNEGDIAIQSLRIP 579 Query: 121 GTSLTQSVEMQQQLERTLKDNFPEIERVFARTGTAEVASDPMPPNISDGYIMLKPQDQWP 180 GTSLTQSVEMQ+QLE LK PEIER+ +RTGTAE+ASDPMPPNISDG +MLKP+ WP Sbjct: 580 GTSLTQSVEMQKQLEVALKQAHPEIERIVSRTGTAEIASDPMPPNISDGLVMLKPEADWP 639 Query: 181 KPRKTRDELIAAIQETVAALPGNSYEFSQPIQLRFNELISGVRSDVAVKVFGDDMDVLND 240 +P+K+RDEL+ AI++TVA LPGN+YEFSQPIQLRFNELISGVRSDVAVK+FGDDM+VLND Sbjct: 640 EPKKSRDELLQAIRDTVAKLPGNNYEFSQPIQLRFNELISGVRSDVAVKLFGDDMEVLND 699 Query: 241 TAAKIAGTLGKVPGATEVKVEQSTGLPMLTVRIDREKTARYGLNIGDVQDTVAMAIGGKE 300 TAA+IA LGK+PGA EVKVEQ+TGLPMLTV IDREKTARYGLN+ DVQDT+A A GGKE Sbjct: 700 TAARIATVLGKIPGAAEVKVEQTTGLPMLTVNIDREKTARYGLNVADVQDTIATATGGKE 759 Query: 301 AGALFQGDRRFDIIVRLPENERNDLDAIKRLPIPLPHNDG---KLSYIPLGEVADFDIAP 357 AG LFQGDRRFDI+VRLPEN RNDL+AIKRLP+PLP G + SYIPLGEVA D+AP Sbjct: 760 AGTLFQGDRRFDILVRLPENVRNDLEAIKRLPLPLPREQGGAARTSYIPLGEVATLDVAP 819 Query: 358 GPNQVSRENGKRRVVVSANVRGRDLGSFVDDAAAGIAAQVKIPTGYWIAWGGQFENLQSA 417 GPNQVSRENGKRR+VVSANVRGRD+GSFV DA I QVKIP GYW++WGGQFE LQSA Sbjct: 820 GPNQVSRENGKRRIVVSANVRGRDIGSFVSDAEQQIEQQVKIPAGYWMSWGGQFEQLQSA 879 Query: 418 TQRLQIVVPVALLLVFVLLFAMFNNVKDGLLVFTGIPFALTGGV 461 T+RLQ+V+PVAL LVF LLF MF N+KDGLLVF+GIPFALTGG+ Sbjct: 880 TERLQLVIPVALALVFTLLFVMFGNMKDGLLVFSGIPFALTGGI 923 >A4G5I5.1 A4G5I5_HERAR Cobalt-zinc-cadmium resistance protein CzcA (Cation efflux system protein CzcA) Length = 1045 Score = 724 bits (1868), Expect = 0.0, Method: Compositional matrix adjust. Identities = 357/464 (76%), Positives = 409/464 (88%), Gaps = 3/464 (0%) Query: 1 MIVYLPMFALTGVEGKMFQPMAFTVVAALLGAMILSVTFIPAAIALFIGDKVDEKENALM 60 M VYLP+FALTGVEG+MF PMAFTVV AL+GAMILS+TFIPAAIALFIG KV+EKEN LM Sbjct: 460 MAVYLPIFALTGVEGRMFHPMAFTVVIALVGAMILSITFIPAAIALFIGGKVEEKENRLM 519 Query: 61 RAAKRAYAPLLQASLRNKLVVLSLAAAVIVLCTLLGTRLGSEFVPSLNEGDLAIQSLRIP 120 + A+ YA L + + NK VVL+ AA ++VL LL TR+GSEFVP+LNEGD AIQ+LRIP Sbjct: 520 QQARTWYASALDSVMLNKPVVLTFAAVLVVLSGLLATRMGSEFVPNLNEGDFAIQALRIP 579 Query: 121 GTSLTQSVEMQQQLERTLKDNFPEIERVFARTGTAEVASDPMPPNISDGYIMLKPQDQWP 180 GTSLTQSV MQQQLE+ LK+ PEIER+FARTGTAE+ASDPMPPNISDGYIMLKPQDQWP Sbjct: 580 GTSLTQSVAMQQQLEKLLKEKHPEIERIFARTGTAEIASDPMPPNISDGYIMLKPQDQWP 639 Query: 181 KPRKTRDELIAAIQETVAALPGNSYEFSQPIQLRFNELISGVRSDVAVKVFGDDMDVLND 240 +P KTRDEL+A +Q+TVA+LPG++YEFSQPIQLRFNELISGVRSDVAVK+FGDDMDVLND Sbjct: 640 EPVKTRDELLAVVQKTVASLPGSNYEFSQPIQLRFNELISGVRSDVAVKLFGDDMDVLND 699 Query: 241 TAAKIAGTLGKVPGATEVKVEQSTGLPMLTVRIDREKTARYGLNIGDVQDTVAMAIGGKE 300 TA+K+A +GK+PGA EVKVEQ+TGLPMLTV IDREKTARYGLNI DVQDTVA AIGGKE Sbjct: 700 TASKVAAVMGKIPGAAEVKVEQTTGLPMLTVNIDREKTARYGLNIADVQDTVATAIGGKE 759 Query: 301 AGALFQGDRRFDIIVRLPENERNDLDAIKRLPIPLPH---NDGKLSYIPLGEVADFDIAP 357 AG LFQGDRRF+IIVRLP++ RNDL+AI+RLPI LP ++G+ SYIPLGEV D+AP Sbjct: 760 AGTLFQGDRRFNIIVRLPDHIRNDLEAIRRLPISLPRAQGSEGRTSYIPLGEVVTLDVAP 819 Query: 358 GPNQVSRENGKRRVVVSANVRGRDLGSFVDDAAAGIAAQVKIPTGYWIAWGGQFENLQSA 417 GPNQ+SRE+GKRR+V+S NVRGRD+GSFV DA A I QV IP+GYW WGGQFE LQSA Sbjct: 820 GPNQISREDGKRRIVISTNVRGRDIGSFVADAEAKIRQQVNIPSGYWTTWGGQFEQLQSA 879 Query: 418 TQRLQIVVPVALLLVFVLLFAMFNNVKDGLLVFTGIPFALTGGV 461 TQRL+IV+PV LLLVFVLLFAMF N+KDGLLVF+GIPFALTGG+ Sbjct: 880 TQRLKIVIPVTLLLVFVLLFAMFGNIKDGLLVFSGIPFALTGGI 923 >F1VV25.1 F1VV25_9BURK Heavy metal efflux pump, CzcA family Length = 749 Score = 712 bits (1837), Expect = 0.0, Method: Compositional matrix adjust. Identities = 346/464 (74%), Positives = 396/464 (85%), Gaps = 3/464 (0%) Query: 1 MIVYLPMFALTGVEGKMFQPMAFTVVAALLGAMILSVTFIPAAIALFIGDKVDEKENALM 60 M+VYLP+FALTGVEG+MF PMA TVV ALLGAMILS TF+PAAIALFIG KV EKENA + Sbjct: 148 MVVYLPIFALTGVEGRMFHPMAITVVMALLGAMILSFTFVPAAIALFIGKKVSEKENAAV 207 Query: 61 RAAKRAYAPLLQASLRNKLVVLSLAAAVIVLCTLLGTRLGSEFVPSLNEGDLAIQSLRIP 120 R AKR YAP + NK + L AA ++VL + TR+GSEFVP++NEGD AIQ+LRIP Sbjct: 208 RGAKRLYAPAFDFVMANKPITLICAAVILVLSGWIATRMGSEFVPNMNEGDFAIQALRIP 267 Query: 121 GTSLTQSVEMQQQLERTLKDNFPEIERVFARTGTAEVASDPMPPNISDGYIMLKPQDQWP 180 GTSLTQSVEMQQ++E LK+ FPEI RVFARTGTAE+ASDPMPPNISDGYIML P+ +WP Sbjct: 268 GTSLTQSVEMQQKIESKLKEKFPEINRVFARTGTAEIASDPMPPNISDGYIMLNPESEWP 327 Query: 181 KPRKTRDELIAAIQETVAALPGNSYEFSQPIQLRFNELISGVRSDVAVKVFGDDMDVLND 240 +PRKTR EL+AAIQE V+ +PGN+YEFSQPIQLRFNELISGVRSDVAVK+FGDDMD+LND Sbjct: 328 EPRKTRPELLAAIQEVVSKVPGNNYEFSQPIQLRFNELISGVRSDVAVKLFGDDMDILND 387 Query: 241 TAAKIAGTLGKVPGATEVKVEQSTGLPMLTVRIDREKTARYGLNIGDVQDTVAMAIGGKE 300 TAAKI+ +GKV GATEVKVEQ++GLPMLTV IDREKT+RYGLN+GDVQD ++ AIGGKE Sbjct: 388 TAAKISAVMGKVQGATEVKVEQTSGLPMLTVNIDREKTSRYGLNVGDVQDVISTAIGGKE 447 Query: 301 AGALFQGDRRFDIIVRLPENERNDLDAIKRLPIPLPH---NDGKLSYIPLGEVADFDIAP 357 AG LFQGDRRFDIIVRLPEN RNDL+AIKRLPI L ++IPLGEVA +IAP Sbjct: 448 AGTLFQGDRRFDIIVRLPENLRNDLEAIKRLPISLQTTGVTSSATTFIPLGEVASLEIAP 507 Query: 358 GPNQVSRENGKRRVVVSANVRGRDLGSFVDDAAAGIAAQVKIPTGYWIAWGGQFENLQSA 417 GPNQ+SRE+GKRR+V+SANV GRD+ SFV DA A IAA+VK+P GYWI WGGQFE LQSA Sbjct: 508 GPNQISREDGKRRIVISANVSGRDISSFVADAEAAIAAEVKVPAGYWITWGGQFEQLQSA 567 Query: 418 TQRLQIVVPVALLLVFVLLFAMFNNVKDGLLVFTGIPFALTGGV 461 TQRL+IVVPVALLLV LLF MF N+K GLLVF+GIPFALTGG+ Sbjct: 568 TQRLKIVVPVALLLVMTLLFTMFGNLKSGLLVFSGIPFALTGGI 611 >E5U976.1 E5U976_ALCXX Cobalt-zinc-cadmium resistance protein czcA Length = 1061 Score = 699 bits (1804), Expect = 0.0, Method: Compositional matrix adjust. Identities = 334/463 (72%), Positives = 394/463 (85%), Gaps = 2/463 (0%) Query: 1 MIVYLPMFALTGVEGKMFQPMAFTVVAALLGAMILSVTFIPAAIALFIGDKVDEKENALM 60 M+VYLP+FALTGVEG+MF PMA TVV ALLGAMILSVTF+PAA+ALFIG KV EKEN LM Sbjct: 460 MVVYLPIFALTGVEGRMFHPMALTVVLALLGAMILSVTFVPAAVALFIGKKVSEKENRLM 519 Query: 61 RAAKRAYAPLLQASLRNKLVVLSLAAAVIVLCTLLGTRLGSEFVPSLNEGDLAIQSLRIP 120 AKR YAPLL +LR +VL+ A + LC ++ R+GSEF+P+LNEGD+AIQ+LRIP Sbjct: 520 LWAKRRYAPLLDLALRRTPLVLAAATLFVALCGVIAARMGSEFIPNLNEGDIAIQALRIP 579 Query: 121 GTSLTQSVEMQQQLERTLKDNFPEIERVFARTGTAEVASDPMPPNISDGYIMLKPQDQWP 180 GTSL+QS+EMQ+QLE LK FPEIERVFARTGTAE+ASDPMPPNISDGYIMLKP+DQWP Sbjct: 580 GTSLSQSLEMQKQLETRLKQKFPEIERVFARTGTAEIASDPMPPNISDGYIMLKPKDQWP 639 Query: 181 KPRKTRDELIAAIQETVAALPGNSYEFSQPIQLRFNELISGVRSDVAVKVFGDDMDVLND 240 PRKT+ EL+ AIQE A +PGN+YEFSQPIQLRFNELISGVRSDVAVK+FGDD DVLN Sbjct: 640 APRKTQAELLRAIQEEAARMPGNNYEFSQPIQLRFNELISGVRSDVAVKIFGDDNDVLNR 699 Query: 241 TAAKIAGTLGKVPGATEVKVEQSTGLPMLTVRIDREKTARYGLNIGDVQDTVAMAIGGKE 300 +AA++A L +PGA+EVK+EQ+TGLP+LTV IDR + ARYGL++ DVQDT+ +AIGG+E Sbjct: 700 SAAEVAQVLQAIPGASEVKIEQTTGLPVLTVNIDRARAARYGLSLADVQDTLGIAIGGRE 759 Query: 301 AGALFQGDRRFDIIVRLPENERNDLDAIKRLPIPLPHNDG--KLSYIPLGEVADFDIAPG 358 AG FQGDRRFDI+VRLPE R + A+++LPI LP ++G + +YIPL EVA FD+APG Sbjct: 760 AGTFFQGDRRFDIVVRLPETVRESIPALRKLPIALPRSEGQAQTAYIPLSEVASFDLAPG 819 Query: 359 PNQVSRENGKRRVVVSANVRGRDLGSFVDDAAAGIAAQVKIPTGYWIAWGGQFENLQSAT 418 PNQ+SRE+GKRR+VVSANVRGRDLGSFV DA A +A ++K+P GYW AWGG FE LQSA Sbjct: 820 PNQISREDGKRRIVVSANVRGRDLGSFVADAEAALAEKIKVPAGYWTAWGGTFEQLQSAA 879 Query: 419 QRLQIVVPVALLLVFVLLFAMFNNVKDGLLVFTGIPFALTGGV 461 QRL+IVVP ALLLVF LLFAMF N+KDGL+VFTGIPFALTGGV Sbjct: 880 QRLRIVVPAALLLVFGLLFAMFGNIKDGLIVFTGIPFALTGGV 922