BLASTP 2.2.21 [Jun-14-2009] Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), "Gapped BLAST and PSI-BLAST: a new generation of protein database search programs", Nucleic Acids Res. 25:3389-3402. Reference for compositional score matrix adjustment: Altschul, Stephen F., John C. Wootton, E. Michael Gertz, Richa Agarwala, Aleksandr Morgulis, Alejandro A. Schaffer, and Yi-Kuo Yu (2005) "Protein database searches using compositionally adjusted substitution matrices", FEBS J. 272:5101-5109. Query= 0031.0004.p (509 letters) Database: pfamseq 15,929,002 sequences; 5,169,768,107 total letters Searching..................................................done Score E Sequences producing significant alignments: (bits) Value A6T3D3.1 A6T3D3_JANMA Multidrug-efflux transporter of the MFS su... 592 e-167 A4G9L9.1 A4G9L9_HERAR Putative Permease of the major facilitator... 590 e-166 D8ISL7.1 D8ISL7_HERSS Permease of the major facilitator superfam... 582 e-164 Q47IU2.1 Q47IU2_DECAR Major facilitator superfamily MFS_1 422 e-116 C6WZ86.1 C6WZ86_METML Major facilitator superfamily MFS_1 413 e-113 >A6T3D3.1 A6T3D3_JANMA Multidrug-efflux transporter of the MFS superfamily Length = 409 Score = 592 bits (1525), Expect = e-167, Method: Compositional matrix adjust. Identities = 297/391 (75%), Positives = 338/391 (86%) Query: 21 GMSGAEVRASASLASIFALRMLGLFLILPVFAVHAKGMSGGESAAMVGLAMGIYGLAQSF 80 GM+ E+RAS SLASIFALRMLGLFLILPVFAVHAK + GGESA +VGLAMGIYGL QSF Sbjct: 12 GMTRTEIRASTSLASIFALRMLGLFLILPVFAVHAKTLPGGESATLVGLAMGIYGLTQSF 71 Query: 81 GQIPFGMASDKYGRKRVIVVGLVLFALGSFVAAGAQDIGWVIAGRAIQGAGAISAAVTAF 140 GQIPFG+ASDKYGRKR+IV+GL+LFALGSF+AA A +I WVI GR++QGAGAISAAVTAF Sbjct: 72 GQIPFGIASDKYGRKRIIVIGLILFALGSFIAAAADNIIWVIIGRSVQGAGAISAAVTAF 131 Query: 141 IADSTREEHRTKAMAMVGGSIGLTFALSLVASPLLYEAIGMGGIFGLTGVLALAAIGVVL 200 IADSTREEHRTKAMAMVGGSIGLTFA SL+ SPLLY+ IGMGGIF LTG+L++ AI VV+ Sbjct: 132 IADSTREEHRTKAMAMVGGSIGLTFAGSLILSPLLYQWIGMGGIFALTGILSVLAIFVVI 191 Query: 201 FVVPDAPMVKARRVPLGEVLRHGELMRLNFGVFALHMTQMAMFVVLPAALVQYAGLPVAE 260 +VVP AP + +V + E+L HGELMRLNFGVFALH+TQMAMFVV+P+AL+++A LP+AE Sbjct: 192 YVVPAAPSLPPAQVSIREILAHGELMRLNFGVFALHLTQMAMFVVVPSALIRFAQLPLAE 251 Query: 261 HWKIYLPVVLASFIFMLPPVFIGEKRGLMKQVFVAAISLLLLVQVGMWATLAHFAAHWWV 320 HWKIYLPVV+ASF+ MLPP+FIGEKRG KQVFVAAI+LLLLVQVGMW L+ HW Sbjct: 252 HWKIYLPVVIASFVLMLPPIFIGEKRGKSKQVFVAAIALLLLVQVGMWLVLSQTQVHWTW 311 Query: 321 LVFLLFAFFIAFNILEACQPSLVSRIAPAAAKGTALGVYNTLQALGLFCGGALGGWLKQF 380 LV LL AFF+AFNILEA QPSLVSRIAP +KG ALGVYNTLQALGLFCGGALGGWL Q Sbjct: 312 LVGLLLAFFVAFNILEASQPSLVSRIAPPGSKGAALGVYNTLQALGLFCGGALGGWLTQH 371 Query: 381 AGAPSVFVMCAVATLTWLIIASNMKNLPRRG 411 G SVFV+ + + WLIIA+NMKNLPRRG Sbjct: 372 VGGASVFVLGSALCVVWLIIAANMKNLPRRG 402 >A4G9L9.1 A4G9L9_HERAR Putative Permease of the major facilitator superfamily Length = 397 Score = 590 bits (1521), Expect = e-166, Method: Compositional matrix adjust. Identities = 300/390 (76%), Positives = 335/390 (85%) Query: 22 MSGAEVRASASLASIFALRMLGLFLILPVFAVHAKGMSGGESAAMVGLAMGIYGLAQSFG 81 M+ E+RAS SLASIFALRMLGLFLILPVF+VHAKG+ GGESA +VGLA+GIYGL QSFG Sbjct: 1 MTSNEIRASTSLASIFALRMLGLFLILPVFSVHAKGLPGGESATLVGLALGIYGLTQSFG 60 Query: 82 QIPFGMASDKYGRKRVIVVGLVLFALGSFVAAGAQDIGWVIAGRAIQGAGAISAAVTAFI 141 QIPFG+ASDKYGRKRVIV+GL+LFALGSF+AA A DI WVI GRA+QGAGAISAAVTAFI Sbjct: 61 QIPFGIASDKYGRKRVIVIGLILFALGSFIAAAADDIVWVIVGRAVQGAGAISAAVTAFI 120 Query: 142 ADSTREEHRTKAMAMVGGSIGLTFALSLVASPLLYEAIGMGGIFGLTGVLALAAIGVVLF 201 ADSTREEHRTKAMAMVG SIG+TFA SLV SPLLY+AIGMGGIF LTG+L++ AI VVL+ Sbjct: 121 ADSTREEHRTKAMAMVGASIGVTFAGSLVLSPLLYQAIGMGGIFALTGILSVLAILVVLY 180 Query: 202 VVPDAPMVKARRVPLGEVLRHGELMRLNFGVFALHMTQMAMFVVLPAALVQYAGLPVAEH 261 +VP AP + RV + EVL +GELMRLN+GVFALH+TQMAMFVV+P+AL+++ LP+ EH Sbjct: 181 IVPAAPALPPGRVSIREVLANGELMRLNYGVFALHVTQMAMFVVMPSALIRFGHLPLGEH 240 Query: 262 WKIYLPVVLASFIFMLPPVFIGEKRGLMKQVFVAAISLLLLVQVGMWATLAHFAAHWWVL 321 WKIYLPVVLASFI MLPP+FI E+RG KQVFVAAI+LLL VQVGMW A HW L Sbjct: 241 WKIYLPVVLASFILMLPPIFIAERRGKSKQVFVAAIALLLAVQVGMWLVFAQTQLHWAWL 300 Query: 322 VFLLFAFFIAFNILEACQPSLVSRIAPAAAKGTALGVYNTLQALGLFCGGALGGWLKQFA 381 V LL FFIAFNILEA QPSLVSRIAP AAKG ALGVYNTLQALGLFCGGALGGWL Q Sbjct: 301 VALLLVFFIAFNILEASQPSLVSRIAPPAAKGAALGVYNTLQALGLFCGGALGGWLTQHT 360 Query: 382 GAPSVFVMCAVATLTWLIIASNMKNLPRRG 411 G SVFV+ AV T+ WLIIA+NMKNLPRRG Sbjct: 361 GGASVFVLGAVLTVAWLIIAANMKNLPRRG 390 >D8ISL7.1 D8ISL7_HERSS Permease of the major facilitator superfamily protein Length = 398 Score = 582 bits (1501), Expect = e-164, Method: Compositional matrix adjust. Identities = 300/398 (75%), Positives = 347/398 (87%) Query: 22 MSGAEVRASASLASIFALRMLGLFLILPVFAVHAKGMSGGESAAMVGLAMGIYGLAQSFG 81 MS AEVRASASLASIF+LRMLGLFL+LPVFAVHA + GG++ +VG+A+GIYGLAQ+FG Sbjct: 1 MSRAEVRASASLASIFSLRMLGLFLVLPVFAVHAHSLPGGDNDTLVGIALGIYGLAQAFG 60 Query: 82 QIPFGMASDKYGRKRVIVVGLVLFALGSFVAAGAQDIGWVIAGRAIQGAGAISAAVTAFI 141 QIP+G+ASD+YGRKR+IV+GL+LFALGSFVAA A + W++ GRA+QG+GAISAA+TAFI Sbjct: 61 QIPYGIASDRYGRKRIIVIGLLLFALGSFVAAAATSVIWLLVGRALQGSGAISAAITAFI 120 Query: 142 ADSTREEHRTKAMAMVGGSIGLTFALSLVASPLLYEAIGMGGIFGLTGVLALAAIGVVLF 201 ADSTREEHRTKAMAMVG SIG+TFA+S+VASPLLY++IGMGGIFGLTGVL+L AI VV++ Sbjct: 121 ADSTREEHRTKAMAMVGASIGVTFAVSMVASPLLYKSIGMGGIFGLTGVLSLIAIAVVVW 180 Query: 202 VVPDAPMVKARRVPLGEVLRHGELMRLNFGVFALHMTQMAMFVVLPAALVQYAGLPVAEH 261 VVP AP+V+ARRVPL EVLRHGELMRLNFGVF LH+TQ+AMF+V+P ALVQ AGLP+ EH Sbjct: 181 VVPAAPLVQARRVPLREVLRHGELMRLNFGVFTLHLTQVAMFMVVPGALVQLAGLPLGEH 240 Query: 262 WKIYLPVVLASFIFMLPPVFIGEKRGLMKQVFVAAISLLLLVQVGMWATLAHFAAHWWVL 321 WKIYLPVVLASF+ MLPPVF+ EK G MKQVF+ AI L+LLVQ+G WA L+H HWW+L Sbjct: 241 WKIYLPVVLASFVLMLPPVFVAEKYGRMKQVFLGAIGLMLLVQLGFWAVLSHPLGHWWML 300 Query: 322 VFLLFAFFIAFNILEACQPSLVSRIAPAAAKGTALGVYNTLQALGLFCGGALGGWLKQFA 381 V LLF FF+AFNILEA QPSLVSRIAP AAKG ALGVYNTLQALGL CGGALGGW+KQ Sbjct: 301 VALLFLFFVAFNILEASQPSLVSRIAPPAAKGAALGVYNTLQALGLSCGGALGGWIKQNV 360 Query: 382 GAPSVFVMCAVATLTWLIIASNMKNLPRRGAQXRGRPA 419 G VF + AV TLTWLIIA+NMKNLPRR A G A Sbjct: 361 GISEVFALSAVVTLTWLIIAANMKNLPRRSAPAAGATA 398 >Q47IU2.1 Q47IU2_DECAR Major facilitator superfamily MFS_1 Length = 407 Score = 422 bits (1084), Expect = e-116, Method: Compositional matrix adjust. Identities = 237/406 (58%), Positives = 293/406 (72%), Gaps = 11/406 (2%) Query: 9 MNANLT-ESAQKAGMSGAEVRASASLASIFALRMLGLFLILPVFAVHAKGMSGGESAAMV 67 M N T SA MS E RA ASLASIFALRMLGLFLILPVF+V+AK + GG++ A+V Sbjct: 1 MQHNQTIMSAPTDRMSPEERRAGASLASIFALRMLGLFLILPVFSVYAKTLPGGDNLALV 60 Query: 68 GLAMGIYGLAQSFGQIPFGMASDKYGRKRVIVVGLVLFALGSFVAAGAQDIGWVIAGRAI 127 G A+G YGL Q+F QIP+G+ASD +GRK VIVVGL++FALGSFVAA A D+ W+I GR + Sbjct: 61 GFALGAYGLTQAFFQIPYGIASDIFGRKLVIVVGLLIFALGSFVAAWAPDMNWIIVGRVL 120 Query: 128 QGAGAISAAVTAFIADSTREEHRTKAMAMVGGSIGLTFALSLVASPLLYEAIGMGGIFGL 187 QGAGAISAAVTA AD TREEHRTK MAM+G SIGL FALSLV +P+LY IGM G+F + Sbjct: 121 QGAGAISAAVTALAADLTREEHRTKVMAMIGSSIGLVFALSLVGAPILYGWIGMSGLFIM 180 Query: 188 TGVLALAAIGVVLFVVPDAPMVKA-RRVPLGEVLRHGELMRLNFGVFALHMTQMAMFVVL 246 TGVLAL+AI +++ VP AP + ++PL V+ +L+RLN G+F LHM QMAMFVVL Sbjct: 181 TGVLALSAIVLLIKAVPPAPAPQGHEKLPLRRVIFDPDLLRLNLGIFTLHMVQMAMFVVL 240 Query: 247 PAALVQYAGLPVAEHWKIYLPVVLASFIFMLPPVFIGEKRGLMKQVFVAAISLLLLVQVG 306 P ALV + GL A HWK+YLP VL SF M+P + E++ M+ +F+AA+ LL++VQ G Sbjct: 241 PHALVNHGGLEAASHWKVYLPAVLVSFAIMVPAIIAAERKDKMRPIFIAAVGLLVVVQAG 300 Query: 307 MWATLAHFAAH--WWVLVFLLFAFFIAFNILEACQPSLVSRIAPAAAKGTALGVYNTLQA 364 + F H W L L FF+AFN+LEA PSLVSR AP AAKG ALGVYNT QA Sbjct: 301 L------FVLHESLWALALWLLLFFVAFNVLEATLPSLVSRTAPPAAKGAALGVYNTTQA 354 Query: 365 LGLFCGGALGGWLKQFAGAPSVFVMCAVATLTWLIIASNMKNLPRR 410 +GLF GGA GG++ Q G +VF C L WL++A++M N P+R Sbjct: 355 IGLFIGGAAGGYIAQHFGDNAVFAACTGLVLIWLVVANSM-NFPQR 399 >C6WZ86.1 C6WZ86_METML Major facilitator superfamily MFS_1 Length = 467 Score = 413 bits (1062), Expect = e-113, Method: Compositional matrix adjust. Identities = 217/393 (55%), Positives = 288/393 (73%), Gaps = 16/393 (4%) Query: 22 MSGAEVRASASLASIFALRMLGLFLILPVFAVHAKGMSGGESAAMVGLAMGIYGLAQSFG 81 M+ AE RA+ SLASI+ LRM G+FLILP+FA++A + G S+ MVGLA+G YGL Q+ Sbjct: 12 MTPAETRATLSLASIYGLRMFGMFLILPIFAIYASTLPGNPSSFMVGLALGAYGLTQALL 71 Query: 82 QIPFGMASDKYGRKRVIVVGLVLFALGSFVAAGAQDIGWVIAGRAIQGAGAISAAVTAFI 141 Q+PFGMASDKYGRK +I +GL +FALGS VAA A I +I GRA+QGAGA+SA VTA + Sbjct: 72 QLPFGMASDKYGRKPMIYLGLAIFALGSLVAALASSIEGIIIGRALQGAGAVSAVVTALV 131 Query: 142 ADSTREEHRTKAMAMVGGSIGLTFALSLVASPLLYEAIGMGGIFGLTGVLALAAIGVVLF 201 AD TR+EHRT AMA +G +IG+ F++SLV P+L + IG+ GIF LTGVL LAAI VV F Sbjct: 132 ADLTRDEHRTNAMATIGMTIGVAFSVSLVGGPILNQWIGVPGIFALTGVLTLAAIAVVRF 191 Query: 202 VVP---------DAPMVKARRVPLGEVLRHGELMRLNFGVFALHMTQMAMFVVLPAALVQ 252 VVP DA AR L +VL++ +L+RLN+G+FALH QMAMFVV+P A+V Sbjct: 192 VVPDPVHSHYHSDASATPAR---LKDVLKNKQLLRLNYGIFALHAAQMAMFVVVPFAIVS 248 Query: 253 YAGLPVAEHWKIYLPVVLASFIFMLPPVFIGEKRGLMKQVFVAAISLLLLVQVGMWATLA 312 +G+ +HW+IYLP+VLASF+ M+P + EK+ MK+VFV AI+++L+ Q+ M++ Sbjct: 249 ASGMHENQHWQIYLPIVLASFVLMVPAIIYAEKQSQMKRVFVLAIAMMLVAQL-MFSVSI 307 Query: 313 HFAAHWWVLVFLLFAFFIAFNILEACQPSLVSRIAPAAAKGTALGVYNTLQALGLFCGGA 372 H+ +W +V L +F+AFN+LEA PSL+S+IAPAAAKGTA+GVYNT Q+LG+F GGA Sbjct: 308 HY---FWGIVASLTVYFVAFNVLEASLPSLISKIAPAAAKGTAMGVYNTAQSLGIFVGGA 364 Query: 373 LGGWLKQFAGAPSVFVMCAVATLTWLIIASNMK 405 LGG+L G SVF+ C L WL++A +M+ Sbjct: 365 LGGYLSHVYGFASVFIFCGTMMLLWLLLAFSMQ 397