BLASTP 2.2.21 [Jun-14-2009] Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), "Gapped BLAST and PSI-BLAST: a new generation of protein database search programs", Nucleic Acids Res. 25:3389-3402. Reference for compositional score matrix adjustment: Altschul, Stephen F., John C. Wootton, E. Michael Gertz, Richa Agarwala, Aleksandr Morgulis, Alejandro A. Schaffer, and Yi-Kuo Yu (2005) "Protein database searches using compositionally adjusted substitution matrices", FEBS J. 272:5101-5109. Query= 0027.0005.p (262 letters) Database: pfamseq 15,929,002 sequences; 5,169,768,107 total letters Searching..................................................done Score E Sequences producing significant alignments: (bits) Value D8J0N2.1 D8J0N2_HERSS Uroporphyrinogen-III C-methyltransferase p... 348 5e-94 A4G7P1.1 A4G7P1_HERAR Uroporphyrinogen-III C-methyltransferase E... 330 1e-88 A6T0V0.1 A6T0V0_JANMA Uroporphyrin-III C-methyltransferase EC=2.... 321 6e-86 F1VWV9.1 F1VWV9_9BURK Uroporphyrinogen-III methyltransferase 308 5e-82 E8YFJ3.1 E8YFJ3_9BURK Uroporphyrin-III C-methyltransferase 246 2e-63 >D8J0N2.1 D8J0N2_HERSS Uroporphyrinogen-III C-methyltransferase protein EC=2.1.1.107 Length = 253 Score = 348 bits (893), Expect = 5e-94, Method: Compositional matrix adjust. Identities = 182/247 (73%), Positives = 210/247 (85%), Gaps = 3/247 (1%) Query: 18 SASSASATDAAPTA---GKVYLIGAGPGAADLITVRGARLLAQADVVLHDALVTEEMLEL 74 +A+S S+ AP+ G V+L+G+GPGAADL+TVR ARLLAQA++VLHDALVT ++L L Sbjct: 6 AATSHSSDSPAPSPEHPGMVWLVGSGPGAADLLTVRAARLLAQAEIVLHDALVTPDILAL 65 Query: 75 CPQAVKISVGKRSGQRSTAQQVINERLIECARQYRLVVRLKGGDPMLFGRADEELRALDS 134 CPQAV +SVGKRSGQRSTAQ VIN++L+E A+QYR VVRLKGGDPMLFGRADEE+RAL+ Sbjct: 66 CPQAVLVSVGKRSGQRSTAQPVINQKLVEAAQQYRRVVRLKGGDPMLFGRADEEMRALEE 125 Query: 135 QNIPYEIVPGITAALAAASSAQRPLTKRGIARSVSLFTSSTAPDEPSEFIMPNGDTLVQY 194 +IPYEIVPGITAALAAAS+A+RPLT+RGIARSVSLFTSST DEP E MPNGDTLVQY Sbjct: 126 HHIPYEIVPGITAALAAASAAKRPLTRRGIARSVSLFTSSTGVDEPDEVRMPNGDTLVQY 185 Query: 195 MGGREAAATAQRLLSLGYARTTPVVVVENCSRDNERILDLELGTLEQGLAQCSGPVLVMI 254 MGGREA ATAQRLL+LG+A TPVVVVENCSR ++ I L+L LE GL CSGPVLVMI Sbjct: 186 MGGREATATAQRLLALGHAPDTPVVVVENCSRPDQHIYHLQLAGLEAGLQACSGPVLVMI 245 Query: 255 GEALASR 261 G ALA R Sbjct: 246 GPALADR 252 >A4G7P1.1 A4G7P1_HERAR Uroporphyrinogen-III C-methyltransferase EC=2.1.1.107 Length = 243 Score = 330 bits (846), Expect = 1e-88, Method: Compositional matrix adjust. Identities = 166/230 (72%), Positives = 194/230 (84%) Query: 32 GKVYLIGAGPGAADLITVRGARLLAQADVVLHDALVTEEMLELCPQAVKISVGKRSGQRS 91 GKVYLIGAGPGA DLITVRGAR+LAQADVVLHDALVT EML LCPQA KISVGKRSGQRS Sbjct: 9 GKVYLIGAGPGAIDLITVRGARILAQADVVLHDALVTPEMLTLCPQAEKISVGKRSGQRS 68 Query: 92 TAQQVINERLIECARQYRLVVRLKGGDPMLFGRADEELRALDSQNIPYEIVPGITAALAA 151 TAQ IN+ LIECA +Y+L+VRLKGGDPMLFGRADEEL+AL++ I EIVPGIT A AA Sbjct: 69 TAQIAINQLLIECAEKYQLIVRLKGGDPMLFGRADEELQALETHGIAVEIVPGITTAFAA 128 Query: 152 ASSAQRPLTKRGIARSVSLFTSSTAPDEPSEFIMPNGDTLVQYMGGREAAATAQRLLSLG 211 A++ Q+PLTKRG+ARS++ FTSSTAP++P + +P+ DTL+QYMGGREA TAQ+LL G Sbjct: 129 AAATQQPLTKRGVARSIAFFTSSTAPNQPDQLTLPDCDTLIQYMGGREAIITAQKLLEQG 188 Query: 212 YARTTPVVVVENCSRDNERILDLELGTLEQGLAQCSGPVLVMIGEALASR 261 + PVVVVENCS +++RI+ + L LEQGL +C GPVLVMIGEALA R Sbjct: 189 RSPRLPVVVVENCSLESQRIMRMTLHELEQGLGECQGPVLVMIGEALAER 238 >A6T0V0.1 A6T0V0_JANMA Uroporphyrin-III C-methyltransferase EC=2.1.1.107 Length = 239 Score = 321 bits (823), Expect = 6e-86, Method: Compositional matrix adjust. Identities = 163/237 (68%), Positives = 193/237 (81%) Query: 25 TDAAPTAGKVYLIGAGPGAADLITVRGARLLAQADVVLHDALVTEEMLELCPQAVKISVG 84 T+ GKVYLIGAGPGA DLITVRGAR+LAQADVVLHDALVT EMLELCPQA KISVG Sbjct: 2 TEEKKAYGKVYLIGAGPGAVDLITVRGARILAQADVVLHDALVTPEMLELCPQAEKISVG 61 Query: 85 KRSGQRSTAQQVINERLIECARQYRLVVRLKGGDPMLFGRADEELRALDSQNIPYEIVPG 144 KRSGQRSTAQ IN+ L++CA +Y+L+VRLKGGDPMLFGRADEEL AL++ I EIVPG Sbjct: 62 KRSGQRSTAQLAINQLLVDCAAKYKLIVRLKGGDPMLFGRADEELHALEAHGIEIEIVPG 121 Query: 145 ITAALAAASSAQRPLTKRGIARSVSLFTSSTAPDEPSEFIMPNGDTLVQYMGGREAAATA 204 IT A AAA++AQ PLTKRGIARS++ FTS+TAP++P + +P+ DTL+QYMGGREA TA Sbjct: 122 ITTAFAAAAAAQLPLTKRGIARSIAFFTSATAPNQPDQLTLPDCDTLIQYMGGREAMVTA 181 Query: 205 QRLLSLGYARTTPVVVVENCSRDNERILDLELGTLEQGLAQCSGPVLVMIGEALASR 261 Q+LL G + PVV+VENCS N++I+ + L LE+GL GPVLVMIG ALA+R Sbjct: 182 QKLLEQGRSPDLPVVIVENCSLPNQKIVRMNLRELERGLQDTQGPVLVMIGAALAAR 238 >F1VWV9.1 F1VWV9_9BURK Uroporphyrinogen-III methyltransferase Length = 243 Score = 308 bits (789), Expect = 5e-82, Method: Compositional matrix adjust. Identities = 159/231 (68%), Positives = 191/231 (82%) Query: 32 GKVYLIGAGPGAADLITVRGARLLAQADVVLHDALVTEEMLELCPQAVKISVGKRSGQRS 91 GKV+L+GAGPGAADLITVRGARLLA+A+VVL+DALVT++ML LCPQAV I+VGKR G RS Sbjct: 5 GKVWLVGAGPGAADLITVRGARLLAEAEVVLYDALVTDDMLALCPQAVLIAVGKRCGLRS 64 Query: 92 TAQQVINERLIECARQYRLVVRLKGGDPMLFGRADEELRALDSQNIPYEIVPGITAALAA 151 AQ IN+++I+ A +Y VVRLKGGDPMLFGRADEELRA++S I +VPGITAALAA Sbjct: 65 MAQLAINQQIIDAAAKYSRVVRLKGGDPMLFGRADEELRAIESHGIECAVVPGITAALAA 124 Query: 152 ASSAQRPLTKRGIARSVSLFTSSTAPDEPSEFIMPNGDTLVQYMGGREAAATAQRLLSLG 211 A+S+++PLT+RGIARSV+ FTSSTAPD P + +P DTLVQYMGGREA TA+ LL+LG Sbjct: 125 AASSKQPLTRRGIARSVAFFTSSTAPDMPEQSTLPACDTLVQYMGGREAVKTARNLLALG 184 Query: 212 YARTTPVVVVENCSRDNERILDLELGTLEQGLAQCSGPVLVMIGEALASRD 262 + TPV+VVENCSR +E I L L LE GL CSGPVL+MIG A+A+RD Sbjct: 185 HPPDTPVIVVENCSRADEHIYRLPLSQLEDGLPNCSGPVLMMIGAAMAARD 235 >E8YFJ3.1 E8YFJ3_9BURK Uroporphyrin-III C-methyltransferase Length = 254 Score = 246 bits (629), Expect = 2e-63, Method: Compositional matrix adjust. Identities = 143/238 (60%), Positives = 173/238 (72%), Gaps = 9/238 (3%) Query: 32 GKVYLIGAGPGAADLITVRGARLLAQADVVLHDALVTEEMLELCP-QAVKISVGKRSGQR 90 GKVYLIGAGPGAADLITVRGARLLA ADVVLHDALV ML+ P A +I+VGKR GQ Sbjct: 2 GKVYLIGAGPGAADLITVRGARLLASADVVLHDALVEPAMLDYAPAHARRIAVGKRCGQL 61 Query: 91 STAQQVINERLIECARQYRLVVRLKGGDPMLFGRADEELRALDSQNIPYEIVPGITAALA 150 S AQQ IN+++++ A ++ +VVRLKGGDPMLFGRADEE+RAL++ IPYE+VPGITAALA Sbjct: 62 SAAQQFINKQIVDAALEHEVVVRLKGGDPMLFGRADEEMRALEAAGIPYEVVPGITAALA 121 Query: 151 AASSAQRPLTKRGIARSVSLFTSSTAP--DEPSEFIMPNGDTLVQYMGGREAAATAQRLL 208 +A+S +R LT RG++RSV+L T S AP DE E + N D+LV YMG AQ+L+ Sbjct: 122 SAASLKRSLTLRGVSRSVALATFSRAPGSDEIREQV--NADSLVFYMGRDSGVEIAQQLI 179 Query: 209 SLGYARTTPVVVVENCSRDNERILDLELGTLEQGLAQ----CSGPVLVMIGEALASRD 262 G R TPV +VE CS + ER+L L L L G AQ S P L+MIGEA A R+ Sbjct: 180 DAGKPRATPVAIVEACSTERERMLTLTLEALAAGEAQRWVDASQPSLLMIGEAFAERE 237