BLASTP 2.2.21 [Jun-14-2009] Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), "Gapped BLAST and PSI-BLAST: a new generation of protein database search programs", Nucleic Acids Res. 25:3389-3402. Reference for compositional score matrix adjustment: Altschul, Stephen F., John C. Wootton, E. Michael Gertz, Richa Agarwala, Aleksandr Morgulis, Alejandro A. Schaffer, and Yi-Kuo Yu (2005) "Protein database searches using compositionally adjusted substitution matrices", FEBS J. 272:5101-5109. Query= 0026.0059.p (420 letters) Database: pfamseq 15,929,002 sequences; 5,169,768,107 total letters Searching..................................................done Score E Sequences producing significant alignments: (bits) Value D8IWB8.1 D8IWB8_HERSS Bcr/CflA family drug resistance transporte... 632 e-179 Q397G2.1 Q397G2_BURS3 Drug resistance transporter Bcr/CflA subfa... 613 e-173 D5NKY0.1 D5NKY0_9BURK Major facilitator superfamily MFS_1 612 e-173 Q13XQ9.1 Q13XQ9_BURXL Major facilitator family (MFS) drug efflux... 611 e-173 F0G9W8.1 F0G9W8_9BURK 2-module integral membrane pump 610 e-172 >D8IWB8.1 D8IWB8_HERSS Bcr/CflA family drug resistance transporter protein Length = 417 Score = 632 bits (1629), Expect = e-179, Method: Compositional matrix adjust. Identities = 320/392 (81%), Positives = 345/392 (88%) Query: 6 NHPRFLIFFICMLASAGQLAIDIYVPALPTMAQYFQTSAQAIQSSVTIYLMAYAFGQLFF 65 NHPRFL+F IC ASAGQLAID+YVPALP MA + TSAQAIQSSVT YL+AYAFGQL F Sbjct: 17 NHPRFLLFLICAFASAGQLAIDLYVPALPEMAIDYATSAQAIQSSVTGYLIAYAFGQLVF 76 Query: 66 GPLADAYGRKTMLILGLAMFTAGCLLTLAANNLETFILARCLQGFGIAATNLLAKAIITD 125 GPLADAYGRK +L LGL +F+ GC+L+LAA NLETF+ AR LQGFGIAATNLLAKAIITD Sbjct: 77 GPLADAYGRKRILALGLGLFSLGCVLSLAAPNLETFVAARVLQGFGIAATNLLAKAIITD 136 Query: 126 SFSGIALMHAFTYMAIAWGLAPILAPVIGAHLQTGFGWRSCLTFLLIYSFVMWAVLSRYK 185 SF+G AL+HA+TYMAIAWGLAPI+APVIGAHLQ FGWRSCL FLL+YS MWAVL RY+ Sbjct: 137 SFAGQALVHAYTYMAIAWGLAPIIAPVIGAHLQEAFGWRSCLVFLLVYSLGMWAVLWRYR 196 Query: 186 ETLKQPVHLHPKTLLRNAGMVLRSPVFQSCFLAQGLCYSILLVFNIVGPFMVQETLHKPP 245 ETL QPV LHP TL RNA MVL SPVFQSCFLAQGLCYSILLVFNIVGPFMVQ TLH+PP Sbjct: 197 ETLAQPVRLHPATLARNARMVLASPVFQSCFLAQGLCYSILLVFNIVGPFMVQNTLHQPP 256 Query: 246 TYFGYLALAIGLMYFLGGISNRIHHPRLPTPEQRLRIGARVMTGAAVVMLILALTVGLEV 305 T+FGYLALAIG+MYFLGGISNRI H RLPT EQRLR+GARVMTGAA VML+LAL+VGL V Sbjct: 257 TFFGYLALAIGMMYFLGGISNRITHRRLPTAEQRLRLGARVMTGAAFVMLLLALSVGLTV 316 Query: 306 WTLTLPVLFMAFCAGAMYPTLMAKGNSIFPHIAGLTSAILGFALLLVSSLMMGLAGFVPF 365 WTL PVL MAFCAGAMYPTLMAKGNSIFPHIAGLTSAILGFALLLVS+ MMGLAGFV Sbjct: 317 WTLCAPVLVMAFCAGAMYPTLMAKGNSIFPHIAGLTSAILGFALLLVSAAMMGLAGFVSI 376 Query: 366 HSLTPMAIFFVIVGLTVISMVGKLLHHLXTGA 397 HSLTP+A FF +VGLTVI MVGKLLHHL A Sbjct: 377 HSLTPLAGFFCVVGLTVIVMVGKLLHHLQVPA 408 >Q397G2.1 Q397G2_BURS3 Drug resistance transporter Bcr/CflA subfamily Length = 469 Score = 613 bits (1580), Expect = e-173, Method: Compositional matrix adjust. Identities = 302/389 (77%), Positives = 336/389 (86%) Query: 5 ANHPRFLIFFICMLASAGQLAIDIYVPALPTMAQYFQTSAQAIQSSVTIYLMAYAFGQLF 64 +N PRFL+F IC+ ASAGQLAIDIYVPALP MA+ F T+ QAIQSSV+ Y+ AYA GQL Sbjct: 63 SNSPRFLLFLICLFASAGQLAIDIYVPALPDMARSFATTPQAIQSSVSGYMAAYALGQLI 122 Query: 65 FGPLADAYGRKTMLILGLAMFTAGCLLTLAANNLETFILARCLQGFGIAATNLLAKAIIT 124 FGP+ADAYGRK +L GL ++T GCLL+L A NLETF+LARCLQGFGIA TNLLAKAIIT Sbjct: 123 FGPVADAYGRKRVLAFGLVIYTIGCLLSLGAQNLETFVLARCLQGFGIATTNLLAKAIIT 182 Query: 125 DSFSGIALMHAFTYMAIAWGLAPILAPVIGAHLQTGFGWRSCLTFLLIYSFVMWAVLSRY 184 DSFSG ALMHAFTYM+IAWGLAPI+APVIGAHLQ FGWR+CL FLL+YS VMWA+L RY Sbjct: 183 DSFSGQALMHAFTYMSIAWGLAPIVAPVIGAHLQEWFGWRACLVFLLVYSLVMWALLWRY 242 Query: 185 KETLKQPVHLHPKTLLRNAGMVLRSPVFQSCFLAQGLCYSILLVFNIVGPFMVQETLHKP 244 +ETL +PVHL P+TL+ NAG VL SPVFQSCFLAQGLCYSILLVFNIVGPFMVQ TLHKP Sbjct: 243 RETLPKPVHLEPRTLMTNAGKVLASPVFQSCFLAQGLCYSILLVFNIVGPFMVQTTLHKP 302 Query: 245 PTYFGYLALAIGLMYFLGGISNRIHHPRLPTPEQRLRIGARVMTGAAVVMLILALTVGLE 304 PT+FGYLAL IGLMYFLGG+SNRIH P LP+ EQRLRIGARVM GA+V ML+LALTVGL Sbjct: 303 PTFFGYLALGIGLMYFLGGLSNRIHRPGLPSAEQRLRIGARVMAGASVAMLVLALTVGLR 362 Query: 305 VWTLTLPVLFMAFCAGAMYPTLMAKGNSIFPHIAGLTSAILGFALLLVSSLMMGLAGFVP 364 VWTL PVL M FCAGAMYPTLMAKGNS+FPHIAGLTSAILG ALLLVSS MMGLAGFV Sbjct: 363 VWTLATPVLVMGFCAGAMYPTLMAKGNSLFPHIAGLTSAILGCALLLVSSAMMGLAGFVS 422 Query: 365 FHSLTPMAIFFVIVGLTVISMVGKLLHHL 393 H LTP+A+FFV++ V+ MV KLL +L Sbjct: 423 IHVLTPLAVFFVVLSCIVVWMVTKLLRYL 451 >D5NKY0.1 D5NKY0_9BURK Major facilitator superfamily MFS_1 Length = 420 Score = 612 bits (1577), Expect = e-173, Method: Compositional matrix adjust. Identities = 302/390 (77%), Positives = 338/390 (86%) Query: 4 TANHPRFLIFFICMLASAGQLAIDIYVPALPTMAQYFQTSAQAIQSSVTIYLMAYAFGQL 63 T N PRFL+F IC+ ASAGQLAIDIYVPALP MA +F TS QAIQSSV+ Y++AYA GQL Sbjct: 15 TPNSPRFLLFLICLFASAGQLAIDIYVPALPAMAHFFATSPQAIQSSVSGYMVAYALGQL 74 Query: 64 FFGPLADAYGRKTMLILGLAMFTAGCLLTLAANNLETFILARCLQGFGIAATNLLAKAII 123 FGP+ADAYGRK +L GL ++T GCLL+LAA++LETFILARCLQGFGIA TNLLAKAII Sbjct: 75 VFGPVADAYGRKRVLAFGLVIYTLGCLLSLAASSLETFILARCLQGFGIATTNLLAKAII 134 Query: 124 TDSFSGIALMHAFTYMAIAWGLAPILAPVIGAHLQTGFGWRSCLTFLLIYSFVMWAVLSR 183 TDSF+G AL+HAFTYM+IAWGLAPI+APVIGAHLQT FGW++CL FLL+YS VMW +L R Sbjct: 135 TDSFTGQALVHAFTYMSIAWGLAPIVAPVIGAHLQTWFGWQACLVFLLVYSLVMWGLLWR 194 Query: 184 YKETLKQPVHLHPKTLLRNAGMVLRSPVFQSCFLAQGLCYSILLVFNIVGPFMVQETLHK 243 Y+ETL QPVHL P+TL+ NAG VL SPVFQSCFLAQGLCYSILLVFNIVGPFMVQ TLHK Sbjct: 195 YRETLVQPVHLAPRTLMANAGKVLSSPVFQSCFLAQGLCYSILLVFNIVGPFMVQNTLHK 254 Query: 244 PPTYFGYLALAIGLMYFLGGISNRIHHPRLPTPEQRLRIGARVMTGAAVVMLILALTVGL 303 PPT+FGYLAL IG MYFLGG+SNR++ RLP EQRLRIGARVM GA++ MLILALTVGL Sbjct: 255 PPTFFGYLALGIGAMYFLGGLSNRVYGARLPNAEQRLRIGARVMAGASIAMLILALTVGL 314 Query: 304 EVWTLTLPVLFMAFCAGAMYPTLMAKGNSIFPHIAGLTSAILGFALLLVSSLMMGLAGFV 363 VWTL LPVL M FCAGAMYPTLMAKGNS+FPHIAGLTSAILG ALLLVSS MMGLAGFV Sbjct: 315 RVWTLALPVLVMGFCAGAMYPTLMAKGNSLFPHIAGLTSAILGCALLLVSSAMMGLAGFV 374 Query: 364 PFHSLTPMAIFFVIVGLTVISMVGKLLHHL 393 LT +A+FFV++ LTV+ MV KLL HL Sbjct: 375 SVQELTSLAVFFVVLALTVVGMVTKLLRHL 404 >Q13XQ9.1 Q13XQ9_BURXL Major facilitator family (MFS) drug efflux pump, Bcr/CflA family Length = 420 Score = 611 bits (1576), Expect = e-173, Method: Compositional matrix adjust. Identities = 300/388 (77%), Positives = 336/388 (86%) Query: 6 NHPRFLIFFICMLASAGQLAIDIYVPALPTMAQYFQTSAQAIQSSVTIYLMAYAFGQLFF 65 N PRFL+F IC+ ASAGQLAIDIYVPALP MA +F TS QAIQSSV+ Y++AYA GQL F Sbjct: 17 NSPRFLLFLICLFASAGQLAIDIYVPALPAMAHFFATSPQAIQSSVSGYMVAYALGQLVF 76 Query: 66 GPLADAYGRKTMLILGLAMFTAGCLLTLAANNLETFILARCLQGFGIAATNLLAKAIITD 125 GP+ADAYGRK +L GL ++T GCLL+L A+NLETF+LARCLQGFGIA TNLLAKAIITD Sbjct: 77 GPVADAYGRKRVLAFGLVIYTLGCLLSLVASNLETFVLARCLQGFGIATTNLLAKAIITD 136 Query: 126 SFSGIALMHAFTYMAIAWGLAPILAPVIGAHLQTGFGWRSCLTFLLIYSFVMWAVLSRYK 185 SF+G AL+HAFTYM+IAWGLAPI+APVIGAHLQT FGW++CL FLL+YS VMW +L RY+ Sbjct: 137 SFAGQALVHAFTYMSIAWGLAPIVAPVIGAHLQTWFGWQACLVFLLVYSLVMWGLLWRYR 196 Query: 186 ETLKQPVHLHPKTLLRNAGMVLRSPVFQSCFLAQGLCYSILLVFNIVGPFMVQETLHKPP 245 ETL QPVHL P+TL+ NAG VL SPVFQSCFLAQGLCYSILLVFNIVGPFMVQ TLHKPP Sbjct: 197 ETLVQPVHLAPRTLMANAGKVLSSPVFQSCFLAQGLCYSILLVFNIVGPFMVQNTLHKPP 256 Query: 246 TYFGYLALAIGLMYFLGGISNRIHHPRLPTPEQRLRIGARVMTGAAVVMLILALTVGLEV 305 T+FGYLAL IG MYFLGG+SNR+H RLP EQRLRIGARVM A++ ML+LALTVGL V Sbjct: 257 TFFGYLALGIGAMYFLGGLSNRVHGARLPDAEQRLRIGARVMAAASIAMLVLALTVGLRV 316 Query: 306 WTLTLPVLFMAFCAGAMYPTLMAKGNSIFPHIAGLTSAILGFALLLVSSLMMGLAGFVPF 365 WTL LPVL M FCAGAMYPTLMAKGNS+FPHIAGLTSAILG ALLLVSS MMGLAGFV Sbjct: 317 WTLALPVLVMGFCAGAMYPTLMAKGNSLFPHIAGLTSAILGCALLLVSSAMMGLAGFVSV 376 Query: 366 HSLTPMAIFFVIVGLTVISMVGKLLHHL 393 LT +A+FFVI+ LTV++MV KLL HL Sbjct: 377 QELTSLAVFFVILALTVVAMVTKLLRHL 404 >F0G9W8.1 F0G9W8_9BURK 2-module integral membrane pump Length = 415 Score = 610 bits (1574), Expect = e-172, Method: Compositional matrix adjust. Identities = 302/389 (77%), Positives = 334/389 (85%) Query: 5 ANHPRFLIFFICMLASAGQLAIDIYVPALPTMAQYFQTSAQAIQSSVTIYLMAYAFGQLF 64 +N PRFL+F IC+ ASAGQLAIDIYVPALP MA+ F T+ QAIQSSV+ Y+ AYA GQL Sbjct: 11 SNSPRFLLFLICLFASAGQLAIDIYVPALPDMARSFATTPQAIQSSVSGYMAAYALGQLI 70 Query: 65 FGPLADAYGRKTMLILGLAMFTAGCLLTLAANNLETFILARCLQGFGIAATNLLAKAIIT 124 FGP+ADAYGRK +L GL ++T GCLL+L A NLETF+LAR LQGFGIA TNLLAKAIIT Sbjct: 71 FGPIADAYGRKRVLAFGLVIYTIGCLLSLGAPNLETFVLARALQGFGIATTNLLAKAIIT 130 Query: 125 DSFSGIALMHAFTYMAIAWGLAPILAPVIGAHLQTGFGWRSCLTFLLIYSFVMWAVLSRY 184 DSFSG ALMHAFTYM+IAWGLAPI+APVIGAHLQT FGWRSCL FLL+YS MWA+L Y Sbjct: 131 DSFSGQALMHAFTYMSIAWGLAPIVAPVIGAHLQTWFGWRSCLVFLLVYSLAMWALLWHY 190 Query: 185 KETLKQPVHLHPKTLLRNAGMVLRSPVFQSCFLAQGLCYSILLVFNIVGPFMVQETLHKP 244 KETL+QPVHL P+TL+ NAG VL SPVFQSCFLAQGLCYSILLVFNIVGPFMVQ TLH+P Sbjct: 191 KETLRQPVHLEPRTLMANAGKVLSSPVFQSCFLAQGLCYSILLVFNIVGPFMVQNTLHRP 250 Query: 245 PTYFGYLALAIGLMYFLGGISNRIHHPRLPTPEQRLRIGARVMTGAAVVMLILALTVGLE 304 PT+FGYLAL IGLMYFLGG+SNRIH PRLP+ EQRLRIGARVM GA+V ML+L LTVGL Sbjct: 251 PTFFGYLALGIGLMYFLGGLSNRIHGPRLPSAEQRLRIGARVMAGASVAMLVLGLTVGLR 310 Query: 305 VWTLTLPVLFMAFCAGAMYPTLMAKGNSIFPHIAGLTSAILGFALLLVSSLMMGLAGFVP 364 VWTL PVL M FCAGAMYPTLMAKGNS+FPHIAGLTSAILG ALLLVSS MMGLAGFV Sbjct: 311 VWTLATPVLVMGFCAGAMYPTLMAKGNSLFPHIAGLTSAILGCALLLVSSAMMGLAGFVS 370 Query: 365 FHSLTPMAIFFVIVGLTVISMVGKLLHHL 393 LTP+A+FFV + L V+ MV KLL +L Sbjct: 371 VQVLTPLAVFFVALSLVVVWMVTKLLRYL 399