BLASTP 2.2.21 [Jun-14-2009] Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), "Gapped BLAST and PSI-BLAST: a new generation of protein database search programs", Nucleic Acids Res. 25:3389-3402. Reference for compositional score matrix adjustment: Altschul, Stephen F., John C. Wootton, E. Michael Gertz, Richa Agarwala, Aleksandr Morgulis, Alejandro A. Schaffer, and Yi-Kuo Yu (2005) "Protein database searches using compositionally adjusted substitution matrices", FEBS J. 272:5101-5109. Query= 0025.0147.p (289 letters) Database: pfamseq 15,929,002 sequences; 5,169,768,107 total letters Searching..................................................done Score E Sequences producing significant alignments: (bits) Value D8IS80.1 D8IS80_HERSS CBS-domain-containing membrane protein 395 e-108 A6SYD0.1 A6SYD0_JANMA Signal transduction protein 349 3e-94 A4G5T1.1 A4G5T1_HERAR Putative HPP family protein with CBS domain 345 4e-93 C6WY38.1 C6WY38_METML CBS domain containing membrane protein 330 1e-88 E4QL93.1 E4QL93_METS6 CBS domain containing membrane protein 322 4e-86 >D8IS80.1 D8IS80_HERSS CBS-domain-containing membrane protein Length = 400 Score = 395 bits (1015), Expect = e-108, Method: Compositional matrix adjust. Identities = 207/271 (76%), Positives = 226/271 (83%), Gaps = 1/271 (0%) Query: 1 MRDSILQWLRSFIPQKTAVDRFERMRASAGALFGILLTGLLSYLILPHNAAAIWLIAPMG 60 M DSI W +SFIP K VDRFERMR+ AG+LFGILL G++SY +LPH A IWLIAPMG Sbjct: 3 MPDSISLWFKSFIPAKANVDRFERMRSCAGSLFGILLVGMVSYAVLPHKAGTIWLIAPMG 62 Query: 61 ASAVLLFAVPSSPLAQPWSIIGGNLVAALVGVTCAKLIGEPALAAALAIALAIACMFALR 120 ASAVLLFAVPSSPLAQPWSIIGGNL AAL+GVTCAKL+ EPALAAALAIALAI MF LR Sbjct: 63 ASAVLLFAVPSSPLAQPWSIIGGNLCAALIGVTCAKLVPEPALAAALAIALAIGAMFYLR 122 Query: 121 CIHPPSGAVALTAVLGGPAVHGMGYGFVLSPVLLNSFLLLAMALFFNNATRRRYPHAQQS 180 CIHPPSGAVALTAVLGGPAV MGYGFVLSPVLLNS LLLA ALFFNNA+ RRYPHAQQS Sbjct: 123 CIHPPSGAVALTAVLGGPAVQAMGYGFVLSPVLLNSVLLLATALFFNNASGRRYPHAQQS 182 Query: 181 EHRNNVHQTHDVAPSARLGFTHEDLDAVLRRYNQVLDISRDDLEEILQQTEMEAYRRRFG 240 + H T D P RLGF+HEDLD VL+RYNQVLDI RDDLEEI QTEM AY RRFG Sbjct: 183 A-APHPHHTRDELPITRLGFSHEDLDEVLKRYNQVLDIGRDDLEEIFLQTEMRAYHRRFG 241 Query: 241 ETVCADIMSSDVVSVEFSTELAEAWRQMRAH 271 +T+CA +MS DVV+VEF+T L EAWR ++AH Sbjct: 242 QTLCASVMSRDVVAVEFATGLDEAWRLLQAH 272 >A6SYD0.1 A6SYD0_JANMA Signal transduction protein Length = 394 Score = 349 bits (895), Expect = 3e-94, Method: Compositional matrix adjust. Identities = 180/271 (66%), Positives = 206/271 (76%) Query: 1 MRDSILQWLRSFIPQKTAVDRFERMRASAGALFGILLTGLLSYLILPHNAAAIWLIAPMG 60 M S + L P VDR+E+MRA AGALFG++LTGL SY IL + A WLIAPMG Sbjct: 1 MVQSAWKSLTRIFPTPGTVDRYEKMRACAGALFGLVLTGLCSYFILGKDIHAAWLIAPMG 60 Query: 61 ASAVLLFAVPSSPLAQPWSIIGGNLVAALVGVTCAKLIGEPALAAALAIALAIACMFALR 120 AS+VLLFAVP+SPLAQPWSI+GGN++AA++GVTCAK+I EP LAA +A ALAI MFA R Sbjct: 61 ASSVLLFAVPASPLAQPWSIMGGNILAAIIGVTCAKMIDEPILAAGVAAALAIGAMFAAR 120 Query: 121 CIHPPSGAVALTAVLGGPAVHGMGYGFVLSPVLLNSFLLLAMALFFNNATRRRYPHAQQS 180 CIHPPSGAVALTAVLGGPAVH MGY FV+ PV LNS LLL ALF+NNAT RRYPH Sbjct: 121 CIHPPSGAVALTAVLGGPAVHAMGYSFVIIPVALNSALLLITALFYNNATGRRYPHRPLP 180 Query: 181 EHRNNVHQTHDVAPSARLGFTHEDLDAVLRRYNQVLDISRDDLEEILQQTEMEAYRRRFG 240 N H T D AP+ R+G DLDAVL RYNQVLDISRDDLE I+ QTEM+AYRRR G Sbjct: 181 PDTANKHNTSDAAPTERIGIAPADLDAVLTRYNQVLDISRDDLEAIMLQTEMQAYRRRLG 240 Query: 241 ETVCADIMSSDVVSVEFSTELAEAWRQMRAH 271 ETVCA +MS DVV+ EF T LA+AW ++ H Sbjct: 241 ETVCAAVMSKDVVTAEFGTTLADAWTLLKQH 271 >A4G5T1.1 A4G5T1_HERAR Putative HPP family protein with CBS domain Length = 390 Score = 345 bits (886), Expect = 4e-93, Method: Compositional matrix adjust. Identities = 188/268 (70%), Positives = 210/268 (78%), Gaps = 1/268 (0%) Query: 4 SILQWLRSFIPQKTAVDRFERMRASAGALFGILLTGLLSYLILPHNAAAIWLIAPMGASA 63 S L+ L +P VDR+E+MRA AGALFGI+LT L SY IL + A WLIAPMGAS+ Sbjct: 4 SKLKLLLRIVPASGLVDRYEKMRACAGALFGIVLTALCSYFILGKDINAAWLIAPMGASS 63 Query: 64 VLLFAVPSSPLAQPWSIIGGNLVAALVGVTCAKLIGEPALAAALAIALAIACMFALRCIH 123 VLLFAVP+SPLAQPWSI+GGN++AA++GVTCAK +GEP LAA LA +LAI MF RCIH Sbjct: 64 VLLFAVPASPLAQPWSIMGGNIIAAIIGVTCAKFVGEPILAAGLAASLAIGAMFTFRCIH 123 Query: 124 PPSGAVALTAVLGGPAVHGMGYGFVLSPVLLNSFLLLAMALFFNNATRRRYPHAQQSEHR 183 PPSGAVALTAVLGGPAVH MGY FVL PV LNS LLL ALFFNNAT RRYPH Q + R Sbjct: 124 PPSGAVALTAVLGGPAVHAMGYSFVLIPVALNSLLLLLTALFFNNATGRRYPHIVQPD-R 182 Query: 184 NNVHQTHDVAPSARLGFTHEDLDAVLRRYNQVLDISRDDLEEILQQTEMEAYRRRFGETV 243 N H T DVAP+ R G T EDLD VL RYNQVLDISRDDLE I+ QTEM+AYRRR T Sbjct: 183 GNKHNTKDVAPTERTGITPEDLDVVLARYNQVLDISRDDLESIMLQTEMQAYRRRLDGTK 242 Query: 244 CADIMSSDVVSVEFSTELAEAWRQMRAH 271 CADIMS DV+ VEF TELAEAWRQ ++H Sbjct: 243 CADIMSKDVIYVEFGTELAEAWRQFKSH 270 >C6WY38.1 C6WY38_METML CBS domain containing membrane protein Length = 394 Score = 330 bits (847), Expect = 1e-88, Method: Compositional matrix adjust. Identities = 173/274 (63%), Positives = 204/274 (74%), Gaps = 13/274 (4%) Query: 3 DSILQWLRSFIPQKTAVDRFERMRASAGALFGILLTGLLSYLILPHNAAAIWLIAPMGAS 62 D + QWLR F+P++ AV+ ER+RA GA GIL TGL++ LI + +LIAPMGAS Sbjct: 2 DKLKQWLRGFVPERIAVNHQERLRAGIGACIGILCTGLITILIEGDASTLPYLIAPMGAS 61 Query: 63 AVLLFAVPSSPLAQPWSIIGGNLVAALVGVTCAKLIGEPALAAALAIALAIACMFALRCI 122 AVLLFAVPSSPLAQPWSIIGGN AAL+GVTCA I PA AAA+A++L+I MF+LRCI Sbjct: 62 AVLLFAVPSSPLAQPWSIIGGNTTAALIGVTCAMWIAHPATAAAVAVSLSIVAMFSLRCI 121 Query: 123 HPPSGAVALTAVLGGPAVHGMGYGFVLSPVLLNSFLLLAMALFFNNATRRRYPH-----A 177 HPPSGAVALTAVLGG ++H GY FVL+PV LNSF+LL +A+ +NNATRR YPH A Sbjct: 122 HPPSGAVALTAVLGGASIHAQGYWFVLTPVALNSFILLLVAILYNNATRRPYPHLVAKPA 181 Query: 178 QQSEHRNNVHQTHDVAPSARLGFTHEDLDAVLRRYNQVLDISRDDLEEILQQTEMEAYRR 237 QQ T D+ R GF EDL+AVL+ YNQVLD+SRDDL+ +LQQTEM AYRR Sbjct: 182 QQ--------LTKDIPAEMRFGFNTEDLNAVLKEYNQVLDVSRDDLQSLLQQTEMHAYRR 233 Query: 238 RFGETVCADIMSSDVVSVEFSTELAEAWRQMRAH 271 RFGE +CADIMS DVVSV F T L +AW MR H Sbjct: 234 RFGEIICADIMSKDVVSVVFGTLLEDAWLLMRQH 267 >E4QL93.1 E4QL93_METS6 CBS domain containing membrane protein Length = 397 Score = 322 bits (825), Expect = 4e-86, Method: Compositional matrix adjust. Identities = 163/269 (60%), Positives = 207/269 (76%), Gaps = 1/269 (0%) Query: 3 DSILQWLRSFIPQKTAVDRFERMRASAGALFGILLTGLLSYLILPHNAAAIWLIAPMGAS 62 ++++Q++R F PQ V ER+RA GAL GIL+T +S L++ NA+ +L+AP+GAS Sbjct: 8 NALMQFMRRFRPQTNIVSHSERLRACGGALLGILITASVSALLV-DNASLPFLMAPIGAS 66 Query: 63 AVLLFAVPSSPLAQPWSIIGGNLVAALVGVTCAKLIGEPALAAALAIALAIACMFALRCI 122 AVLL+A P+SPLAQPWSI+GGN+++A+ GV CA I P LAAA AI LAI MFA+RC+ Sbjct: 67 AVLLYAAPASPLAQPWSIMGGNMLSAIAGVLCASWISSPLLAAAAAIFLAIGLMFAMRCL 126 Query: 123 HPPSGAVALTAVLGGPAVHGMGYGFVLSPVLLNSFLLLAMALFFNNATRRRYPHAQQSEH 182 HPP GAVALTAV+GGPA+H +G+G+VL PV LNS LLL +AL +NNATRR YPHAQQ E Sbjct: 127 HPPGGAVALTAVIGGPAIHQLGWGYVLMPVGLNSLLLLVVALIYNNATRRPYPHAQQLEP 186 Query: 183 RNNVHQTHDVAPSARLGFTHEDLDAVLRRYNQVLDISRDDLEEILQQTEMEAYRRRFGET 242 ++H+T D+ P AR+GFTH D+DAVL+ YNQVLDISRDDLE + QTEM AYRRRFGE Sbjct: 187 ERSLHETQDIPPLARMGFTHADMDAVLKDYNQVLDISRDDLESLFLQTEMHAYRRRFGEI 246 Query: 243 VCADIMSSDVVSVEFSTELAEAWRQMRAH 271 C DIMS +++VEF T L EAW+ + H Sbjct: 247 RCQDIMSRSLITVEFGTTLEEAWQLLLRH 275