BLASTP 2.2.21 [Jun-14-2009] Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), "Gapped BLAST and PSI-BLAST: a new generation of protein database search programs", Nucleic Acids Res. 25:3389-3402. Reference for compositional score matrix adjustment: Altschul, Stephen F., John C. Wootton, E. Michael Gertz, Richa Agarwala, Aleksandr Morgulis, Alejandro A. Schaffer, and Yi-Kuo Yu (2005) "Protein database searches using compositionally adjusted substitution matrices", FEBS J. 272:5101-5109. Query= 0025.0119.p (260 letters) Database: pfamseq 15,929,002 sequences; 5,169,768,107 total letters Searching..................................................done Score E Sequences producing significant alignments: (bits) Value D8IZS2.1 D8IZS2_HERSS Uroporphyrinogen-III synthase protein EC=4... 266 3e-69 A6SX36.1 A6SX36_JANMA Uroporphyrinogen-III synthase EC=4.2.1.75 243 2e-62 A4G3V3.1 A4G3V3_HERAR Uroporphyrinogen III synthase (UROS) (Urop... 227 1e-57 F1VWN3.1 F1VWN3_9BURK Uroporphyrinogen III synthase 213 2e-53 B1FY92.1 B1FY92_9BURK Putative uncharacterized protein 211 8e-53 >D8IZS2.1 D8IZS2_HERSS Uroporphyrinogen-III synthase protein EC=4.2.1.75 Length = 269 Score = 266 bits (679), Expect = 3e-69, Method: Compositional matrix adjust. Identities = 145/250 (58%), Positives = 183/250 (73%), Gaps = 3/250 (1%) Query: 5 ASRPVVITRPLAQAGAFATQVTAIGRMPVIFPLLEIAPVADSTELRRVLSVLERYALVVF 64 A+ PVV+TRP QA AFA V A+GR V+FPLLEI+ V D L+ +L+ LE +ALVVF Sbjct: 9 AALPVVVTRPRQQAHAFAASVQALGRPAVVFPLLEISAVEDVATLQAMLARLEEFALVVF 68 Query: 65 VSPNAIDAAFQFIAS---WPQAVAIGIVGEGSRLALRRHGVDDAHATIHAPRNSARMDSE 121 VSPNAIDAAF + + WP VAIGIVGEGSRLALR HGVD A AT++ P+ + +MDSE Sbjct: 69 VSPNAIDAAFAQLPAGRPWPAKVAIGIVGEGSRLALRAHGVDAACATLYGPQRADKMDSE 128 Query: 122 ELFKALDPEALHGKRVLIVRGQAGRDFLTDMLRDRQVEVEHVTAYQRLLPQIDAEKAAHL 181 EL K+L L G+R LIVRGQ+GRDFL++ L+ + V VE++TAY+R P++DA+ L Sbjct: 129 ELLKSLPLAQLRGQRALIVRGQSGRDFLSEALQQQGVTVEYLTAYRRTAPRLDAQNGPLL 188 Query: 182 RSLIEAGSEWVVTSSEALRNLRQITADALGQDCVVKLQRNEIIVSHQRIAETAHSLGFSH 241 L++ G++WV+TSSEALRNL +T A G++ VVKLQR I VSH RIAETA GF Sbjct: 189 LDLLDGGADWVITSSEALRNLVDLTRLAGGEERVVKLQRQRIFVSHHRIAETAREQGFER 248 Query: 242 VTVTGSGDER 251 V +TGSGDER Sbjct: 249 VVLTGSGDER 258 >A6SX36.1 A6SX36_JANMA Uroporphyrinogen-III synthase EC=4.2.1.75 Length = 256 Score = 243 bits (620), Expect = 2e-62, Method: Compositional matrix adjust. Identities = 127/250 (50%), Positives = 168/250 (67%) Query: 9 VVITRPLAQAGAFATQVTAIGRMPVIFPLLEIAPVADSTELRRVLSVLERYALVVFVSPN 68 VVITRPLAQA A A +VT +GR VIFPLLEI P+ D LR+ L L++YAL+ FVSPN Sbjct: 5 VVITRPLAQADALAQRVTELGRKAVIFPLLEILPLDDQQSLRQALRELDQYALIAFVSPN 64 Query: 69 AIDAAFQFIASWPQAVAIGIVGEGSRLALRRHGVDDAHATIHAPRNSARMDSEELFKALD 128 AIDAAF WP + + +VGEGSR+AL RHG ++TI +P + R DS+ L LD Sbjct: 65 AIDAAFNARPDWPWQIPLAVVGEGSRMALLRHGATTGNSTIISPTDLERTDSQTLLAELD 124 Query: 129 PEALHGKRVLIVRGQAGRDFLTDMLRDRQVEVEHVTAYQRLLPQIDAEKAAHLRSLIEAG 188 L GK+VLI+RG+ GR+ L D LR V V + AY+R+ P+++ + L+ L+ Sbjct: 125 LPVLRGKQVLIIRGETGRELLGDTLRAAGVGVTPLAAYRRVAPELNNARRGELKRLLSCQ 184 Query: 189 SEWVVTSSEALRNLRQITADALGQDCVVKLQRNEIIVSHQRIAETAHSLGFSHVTVTGSG 248 ++W+VTSSE LR L ++ A V K+Q+ IIVSH RIAETA LGFS++T+T SG Sbjct: 185 NDWIVTSSEGLRFLTEMVAQLDEAGSVAKMQQQRIIVSHVRIAETAQLLGFSNITLTRSG 244 Query: 249 DERLIAALQS 258 D+ L+AALQS Sbjct: 245 DDGLLAALQS 254 >A4G3V3.1 A4G3V3_HERAR Uroporphyrinogen III synthase (UROS) (Uroporphyrinogen-III cosynthetase) (Hydroxymethylbilane hydrolyase [cyclizing]) EC=4.2.1.75 Length = 260 Score = 227 bits (579), Expect = 1e-57, Method: Compositional matrix adjust. Identities = 128/250 (51%), Positives = 168/250 (67%) Query: 9 VVITRPLAQAGAFATQVTAIGRMPVIFPLLEIAPVADSTELRRVLSVLERYALVVFVSPN 68 VVITRPLAQA A +VTA+GR +FPLL+I P+AD L++ L L YAL+ FVSPN Sbjct: 9 VVITRPLAQAEGLARRVTALGRKATVFPLLDILPLADQASLQQALRDLSGYALIAFVSPN 68 Query: 69 AIDAAFQFIASWPQAVAIGIVGEGSRLALRRHGVDDAHATIHAPRNSARMDSEELFKALD 128 AIDAA A WP+ + + +VGEGSRLAL RHG+ ++TI +P + R DSE L LD Sbjct: 69 AIDAALAARADWPRDIPMAVVGEGSRLALARHGLTAENSTIISPTDLDRTDSETLLAELD 128 Query: 129 PEALHGKRVLIVRGQAGRDFLTDMLRDRQVEVEHVTAYQRLLPQIDAEKAAHLRSLIEAG 188 AL K++LIVRG+ GR L++ LR +V + AY+R+ P DA + L+ L+ Sbjct: 129 LPALRNKQILIVRGETGRPLLSEALRAAGAQVTLLAAYRRVAPVFDATRRRELKRLLHGQ 188 Query: 189 SEWVVTSSEALRNLRQITADALGQDCVVKLQRNEIIVSHQRIAETAHSLGFSHVTVTGSG 248 ++W+VTSSEALR L Q+ A + V K+Q+ IIVSH RI ETA LGFS++TVT SG Sbjct: 189 NDWIVTSSEALRFLMQMVAQLDEAEGVAKMQQQRIIVSHIRIGETAQLLGFSNITVTRSG 248 Query: 249 DERLIAALQS 258 D+ L+AALQS Sbjct: 249 DDGLLAALQS 258 >F1VWN3.1 F1VWN3_9BURK Uroporphyrinogen III synthase Length = 256 Score = 213 bits (542), Expect = 2e-53, Method: Compositional matrix adjust. Identities = 126/253 (49%), Positives = 166/253 (65%) Query: 6 SRPVVITRPLAQAGAFATQVTAIGRMPVIFPLLEIAPVADSTELRRVLSVLERYALVVFV 65 +RP+VITRPLAQ+ A A Q+ R VI PLLEI P+ D++ L+ VL+ LE +ALV FV Sbjct: 2 ARPLVITRPLAQSLALAQQLRDGDRELVILPLLEILPLPDTSALQAVLAQLESFALVAFV 61 Query: 66 SPNAIDAAFQFIASWPQAVAIGIVGEGSRLALRRHGVDDAHATIHAPRNSARMDSEELFK 125 SPNAIDA F +A WP +V + ++GEGSR AL RHGV I +P ++ R DS+ L + Sbjct: 62 SPNAIDATFAQLACWPPSVPLAVMGEGSRRALARHGVAAGLYQITSPLDTQRTDSQTLLE 121 Query: 126 ALDPEALHGKRVLIVRGQAGRDFLTDMLRDRQVEVEHVTAYQRLLPQIDAEKAAHLRSLI 185 ALD L G++VLIVRG++GR+ L D LRD + V+ V AY+R P +D L L+ Sbjct: 122 ALDLSRLQGRQVLIVRGESGRELLADALRDAGISVQQVAAYRRAAPLLDDALRQRLTDLL 181 Query: 186 EAGSEWVVTSSEALRNLRQITADALGQDCVVKLQRNEIIVSHQRIAETAHSLGFSHVTVT 245 +WV+TSSEAL+ L + V K+QR ++ V H+RIAETA SLGF V +T Sbjct: 182 AQEGDWVITSSEALQVLMHFVQQVDAESGVDKIQRMKLFVPHRRIAETALSLGFRSVCLT 241 Query: 246 GSGDERLIAALQS 258 GSGDE L+ ALQS Sbjct: 242 GSGDEGLLTALQS 254 >B1FY92.1 B1FY92_9BURK Putative uncharacterized protein Length = 677 Score = 211 bits (537), Expect = 8e-53, Method: Compositional matrix adjust. Identities = 127/260 (48%), Positives = 166/260 (63%), Gaps = 13/260 (5%) Query: 9 VVITRPLAQAGAFATQVTAIGRMPVIFPLLEIAPVADSTELRRVLSVLERYALVVFVSPN 68 VVITRP Q+ ++ A G + + FPL++IAPV D LR L LERYALVVFVSPN Sbjct: 25 VVITRPAGQSNELIERLAAAGAVTLDFPLIDIAPVEDDAPLRAALGSLERYALVVFVSPN 84 Query: 69 AIDAAF-QFIASWPQAVAIGIVGEGSRLALRRHGVD-DAHATIH----APRNSARMDSEE 122 AID AF + A WP A+ +G+VG GS AL RHGV+ AH I A ++ R DSE Sbjct: 85 AIDHAFARSGAIWPHALPVGVVGPGSVRALARHGVNAPAHQVISPASDADEDNGRFDSEG 144 Query: 123 LFKALDP---EA-LHGKRVLIVRGQAGRDFLTDMLRDRQVEVEHVTAYQRLLPQIDAEKA 178 LF A+D EA L GKRVLIVRG GR++L D LR+ EVE V AY+RL+P+ Sbjct: 145 LFAAIDAALGEANLEGKRVLIVRGDGGREWLADRLREAGAEVETVAAYRRLVPEPSIAAW 204 Query: 179 AHLRSLIEAGSE--WVVTSSEALRNLRQITADALGQDCVVKLQRNEIIVSHQRIAETAHS 236 A + L+ AG W++TSSE +RNL ++ + L D + +L+R I+ H RIA+TA + Sbjct: 205 ARVHRLL-AGEPHAWLLTSSEGVRNLHELAQEHLTADEIAQLKRAPIVAPHPRIAQTARA 263 Query: 237 LGFSHVTVTGSGDERLIAAL 256 LGF +TV+G+GDER+ AL Sbjct: 264 LGFDRITVSGAGDERIAQAL 283