BLASTP 2.2.21 [Jun-14-2009] Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), "Gapped BLAST and PSI-BLAST: a new generation of protein database search programs", Nucleic Acids Res. 25:3389-3402. Reference for compositional score matrix adjustment: Altschul, Stephen F., John C. Wootton, E. Michael Gertz, Richa Agarwala, Aleksandr Morgulis, Alejandro A. Schaffer, and Yi-Kuo Yu (2005) "Protein database searches using compositionally adjusted substitution matrices", FEBS J. 272:5101-5109. Query= 0025.0113.p (463 letters) Database: pfamseq 15,929,002 sequences; 5,169,768,107 total letters Searching..................................................done Score E Sequences producing significant alignments: (bits) Value D8IZS8.1 D8IZS8_HERSS Argininosuccinate lyase EC=4.3.2.1 847 0.0 A6SX31.1 ARLY_JANMA Argininosuccinate lyase EC=4.3.2.1 832 0.0 F1W548.1 F1W548_9BURK Argininosuccinate lyase 826 0.0 A4G3U8.1 ARLY_HERAR Argininosuccinate lyase EC=4.3.2.1 824 0.0 Q474V6.1 ARLY_CUPPJ Argininosuccinate lyase EC=4.3.2.1 773 0.0 >D8IZS8.1 D8IZS8_HERSS Argininosuccinate lyase EC=4.3.2.1 Length = 464 Score = 847 bits (2187), Expect = 0.0, Method: Compositional matrix adjust. Identities = 421/463 (90%), Positives = 440/463 (95%) Query: 1 MTAQLSKKGEAWSARFSEPVSDLVKRYTASVFFDNRLAQFDIQGSLAHAEMLAHQQIISA 60 MT Q +KKGEAWSARFSEPVSDLVKRYTASVFFDNR+AQ DIQGSLAHAEMLAHQ IISA Sbjct: 1 MTDQFAKKGEAWSARFSEPVSDLVKRYTASVFFDNRMAQVDIQGSLAHAEMLAHQGIISA 60 Query: 61 QDYADIQRGMTQIKGEIDGGKFEWLLDLEDVHLNIEKRLTELVGDAGKRLHTGRSRNDQV 120 DYA+IQRGM QIKGEI+ G+FEWLLDLEDVHLNIEKRLTELVGDAGKRLHTGRSRNDQV Sbjct: 61 ADYAEIQRGMAQIKGEIEAGQFEWLLDLEDVHLNIEKRLTELVGDAGKRLHTGRSRNDQV 120 Query: 121 ATDIRLYMRAAIDDISGLLRDLRSALVDLAEQHADTILPGFTHMQVAQPITFGHHVLAYV 180 ATDIRLYMR A+DDI GLLR+LR AL+DLAEQHADTILPGFTHMQVAQPITFGHHVLAYV Sbjct: 121 ATDIRLYMRGAVDDIIGLLRELRLALLDLAEQHADTILPGFTHMQVAQPITFGHHVLAYV 180 Query: 181 EMFGRDAERMADARKRVNRLPLGAAALAGTTFPIDRLRVAKTLGFDDVCRNSLDAVSDRD 240 EMFGRDAERM DARKR+NRLPLGAAALAGTTFPIDRLRVAKTLGFDDVCRNSLDAVSDRD Sbjct: 181 EMFGRDAERMIDARKRINRLPLGAAALAGTTFPIDRLRVAKTLGFDDVCRNSLDAVSDRD 240 Query: 241 FAIEFCAAAALVMTHISRMSEELVIWMSPRVGFIDIADRFCTGSSIMPQKKNPDVPELAR 300 FAIEFCA AALVMTHISRMSEELVIWMSPRVGFIDIADRFCTGSSIMPQKKNPDVPELAR Sbjct: 241 FAIEFCAGAALVMTHISRMSEELVIWMSPRVGFIDIADRFCTGSSIMPQKKNPDVPELAR 300 Query: 301 GKTGRVNGHLIALLTLMKGQPLAYNKDNQEDKEPLFDTVDTLTDTLRIFADMASGITVKP 360 GKTGRVNGHLIALLTLMKGQPLAYNKDNQEDKEPLFDTVDTLTDTLRIFADMA GI+VKP Sbjct: 301 GKTGRVNGHLIALLTLMKGQPLAYNKDNQEDKEPLFDTVDTLTDTLRIFADMARGISVKP 360 Query: 361 DAMRAAALQGYATATDLADYLVKKGLPFRDAHEAVAHAVRTCVDRNCDLSDLTLDELRVY 420 +AMRAAALQGYATATDLADYLVKKGLPFRDAHEAVAHAVRTCVD+ CDL+DL+L +LR + Sbjct: 361 EAMRAAALQGYATATDLADYLVKKGLPFRDAHEAVAHAVRTCVDKGCDLADLSLADLRAF 420 Query: 421 SPLIDNDIFGVLTLEGSVAARDHIGGTAPNQVRLAIAEVRKSL 463 S LI D+F VLTLEGSVAARDHIGGTAP QVR AIA++RK L Sbjct: 421 SDLIGEDVFAVLTLEGSVAARDHIGGTAPKQVRAAIAQLRKEL 463 >A6SX31.1 ARLY_JANMA Argininosuccinate lyase EC=4.3.2.1 Length = 464 Score = 832 bits (2149), Expect = 0.0, Method: Compositional matrix adjust. Identities = 414/463 (89%), Positives = 436/463 (94%) Query: 1 MTAQLSKKGEAWSARFSEPVSDLVKRYTASVFFDNRLAQFDIQGSLAHAEMLAHQQIISA 60 MTAQLSKK EAWSARF+EPVSDLVKRYTASVFFD RLAQ DIQGSLAHAEMLAHQ+IIS Sbjct: 1 MTAQLSKKSEAWSARFNEPVSDLVKRYTASVFFDKRLAQVDIQGSLAHAEMLAHQKIISQ 60 Query: 61 QDYADIQRGMTQIKGEIDGGKFEWLLDLEDVHLNIEKRLTELVGDAGKRLHTGRSRNDQV 120 QD+A+IQRGM QI+ EI GKFEWLLDLEDVHLNIEKRLTELVGDAGKRLHTGRSRNDQV Sbjct: 61 QDHAEIQRGMAQIQEEIASGKFEWLLDLEDVHLNIEKRLTELVGDAGKRLHTGRSRNDQV 120 Query: 121 ATDIRLYMRAAIDDISGLLRDLRSALVDLAEQHADTILPGFTHMQVAQPITFGHHVLAYV 180 ATDIRLY+R+ ID+I GLLRDLR AL+DLAE+HADTILPGFTHMQVAQPITFGHH+LAYV Sbjct: 121 ATDIRLYVRSEIDNIVGLLRDLRLALLDLAEKHADTILPGFTHMQVAQPITFGHHMLAYV 180 Query: 181 EMFGRDAERMADARKRVNRLPLGAAALAGTTFPIDRLRVAKTLGFDDVCRNSLDAVSDRD 240 EMF RDAERM D RKRVNRLPLGAAALAGTTFPIDR RVA+TL F+DVC NSLDAVSDRD Sbjct: 181 EMFSRDAERMLDCRKRVNRLPLGAAALAGTTFPIDRERVARTLDFEDVCHNSLDAVSDRD 240 Query: 241 FAIEFCAAAALVMTHISRMSEELVIWMSPRVGFIDIADRFCTGSSIMPQKKNPDVPELAR 300 FAIEFCAAAAL+MTH+SRMSEELVIWMSPRVGFIDIADRFCTGSSIMPQKKNPDVPELAR Sbjct: 241 FAIEFCAAAALIMTHVSRMSEELVIWMSPRVGFIDIADRFCTGSSIMPQKKNPDVPELAR 300 Query: 301 GKTGRVNGHLIALLTLMKGQPLAYNKDNQEDKEPLFDTVDTLTDTLRIFADMASGITVKP 360 GKTGRVNGHLIALLTLMKGQPLAYNKDNQEDKEPLFDTVDT+ DTLRIFADMA+GITVKP Sbjct: 301 GKTGRVNGHLIALLTLMKGQPLAYNKDNQEDKEPLFDTVDTVVDTLRIFADMATGITVKP 360 Query: 361 DAMRAAALQGYATATDLADYLVKKGLPFRDAHEAVAHAVRTCVDRNCDLSDLTLDELRVY 420 DAMRAAALQGYATATDLADYLVKKGLPFRDAHEAVAHAVR CVDR CDLSDLTL+E+RV+ Sbjct: 361 DAMRAAALQGYATATDLADYLVKKGLPFRDAHEAVAHAVRACVDRGCDLSDLTLEEMRVF 420 Query: 421 SPLIDNDIFGVLTLEGSVAARDHIGGTAPNQVRLAIAEVRKSL 463 SPLI+ DIF VLTLEGSVAAR+HIGGTAP QVRLAIA R L Sbjct: 421 SPLIEADIFEVLTLEGSVAARNHIGGTAPQQVRLAIARHRSKL 463 >F1W548.1 F1W548_9BURK Argininosuccinate lyase Length = 576 Score = 826 bits (2133), Expect = 0.0, Method: Compositional matrix adjust. Identities = 403/463 (87%), Positives = 429/463 (92%) Query: 1 MTAQLSKKGEAWSARFSEPVSDLVKRYTASVFFDNRLAQFDIQGSLAHAEMLAHQQIISA 60 MTAQ SKK EAWSARFSEPVSDLVKRYTASVFFD RLA+ DIQGSLAHA+MLA Q IIS+ Sbjct: 112 MTAQFSKKSEAWSARFSEPVSDLVKRYTASVFFDKRLAEVDIQGSLAHAQMLAQQNIISS 171 Query: 61 QDYADIQRGMTQIKGEIDGGKFEWLLDLEDVHLNIEKRLTELVGDAGKRLHTGRSRNDQV 120 D A I+ G+ QI EI G+FEWLLDLEDVHLNIEKRLTELVGDAGKRLHTGRSRNDQV Sbjct: 172 DDLAAIRGGLQQIGSEIAEGRFEWLLDLEDVHLNIEKRLTELVGDAGKRLHTGRSRNDQV 231 Query: 121 ATDIRLYMRAAIDDISGLLRDLRSALVDLAEQHADTILPGFTHMQVAQPITFGHHVLAYV 180 ATDIRLY+R AIDD++ LL DLR ALVDLAEQHADTILPGFTHMQVAQP+TFGHH+LAYV Sbjct: 232 ATDIRLYLRGAIDDLTILLGDLRLALVDLAEQHADTILPGFTHMQVAQPVTFGHHLLAYV 291 Query: 181 EMFGRDAERMADARKRVNRLPLGAAALAGTTFPIDRLRVAKTLGFDDVCRNSLDAVSDRD 240 EMFGRDAER+AD RKRVNRLPLGAAALAGTTFPIDR VA+ LGFD+VC NSLDAVSDRD Sbjct: 292 EMFGRDAERLADCRKRVNRLPLGAAALAGTTFPIDRELVAQLLGFDEVCFNSLDAVSDRD 351 Query: 241 FAIEFCAAAALVMTHISRMSEELVIWMSPRVGFIDIADRFCTGSSIMPQKKNPDVPELAR 300 FAIEFCAAAALVMTH+SRMSEELVIWMSPRVGFIDIADRFCTGSSIMPQKKNPDVPELAR Sbjct: 352 FAIEFCAAAALVMTHVSRMSEELVIWMSPRVGFIDIADRFCTGSSIMPQKKNPDVPELAR 411 Query: 301 GKTGRVNGHLIALLTLMKGQPLAYNKDNQEDKEPLFDTVDTLTDTLRIFADMASGITVKP 360 GKTGRV GHLI+LLTLMKGQPLAYNKDNQEDKEPLFDTVDTLTDTLRIFADMA GITVKP Sbjct: 412 GKTGRVTGHLISLLTLMKGQPLAYNKDNQEDKEPLFDTVDTLTDTLRIFADMARGITVKP 471 Query: 361 DAMRAAALQGYATATDLADYLVKKGLPFRDAHEAVAHAVRTCVDRNCDLSDLTLDELRVY 420 +AMRAAALQGYATATDLADYLVKKGLPFRDAHEAVAHAVR CVD+ CDLSDLTLD+L+ + Sbjct: 472 EAMRAAALQGYATATDLADYLVKKGLPFRDAHEAVAHAVRVCVDKGCDLSDLTLDQLKAF 531 Query: 421 SPLIDNDIFGVLTLEGSVAARDHIGGTAPNQVRLAIAEVRKSL 463 SPL+++DI+ VLTLEGSVAARDH+GGTAP QVRLAIA VR L Sbjct: 532 SPLVEDDIYQVLTLEGSVAARDHVGGTAPRQVRLAIARVRAQL 574 >A4G3U8.1 ARLY_HERAR Argininosuccinate lyase EC=4.3.2.1 Length = 464 Score = 824 bits (2129), Expect = 0.0, Method: Compositional matrix adjust. Identities = 410/463 (88%), Positives = 432/463 (93%) Query: 1 MTAQLSKKGEAWSARFSEPVSDLVKRYTASVFFDNRLAQFDIQGSLAHAEMLAHQQIISA 60 MTAQLSKKGEAWSARF+EPVSDLVKRYTASVFFD RLAQ DIQGSLAHAEMLAHQ IIS Sbjct: 1 MTAQLSKKGEAWSARFNEPVSDLVKRYTASVFFDKRLAQVDIQGSLAHAEMLAHQNIISQ 60 Query: 61 QDYADIQRGMTQIKGEIDGGKFEWLLDLEDVHLNIEKRLTELVGDAGKRLHTGRSRNDQV 120 +D+A+I+RGM QI EI GKFEWLLDLEDVHLNIEKRLTELVGDAGKRLHTGRSRNDQV Sbjct: 61 EDHAEIRRGMAQILEEITAGKFEWLLDLEDVHLNIEKRLTELVGDAGKRLHTGRSRNDQV 120 Query: 121 ATDIRLYMRAAIDDISGLLRDLRSALVDLAEQHADTILPGFTHMQVAQPITFGHHVLAYV 180 ATDIRLY+R+ ID+I GLLRDLR AL+DLAEQHADTILPGFTHMQVAQPITFGHH+LAYV Sbjct: 121 ATDIRLYVRSEIDNIVGLLRDLRLALLDLAEQHADTILPGFTHMQVAQPITFGHHMLAYV 180 Query: 181 EMFGRDAERMADARKRVNRLPLGAAALAGTTFPIDRLRVAKTLGFDDVCRNSLDAVSDRD 240 EMF RDAERM D RKRVNRLPLGAAALAGTTFPIDR RVAKTLGFDDVC NSLDAVSDRD Sbjct: 181 EMFSRDAERMQDCRKRVNRLPLGAAALAGTTFPIDRERVAKTLGFDDVCHNSLDAVSDRD 240 Query: 241 FAIEFCAAAALVMTHISRMSEELVIWMSPRVGFIDIADRFCTGSSIMPQKKNPDVPELAR 300 FAIEFCAAAAL+MTH+SRMSEELVIWMSPR+GFIDIADRFCTGSSIMPQKKNPDVPELAR Sbjct: 241 FAIEFCAAAALIMTHVSRMSEELVIWMSPRIGFIDIADRFCTGSSIMPQKKNPDVPELAR 300 Query: 301 GKTGRVNGHLIALLTLMKGQPLAYNKDNQEDKEPLFDTVDTLTDTLRIFADMASGITVKP 360 GKTGRVNGHLIALLTLMKGQPLAYNKDNQEDKEPLFDTVDT+ DTLRIFADMA+GITVKP Sbjct: 301 GKTGRVNGHLIALLTLMKGQPLAYNKDNQEDKEPLFDTVDTVVDTLRIFADMATGITVKP 360 Query: 361 DAMRAAALQGYATATDLADYLVKKGLPFRDAHEAVAHAVRTCVDRNCDLSDLTLDELRVY 420 DAMRAAALQGYATATDLADYLVKKGLPFRDAHEAVAHAVR CVDR DLSDLTL+E++ + Sbjct: 361 DAMRAAALQGYATATDLADYLVKKGLPFRDAHEAVAHAVRACVDRGIDLSDLTLEEMQAF 420 Query: 421 SPLIDNDIFGVLTLEGSVAARDHIGGTAPNQVRLAIAEVRKSL 463 S LI+ DIF VLTLEGSVAAR+H+GGTAP QVR AIA R L Sbjct: 421 SKLIEADIFAVLTLEGSVAARNHVGGTAPQQVRAAIARHRAKL 463 >Q474V6.1 ARLY_CUPPJ Argininosuccinate lyase EC=4.3.2.1 Length = 470 Score = 773 bits (1997), Expect = 0.0, Method: Compositional matrix adjust. Identities = 379/457 (82%), Positives = 410/457 (89%), Gaps = 6/457 (1%) Query: 2 TAQLSKKGEAWSARFSEPVSDLVKRYTASVFFDNRLAQFDIQGSLAHAEMLAHQQIISAQ 61 T+QL+KKGEAWSARFSEP+SDLVKRYTASVFFD RLA FDIQGSLAHA MLA Q II+ Sbjct: 3 TSQLAKKGEAWSARFSEPMSDLVKRYTASVFFDKRLALFDIQGSLAHAAMLAKQGIIAEA 62 Query: 62 DYADIQRGMTQIKGEIDGGKFEWLLDLEDVHLNIEKRLTELVGDAGKRLHTGRSRNDQVA 121 D A+I+RGM QIKGEI+ G FEW LDLEDVHLNIE RLT LVGDAGKRLHTGRSRNDQVA Sbjct: 63 DRAEIERGMAQIKGEIEAGGFEWKLDLEDVHLNIEARLTALVGDAGKRLHTGRSRNDQVA 122 Query: 122 TDIRLYMRAAIDDISGLLRDLRSALVDLAEQHADTILPGFTHMQVAQPITFGHHVLAYVE 181 TDIRL++R+ ID+I LL LR +L+DLA+Q+ADTILPGFTH+QVAQP+TFGHH+LAYVE Sbjct: 123 TDIRLWLRSEIDNIIALLGALRGSLLDLADQNADTILPGFTHLQVAQPVTFGHHLLAYVE 182 Query: 182 MFGRDAERMADARKRVNRLPLGAAALAGTTFPIDRLRVAKTLGFDDVCRNSLDAVSDRDF 241 MF RDAERMAD RKRVNRLPLGAAALAGT++PIDR VA+ LGFD VCRNSLDAVSDRDF Sbjct: 183 MFTRDAERMADCRKRVNRLPLGAAALAGTSYPIDREFVAQQLGFDGVCRNSLDAVSDRDF 242 Query: 242 AIEFCAAAALVMTHISRMSEELVIWMSPRVGFIDIADRFCTGSSIMPQKKNPDVPELARG 301 AIEFCAAAALVMTH+SR SEELV+WMSPRVGFIDIADRFCTGSSIMPQKKNPDVPELARG Sbjct: 243 AIEFCAAAALVMTHVSRFSEELVLWMSPRVGFIDIADRFCTGSSIMPQKKNPDVPELARG 302 Query: 302 KTGRVNGHLIALLTLMKGQPLAYNKDNQEDKEPLFDTVDTLTDTLRIFADMASGITVKPD 361 KTGRVNGHLI LLTLMKGQPLAYNKDNQEDKEPLFDTVDT+ DTLRIFADM GITVKP+ Sbjct: 303 KTGRVNGHLIGLLTLMKGQPLAYNKDNQEDKEPLFDTVDTVVDTLRIFADMVPGITVKPE 362 Query: 362 AMRAAALQGYATATDLADYLVKKGLPFRDAHEAVAHAVRTCVDRNCDLSDLTLDELRVY- 420 AMRAAALQGYATATDLADYLVKKGLPFRDAHEAVAHAVR C RNCDL+DLT+ ELR Sbjct: 363 AMRAAALQGYATATDLADYLVKKGLPFRDAHEAVAHAVRACDSRNCDLADLTVAELREVS 422 Query: 421 -----SPLIDNDIFGVLTLEGSVAARDHIGGTAPNQV 452 S LI +D+ VLTLEGSVAAR+HIGGTAP+QV Sbjct: 423 GLGDKSALIGDDVHTVLTLEGSVAARNHIGGTAPDQV 459