BLASTP 2.2.21 [Jun-14-2009] Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), "Gapped BLAST and PSI-BLAST: a new generation of protein database search programs", Nucleic Acids Res. 25:3389-3402. Reference for compositional score matrix adjustment: Altschul, Stephen F., John C. Wootton, E. Michael Gertz, Richa Agarwala, Aleksandr Morgulis, Alejandro A. Schaffer, and Yi-Kuo Yu (2005) "Protein database searches using compositionally adjusted substitution matrices", FEBS J. 272:5101-5109. Query= 0025.0068.p (280 letters) Database: pfamseq 15,929,002 sequences; 5,169,768,107 total letters Searching..................................................done Score E Sequences producing significant alignments: (bits) Value A6SXH7.1 A6SXH7_JANMA Metallo-beta-lactamase superfamily protein 375 e-102 A4G722.1 A4G722_HERAR Putative metallo-hydrolase/oxidoreductase ... 358 5e-97 D8J1X2.1 D8J1X2_HERSS Metal-dependent hydrolases of the beta-lac... 341 7e-92 F1VXD1.1 F1VXD1_9BURK Putative Metallo-beta-lactamase family pro... 333 1e-89 E1T434.1 E1T434_BURSG Beta-lactamase domain protein 286 2e-75 >A6SXH7.1 A6SXH7_JANMA Metallo-beta-lactamase superfamily protein Length = 259 Score = 375 bits (963), Expect = e-102, Method: Compositional matrix adjust. Identities = 175/231 (75%), Positives = 200/231 (86%), Gaps = 1/231 (0%) Query: 1 LKFASLGSGSEGNALIISGTSGATTTTVMLDCGFGIKETERRLTRIGKLPQDINGIVVTH 60 +KFASLGSGSEGNAL+IS SG+T TT+MLDCGFGIKETERRL R+ LP D++GI+VTH Sbjct: 1 MKFASLGSGSEGNALLISTQSGSTRTTLMLDCGFGIKETERRLARLQMLPTDLSGIIVTH 60 Query: 61 EHQDHVGGVFKFARRHRIPVWLTYGTFQAVGEEACKNVQLHFCRDSEAVVIGDLSLMPYT 120 EHQDHVGGVFKFARRH++PVWLTYGT+QAV + C VQLHFCRD+E IGDL L+PYT Sbjct: 61 EHQDHVGGVFKFARRHKLPVWLTYGTYQAV-HDKCDGVQLHFCRDNERFAIGDLELLPYT 119 Query: 121 VPHDAREPVQYVAGDGKRKLGVLTDAGQSTTHLVQALGGCDALVLECNHDRQMLADSAYP 180 VPHDAREPVQYVA DG R+LGVLTDAG T H+V ALGGCDAL+LECNHDRQML +S YP Sbjct: 120 VPHDAREPVQYVASDGTRRLGVLTDAGHGTAHMVAALGGCDALMLECNHDRQMLVNSTYP 179 Query: 181 PSLKRRIGGAYGHLANDTSAEILAALDKQKLKTVIGAHLSLKNNTPGLARA 231 PSLK+RIGG YGHL+N + EILAALDK +L+ ++GAHLSLKNNTP LARA Sbjct: 180 PSLKQRIGGEYGHLSNHAAGEILAALDKSRLQRIVGAHLSLKNNTPELARA 230 >A4G722.1 A4G722_HERAR Putative metallo-hydrolase/oxidoreductase superfamily protein Length = 261 Score = 358 bits (919), Expect = 5e-97, Method: Compositional matrix adjust. Identities = 169/231 (73%), Positives = 192/231 (83%), Gaps = 1/231 (0%) Query: 1 LKFASLGSGSEGNALIISGTSGATTTTVMLDCGFGIKETERRLTRIGKLPQDINGIVVTH 60 LKFASLGSGSEGNAL+IS SG T TTVMLDCGFGI+ETERRL R+ LP D+ GI+VTH Sbjct: 3 LKFASLGSGSEGNALLISTQSGTTRTTVMLDCGFGIRETERRLERLQLLPADLAGIIVTH 62 Query: 61 EHQDHVGGVFKFARRHRIPVWLTYGTFQAVGEEACKNVQLHFCRDSEAVVIGDLSLMPYT 120 EHQDHVGGVFKFARRHR+PVWLT+GT+QA + C +V++H CRD IGDL L PYT Sbjct: 63 EHQDHVGGVFKFARRHRLPVWLTFGTYQAT-RDRCDDVEIHICRDGAVFAIGDLELSPYT 121 Query: 121 VPHDAREPVQYVAGDGKRKLGVLTDAGQSTTHLVQALGGCDALVLECNHDRQMLADSAYP 180 VPHDAREPVQYVA DG +LGVLTDAG +T HL++AL CDAL+LECNHD QML DSAYP Sbjct: 122 VPHDAREPVQYVASDGALRLGVLTDAGHATAHLIEALAACDALMLECNHDIQMLRDSAYP 181 Query: 181 PSLKRRIGGAYGHLANDTSAEILAALDKQKLKTVIGAHLSLKNNTPGLARA 231 PSLK+RIGG YGHL+N + EIL+ LDK +LK V+GAHLSLKNNTP LARA Sbjct: 182 PSLKQRIGGDYGHLSNQMAGEILSGLDKSRLKRVVGAHLSLKNNTPELARA 232 >D8J1X2.1 D8J1X2_HERSS Metal-dependent hydrolases of the beta-lactamase superfamily I protein Length = 261 Score = 341 bits (874), Expect = 7e-92, Method: Compositional matrix adjust. Identities = 169/248 (68%), Positives = 195/248 (78%), Gaps = 7/248 (2%) Query: 1 LKFASLGSGSEGNALIISGTSG----ATTTTVMLDCGFGIKETERRLTRIGKLPQDINGI 56 +KFASLGSGSEGNAL+IS +G ++ TTVMLDCGF ++E ERR+ R+G P D++ I Sbjct: 1 MKFASLGSGSEGNALLISAAAGDQRPSSGTTVMLDCGFTLREAERRMLRLGLDPSDVSAI 60 Query: 57 VVTHEHQDHVGGVFKFARRHRIPVWLTYGTFQAVGEEACKNVQLHFCRDSEAVVIGDLSL 116 VVTHEH DHV GVFKFARR+RIPVWL+YGT+QAV ++A +V + FC D + + IGDL L Sbjct: 61 VVTHEHSDHVSGVFKFARRYRIPVWLSYGTWQAVADQA-TDVDVQFCADGQKLAIGDLEL 119 Query: 117 MPYTVPHDAREPVQYVAGDGKRKLGVLTDAGQSTTHLVQALGGCDALVLECNHDRQMLAD 176 PYTVPHDAREP+QYVAGDG R+LGVLTDAGQ T HLVQALG CDAL+LECNHDR ML Sbjct: 120 SPYTVPHDAREPIQYVAGDGDRRLGVLTDAGQPTAHLVQALGACDALLLECNHDRDMLDR 179 Query: 177 SAYPPSLKRRIGGAYGHLANDTSAEILAALDKQKLKTVIGAHLSLKNNTPGLARARARAV 236 S YP LKRRIGG YGHLAND SAEIL LDK +LK VIGAHLS +NNTP LARA V Sbjct: 180 SPYPAFLKRRIGGDYGHLANDASAEILRMLDKSRLKRVIGAHLSQQNNTPELARAALEGV 239 Query: 237 RRIGRTSG 244 +G T G Sbjct: 240 --LGMTFG 245 >F1VXD1.1 F1VXD1_9BURK Putative Metallo-beta-lactamase family protein Length = 258 Score = 333 bits (855), Expect = 1e-89, Method: Compositional matrix adjust. Identities = 157/220 (71%), Positives = 182/220 (82%), Gaps = 1/220 (0%) Query: 1 LKFASLGSGSEGNALIISGTSGATTTTVMLDCGFGIKETERRLTRIGKLPQDINGIVVTH 60 +KFASLGSGSEGNAL+I+ SG T TTVMLDCGF +KETERR+ RIG +++ IV+TH Sbjct: 1 MKFASLGSGSEGNALLITAASGMTRTTVMLDCGFSVKETERRMARIGMAAAELSAIVITH 60 Query: 61 EHQDHVGGVFKFARRHRIPVWLTYGTFQAVGEEACKNVQLHFCRDSEAVVIGDLSLMPYT 120 EH DHV G KFARR+ +PVWL+YGTFQAV + CK V + FCRD A+ IGDL LMPYT Sbjct: 61 EHSDHVSGALKFARRYHVPVWLSYGTFQAV-QGDCKGVDVRFCRDGIAIPIGDLELMPYT 119 Query: 121 VPHDAREPVQYVAGDGKRKLGVLTDAGQSTTHLVQALGGCDALVLECNHDRQMLADSAYP 180 VPHDAREPVQYVA DG+ +LGVLTDAG ST HLV AL GCDALVLECNHD+ MLA+S YP Sbjct: 120 VPHDAREPVQYVASDGRMRLGVLTDAGHSTPHLVGALDGCDALVLECNHDKLMLANSVYP 179 Query: 181 PSLKRRIGGAYGHLANDTSAEILAALDKQKLKTVIGAHLS 220 PSLKRRIGG YGHL+ND+S +ILAALD+ +L+ VIGAHLS Sbjct: 180 PSLKRRIGGVYGHLSNDSSTQILAALDRSRLRMVIGAHLS 219 >E1T434.1 E1T434_BURSG Beta-lactamase domain protein Length = 257 Score = 286 bits (733), Expect = 2e-75, Method: Compositional matrix adjust. Identities = 136/231 (58%), Positives = 173/231 (74%), Gaps = 1/231 (0%) Query: 1 LKFASLGSGSEGNALIISGTSGATTTTVMLDCGFGIKETERRLTRIGKLPQDINGIVVTH 60 ++FASLGSGSEGNAL++ SGATTT V+LDCGF KE ERRL R+G + ++ I++TH Sbjct: 1 MRFASLGSGSEGNALLVEAQSGATTTRVLLDCGFSAKEVERRLNRLGSSAEALDAILITH 60 Query: 61 EHQDHVGGVFKFARRHRIPVWLTYGTFQAVGEEACKNVQLHFCRDSEAVVIGDLSLMPYT 120 EH DH+G AR+ IP+++++GT +AVG + +V LH EAV IGDLS++PYT Sbjct: 61 EHSDHIGSALTLARKWSIPLFMSWGTARAVGADEA-DVDLHVLWGDEAVAIGDLSVLPYT 119 Query: 121 VPHDAREPVQYVAGDGKRKLGVLTDAGQSTTHLVQALGGCDALVLECNHDRQMLADSAYP 180 VPHDAREP+QYV +G +LGVLTD G ST H+ L GCDALVLECNHD MLA S YP Sbjct: 120 VPHDAREPLQYVFSNGVSRLGVLTDVGTSTPHISAVLSGCDALVLECNHDVGMLAGSRYP 179 Query: 181 PSLKRRIGGAYGHLANDTSAEILAALDKQKLKTVIGAHLSLKNNTPGLARA 231 SLK RIGG +GHL ND +AEILA+LD+ +L+ ++ AHLSL+NN P LA+A Sbjct: 180 QSLKARIGGNHGHLNNDAAAEILASLDRSRLRHLVAAHLSLQNNLPELAQA 230