BLASTP 2.2.21 [Jun-14-2009] Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), "Gapped BLAST and PSI-BLAST: a new generation of protein database search programs", Nucleic Acids Res. 25:3389-3402. Reference for compositional score matrix adjustment: Altschul, Stephen F., John C. Wootton, E. Michael Gertz, Richa Agarwala, Aleksandr Morgulis, Alejandro A. Schaffer, and Yi-Kuo Yu (2005) "Protein database searches using compositionally adjusted substitution matrices", FEBS J. 272:5101-5109. Query= 0025.0043.p (356 letters) Database: pfamseq 15,929,002 sequences; 5,169,768,107 total letters Searching..................................................done Score E Sequences producing significant alignments: (bits) Value D8J1Z5.1 D8J1Z5_HERSS 3-isopropylmalate dehydrogenase oxidoreduc... 681 0.0 A2RPT8.1 A2RPT8_HERSE 3-isopropylmalate dehydrogenase oxidoreduc... 681 0.0 Q0K8H0.1 Q0K8H0_CUPNH 3-Isopropylmalate dehydrogenase EC=1.1.1.85 664 0.0 Q1LKH7.1 LEU3_RALME 3-isopropylmalate dehydrogenase EC=1.1.1.85 660 0.0 Q46YW0.1 LEU3_CUPPJ 3-isopropylmalate dehydrogenase EC=1.1.1.85 658 0.0 >D8J1Z5.1 D8J1Z5_HERSS 3-isopropylmalate dehydrogenase oxidoreductase protein EC=1.1.1.85 Length = 356 Score = 681 bits (1758), Expect = 0.0, Method: Compositional matrix adjust. Identities = 331/355 (93%), Positives = 341/355 (96%) Query: 1 MKIAILPGDGIGPEIIEQAVRVLNTLGEKFEMETAPVGGAGYEAHGHPLPDGTLKLAKES 60 MKIAILPGDGIGPEI+ +AVRVLN L EKFEMETAPVGGAGYEAHGHPLPDGTLKLAKE+ Sbjct: 1 MKIAILPGDGIGPEIVNEAVRVLNALDEKFEMETAPVGGAGYEAHGHPLPDGTLKLAKEA 60 Query: 61 DAILFGAVGDWKYDTLDRPLRPEQAILGLRKHLQLFANFRPAICYPELTGASSLKPELVA 120 DAILFGAVGDWKYD L+R LRPEQAILGLRKHLQLFANFRPAICYPELTGASSLKPELVA Sbjct: 61 DAILFGAVGDWKYDKLERALRPEQAILGLRKHLQLFANFRPAICYPELTGASSLKPELVA 120 Query: 121 GLDILIVRELNGDIYFGQPRGMREAPDGPFKGAREGFDTMRYSEPEIRRIAHVAFQAAAK 180 LDILIVRELNGDIYFGQPRGMREAPDGPFKGAREGFDTMRYSEPEIRRIAHVAFQAAAK Sbjct: 121 NLDILIVRELNGDIYFGQPRGMREAPDGPFKGAREGFDTMRYSEPEIRRIAHVAFQAAAK 180 Query: 181 RGNRLCSVDKANVLETFQFWKDIVTDVHKEYPQVELTHMYVDNAAMQLVKAPKNFDVIVT 240 RG RLCSVDKANVLETFQFWKDIVT+V KEYP VEL+HMYVDNAAMQLVKAPKNFDVIVT Sbjct: 181 RGKRLCSVDKANVLETFQFWKDIVTEVGKEYPDVELSHMYVDNAAMQLVKAPKNFDVIVT 240 Query: 241 GNMFGDILSDAAAMLTGSIGMLPSASLDANNKGLYEPSHGSAPDIAGKGIANPLATILSA 300 GNMFGDILSDAAAMLTGSIGMLPSASLDANNKGLYEPSHGSAPDIAG+GIANPLATILSA Sbjct: 241 GNMFGDILSDAAAMLTGSIGMLPSASLDANNKGLYEPSHGSAPDIAGRGIANPLATILSA 300 Query: 301 AMMLRFSLNKAEQADRIEAAVKKVLAQGYRTGDIYEEGTTKVGTKEMGDAVVKAL 355 AMMLRFSLNKAEQADRIE AVKKVLAQG RT DIYEEG TKV T++MG+AVVKAL Sbjct: 301 AMMLRFSLNKAEQADRIENAVKKVLAQGLRTADIYEEGCTKVNTQQMGEAVVKAL 355 >A2RPT8.1 A2RPT8_HERSE 3-isopropylmalate dehydrogenase oxidoreductase protein Length = 356 Score = 681 bits (1758), Expect = 0.0, Method: Compositional matrix adjust. Identities = 331/355 (93%), Positives = 341/355 (96%) Query: 1 MKIAILPGDGIGPEIIEQAVRVLNTLGEKFEMETAPVGGAGYEAHGHPLPDGTLKLAKES 60 MKIAILPGDGIGPEI+ +AVRVLN L EKFEMETAPVGGAGYEAHGHPLPDGTLKLAKE+ Sbjct: 1 MKIAILPGDGIGPEIVNEAVRVLNALDEKFEMETAPVGGAGYEAHGHPLPDGTLKLAKEA 60 Query: 61 DAILFGAVGDWKYDTLDRPLRPEQAILGLRKHLQLFANFRPAICYPELTGASSLKPELVA 120 DAILFGAVGDWKYD L+R LRPEQAILGLRKHLQLFANFRPAICYPELTGASSLKPELVA Sbjct: 61 DAILFGAVGDWKYDKLERALRPEQAILGLRKHLQLFANFRPAICYPELTGASSLKPELVA 120 Query: 121 GLDILIVRELNGDIYFGQPRGMREAPDGPFKGAREGFDTMRYSEPEIRRIAHVAFQAAAK 180 LDILIVRELNGDIYFGQPRGMREAPDGPFKGAREGFDTMRYSEPEIRRIAHVAFQAAAK Sbjct: 121 NLDILIVRELNGDIYFGQPRGMREAPDGPFKGAREGFDTMRYSEPEIRRIAHVAFQAAAK 180 Query: 181 RGNRLCSVDKANVLETFQFWKDIVTDVHKEYPQVELTHMYVDNAAMQLVKAPKNFDVIVT 240 RG RLCSVDKANVLETFQFWKDIVT+V KEYP VEL+HMYVDNAAMQLVKAPKNFDVIVT Sbjct: 181 RGKRLCSVDKANVLETFQFWKDIVTEVGKEYPDVELSHMYVDNAAMQLVKAPKNFDVIVT 240 Query: 241 GNMFGDILSDAAAMLTGSIGMLPSASLDANNKGLYEPSHGSAPDIAGKGIANPLATILSA 300 GNMFGDILSDAAAMLTGSIGMLPSASLDANNKGLYEPSHGSAPDIAG+GIANPLATILSA Sbjct: 241 GNMFGDILSDAAAMLTGSIGMLPSASLDANNKGLYEPSHGSAPDIAGRGIANPLATILSA 300 Query: 301 AMMLRFSLNKAEQADRIEAAVKKVLAQGYRTGDIYEEGTTKVGTKEMGDAVVKAL 355 AMMLRFSLNKAEQADRIE AVKKVLAQG RT DIYEEG TKV T++MG+AVVKAL Sbjct: 301 AMMLRFSLNKAEQADRIENAVKKVLAQGLRTADIYEEGCTKVNTQQMGEAVVKAL 355 >Q0K8H0.1 Q0K8H0_CUPNH 3-Isopropylmalate dehydrogenase EC=1.1.1.85 Length = 355 Score = 664 bits (1712), Expect = 0.0, Method: Compositional matrix adjust. Identities = 319/355 (89%), Positives = 339/355 (95%) Query: 1 MKIAILPGDGIGPEIIEQAVRVLNTLGEKFEMETAPVGGAGYEAHGHPLPDGTLKLAKES 60 MKIA+LPGDGIGPEI+ +AV+VLN L EKFE+ETAPVGGAGYEA GHPLP+ TLKLAKE+ Sbjct: 1 MKIAVLPGDGIGPEIVAEAVKVLNALDEKFELETAPVGGAGYEAEGHPLPENTLKLAKEA 60 Query: 61 DAILFGAVGDWKYDTLDRPLRPEQAILGLRKHLQLFANFRPAICYPELTGASSLKPELVA 120 DAILFGAVGDWKYD+LDRPLRPEQAILGLRKHLQLFANFRPAICYPELTGASSLKPELVA Sbjct: 61 DAILFGAVGDWKYDSLDRPLRPEQAILGLRKHLQLFANFRPAICYPELTGASSLKPELVA 120 Query: 121 GLDILIVRELNGDIYFGQPRGMREAPDGPFKGAREGFDTMRYSEPEIRRIAHVAFQAAAK 180 GLDILIVRELNGDIYFGQPRG+REAPDG FKGAREGFDTMRYSEPEIRRIAHVAFQAAAK Sbjct: 121 GLDILIVRELNGDIYFGQPRGVREAPDGLFKGAREGFDTMRYSEPEIRRIAHVAFQAAAK 180 Query: 181 RGNRLCSVDKANVLETFQFWKDIVTDVHKEYPQVELTHMYVDNAAMQLVKAPKNFDVIVT 240 RG +LCSVDKANVLETFQFWKDIV +VHKEYP+VEL+HMYVDNAAMQLVKAPK+FDVIVT Sbjct: 181 RGKKLCSVDKANVLETFQFWKDIVIEVHKEYPEVELSHMYVDNAAMQLVKAPKSFDVIVT 240 Query: 241 GNMFGDILSDAAAMLTGSIGMLPSASLDANNKGLYEPSHGSAPDIAGKGIANPLATILSA 300 GNMFGDILSD AAMLTGSIGMLPSASLDANNKGLYEPSHGSAPDIAGKG+ANPLATILSA Sbjct: 241 GNMFGDILSDEAAMLTGSIGMLPSASLDANNKGLYEPSHGSAPDIAGKGVANPLATILSA 300 Query: 301 AMMLRFSLNKAEQADRIEAAVKKVLAQGYRTGDIYEEGTTKVGTKEMGDAVVKAL 355 AMMLR+SLN+AEQADRIE AVKKVLAQGYRTGDI G +VGT+EMGDAV+ AL Sbjct: 301 AMMLRYSLNRAEQADRIENAVKKVLAQGYRTGDILTPGCKQVGTREMGDAVLAAL 355 >Q1LKH7.1 LEU3_RALME 3-isopropylmalate dehydrogenase EC=1.1.1.85 Length = 355 Score = 660 bits (1704), Expect = 0.0, Method: Compositional matrix adjust. Identities = 318/355 (89%), Positives = 336/355 (94%) Query: 1 MKIAILPGDGIGPEIIEQAVRVLNTLGEKFEMETAPVGGAGYEAHGHPLPDGTLKLAKES 60 MKIA+LPGDGIGPEI+ +AV+VLN L EKFEMETAPVGGAGYEA GHPLPD TLKLAKE+ Sbjct: 1 MKIAVLPGDGIGPEIVAEAVKVLNALDEKFEMETAPVGGAGYEAEGHPLPDNTLKLAKEA 60 Query: 61 DAILFGAVGDWKYDTLDRPLRPEQAILGLRKHLQLFANFRPAICYPELTGASSLKPELVA 120 DAILFGAVGDWKYD+LDRPLRPEQAILGLRKHLQLFANFRPAICYPELTGASSLKPELVA Sbjct: 61 DAILFGAVGDWKYDSLDRPLRPEQAILGLRKHLQLFANFRPAICYPELTGASSLKPELVA 120 Query: 121 GLDILIVRELNGDIYFGQPRGMREAPDGPFKGAREGFDTMRYSEPEIRRIAHVAFQAAAK 180 GLDILIVRELNGDIYFGQPRG+REAPDG FKGAREGFDTMRYSEPE+RRIAHVAFQAAAK Sbjct: 121 GLDILIVRELNGDIYFGQPRGVREAPDGLFKGAREGFDTMRYSEPEVRRIAHVAFQAAAK 180 Query: 181 RGNRLCSVDKANVLETFQFWKDIVTDVHKEYPQVELTHMYVDNAAMQLVKAPKNFDVIVT 240 RG +LCSVDKANVLETFQFWKDIV DV KEYP VEL+HMYVDNAAMQLVKAPK+FDVIVT Sbjct: 181 RGKKLCSVDKANVLETFQFWKDIVIDVSKEYPDVELSHMYVDNAAMQLVKAPKSFDVIVT 240 Query: 241 GNMFGDILSDAAAMLTGSIGMLPSASLDANNKGLYEPSHGSAPDIAGKGIANPLATILSA 300 GNMFGDILSD AAMLTGSIGMLPSASLDANNKGLYEPSHGSAPDIAGKG+ANPLATILSA Sbjct: 241 GNMFGDILSDEAAMLTGSIGMLPSASLDANNKGLYEPSHGSAPDIAGKGVANPLATILSA 300 Query: 301 AMMLRFSLNKAEQADRIEAAVKKVLAQGYRTGDIYEEGTTKVGTKEMGDAVVKAL 355 AMMLR+SLN+AEQADRIE AVKKVLAQGYRT DI G +VGT+EMG+AV+ AL Sbjct: 301 AMMLRYSLNRAEQADRIENAVKKVLAQGYRTADIVTPGCKQVGTREMGEAVLAAL 355 >Q46YW0.1 LEU3_CUPPJ 3-isopropylmalate dehydrogenase EC=1.1.1.85 Length = 355 Score = 658 bits (1697), Expect = 0.0, Method: Compositional matrix adjust. Identities = 318/355 (89%), Positives = 336/355 (94%) Query: 1 MKIAILPGDGIGPEIIEQAVRVLNTLGEKFEMETAPVGGAGYEAHGHPLPDGTLKLAKES 60 MKIA+LPGDGIGPEI+ +AV+VLN L EKFEMETAPVGGAGYEA GHPLP+ TLKLAKE+ Sbjct: 1 MKIAVLPGDGIGPEIVAEAVKVLNALDEKFEMETAPVGGAGYEAEGHPLPENTLKLAKEA 60 Query: 61 DAILFGAVGDWKYDTLDRPLRPEQAILGLRKHLQLFANFRPAICYPELTGASSLKPELVA 120 DAILFGAVGDWKYD+L+R LRPEQAILGLRKHLQLFANFRPAICYPELTGASSLKPELVA Sbjct: 61 DAILFGAVGDWKYDSLERALRPEQAILGLRKHLQLFANFRPAICYPELTGASSLKPELVA 120 Query: 121 GLDILIVRELNGDIYFGQPRGMREAPDGPFKGAREGFDTMRYSEPEIRRIAHVAFQAAAK 180 GLDILIVRELNGDIYFGQPRG+REAPDG FKGAREGFDTMRYSEPEIRRIAHVAFQAAAK Sbjct: 121 GLDILIVRELNGDIYFGQPRGVREAPDGLFKGAREGFDTMRYSEPEIRRIAHVAFQAAAK 180 Query: 181 RGNRLCSVDKANVLETFQFWKDIVTDVHKEYPQVELTHMYVDNAAMQLVKAPKNFDVIVT 240 RG +LCSVDKANVLETFQFWKDIV DV KEYP VEL+HMYVDNAAMQLVKAPK+FDVIVT Sbjct: 181 RGKKLCSVDKANVLETFQFWKDIVIDVSKEYPDVELSHMYVDNAAMQLVKAPKSFDVIVT 240 Query: 241 GNMFGDILSDAAAMLTGSIGMLPSASLDANNKGLYEPSHGSAPDIAGKGIANPLATILSA 300 GNMFGDILSD AAMLTGSIGMLPSASLDANNKGLYEPSHGSAPDIAGKG+ANPLATILSA Sbjct: 241 GNMFGDILSDEAAMLTGSIGMLPSASLDANNKGLYEPSHGSAPDIAGKGVANPLATILSA 300 Query: 301 AMMLRFSLNKAEQADRIEAAVKKVLAQGYRTGDIYEEGTTKVGTKEMGDAVVKAL 355 AMMLR+SLNKAEQADRIE AVKKVLAQGYRTGDI G +VGT+EMG+AV+ AL Sbjct: 301 AMMLRYSLNKAEQADRIENAVKKVLAQGYRTGDILTPGCKQVGTREMGEAVLAAL 355