BLASTP 2.2.21 [Jun-14-2009] Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), "Gapped BLAST and PSI-BLAST: a new generation of protein database search programs", Nucleic Acids Res. 25:3389-3402. Reference for compositional score matrix adjustment: Altschul, Stephen F., John C. Wootton, E. Michael Gertz, Richa Agarwala, Aleksandr Morgulis, Alejandro A. Schaffer, and Yi-Kuo Yu (2005) "Protein database searches using compositionally adjusted substitution matrices", FEBS J. 272:5101-5109. Query= 0023.0026.p (302 letters) Database: pfamseq 15,929,002 sequences; 5,169,768,107 total letters Searching..................................................done Score E Sequences producing significant alignments: (bits) Value D8IRX0.1 D8IRX0_HERSS Permease of the drug/metabolite transporte... 490 e-136 A4G1W4.2 A4G1W4_HERAR Putative permease of the drug/metabolite t... 342 4e-92 A6SUS0.1 A6SUS0_JANMA Transporter of the DMT superfamily 340 2e-91 F1W0C1.1 F1W0C1_9BURK Putative permease of the drug/metabolite t... 325 4e-87 C3X5Y1.1 C3X5Y1_OXAFO DMT family permease 309 3e-82 >D8IRX0.1 D8IRX0_HERSS Permease of the drug/metabolite transporter (DMT) superfamily protein Length = 305 Score = 490 bits (1261), Expect = e-136, Method: Compositional matrix adjust. Identities = 234/302 (77%), Positives = 273/302 (90%), Gaps = 2/302 (0%) Query: 1 MLVASFLFSIMGVCVKLSSDYYSTAEVVLCRGIVGVAFIYGLVKIRGGTLRTPYPRDHLI 60 MLVASFLFSIMGVCVKL+SDYYST+E+VLCRG++G++ I LV++RGGT RTP+PRDHLI Sbjct: 6 MLVASFLFSIMGVCVKLASDYYSTSEIVLCRGLIGISVIAALVRVRGGTFRTPFPRDHLI 65 Query: 61 RGGVGVISLWLWFYSFGLLPVATATTLNYMSSIWIAAMLFGVAWWQGKKRFEWGLAGTVL 120 RGGVGVISLWLWFYSF LLPVATATTLNYMSSIWIA MLF AWWQG K+FEWGLA TV+ Sbjct: 66 RGGVGVISLWLWFYSFSLLPVATATTLNYMSSIWIAVMLFAAAWWQGNKKFEWGLAATVV 125 Query: 121 LSFVGVAMLLRPSIDSDQLLGGLIALFSGVLSALVYLQVRKLGLLGEPEYRVVFYFSFTG 180 LSF+GVA+L+RPS+D+DQLLGG I+LFSGVLSALVYLQVRKLGLLGEPEYRVVFYFS TG Sbjct: 126 LSFIGVALLMRPSLDADQLLGGAISLFSGVLSALVYLQVRKLGLLGEPEYRVVFYFSLTG 185 Query: 181 LLAGLAGSVVIGRIPFWHAHSAKGLALLVTIGLTATLAQIAMTRAYRLGNTLVTANLQYT 240 +LAGL GSV GR+P WH+HS +G AL++ IGLTATLAQIAMTRAYRLGNTLVTANLQYT Sbjct: 186 VLAGLVGSVATGRVPLWHSHSWQGAALVIMIGLTATLAQIAMTRAYRLGNTLVTANLQYT 245 Query: 241 GIVFASLWGLFIWNDAPGWMGWTGIAIILMSGVVSTFYNQRSQQQSRQSRNLPAIDPIAT 300 GIVF+SL+G+ +WNDAPGW+GW G+ +IL SG+++T++N RS Q + +RNLP +DPIAT Sbjct: 246 GIVFSSLFGVLVWNDAPGWLGWLGMGVILASGLLATYHNHRSSQIA--ARNLPKVDPIAT 303 Query: 301 EV 302 EV Sbjct: 304 EV 305 >A4G1W4.2 A4G1W4_HERAR Putative permease of the drug/metabolite transporter (DMT) superfamily Length = 309 Score = 342 bits (877), Expect = 4e-92, Method: Compositional matrix adjust. Identities = 182/307 (59%), Positives = 230/307 (74%), Gaps = 8/307 (2%) Query: 1 MLVASFLFSIMGVCVKLSSDYYSTAEVVLCRGIVGVAFIYGLVKIRGGTLRTPYPRDHLI 60 ML A+F+FSIMGVCVKL+S+ Y+ AE+V+ RG +G+ FIY L+ +GGTL+T HL Sbjct: 6 MLFATFVFSIMGVCVKLASETYTVAEIVMYRGFIGIIFIYALILQQGGTLKTRLAWQHLW 65 Query: 61 RGGVGVISLWLWFYSFGLLPVATATTLNYMSSIWIAAMLFGVAWWQGKKRFEWGLAGTVL 120 R VGV SLWLWF + LLP+ATA TLNYM+ IWI+ +LF +AW GK+RFEWGL + Sbjct: 66 RCVVGVTSLWLWFCAIALLPLATAMTLNYMAPIWISGILFVIAWRSGKRRFEWGLVAAIF 125 Query: 121 LSFVGVAMLLRPSIDSDQLLGGLIALFSGVLSALVYLQVRKLGLLGEPEYRVVFYFSFTG 180 +SF G+ +LLRPSI ++QL+G L+ L SG+LSAL YLQVR LG LGEPE RVVFYFS TG Sbjct: 126 MSFAGLTLLLRPSIHAEQLIGALLGLCSGILSALAYLQVRHLGQLGEPESRVVFYFSATG 185 Query: 181 LLAGLAGSV---VIGRIPF--WHAHSAKGLALLVTIGLTATLAQIAMTRAYRLGNTLVTA 235 +AGLAG + + G F H++ GL LL+ IG+ A +AQ+AMTRAYRLGN LVTA Sbjct: 186 FVAGLAGCLFDAITGGTTFTLLRPHTSYGLILLLGIGVLAAMAQMAMTRAYRLGNALVTA 245 Query: 236 NLQYTGIVFASLWGLFIWNDAPGWMGWTGIAIILMSGVVSTFYNQRSQQQSRQSRNLPAI 295 NLQYTGIVFAS+WG+ IWND GW+ W GI IIL SG+V+TFYN RS + S+++P + Sbjct: 246 NLQYTGIVFASIWGILIWNDVLGWLSWLGIVIILASGIVATFYNIRS---TAASKSMPPL 302 Query: 296 DPIATEV 302 DPIA E+ Sbjct: 303 DPIAAEL 309 >A6SUS0.1 A6SUS0_JANMA Transporter of the DMT superfamily Length = 304 Score = 340 bits (871), Expect = 2e-91, Method: Compositional matrix adjust. Identities = 183/307 (59%), Positives = 228/307 (74%), Gaps = 8/307 (2%) Query: 1 MLVASFLFSIMGVCVKLSSDYYSTAEVVLCRGIVGVAFIYGLVKIRGGTLRTPYPRDHLI 60 MLVA+ +FSIMGVCVKL+S+ YS AE+++ RG +GV FIY L+ +GG+LRT HL Sbjct: 1 MLVATLMFSIMGVCVKLASETYSVAEIIMYRGFIGVIFIYILILQQGGSLRTHLIWQHLW 60 Query: 61 RGGVGVISLWLWFYSFGLLPVATATTLNYMSSIWIAAMLFGVAWWQGKKRFEWGLAGTVL 120 R VGV +LWLWF + GLLP+ATA TLNYM+ IWI+ +LF AW GK+RFEWGL + Sbjct: 61 RCVVGVTALWLWFCAIGLLPLATAMTLNYMAPIWISGILFVAAWRAGKRRFEWGLVLAIT 120 Query: 121 LSFVGVAMLLRPSIDSDQLLGGLIALFSGVLSALVYLQVRKLGLLGEPEYRVVFYFSFTG 180 SFVGV +LLRPSI +DQ LGG + L SG LSAL YLQVR LG LGEPE RVVFYFS TG Sbjct: 121 ASFVGVTLLLRPSIHADQWLGGFLGLCSGALSALAYLQVRHLGQLGEPESRVVFYFSATG 180 Query: 181 LLAGLAGSV----VIGR-IPFWHAHSAKGLALLVTIGLTATLAQIAMTRAYRLGNTLVTA 235 +AGLAG + + G I +HS G+ LL++IG+ A +AQ+AMTRAYRLGNTLVTA Sbjct: 181 FIAGLAGCLFGPGLHGESISLLRSHSTYGMFLLLSIGVFAAIAQMAMTRAYRLGNTLVTA 240 Query: 236 NLQYTGIVFASLWGLFIWNDAPGWMGWTGIAIILMSGVVSTFYNQRSQQQSRQSRNLPAI 295 NLQYTGIVF+S+WG+ IW+D G+ W GIAIIL+SG+V+TFYN R+ S + + Sbjct: 241 NLQYTGIVFSSIWGVLIWSDILGFFSWLGIAIILVSGIVATFYNIRN---SATVKAVTPA 297 Query: 296 DPIATEV 302 DPI+TE+ Sbjct: 298 DPISTEL 304 >F1W0C1.1 F1W0C1_9BURK Putative permease of the drug/metabolite transporter (DMT) superfamily Length = 309 Score = 325 bits (834), Expect = 4e-87, Method: Compositional matrix adjust. Identities = 167/286 (58%), Positives = 214/286 (74%), Gaps = 4/286 (1%) Query: 1 MLVASFLFSIMGVCVKLSSDYYSTAEVVLCRGIVGVAFIYGLVKIRGGTLRTPYPRDHLI 60 ML+A+FLF+IMGVCVKL+SDYYS AE+V+ RG +GV I LV +RG TLRT + R HL Sbjct: 6 MLLATFLFAIMGVCVKLASDYYSIAEIVMARGAIGVIVIGALVLLRGDTLRTRFARHHLW 65 Query: 61 RGGVGVISLWLWFYSFGLLPVATATTLNYMSSIWIAAMLFGVAWWQGKKRFEWGLAGTVL 120 RG VGV + W+WFY+ LP++ A TLNYM+ IWIAA+LF WW+G + FE G+ ++ Sbjct: 66 RGTVGVTAFWMWFYAIATLPLSMAMTLNYMAPIWIAAILFTGGWWRGVRSFEPGMILAIM 125 Query: 121 LSFVGVAMLLRPSIDSDQLLGGLIALFSGVLSALVYLQVRKLGLLGEPEYRVVFYFSFTG 180 SF+GV +LL+P++ + Q +G LIAL SG+L+AL YLQVR+LG +GEPE RVVFYFS T Sbjct: 126 ASFIGVTLLLQPAMHASQWMGALIALASGMLAALAYLQVRELGKMGEPESRVVFYFSLTS 185 Query: 181 LLAGLAGSVV----IGRIPFWHAHSAKGLALLVTIGLTATLAQIAMTRAYRLGNTLVTAN 236 LAGL G ++ + WH S +GL LL+ IG AT+AQ+AMTRAYRLG LVTAN Sbjct: 186 TLAGLGGVLLAPGPLADAALWHVPSTRGLLLLLAIGGCATVAQMAMTRAYRLGKILVTAN 245 Query: 237 LQYTGIVFASLWGLFIWNDAPGWMGWTGIAIILMSGVVSTFYNQRS 282 LQYTGIVF+S WG+ +W D GW GW+GIA+IL SG+V+T+YN RS Sbjct: 246 LQYTGIVFSSFWGVLLWQDVLGWKGWSGIAVILSSGLVATYYNTRS 291 >C3X5Y1.1 C3X5Y1_OXAFO DMT family permease Length = 298 Score = 309 bits (792), Expect = 3e-82, Method: Compositional matrix adjust. Identities = 157/278 (56%), Positives = 203/278 (73%), Gaps = 5/278 (1%) Query: 11 MGVCVKLSSDYYSTAEVVLCRGIVGVAFIYGLVKIRGGTLRTPYPRDHLIRGGVGVISLW 70 MGVCVKL SD YST E+V+ R ++G F+ LV IRGG+ +T YP HL RG VG + Sbjct: 1 MGVCVKLVSDDYSTPEIVMYRSLIGALFLGCLVYIRGGSFKTSYPLQHLWRGVVGATAFG 60 Query: 71 LWFYSFGLLPVATATTLNYMSSIWIAAMLFGVAWWQGKKRFEWGLAGTVLLSFVGVAMLL 130 LWF+SF LP+ATA TLNYMS IWIA +LFG+ ++GK RFEW LA ++ SFVGV +LL Sbjct: 61 LWFFSFRGLPLATAMTLNYMSPIWIAGILFGIGLYRGKVRFEWKLACAIIASFVGVVLLL 120 Query: 131 RPSIDSDQLLGGLIALFSGVLSALVYLQVRKLGLLGEPEYRVVFYFSFTGLLAGLAGSVV 190 +P+I +DQ G++AL SGVL+AL YLQVR LG LGEPEYRVVFYF G + G S++ Sbjct: 121 QPTIHADQWQSGVVALVSGVLAALAYLQVRHLGNLGEPEYRVVFYFCLIGTVGGALISLI 180 Query: 191 IGRIP-----FWHAHSAKGLALLVTIGLTATLAQIAMTRAYRLGNTLVTANLQYTGIVFA 245 ++P +H+HS KGL LL IG+ A + Q+AMTRAY LG TLVTANLQY+GIVF+ Sbjct: 181 CAQLPGSDGIAFHSHSIKGLVLLTLIGVFAAVGQMAMTRAYHLGKTLVTANLQYSGIVFS 240 Query: 246 SLWGLFIWNDAPGWMGWTGIAIILMSGVVSTFYNQRSQ 283 S+WG+ IW D GW+GW G+A+I+ SG+ +TF++ R + Sbjct: 241 SVWGILIWEDFLGWIGWLGVAVIMGSGISTTFFDVRHK 278