BLASTP 2.2.21 [Jun-14-2009] Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), "Gapped BLAST and PSI-BLAST: a new generation of protein database search programs", Nucleic Acids Res. 25:3389-3402. Reference for compositional score matrix adjustment: Altschul, Stephen F., John C. Wootton, E. Michael Gertz, Richa Agarwala, Aleksandr Morgulis, Alejandro A. Schaffer, and Yi-Kuo Yu (2005) "Protein database searches using compositionally adjusted substitution matrices", FEBS J. 272:5101-5109. Query= 0020.0017.p (436 letters) Database: pfamseq 15,929,002 sequences; 5,169,768,107 total letters Searching..................................................done Score E Sequences producing significant alignments: (bits) Value D8IT35.1 D8IT35_HERSS Homoserine dehydrogenase EC=1.1.1.3 830 0.0 A6SXK5.1 A6SXK5_JANMA Homoserine dehydrogenase EC=1.1.1.3 759 0.0 F1W2Q6.1 F1W2Q6_9BURK Homoserine dehydrogenase 736 0.0 A4G700.1 A4G700_HERAR Homoserine dehydrogenase EC=1.1.1.3 734 0.0 Q0K9F8.1 Q0K9F8_CUPNH Homoserine dehydrogenase EC=1.1.1.3 724 0.0 >D8IT35.1 D8IT35_HERSS Homoserine dehydrogenase EC=1.1.1.3 Length = 436 Score = 830 bits (2145), Expect = 0.0, Method: Compositional matrix adjust. Identities = 412/435 (94%), Positives = 425/435 (97%) Query: 1 MKSIKVGLLGIGTVGSGTFNVLKRNQEEIARRAGRGIEITMVADLNTERATELTNGQVKV 60 MKSIKVGLLGIGTVGSGTFNVLKRNQEEIARRAGRGIEITMVADLNTERATELTNG+VKV Sbjct: 1 MKSIKVGLLGIGTVGSGTFNVLKRNQEEIARRAGRGIEITMVADLNTERATELTNGEVKV 60 Query: 61 VNDANLVVNDPDIDIVIELIGGYGLAKDLVLKAIANGKHVVTANKALIATHGNEIFKAAQ 120 VNDANLVV++PDIDIVIELIGGYG+AKDLVLKAIANGKHVVTANKALIATHGNEIFKAAQ Sbjct: 61 VNDANLVVSNPDIDIVIELIGGYGIAKDLVLKAIANGKHVVTANKALIATHGNEIFKAAQ 120 Query: 121 EKGVMVAFEAAVAGGIPIIKALREGLTANRIQWIAGIINGTTNFILSEMRDKGLDFDVVL 180 EKGVMVAFEAAVAGGIPIIKALREGLTANRIQWIAGIINGTTNFILSEMRDKGLDFDVVL Sbjct: 121 EKGVMVAFEAAVAGGIPIIKALREGLTANRIQWIAGIINGTTNFILSEMRDKGLDFDVVL 180 Query: 181 KEAQRLGYAEADPTFDIEGVDAAHKLTIMASIAFGIPVQFDKAHVEGITKLQATDIRYAE 240 KEAQRLGYAEADPTFDIEGVDAAHKLTIMASIAFGIPVQFDKAHVEGITKLQA+DI YAE Sbjct: 181 KEAQRLGYAEADPTFDIEGVDAAHKLTIMASIAFGIPVQFDKAHVEGITKLQASDITYAE 240 Query: 241 QLGYRIKLLGITRQTEKGIELRVHPTLIPTGRLIANVEGAMNAVMVRGDAVGETLYYGKG 300 QLGYRIKLLGITRQT KGIELRVHPTLIP RLIANVEGAMNAV+VRGDAVGETLYYGKG Sbjct: 241 QLGYRIKLLGITRQTAKGIELRVHPTLIPAARLIANVEGAMNAVVVRGDAVGETLYYGKG 300 Query: 301 AGSEPTASAVIADLVDITRLATADPEHRVPSLAFQPNAMADTPVLPIQDVTTSYYLRMHV 360 AGSEPTASAVIADLVDITRLATADPEHRVP LAFQPNAMADTPVLP+ +V+TSYYLRM V Sbjct: 301 AGSEPTASAVIADLVDITRLATADPEHRVPYLAFQPNAMADTPVLPMSEVSTSYYLRMRV 360 Query: 361 ADKPGVLADVTRILADSSISIDAMLQKEPAEGEQQTDIIMLTHQTQERNIEAAIAKIEAL 420 AD+ GVLADVTRILADS+ISIDAMLQKEPAEGEQQTDIIMLTHQTQE+NIEAAIAKIEAL Sbjct: 361 ADQAGVLADVTRILADSTISIDAMLQKEPAEGEQQTDIIMLTHQTQEKNIEAAIAKIEAL 420 Query: 421 PTVMGSVMKIRLEEL 435 TVMG+V KIRLEEL Sbjct: 421 TTVMGTVTKIRLEEL 435 >A6SXK5.1 A6SXK5_JANMA Homoserine dehydrogenase EC=1.1.1.3 Length = 436 Score = 759 bits (1960), Expect = 0.0, Method: Compositional matrix adjust. Identities = 371/436 (85%), Positives = 403/436 (92%) Query: 1 MKSIKVGLLGIGTVGSGTFNVLKRNQEEIARRAGRGIEITMVADLNTERATELTNGQVKV 60 MK+IKVGLLGIGTVG+GTFNVLKRNQEEI+RRAG GIEI MVADL+ RA EL +V Sbjct: 1 MKTIKVGLLGIGTVGAGTFNVLKRNQEEISRRAGHGIEIVMVADLDVARAKELVGSHCEV 60 Query: 61 VNDANLVVNDPDIDIVIELIGGYGLAKDLVLKAIANGKHVVTANKALIATHGNEIFKAAQ 120 VND NLVV++P++DIV+ELIGGYG+AKDLVLKAIANGKHVVTANKAL+ATHG+EIF+AAQ Sbjct: 61 VNDGNLVVSNPEVDIVVELIGGYGIAKDLVLKAIANGKHVVTANKALLATHGDEIFQAAQ 120 Query: 121 EKGVMVAFEAAVAGGIPIIKALREGLTANRIQWIAGIINGTTNFILSEMRDKGLDFDVVL 180 KGVMVA+EAAVAGGIPIIKALREGLTANRI+WIAGIINGTTNFILSEMRDKGLDFD VL Sbjct: 121 NKGVMVAYEAAVAGGIPIIKALREGLTANRIEWIAGIINGTTNFILSEMRDKGLDFDTVL 180 Query: 181 KEAQRLGYAEADPTFDIEGVDAAHKLTIMASIAFGIPVQFDKAHVEGITKLQATDIRYAE 240 KEAQRLGYAEADPTFDIEGVDAAHK T+MA+IAFGIPVQFDKAHVEGITKL+A DIRYAE Sbjct: 181 KEAQRLGYAEADPTFDIEGVDAAHKATLMAAIAFGIPVQFDKAHVEGITKLEAVDIRYAE 240 Query: 241 QLGYRIKLLGITRQTEKGIELRVHPTLIPTGRLIANVEGAMNAVMVRGDAVGETLYYGKG 300 QLGYRIKLLGI ++T +GIELRVHPTLIP RLIANVEGAMNAV+V+GDAVG TLYYGKG Sbjct: 241 QLGYRIKLLGIAKRTSQGIELRVHPTLIPAKRLIANVEGAMNAVLVQGDAVGATLYYGKG 300 Query: 301 AGSEPTASAVIADLVDITRLATADPEHRVPSLAFQPNAMADTPVLPIQDVTTSYYLRMHV 360 AG+EPTASAVIADLVDI RLA ADP HRVP LAFQPNAMADTP+LPI +VTTSYYLRMHV Sbjct: 301 AGAEPTASAVIADLVDIARLADADPAHRVPHLAFQPNAMADTPILPISEVTTSYYLRMHV 360 Query: 361 ADKPGVLADVTRILADSSISIDAMLQKEPAEGEQQTDIIMLTHQTQERNIEAAIAKIEAL 420 ADK GVLA+VT ILADS+ISIDAMLQKEPA GE QTDIIMLTHQTQE+N+EAAI KIEAL Sbjct: 361 ADKLGVLANVTSILADSTISIDAMLQKEPALGETQTDIIMLTHQTQEKNVEAAIKKIEAL 420 Query: 421 PTVMGSVMKIRLEELN 436 PTVMG V KIRLE L+ Sbjct: 421 PTVMGQVTKIRLEHLS 436 >F1W2Q6.1 F1W2Q6_9BURK Homoserine dehydrogenase Length = 436 Score = 736 bits (1899), Expect = 0.0, Method: Compositional matrix adjust. Identities = 363/435 (83%), Positives = 397/435 (91%) Query: 1 MKSIKVGLLGIGTVGSGTFNVLKRNQEEIARRAGRGIEITMVADLNTERATELTNGQVKV 60 MK IKVGLLGIGTVG+GTFNVLKRN EEI RRAGR IEI MVADLN ERA LTN + +V Sbjct: 1 MKPIKVGLLGIGTVGAGTFNVLKRNAEEITRRAGRRIEIAMVADLNVERARALTNNECEV 60 Query: 61 VNDANLVVNDPDIDIVIELIGGYGLAKDLVLKAIANGKHVVTANKALIATHGNEIFKAAQ 120 V+DANLVVN PDIDIVIELIGGYG+AK LVL+AIANGKHVVTANKAL+A HGNEIFKAAQ Sbjct: 61 VDDANLVVNHPDIDIVIELIGGYGIAKSLVLQAIANGKHVVTANKALLALHGNEIFKAAQ 120 Query: 121 EKGVMVAFEAAVAGGIPIIKALREGLTANRIQWIAGIINGTTNFILSEMRDKGLDFDVVL 180 EKGV+VAFEAAVAGGIPIIK+LREGLTANRIQWIAGIINGTTNFILSEMRD+GLDF+ L Sbjct: 121 EKGVIVAFEAAVAGGIPIIKSLREGLTANRIQWIAGIINGTTNFILSEMRDRGLDFNTAL 180 Query: 181 KEAQRLGYAEADPTFDIEGVDAAHKLTIMASIAFGIPVQFDKAHVEGITKLQATDIRYAE 240 EAQ+LGYAEADPTFDIEG+DAAHK T+MASIAFGIPVQFDKAHVEGIT+LQA DI YAE Sbjct: 181 LEAQQLGYAEADPTFDIEGIDAAHKATLMASIAFGIPVQFDKAHVEGITQLQAIDISYAE 240 Query: 241 QLGYRIKLLGITRQTEKGIELRVHPTLIPTGRLIANVEGAMNAVMVRGDAVGETLYYGKG 300 QLGYRIKLLGIT++T GIELRVHPTLIP RLIANVEGAMNAV+V+GDAVG TLYYGKG Sbjct: 241 QLGYRIKLLGITKRTPLGIELRVHPTLIPAKRLIANVEGAMNAVVVQGDAVGATLYYGKG 300 Query: 301 AGSEPTASAVIADLVDITRLATADPEHRVPSLAFQPNAMADTPVLPIQDVTTSYYLRMHV 360 AG+EPTASAVIADLVDITRL TA+P HRVP LAFQP+AM DTP+LP+ ++TTSYYLR+HV Sbjct: 301 AGAEPTASAVIADLVDITRLFTAEPGHRVPHLAFQPDAMTDTPILPMSEITTSYYLRLHV 360 Query: 361 ADKPGVLADVTRILADSSISIDAMLQKEPAEGEQQTDIIMLTHQTQERNIEAAIAKIEAL 420 ADK GVLA VTRILADS ISIDAMLQKEPA+GE QTDIIMLTHQTQE+ ++ AIA+IEAL Sbjct: 361 ADKLGVLAAVTRILADSDISIDAMLQKEPADGETQTDIIMLTHQTQEKRVDVAIARIEAL 420 Query: 421 PTVMGSVMKIRLEEL 435 TV+G V +IRLEEL Sbjct: 421 ATVIGKVTRIRLEEL 435 >A4G700.1 A4G700_HERAR Homoserine dehydrogenase EC=1.1.1.3 Length = 437 Score = 734 bits (1894), Expect = 0.0, Method: Compositional matrix adjust. Identities = 360/437 (82%), Positives = 398/437 (91%), Gaps = 1/437 (0%) Query: 1 MKSIKVGLLGIGTVGSGTFNVLKRNQEEIARRAGRGIEITMVADLNTERATELT-NGQVK 59 MKSIKVGLLG GTVG+GTFN+LKRNQEEI+RRAG IEI MVADL+ RA EL + + + Sbjct: 1 MKSIKVGLLGAGTVGAGTFNILKRNQEEISRRAGHKIEIVMVADLDLARAKELVGSAECE 60 Query: 60 VVNDANLVVNDPDIDIVIELIGGYGLAKDLVLKAIANGKHVVTANKALIATHGNEIFKAA 119 VVND NLVVN PDI+IV+ELIGGYG+AKDLVLKAIANGKHVVTANKAL+A HG+EIFKAA Sbjct: 61 VVNDGNLVVNHPDIEIVVELIGGYGIAKDLVLKAIANGKHVVTANKALLAVHGDEIFKAA 120 Query: 120 QEKGVMVAFEAAVAGGIPIIKALREGLTANRIQWIAGIINGTTNFILSEMRDKGLDFDVV 179 Q+KGVMVA+EAAVAGGIPIIKALREGLTANRI+WIAGIINGTTNFILSEMRDKGLDFD V Sbjct: 121 QDKGVMVAYEAAVAGGIPIIKALREGLTANRIEWIAGIINGTTNFILSEMRDKGLDFDTV 180 Query: 180 LKEAQRLGYAEADPTFDIEGVDAAHKLTIMASIAFGIPVQFDKAHVEGITKLQATDIRYA 239 LKEAQRLGYAEADPTFDIEGVDAAHK T+MASIAFGIPVQFDKAH+EGITKL+A DIRYA Sbjct: 181 LKEAQRLGYAEADPTFDIEGVDAAHKATLMASIAFGIPVQFDKAHIEGITKLEAIDIRYA 240 Query: 240 EQLGYRIKLLGITRQTEKGIELRVHPTLIPTGRLIANVEGAMNAVMVRGDAVGETLYYGK 299 EQLGYRIKLLGI ++T +GIELRVHPTLIP RLIANVEGAMNAV+V+GDAVG TLYYGK Sbjct: 241 EQLGYRIKLLGIAKRTPQGIELRVHPTLIPAKRLIANVEGAMNAVVVQGDAVGATLYYGK 300 Query: 300 GAGSEPTASAVIADLVDITRLATADPEHRVPSLAFQPNAMADTPVLPIQDVTTSYYLRMH 359 GAG+EPT SAVIADLVDI RLA ADP HRVP LAFQPNAM+ P+LPI +VTTSYYLR+H Sbjct: 301 GAGAEPTGSAVIADLVDIARLADADPAHRVPHLAFQPNAMSALPILPISEVTTSYYLRLH 360 Query: 360 VADKPGVLADVTRILADSSISIDAMLQKEPAEGEQQTDIIMLTHQTQERNIEAAIAKIEA 419 V+DK GVLA+VT ILA+S+IS+DAMLQKEP GE QTDII+LTHQTQE+N+EAAI+KIEA Sbjct: 361 VSDKLGVLANVTSILAESTISVDAMLQKEPELGESQTDIIILTHQTQEKNVEAAISKIEA 420 Query: 420 LPTVMGSVMKIRLEELN 436 LPTV G V KIRLE L+ Sbjct: 421 LPTVHGKVTKIRLEHLS 437 >Q0K9F8.1 Q0K9F8_CUPNH Homoserine dehydrogenase EC=1.1.1.3 Length = 436 Score = 724 bits (1870), Expect = 0.0, Method: Compositional matrix adjust. Identities = 351/436 (80%), Positives = 402/436 (92%) Query: 1 MKSIKVGLLGIGTVGSGTFNVLKRNQEEIARRAGRGIEITMVADLNTERATELTNGQVKV 60 M IKVGLLGIGTVGSGTFNVLKRNQEEI RRAGRGIEI +VADLNTERA ELTNG+V++ Sbjct: 1 MNPIKVGLLGIGTVGSGTFNVLKRNQEEIRRRAGRGIEIAVVADLNTERARELTNGEVEI 60 Query: 61 VNDANLVVNDPDIDIVIELIGGYGLAKDLVLKAIANGKHVVTANKALIATHGNEIFKAAQ 120 V+DAN VV+ PDIDIVIELIGGYG+A++LVLKAI NGKHVVTANKAL+A HGNEIF+AA+ Sbjct: 61 VSDANEVVSRPDIDIVIELIGGYGIARELVLKAIENGKHVVTANKALLAVHGNEIFEAAR 120 Query: 121 EKGVMVAFEAAVAGGIPIIKALREGLTANRIQWIAGIINGTTNFILSEMRDKGLDFDVVL 180 +KGV+VAFEAAVAGGIPIIKALREGLTANRIQWIAGIINGTTNFILSEMRDKGLDFDVVL Sbjct: 121 KKGVIVAFEAAVAGGIPIIKALREGLTANRIQWIAGIINGTTNFILSEMRDKGLDFDVVL 180 Query: 181 KEAQRLGYAEADPTFDIEGVDAAHKLTIMASIAFGIPVQFDKAHVEGITKLQATDIRYAE 240 KEAQ+LGYAEADPTFDIEGVDAAHK+T+M++IAFG+PVQFDKAHVEGITKL A DI+YAE Sbjct: 181 KEAQQLGYAEADPTFDIEGVDAAHKVTLMSAIAFGMPVQFDKAHVEGITKLSAIDIKYAE 240 Query: 241 QLGYRIKLLGITRQTEKGIELRVHPTLIPTGRLIANVEGAMNAVMVRGDAVGETLYYGKG 300 +LGYRIKLLGITR+ + G+ELRVHPTL+P RLIANVEGAMNAV+V+GDAVG TLYYGKG Sbjct: 241 ELGYRIKLLGITRRRDDGVELRVHPTLVPASRLIANVEGAMNAVLVQGDAVGATLYYGKG 300 Query: 301 AGSEPTASAVIADLVDITRLATADPEHRVPSLAFQPNAMADTPVLPIQDVTTSYYLRMHV 360 AG+EPTASAVIADLVD+TRL TADP HRVP LAFQP+ ++ PVLPI+++ +SYYLRM V Sbjct: 301 AGAEPTASAVIADLVDVTRLHTADPNHRVPHLAFQPDELSSVPVLPIEEINSSYYLRMRV 360 Query: 361 ADKPGVLADVTRILADSSISIDAMLQKEPAEGEQQTDIIMLTHQTQERNIEAAIAKIEAL 420 AD+ GVLA++TRILA+ ISIDAMLQKE EGE QTDII+LTH T+E+++ AAIAKIEAL Sbjct: 361 ADETGVLAEITRILAEGGISIDAMLQKESREGEPQTDIIILTHITREKHVNAAIAKIEAL 420 Query: 421 PTVMGSVMKIRLEELN 436 PTV+ +V ++R+EELN Sbjct: 421 PTVLSAVTRLRMEELN 436