BLASTP 2.2.21 [Jun-14-2009] Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), "Gapped BLAST and PSI-BLAST: a new generation of protein database search programs", Nucleic Acids Res. 25:3389-3402. Reference for compositional score matrix adjustment: Altschul, Stephen F., John C. Wootton, E. Michael Gertz, Richa Agarwala, Aleksandr Morgulis, Alejandro A. Schaffer, and Yi-Kuo Yu (2005) "Protein database searches using compositionally adjusted substitution matrices", FEBS J. 272:5101-5109. Query= 0015.0126.p (476 letters) Database: pfamseq 15,929,002 sequences; 5,169,768,107 total letters Searching..................................................done Score E Sequences producing significant alignments: (bits) Value B8GQD6.1 LEUC_THISH 3-isopropylmalate dehydratase large subunit ... 623 e-176 C6BI96.1 C6BI96_RALP1 3-isopropylmalate dehydratase large subuni... 618 e-175 B2UBK2.1 B2UBK2_RALPJ 3-isopropylmalate dehydratase large subuni... 618 e-175 E2T1X6.1 E2T1X6_9RALS 3-isopropylmalate dehydratase large subuni... 618 e-175 Q2Y7Q5.1 Q2Y7Q5_NITMU 3-isopropylmalate dehydratase large subuni... 616 e-174 >B8GQD6.1 LEUC_THISH 3-isopropylmalate dehydratase large subunit EC=4.2.1.33 Length = 470 Score = 623 bits (1607), Expect = e-176, Method: Compositional matrix adjust. Identities = 303/461 (65%), Positives = 372/461 (80%) Query: 11 TLFEKLWQAHVVSSDDEGNALVYIDRQYVYEVTSPQAFEGLREKKRKVRRPGTVLATVDH 70 TL++KLW AHVV ++ +G AL+YIDR V+EVTSPQAFEGLR RK R TVLA DH Sbjct: 5 TLYDKLWDAHVVRTEPDGTALLYIDRHLVHEVTSPQAFEGLRLAGRKPWRTDTVLAVPDH 64 Query: 71 NVPTTARDVPMRDRLAQLQVDTLTSNCADFGIPYFDIRDVRQGIVHVVGPEQGATLPGST 130 NVPTT RD + D ++++QV+TL +N +FGI +F + DVRQGIVHV+GPEQGATLPG T Sbjct: 65 NVPTTHRDQGISDPVSRIQVETLDANVHEFGITFFPMNDVRQGIVHVIGPEQGATLPGMT 124 Query: 131 VICGDSHTSTHGAFGALAWGVGTTEVEHALATHCLWLVRPLTTRITVKGTLAPGVGAKDL 190 V+CGDSHTSTHGAFGALA+G+GT+EVEH LAT CL + ++V G + PGV AKD+ Sbjct: 125 VVCGDSHTSTHGAFGALAFGIGTSEVEHVLATQCLLQKKMKNMLVSVDGRVGPGVTAKDI 184 Query: 191 ALYLIGFLGTQGGIGHAIEFAGDAIAALSMEGRMTLCNMAVEAGARFGLVAVDDTTIDYL 250 L +IG +GT GG G+AIEF G+AI LSMEGRMT+CNMA+EAGAR G+VAVD+TTI+Y+ Sbjct: 185 VLAIIGEIGTAGGTGYAIEFGGEAIRDLSMEGRMTVCNMAIEAGARAGMVAVDETTIEYV 244 Query: 251 QGRPLVPSGAQWDAANAYWRQLRSDSGAQFYRELEIDAGTVKPMVTWGTSPDMCVGVDGV 310 +GR P+G QW++A A WR+L SD+ A+F R + +DA + P V+WGTSP+M V V G Sbjct: 245 KGRTYAPTGEQWESAVAAWRELNSDADARFDRVVRLDATAIAPQVSWGTSPEMVVPVTGR 304 Query: 311 VPDPSQEENITRQSGMRKALAYMDISAGTPMEQLALDKVFIGSCTNARIEDLRAAAAVVR 370 VPDP++ + + SGM++AL YM ++A TP+EQ+A+DKVFIGSCTN+RIEDLRAAAAVVR Sbjct: 305 VPDPAEATDPVKASGMKRALEYMGLAANTPIEQIAIDKVFIGSCTNSRIEDLRAAAAVVR 364 Query: 371 GYTVSQTIRQALVVPGSGLVKRQAEQEGLDKVFLAAGFEWREPGCSMCLGMNDDRLAPGE 430 G V+ ++ A+VVPGSGLVK+QAEQEGLD+VFL AGFEWREPGCSMCL MN DRL PGE Sbjct: 365 GRKVAGNVKLAMVVPGSGLVKQQAEQEGLDQVFLEAGFEWREPGCSMCLAMNADRLEPGE 424 Query: 431 RCASTSNRNFEGRQGPGGRSHLVSPATAAAAAICGHFTDVR 471 RCASTSNRNFEGRQG GGR+HLVSPA AAAAA+ GHFTDVR Sbjct: 425 RCASTSNRNFEGRQGQGGRTHLVSPAMAAAAAVTGHFTDVR 465 >C6BI96.1 C6BI96_RALP1 3-isopropylmalate dehydratase large subunit 1 EC=4.2.1.33 Length = 480 Score = 618 bits (1593), Expect = e-175, Method: Compositional matrix adjust. Identities = 301/460 (65%), Positives = 361/460 (78%) Query: 11 TLFEKLWQAHVVSSDDEGNALVYIDRQYVYEVTSPQAFEGLREKKRKVRRPGTVLATVDH 70 TLF KLWQ H V D+G+ L+YID V EVTSPQAFEGLR + RP +VLAT DH Sbjct: 5 TLFAKLWQRHAVRDTDDGHTLLYIDLHLVNEVTSPQAFEGLRISRLHPWRPASVLATEDH 64 Query: 71 NVPTTARDVPMRDRLAQLQVDTLTSNCADFGIPYFDIRDVRQGIVHVVGPEQGATLPGST 130 NVPT R + D +A+ QV+ L SNCA FGI + ++D RQGI+HV+GPEQGATLPG T Sbjct: 65 NVPTANRAAGITDDIARRQVEALRSNCARFGITEYPMQDARQGILHVIGPEQGATLPGMT 124 Query: 131 VICGDSHTSTHGAFGALAWGVGTTEVEHALATHCLWLVRPLTTRITVKGTLAPGVGAKDL 190 ++CGDSHT+THGAF LA+G+GT+E+EH LAT CL + + T R+ V+G L+PGV +KD+ Sbjct: 125 IVCGDSHTTTHGAFATLAFGIGTSEIEHVLATQCLIVKKMKTMRVLVEGDLSPGVTSKDV 184 Query: 191 ALYLIGFLGTQGGIGHAIEFAGDAIAALSMEGRMTLCNMAVEAGARFGLVAVDDTTIDYL 250 AL LIG +GT G G+AIEFAG AI+A+SM+ RMTLCNM +EAGAR G+VAVDD TI+YL Sbjct: 185 ALALIGRIGTAGATGYAIEFAGSAISAMSMDARMTLCNMVIEAGARCGMVAVDDKTINYL 244 Query: 251 QGRPLVPSGAQWDAANAYWRQLRSDSGAQFYRELEIDAGTVKPMVTWGTSPDMCVGVDGV 310 +GR P GAQWDAA AYWR LRSD GAQF R + +DA T++P VTWGTSP+M V +DG Sbjct: 245 RGRARAPQGAQWDAAQAYWRTLRSDEGAQFDRTIALDATTIRPHVTWGTSPEMVVTIDGR 304 Query: 311 VPDPSQEENITRQSGMRKALAYMDISAGTPMEQLALDKVFIGSCTNARIEDLRAAAAVVR 370 VPDP++E + ++ G+ +AL YM + GTP+ +ALDK+FIGSCTNARIEDLRAAA VV Sbjct: 305 VPDPAEESDPIKRQGITRALTYMGLEPGTPLRDIALDKIFIGSCTNARIEDLRAAARVVA 364 Query: 371 GYTVSQTIRQALVVPGSGLVKRQAEQEGLDKVFLAAGFEWREPGCSMCLGMNDDRLAPGE 430 G V+ I QALVVPGSGLVKRQAE EGLD++F+ AGFEWR+PGCSMCLGMNDDRL PGE Sbjct: 365 GKHVAANIVQALVVPGSGLVKRQAEAEGLDRIFVDAGFEWRDPGCSMCLGMNDDRLQPGE 424 Query: 431 RCASTSNRNFEGRQGPGGRSHLVSPATAAAAAICGHFTDV 470 RCASTSNRNFEGRQG GGR+HLVSP AAAAAI GHF V Sbjct: 425 RCASTSNRNFEGRQGAGGRTHLVSPPMAAAAAIAGHFVAV 464 >B2UBK2.1 B2UBK2_RALPJ 3-isopropylmalate dehydratase large subunit 1 EC=4.2.1.33 Length = 480 Score = 618 bits (1593), Expect = e-175, Method: Compositional matrix adjust. Identities = 301/460 (65%), Positives = 361/460 (78%) Query: 11 TLFEKLWQAHVVSSDDEGNALVYIDRQYVYEVTSPQAFEGLREKKRKVRRPGTVLATVDH 70 TLF KLWQ H V D+G+ L+YID V EVTSPQAFEGLR + RP +VLAT DH Sbjct: 5 TLFAKLWQRHAVRDTDDGHTLLYIDLHLVNEVTSPQAFEGLRISRLHPWRPASVLATEDH 64 Query: 71 NVPTTARDVPMRDRLAQLQVDTLTSNCADFGIPYFDIRDVRQGIVHVVGPEQGATLPGST 130 NVPT R + D +A+ QV+ L SNCA FGI + ++D RQGI+HV+GPEQGATLPG T Sbjct: 65 NVPTANRAAGITDDIARRQVEALRSNCARFGITEYPMQDARQGILHVIGPEQGATLPGMT 124 Query: 131 VICGDSHTSTHGAFGALAWGVGTTEVEHALATHCLWLVRPLTTRITVKGTLAPGVGAKDL 190 ++CGDSHT+THGAF LA+G+GT+E+EH LAT CL + + T R+ V+G L+PGV +KD+ Sbjct: 125 IVCGDSHTTTHGAFATLAFGIGTSEIEHVLATQCLIVKKMKTMRVLVEGDLSPGVTSKDV 184 Query: 191 ALYLIGFLGTQGGIGHAIEFAGDAIAALSMEGRMTLCNMAVEAGARFGLVAVDDTTIDYL 250 AL LIG +GT G G+AIEFAG AI+A+SM+ RMTLCNM +EAGAR G+VAVDD TI+YL Sbjct: 185 ALALIGRIGTAGATGYAIEFAGSAISAMSMDARMTLCNMVIEAGARCGMVAVDDKTINYL 244 Query: 251 QGRPLVPSGAQWDAANAYWRQLRSDSGAQFYRELEIDAGTVKPMVTWGTSPDMCVGVDGV 310 +GR P GAQWDAA AYWR LRSD GAQF R + +DA T++P VTWGTSP+M V +DG Sbjct: 245 RGRARAPQGAQWDAAQAYWRTLRSDEGAQFDRTIALDATTIRPHVTWGTSPEMVVTIDGR 304 Query: 311 VPDPSQEENITRQSGMRKALAYMDISAGTPMEQLALDKVFIGSCTNARIEDLRAAAAVVR 370 VPDP++E + ++ G+ +AL YM + GTP+ +ALDK+FIGSCTNARIEDLRAAA VV Sbjct: 305 VPDPAEESDPIKRQGITRALTYMGLEPGTPLRDIALDKIFIGSCTNARIEDLRAAARVVA 364 Query: 371 GYTVSQTIRQALVVPGSGLVKRQAEQEGLDKVFLAAGFEWREPGCSMCLGMNDDRLAPGE 430 G V+ I QALVVPGSGLVKRQAE EGLD++F+ AGFEWR+PGCSMCLGMNDDRL PGE Sbjct: 365 GKHVAANIVQALVVPGSGLVKRQAEAEGLDRIFVDAGFEWRDPGCSMCLGMNDDRLQPGE 424 Query: 431 RCASTSNRNFEGRQGPGGRSHLVSPATAAAAAICGHFTDV 470 RCASTSNRNFEGRQG GGR+HLVSP AAAAAI GHF V Sbjct: 425 RCASTSNRNFEGRQGAGGRTHLVSPPMAAAAAIAGHFVAV 464 >E2T1X6.1 E2T1X6_9RALS 3-isopropylmalate dehydratase large subunit 1 EC=4.2.1.33 Length = 480 Score = 618 bits (1593), Expect = e-175, Method: Compositional matrix adjust. Identities = 301/460 (65%), Positives = 361/460 (78%) Query: 11 TLFEKLWQAHVVSSDDEGNALVYIDRQYVYEVTSPQAFEGLREKKRKVRRPGTVLATVDH 70 TLF KLWQ H V D+G+ L+YID V EVTSPQAFEGLR + RP +VLAT DH Sbjct: 5 TLFAKLWQRHAVRDTDDGHTLLYIDLHLVNEVTSPQAFEGLRISRLHPWRPASVLATEDH 64 Query: 71 NVPTTARDVPMRDRLAQLQVDTLTSNCADFGIPYFDIRDVRQGIVHVVGPEQGATLPGST 130 NVPT R + D +A+ QV+ L SNCA FGI + ++D RQGI+HV+GPEQGATLPG T Sbjct: 65 NVPTANRAAGITDDIARRQVEALRSNCARFGITEYPMQDARQGILHVIGPEQGATLPGMT 124 Query: 131 VICGDSHTSTHGAFGALAWGVGTTEVEHALATHCLWLVRPLTTRITVKGTLAPGVGAKDL 190 ++CGDSHT+THGAF LA+G+GT+E+EH LAT CL + + T R+ V+G L+PGV +KD+ Sbjct: 125 IVCGDSHTTTHGAFATLAFGIGTSEIEHVLATQCLIVKKMKTMRVLVEGDLSPGVTSKDV 184 Query: 191 ALYLIGFLGTQGGIGHAIEFAGDAIAALSMEGRMTLCNMAVEAGARFGLVAVDDTTIDYL 250 AL LIG +GT G G+AIEFAG AI+A+SM+ RMTLCNM +EAGAR G+VAVDD TI+YL Sbjct: 185 ALALIGRIGTAGATGYAIEFAGSAISAMSMDARMTLCNMVIEAGARCGMVAVDDKTINYL 244 Query: 251 QGRPLVPSGAQWDAANAYWRQLRSDSGAQFYRELEIDAGTVKPMVTWGTSPDMCVGVDGV 310 +GR P GAQWDAA AYWR LRSD GAQF R + +DA T++P VTWGTSP+M V +DG Sbjct: 245 RGRARAPQGAQWDAAQAYWRTLRSDEGAQFDRTIALDATTIRPHVTWGTSPEMVVTIDGR 304 Query: 311 VPDPSQEENITRQSGMRKALAYMDISAGTPMEQLALDKVFIGSCTNARIEDLRAAAAVVR 370 VPDP++E + ++ G+ +AL YM + GTP+ +ALDK+FIGSCTNARIEDLRAAA VV Sbjct: 305 VPDPAEESDPIKRQGITRALTYMGLEPGTPLRDIALDKIFIGSCTNARIEDLRAAARVVA 364 Query: 371 GYTVSQTIRQALVVPGSGLVKRQAEQEGLDKVFLAAGFEWREPGCSMCLGMNDDRLAPGE 430 G V+ I QALVVPGSGLVKRQAE EGLD++F+ AGFEWR+PGCSMCLGMNDDRL PGE Sbjct: 365 GKHVAANIVQALVVPGSGLVKRQAEAEGLDRIFVDAGFEWRDPGCSMCLGMNDDRLQPGE 424 Query: 431 RCASTSNRNFEGRQGPGGRSHLVSPATAAAAAICGHFTDV 470 RCASTSNRNFEGRQG GGR+HLVSP AAAAAI GHF V Sbjct: 425 RCASTSNRNFEGRQGAGGRTHLVSPPMAAAAAIAGHFVAV 464 >Q2Y7Q5.1 Q2Y7Q5_NITMU 3-isopropylmalate dehydratase large subunit EC=4.2.1.33 Length = 469 Score = 616 bits (1589), Expect = e-174, Method: Compositional matrix adjust. Identities = 300/464 (64%), Positives = 363/464 (78%), Gaps = 3/464 (0%) Query: 11 TLFEKLWQAHVV---SSDDEGNALVYIDRQYVYEVTSPQAFEGLREKKRKVRRPGTVLAT 67 TL++KLWQ+HVV S D EG AL+YIDR V+EVTSPQAFEGL+ RK R ++LA Sbjct: 3 TLYDKLWQSHVVHEESDDAEGMALLYIDRHLVHEVTSPQAFEGLKLAGRKPWRLNSILAV 62 Query: 68 VDHNVPTTARDVPMRDRLAQLQVDTLTSNCADFGIPYFDIRDVRQGIVHVVGPEQGATLP 127 DHNVPTT RD + D +++LQV+TL NC + GI F + D RQGIVHV+GPEQGATLP Sbjct: 63 ADHNVPTTGRDHGISDPVSRLQVETLDQNCEELGITEFRMNDQRQGIVHVIGPEQGATLP 122 Query: 128 GSTVICGDSHTSTHGAFGALAWGVGTTEVEHALATHCLWLVRPLTTRITVKGTLAPGVGA 187 G TV+CGDSHTSTHGAFG LA+G+GT+EVEH LAT CL + T +I V G L G+ A Sbjct: 123 GMTVVCGDSHTSTHGAFGCLAFGIGTSEVEHVLATQCLLAKKSRTMQIVVDGNLGNGITA 182 Query: 188 KDLALYLIGFLGTQGGIGHAIEFAGDAIAALSMEGRMTLCNMAVEAGARFGLVAVDDTTI 247 KD+AL ++G +GT GG G+AIEFAG AI LSMEGRMTLCNMA+EAGAR G+VAVDD TI Sbjct: 183 KDVALAVVGRIGTAGGTGYAIEFAGSAIRGLSMEGRMTLCNMAIEAGARAGMVAVDDVTI 242 Query: 248 DYLQGRPLVPSGAQWDAANAYWRQLRSDSGAQFYRELEIDAGTVKPMVTWGTSPDMCVGV 307 +YL+GRP P G W+ A AYWR L+SD GA F + +++DA ++KP VTWGTSP+M V Sbjct: 243 EYLRGRPFAPKGDLWEKAVAYWRTLKSDEGASFDKGVQLDAASIKPQVTWGTSPEMVATV 302 Query: 308 DGVVPDPSQEENITRQSGMRKALAYMDISAGTPMEQLALDKVFIGSCTNARIEDLRAAAA 367 DG VPDP++ + ++ M +AL YM ++ TP+ ++ DK+FIGSCTNARIEDLRAAA Sbjct: 303 DGKVPDPTEIADAVKRHDMERALKYMALAPNTPISEIRPDKIFIGSCTNARIEDLRAAAE 362 Query: 368 VVRGYTVSQTIRQALVVPGSGLVKRQAEQEGLDKVFLAAGFEWREPGCSMCLGMNDDRLA 427 VVRG ++++I+ A+VVPGSGLVK QAEQEGLD++F AGFEWREPGCSMCL MNDDRL Sbjct: 363 VVRGRRIAKSIKLAMVVPGSGLVKHQAEQEGLDRIFRDAGFEWREPGCSMCLAMNDDRLE 422 Query: 428 PGERCASTSNRNFEGRQGPGGRSHLVSPATAAAAAICGHFTDVR 471 PGERCASTSNRNFEGRQGP GR+HLVSPA AAAAA+ GHF DVR Sbjct: 423 PGERCASTSNRNFEGRQGPAGRTHLVSPAMAAAAAVAGHFVDVR 466