BLASTP 2.2.21 [Jun-14-2009] Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), "Gapped BLAST and PSI-BLAST: a new generation of protein database search programs", Nucleic Acids Res. 25:3389-3402. Reference for compositional score matrix adjustment: Altschul, Stephen F., John C. Wootton, E. Michael Gertz, Richa Agarwala, Aleksandr Morgulis, Alejandro A. Schaffer, and Yi-Kuo Yu (2005) "Protein database searches using compositionally adjusted substitution matrices", FEBS J. 272:5101-5109. Query= 0015.0012.p (379 letters) Database: pfamseq 15,929,002 sequences; 5,169,768,107 total letters Searching..................................................done Score E Sequences producing significant alignments: (bits) Value D8IXI8.1 D8IXI8_HERSS L-lactate dehydrogenase protein EC=1.1.2.3 714 0.0 A4SYM1.1 A4SYM1_POLSQ L-lactate dehydrogenase (Cytochrome) EC=1.... 562 e-158 A9ASD6.1 A9ASD6_BURM1 FMN-dependent alpha-hydroxy acid dehydroge... 553 e-155 D8D995.1 D8D995_COMTE FMN-dependent alpha-hydroxy acid dehydroge... 553 e-155 D0J114.1 D0J114_COMT2 FMN-dependent alpha-hydroxy acid dehydroge... 553 e-155 >D8IXI8.1 D8IXI8_HERSS L-lactate dehydrogenase protein EC=1.1.2.3 Length = 380 Score = 714 bits (1844), Expect = 0.0, Method: Compositional matrix adjust. Identities = 346/379 (91%), Positives = 366/379 (96%), Gaps = 2/379 (0%) Query: 1 MPVITCVEDLRVLAKKRVPKAFYDYADSGSYTESTYRANTDDLAALKLRQRVAINVDQRS 60 MPV+TCVED R+LAKKRVPKAFYDYADSGSYTESTYRAN+ DLAALKLRQRVAINVD+RS Sbjct: 1 MPVMTCVEDFRLLAKKRVPKAFYDYADSGSYTESTYRANSKDLAALKLRQRVAINVDERS 60 Query: 61 TRTTMIGHDVAMPVAIAPTGLTGMQWANGEMLGAIAAEKFGIPFTLSTMSICSIEDVASV 120 TRTTMIGHDV MPVAIAPTGLTGMQWANGEMLGAIAAEKFGIPFTLSTMSICSIEDVASV Sbjct: 61 TRTTMIGHDVTMPVAIAPTGLTGMQWANGEMLGAIAAEKFGIPFTLSTMSICSIEDVASV 120 Query: 121 TTKPFWFQLYVMRDRGFVKSMIDRAKAAKCSALVLTLDLQILGQRHKDLKNGMSVPPKLT 180 TTKPFWFQLYVMRDRGFVKS+I+RAKAAKCSALVLTLDLQILGQRHKDLKNGMSVPPKLT Sbjct: 121 TTKPFWFQLYVMRDRGFVKSLIERAKAAKCSALVLTLDLQILGQRHKDLKNGMSVPPKLT 180 Query: 181 LDTLMDLASKPAWALRALTGRKTFGNLAGHITG--GGSGIQTLSQWTASQFDPTLNWDDV 238 L+TL+DLASKP WALRAL GRKTFGNLAGHI G G G+QTLS+WTASQFDPTLNWDDV Sbjct: 181 LETLLDLASKPGWALRALGGRKTFGNLAGHIKGGEGAGGVQTLSKWTASQFDPTLNWDDV 240 Query: 239 AWIKEQWGGKLILKGILDVEDAKLAAQTGADALVVSNHGGRQLDGAMSSIEALPAIAEAV 298 AWIK+QWGGKLILKGILDVEDAKLA Q+GADA+VVSNHGGRQLDGAMSSIEALPAIA+AV Sbjct: 241 AWIKQQWGGKLILKGILDVEDAKLAVQSGADAIVVSNHGGRQLDGAMSSIEALPAIAQAV 300 Query: 299 GDQIEVWFDGGIRSGQDILKATALGAKGTMIGRAFLYSLGAMGGEGVTKMLQILHKELDV 358 GDQIEVWFDGGIRSGQD+LKA ALGA+GTMIGRAFLYSLGAMGGEGV++ML+I+ KELDV Sbjct: 301 GDQIEVWFDGGIRSGQDVLKAVALGARGTMIGRAFLYSLGAMGGEGVSQMLEIMRKELDV 360 Query: 359 SMALTGTKDIKDVGPQILI 377 SMALTGTKDIKDVGPQILI Sbjct: 361 SMALTGTKDIKDVGPQILI 379 >A4SYM1.1 A4SYM1_POLSQ L-lactate dehydrogenase (Cytochrome) EC=1.1.2.3 Length = 381 Score = 562 bits (1449), Expect = e-158, Method: Compositional matrix adjust. Identities = 268/377 (71%), Positives = 319/377 (84%), Gaps = 2/377 (0%) Query: 1 MPVITCVEDLRVLAKKRVPKAFYDYADSGSYTESTYRANTDDLAALKLRQRVAINVDQRS 60 MP+IT +EDLRVL KKR PK FYDYADSGS+TESTYRAN D +KLRQRVA+N+ R+ Sbjct: 1 MPIITNIEDLRVLHKKRTPKMFYDYADSGSWTESTYRANESDFQKIKLRQRVAVNMTNRT 60 Query: 61 TRTTMIGHDVAMPVAIAPTGLTGMQWANGEMLGAIAAEKFGIPFTLSTMSICSIEDVASV 120 T+TTM+G +VAMPVA+APTGLTGMQ A+GE+L A AAEKFG+PF LSTMSICSIEDVA Sbjct: 61 TKTTMVGQEVAMPVALAPTGLTGMQHADGEILAAKAAEKFGVPFCLSTMSICSIEDVAEQ 120 Query: 121 TTKPFWFQLYVMRDRGFVKSMIDRAKAAKCSALVLTLDLQILGQRHKDLKNGMSVPPKLT 180 TTKPFWFQLYVM+DRGF++ +I+RAKAAKCSALVLTLDLQILGQRHKDLKNG+S PPKLT Sbjct: 121 TTKPFWFQLYVMKDRGFIERLIERAKAAKCSALVLTLDLQILGQRHKDLKNGLSAPPKLT 180 Query: 181 LDTLMDLASKPAWAL-RALTGRKTFGNLAGHITGGGSGIQTLSQWTASQFDPTLNWDDVA 239 + ++++A+KP W L A+T R+TF N+ GH TG G+ + +LS WTA QFDP LNW DV Sbjct: 181 IANMINMATKPRWCLGMAMTPRRTFRNIVGHATGVGN-MSSLSSWTAEQFDPGLNWGDVE 239 Query: 240 WIKEQWGGKLILKGILDVEDAKLAAQTGADALVVSNHGGRQLDGAMSSIEALPAIAEAVG 299 WIK+ WGGKLI+KGILD +DA+LAA +GADAL+VSNHGGRQLDGA+SSI+ALP I AVG Sbjct: 240 WIKKLWGGKLIIKGILDEDDARLAANSGADALIVSNHGGRQLDGAVSSIQALPGIVNAVG 299 Query: 300 DQIEVWFDGGIRSGQDILKATALGAKGTMIGRAFLYSLGAMGGEGVTKMLQILHKELDVS 359 + IEVW DGGIRSGQD+LKA ALGA+GTMIGR FLY LGAMG GVTK L+++H ELD++ Sbjct: 300 NDIEVWMDGGIRSGQDVLKAWALGARGTMIGRPFLYGLGAMGEAGVTKCLELIHNELDIT 359 Query: 360 MALTGTKDIKDVGPQIL 376 MA TG +DI++V IL Sbjct: 360 MAFTGHRDIQNVTKDIL 376 >A9ASD6.1 A9ASD6_BURM1 FMN-dependent alpha-hydroxy acid dehydrogenase EC=1.1.2.3 Length = 383 Score = 553 bits (1426), Expect = e-155, Method: Compositional matrix adjust. Identities = 268/378 (70%), Positives = 314/378 (83%), Gaps = 2/378 (0%) Query: 1 MPVITCVEDLRVLAKKRVPKAFYDYADSGSYTESTYRANTDDLAALKLRQRVAINVDQRS 60 M +IT VEDLRVLA++RVP+ FYDYADSGS+TESTYRAN D +KLRQRVA+N++ R+ Sbjct: 1 MSIITTVEDLRVLAERRVPRMFYDYADSGSWTESTYRANESDFQKIKLRQRVAVNMEGRT 60 Query: 61 TRTTMIGHDVAMPVAIAPTGLTGMQWANGEMLGAIAAEKFGIPFTLSTMSICSIEDVASV 120 TRT MI DVAMPVAIAPTG TGMQ A+GE+L A AAEKFGIPF+LSTMSICSIEDVA+ Sbjct: 61 TRTAMIEQDVAMPVAIAPTGFTGMQHADGEILAARAAEKFGIPFSLSTMSICSIEDVAAH 120 Query: 121 TTKPFWFQLYVMRDRGFVKSMIDRAKAAKCSALVLTLDLQILGQRHKDLKNGMSVPPKLT 180 T PFWFQLYVMRD+ FV+ +I+RAKAA+CSAL+LTLDLQ+LGQRHKDLKNG+S PPK T Sbjct: 121 TQAPFWFQLYVMRDKDFVERLIERAKAAECSALILTLDLQVLGQRHKDLKNGLSAPPKPT 180 Query: 181 LDTLMDLASKPAWALRAL-TGRKTFGNLAGHITGGGSGIQTLSQWTASQFDPTLNWDDVA 239 + L++LA+KP W L L T R+TFGN+ GH G G + +LS WTA QFDP L+W DV Sbjct: 181 IANLINLATKPRWCLGMLGTKRRTFGNIVGHAKGVGD-LSSLSSWTAEQFDPALSWADVE 239 Query: 240 WIKEQWGGKLILKGILDVEDAKLAAQTGADALVVSNHGGRQLDGAMSSIEALPAIAEAVG 299 WIK+ WGGKLILKGI+D EDA+LAA +GADAL+VSNHGGRQLDGA S+IEALP I EAVG Sbjct: 240 WIKKLWGGKLILKGIMDAEDARLAAASGADALIVSNHGGRQLDGAPSTIEALPPIVEAVG 299 Query: 300 DQIEVWFDGGIRSGQDILKATALGAKGTMIGRAFLYSLGAMGGEGVTKMLQILHKELDVS 359 QIEVW D GIRSGQD+LKA ALGA+GTMIGRAFLY LGAMG GVTK L+I+HKELD++ Sbjct: 300 TQIEVWLDSGIRSGQDVLKAIALGARGTMIGRAFLYGLGAMGEAGVTKTLEIIHKELDIT 359 Query: 360 MALTGTKDIKDVGPQILI 377 MA G +DI+ V IL+ Sbjct: 360 MAFCGHRDIRTVDRSILL 377 >D8D995.1 D8D995_COMTE FMN-dependent alpha-hydroxy acid dehydrogenase Length = 392 Score = 553 bits (1426), Expect = e-155, Method: Compositional matrix adjust. Identities = 264/376 (70%), Positives = 317/376 (84%), Gaps = 3/376 (0%) Query: 4 ITCVEDLRVLAKKRVPKAFYDYADSGSYTESTYRANTDDLAALKLRQRVAINVDQRSTRT 63 ITC+EDLRV+AK+RVP+ FYDYADSGSYT+ TYRAN D+ ++KLRQRVA+N++ RSTRT Sbjct: 7 ITCIEDLRVVAKRRVPRMFYDYADSGSYTQGTYRANEDEFQSIKLRQRVAVNMEGRSTRT 66 Query: 64 TMIGHDVAMPVAIAPTGLTGMQWANGEMLGAIAAEKFGIPFTLSTMSICSIEDVASVTTK 123 TMIG +VAMPVAIAPTGLTGMQ A+GE+LGA AA+ FG+PFTLSTMSICS+ED+A T + Sbjct: 67 TMIGEEVAMPVAIAPTGLTGMQHADGEILGAKAAKAFGVPFTLSTMSICSLEDIAEHTDR 126 Query: 124 -PFWFQLYVMRDRGFVKSMIDRAKAAKCSALVLTLDLQILGQRHKDLKNGMSVPPKLTLD 182 PFWFQLYVMRD+ F++ +I+RAKAA CSALV+TLDLQILGQRHKD+KNG+S PPK TL Sbjct: 127 HPFWFQLYVMRDKAFMERLINRAKAANCSALVVTLDLQILGQRHKDIKNGLSTPPKPTLA 186 Query: 183 TLMDLASKPAWALRAL-TGRKTFGNLAGHITGGGSGIQTLSQWTASQFDPTLNWDDVAWI 241 L++LA+KP W L L T R++FGN+ GH+ G G + +LS WTA QFDP+LNW DV WI Sbjct: 187 NLINLATKPHWCLGMLGTKRRSFGNIVGHVDGVGD-VSSLSSWTADQFDPSLNWSDVEWI 245 Query: 242 KEQWGGKLILKGILDVEDAKLAAQTGADALVVSNHGGRQLDGAMSSIEALPAIAEAVGDQ 301 K+ WGGK+ILKG++D EDA+LAAQ+GADALVVSNHGGRQLDGA SSI ALP+IAEA G Sbjct: 246 KKLWGGKIILKGVMDAEDARLAAQSGADALVVSNHGGRQLDGAPSSIAALPSIAEAAGKD 305 Query: 302 IEVWFDGGIRSGQDILKATALGAKGTMIGRAFLYSLGAMGGEGVTKMLQILHKELDVSMA 361 IEVW DGGIRSGQD+LKA ALGA+GTMIGR+FLY LGA G GV+K LQI+HKELD +MA Sbjct: 306 IEVWMDGGIRSGQDVLKARALGAQGTMIGRSFLYGLGAYGQAGVSKALQIIHKELDTTMA 365 Query: 362 LTGTKDIKDVGPQILI 377 G +I VG +IL+ Sbjct: 366 FCGHTNINQVGKEILL 381 >D0J114.1 D0J114_COMT2 FMN-dependent alpha-hydroxy acid dehydrogenase Length = 392 Score = 553 bits (1426), Expect = e-155, Method: Compositional matrix adjust. Identities = 264/376 (70%), Positives = 317/376 (84%), Gaps = 3/376 (0%) Query: 4 ITCVEDLRVLAKKRVPKAFYDYADSGSYTESTYRANTDDLAALKLRQRVAINVDQRSTRT 63 ITC+EDLRV+AK+RVP+ FYDYADSGSYT+ TYRAN D+ ++KLRQRVA+N++ RSTRT Sbjct: 7 ITCIEDLRVVAKRRVPRMFYDYADSGSYTQGTYRANEDEFQSIKLRQRVAVNMEGRSTRT 66 Query: 64 TMIGHDVAMPVAIAPTGLTGMQWANGEMLGAIAAEKFGIPFTLSTMSICSIEDVASVTTK 123 TMIG +VAMPVAIAPTGLTGMQ A+GE+LGA AA+ FG+PFTLSTMSICS+ED+A T + Sbjct: 67 TMIGEEVAMPVAIAPTGLTGMQHADGEILGAKAAKAFGVPFTLSTMSICSLEDIAEHTDR 126 Query: 124 -PFWFQLYVMRDRGFVKSMIDRAKAAKCSALVLTLDLQILGQRHKDLKNGMSVPPKLTLD 182 PFWFQLYVMRD+ F++ +I+RAKAA CSALV+TLDLQILGQRHKD+KNG+S PPK TL Sbjct: 127 HPFWFQLYVMRDKAFMERLINRAKAANCSALVVTLDLQILGQRHKDIKNGLSTPPKPTLA 186 Query: 183 TLMDLASKPAWALRAL-TGRKTFGNLAGHITGGGSGIQTLSQWTASQFDPTLNWDDVAWI 241 L++LA+KP W L L T R++FGN+ GH+ G G + +LS WTA QFDP+LNW DV WI Sbjct: 187 NLINLATKPHWCLGMLGTKRRSFGNIVGHVDGVGD-VSSLSSWTADQFDPSLNWSDVEWI 245 Query: 242 KEQWGGKLILKGILDVEDAKLAAQTGADALVVSNHGGRQLDGAMSSIEALPAIAEAVGDQ 301 K+ WGGK+ILKG++D EDA+LAAQ+GADALVVSNHGGRQLDGA SSI ALP+IAEA G Sbjct: 246 KKLWGGKIILKGVMDAEDARLAAQSGADALVVSNHGGRQLDGAPSSIAALPSIAEAAGKD 305 Query: 302 IEVWFDGGIRSGQDILKATALGAKGTMIGRAFLYSLGAMGGEGVTKMLQILHKELDVSMA 361 IEVW DGGIRSGQD+LKA ALGA+GTMIGR+FLY LGA G GV+K LQI+HKELD +MA Sbjct: 306 IEVWMDGGIRSGQDVLKARALGAQGTMIGRSFLYGLGAYGQAGVSKALQIIHKELDTTMA 365 Query: 362 LTGTKDIKDVGPQILI 377 G +I VG +IL+ Sbjct: 366 FCGHTNINQVGKEILL 381