BLASTP 2.2.21 [Jun-14-2009] Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), "Gapped BLAST and PSI-BLAST: a new generation of protein database search programs", Nucleic Acids Res. 25:3389-3402. Reference for compositional score matrix adjustment: Altschul, Stephen F., John C. Wootton, E. Michael Gertz, Richa Agarwala, Aleksandr Morgulis, Alejandro A. Schaffer, and Yi-Kuo Yu (2005) "Protein database searches using compositionally adjusted substitution matrices", FEBS J. 272:5101-5109. Query= 0013.0140.p (295 letters) Database: pfamseq 15,929,002 sequences; 5,169,768,107 total letters Searching..................................................done Score E Sequences producing significant alignments: (bits) Value D8IYV5.1 D8IYV5_HERSS Zinc-type alcohol dehydrogenase transmembr... 445 e-123 A1WN18.1 A1WN18_VEREI Alcohol dehydrogenase, zinc-binding domain... 381 e-104 A6EXF6.1 A6EXF6_9ALTE Alcohol dehydrogenase 318 5e-85 A9CGD8.1 A9CGD8_AGRT5 Alcohol dehydrogenase 318 8e-85 A3JFB7.1 A3JFB7_9ALTE Alcohol dehydrogenase 305 7e-81 >D8IYV5.1 D8IYV5_HERSS Zinc-type alcohol dehydrogenase transmembrane protein EC=1.1.1.1 Length = 374 Score = 445 bits (1145), Expect = e-123, Method: Compositional matrix adjust. Identities = 218/239 (91%), Positives = 233/239 (97%) Query: 57 NKPVNHHMGVSAFADHAVVSRRSCVKIEADIDPVEAALFGCAVLTGVGAAVNTAEVKAGT 116 +PV+HH+GVSAFADHAVVSRRSCVKIEADIDPV+AALFGCAVLTGVGAAVNTAEVKAGT Sbjct: 136 TQPVHHHLGVSAFADHAVVSRRSCVKIEADIDPVQAALFGCAVLTGVGAAVNTAEVKAGT 195 Query: 117 TAAVLGLGGVGLCAMLGALASGAREVIAVDLHDSKLALAKSLGATATVNARDPDAVEKVR 176 TAAVLGLGGVGLCAMLGALASGAREVIAVDLHDSKLALA+SLGATATVNARDPDAVEKVR Sbjct: 196 TAAVLGLGGVGLCAMLGALASGAREVIAVDLHDSKLALARSLGATATVNARDPDAVEKVR 255 Query: 177 ALTKGGVDYAFEMAGSVQAMEAAYRMTRRGGMTVTAGLPAPDQKWALQQVSLVAEERTVK 236 ALT+GGVDYAFEMAGSVQAMEAAYRMTRRGGMTVTAGLPAP Q WALQQVSLVAEERTVK Sbjct: 256 ALTRGGVDYAFEMAGSVQAMEAAYRMTRRGGMTVTAGLPAPGQHWALQQVSLVAEERTVK 315 Query: 237 GSYIGSCVPLRDIPRYIGLYKSGRLPIDKLMGQRLALSDINSGFDRLASGEGLRDLIVF 295 GSYIGSCVP+RDIPRYIGL+++G+LP+D+LMG+RLAL+DIN GFDRL GEGLRDLIVF Sbjct: 316 GSYIGSCVPVRDIPRYIGLFQAGKLPVDRLMGERLALADINRGFDRLHGGEGLRDLIVF 374 Score = 96.3 bits (238), Expect = 5e-18, Method: Compositional matrix adjust. Identities = 49/74 (66%), Positives = 57/74 (77%), Gaps = 3/74 (4%) Query: 1 MKIQAAVLRETTTVEPFASSRPLRIEELDLDAPGPGEVLVKMRAAGLCHSDLSVIXN--- 57 MKIQAAVLRE + PFA S+PL+IEELDLD PGPGEVLV+M+AAGLCHSDLSVI Sbjct: 1 MKIQAAVLREMSDAHPFAVSQPLKIEELDLDPPGPGEVLVRMKAAGLCHSDLSVITGVRP 60 Query: 58 KPVNHHMGVSAFAD 71 +PV +G A A+ Sbjct: 61 RPVPMALGHEASAE 74 >A1WN18.1 A1WN18_VEREI Alcohol dehydrogenase, zinc-binding domain protein Length = 374 Score = 381 bits (979), Expect = e-104, Method: Compositional matrix adjust. Identities = 180/241 (74%), Positives = 214/241 (88%) Query: 55 IXNKPVNHHMGVSAFADHAVVSRRSCVKIEADIDPVEAALFGCAVLTGVGAAVNTAEVKA 114 + N V HH GVSAF+DHAVVSR+SCVK++ADIDPV+AA+FGCAVLTGVGA +NTA +A Sbjct: 134 LRNTAVYHHTGVSAFSDHAVVSRQSCVKVDADIDPVQAAMFGCAVLTGVGAVINTAGAQA 193 Query: 115 GTTAAVLGLGGVGLCAMLGALASGAREVIAVDLHDSKLALAKSLGATATVNARDPDAVEK 174 G+TAA++GLGGVGLCA+L A+ASG R+V+AVD+HDSKLALA+SLGA+A VNARDPDAVE+ Sbjct: 194 GSTAALVGLGGVGLCALLAAVASGCRQVVAVDIHDSKLALARSLGASAAVNARDPDAVEQ 253 Query: 175 VRALTKGGVDYAFEMAGSVQAMEAAYRMTRRGGMTVTAGLPAPDQKWALQQVSLVAEERT 234 +RALT GGVDY+FEMAGSV +ME AY +TRRGGMTVTAGLPAP +W L+Q+SLV EERT Sbjct: 254 IRALTHGGVDYSFEMAGSVPSMETAYSITRRGGMTVTAGLPAPTDRWPLRQLSLVVEERT 313 Query: 235 VKGSYIGSCVPLRDIPRYIGLYKSGRLPIDKLMGQRLALSDINSGFDRLASGEGLRDLIV 294 VKGSYIGSCVP+RD+PRYI +Y G+LPID+LMGQR L DIN+GFDRL SGE LRD+IV Sbjct: 314 VKGSYIGSCVPVRDVPRYIAMYLGGQLPIDRLMGQRHPLDDINAGFDRLNSGESLRDVIV 373 Query: 295 F 295 F Sbjct: 374 F 374 Score = 84.7 bits (208), Expect = 1e-14, Method: Compositional matrix adjust. Identities = 40/55 (72%), Positives = 45/55 (81%) Query: 1 MKIQAAVLRETTTVEPFASSRPLRIEELDLDAPGPGEVLVKMRAAGLCHSDLSVI 55 M I++AVL E PFA +RPLRIEEL+LD PGPG+VLVKM AAGLCHSDLSVI Sbjct: 1 MLIRSAVLHEMNAATPFAQTRPLRIEELELDEPGPGQVLVKMVAAGLCHSDLSVI 55 >A6EXF6.1 A6EXF6_9ALTE Alcohol dehydrogenase Length = 378 Score = 318 bits (815), Expect = 5e-85, Method: Compositional matrix adjust. Identities = 154/237 (64%), Positives = 197/237 (83%) Query: 59 PVNHHMGVSAFADHAVVSRRSCVKIEADIDPVEAALFGCAVLTGVGAAVNTAEVKAGTTA 118 PVNHH+GVSAFADHAVVSR S V+I+ D+ AALFGCAVLTGVGAA+N+A++KAG T Sbjct: 139 PVNHHLGVSAFADHAVVSRHSLVRIDPDLPFHHAALFGCAVLTGVGAAINSADIKAGQTV 198 Query: 119 AVLGLGGVGLCAMLGALASGAREVIAVDLHDSKLALAKSLGATATVNARDPDAVEKVRAL 178 AV+GLGGVGL ++LGAL +GA +VIA+DL + KLA+AKSLGA+A +NA D D V +V+AL Sbjct: 199 AVIGLGGVGLNSVLGALVAGAGQVIAIDLDEDKLAMAKSLGASAGINAADEDCVSQVKAL 258 Query: 179 TKGGVDYAFEMAGSVQAMEAAYRMTRRGGMTVTAGLPAPDQKWALQQVSLVAEERTVKGS 238 T GGVD A EMAGS +A+E AY++TRRGG TVT GL PD+K ++QQVSLVAEERT+KGS Sbjct: 259 TNGGVDCAIEMAGSEKALELAYQLTRRGGTTVTGGLAHPDRKVSIQQVSLVAEERTLKGS 318 Query: 239 YIGSCVPLRDIPRYIGLYKSGRLPIDKLMGQRLALSDINSGFDRLASGEGLRDLIVF 295 Y+GSCVP+RD+ RY+ L++ GRLP+DKL+ L L +IN GF+RLA+G+ +R +I+F Sbjct: 319 YVGSCVPVRDVARYVSLFRQGRLPVDKLLSDTLTLDEINEGFERLANGKAIRQVILF 375 Score = 77.4 bits (189), Expect = 2e-12, Method: Compositional matrix adjust. Identities = 39/60 (65%), Positives = 46/60 (76%), Gaps = 1/60 (1%) Query: 1 MKIQAAVLRETTTVEPFASSRPLRIEELDLDAPGPGEVLVKMRAAGLCHSDLSVIX-NKP 59 MKI+AAVL +PF +RPL IEEL+LD PG EVLV++RAAGLCHSDLSVI N+P Sbjct: 1 MKIRAAVLETIGAPQPFDENRPLTIEELELDPPGDHEVLVQIRAAGLCHSDLSVIDGNRP 60 >A9CGD8.1 A9CGD8_AGRT5 Alcohol dehydrogenase Length = 312 Score = 318 bits (814), Expect = 8e-85, Method: Compositional matrix adjust. Identities = 158/236 (66%), Positives = 188/236 (79%) Query: 60 VNHHMGVSAFADHAVVSRRSCVKIEADIDPVEAALFGCAVLTGVGAAVNTAEVKAGTTAA 119 V+HH+GVSAFA++AVVSR S VKI+ D+ VEAALFGCAVLTGVGA VNTA V+ G+TA Sbjct: 77 VHHHLGVSAFAEYAVVSRNSLVKIDRDLPFVEAALFGCAVLTGVGAVVNTARVRTGSTAV 136 Query: 120 VLGLGGVGLCAMLGALASGAREVIAVDLHDSKLALAKSLGATATVNARDPDAVEKVRALT 179 V+GLGGVGL A+LGA A+GA +++AVDL KLALA LGATA VN RD DAVE+VR LT Sbjct: 137 VIGLGGVGLAAVLGARAAGASKIVAVDLSQEKLALASELGATAIVNGRDEDAVEQVRELT 196 Query: 180 KGGVDYAFEMAGSVQAMEAAYRMTRRGGMTVTAGLPAPDQKWALQQVSLVAEERTVKGSY 239 GG DYAFEMAGS++A+E A+RMT+RGG TVTAGLP P L V LV EERT+KGSY Sbjct: 197 SGGADYAFEMAGSIRALENAFRMTKRGGTTVTAGLPPPGAALPLNVVQLVGEERTLKGSY 256 Query: 240 IGSCVPLRDIPRYIGLYKSGRLPIDKLMGQRLALSDINSGFDRLASGEGLRDLIVF 295 IG+CVPLRDIPR+I LY+ GRLP+++L+ RL L DIN GFDRL G +R +I F Sbjct: 257 IGTCVPLRDIPRFIALYRDGRLPVNRLLSGRLKLEDINEGFDRLHDGSAVRQVIEF 312 >A3JFB7.1 A3JFB7_9ALTE Alcohol dehydrogenase Length = 377 Score = 305 bits (780), Expect = 7e-81, Method: Compositional matrix adjust. Identities = 147/237 (62%), Positives = 191/237 (80%) Query: 59 PVNHHMGVSAFADHAVVSRRSCVKIEADIDPVEAALFGCAVLTGVGAAVNTAEVKAGTTA 118 P+NHH+GVSAFADH VVSR S +K++A + AALFGCAVLTGVGA +N+A++KAG T Sbjct: 139 PINHHLGVSAFADHVVVSRNSLIKVDASLPFHHAALFGCAVLTGVGAVINSADIKAGQTV 198 Query: 119 AVLGLGGVGLCAMLGALASGAREVIAVDLHDSKLALAKSLGATATVNARDPDAVEKVRAL 178 AV+GLGGVGL ++LGAL +GA EVIA+DL +SKLALAK LGA+ T N+ + V+ ++AL Sbjct: 199 AVIGLGGVGLNSVLGALVAGAGEVIAIDLDNSKLALAKELGASHTFNSAEDGCVDTIKAL 258 Query: 179 TKGGVDYAFEMAGSVQAMEAAYRMTRRGGMTVTAGLPAPDQKWALQQVSLVAEERTVKGS 238 T GGVD A EMAGS +A+E AY++TRRGG TVT GL PD+K A+QQVSLVAEERT+KGS Sbjct: 259 TNGGVDCAIEMAGSEKALEFAYQVTRRGGTTVTGGLAHPDKKVAIQQVSLVAEERTLKGS 318 Query: 239 YIGSCVPLRDIPRYIGLYKSGRLPIDKLMGQRLALSDINSGFDRLASGEGLRDLIVF 295 Y+GSCVP+RD+ RY+ L++ G+LP+DKL+ L L IN GF+ LA+G+ +R +I+F Sbjct: 319 YVGSCVPVRDVARYVSLFRQGKLPVDKLLSATLRLEQINEGFEALAAGKAIRQVILF 375 Score = 71.6 bits (174), Expect = 1e-10, Method: Compositional matrix adjust. Identities = 36/60 (60%), Positives = 46/60 (76%), Gaps = 1/60 (1%) Query: 1 MKIQAAVLRETTTVEPFASSRPLRIEELDLDAPGPGEVLVKMRAAGLCHSDLSVIX-NKP 59 MKI+AAVL+ P++ ++PL IEEL LD PG EVLV+++AAGLCHSDLSVI N+P Sbjct: 1 MKIRAAVLQAIGVQRPYSDTQPLIIEELVLDPPGDHEVLVQIKAAGLCHSDLSVIDGNRP 60