BLASTP 2.2.21 [Jun-14-2009] Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), "Gapped BLAST and PSI-BLAST: a new generation of protein database search programs", Nucleic Acids Res. 25:3389-3402. Reference for compositional score matrix adjustment: Altschul, Stephen F., John C. Wootton, E. Michael Gertz, Richa Agarwala, Aleksandr Morgulis, Alejandro A. Schaffer, and Yi-Kuo Yu (2005) "Protein database searches using compositionally adjusted substitution matrices", FEBS J. 272:5101-5109. Query= 0012.0136.p (472 letters) Database: pfamseq 15,929,002 sequences; 5,169,768,107 total letters Searching..................................................done Score E Sequences producing significant alignments: (bits) Value D8IPZ4.1 D8IPZ4_HERSS Permease of the major facilitator superfam... 724 0.0 B0UEC3.1 B0UEC3_METS4 Major facilitator superfamily MFS_1 545 e-153 B8IF45.1 B8IF45_METNO Drug resistance transporter, EmrB/QacA sub... 538 e-151 Q7NSA2.1 Q7NSA2_CHRVO Probable multidrug efflux protein 534 e-149 A8II75.1 A8II75_AZOC5 Putative multidrug efflux protein 530 e-148 >D8IPZ4.1 D8IPZ4_HERSS Permease of the major facilitator superfamily protein Length = 446 Score = 724 bits (1869), Expect = 0.0, Method: Compositional matrix adjust. Identities = 357/444 (80%), Positives = 400/444 (90%) Query: 22 MDSTVISTSLPVLAIDMAVDPISLKLALTSYLVSLAVFIPISGWMADRFGALTIFRSAIC 81 MDSTVISTSLP LA+DM VDPISLKLALTSYLVSLAVFIPISGWMADRFG+LTIFRSAIC Sbjct: 1 MDSTVISTSLPALALDMNVDPISLKLALTSYLVSLAVFIPISGWMADRFGSLTIFRSAIC 60 Query: 82 VFMLGSILCGVSQSLPEFVAARFFQGIGGAMMVPVGRLVILRSVDKANLVKALSYLTIPA 141 VFMLGSILCGVS +LP+FVAARF QGIGGAMMVPVGRLVILRSV+K NLVKALSYLTIPA Sbjct: 61 VFMLGSILCGVSSTLPQFVAARFLQGIGGAMMVPVGRLVILRSVEKVNLVKALSYLTIPA 120 Query: 142 MFGPVLGPPLGGFITTYFHWRWIFFINIPISILGLYLATRFIANAKSESVAPLDWVGFVL 201 +FGPVLGPPLGGFITTYFHWRWIFFINIPISILGLYLATRFI + K+E VAPLD GF+L Sbjct: 121 LFGPVLGPPLGGFITTYFHWRWIFFINIPISILGLYLATRFIPDLKAEQVAPLDLKGFLL 180 Query: 202 SALGCSMVMMGLATTGRHLVSGDISLACVVLGSLSLAAYVWHARRTEHPLIDLKLLRIET 261 SALGCS++MMGLAT GRHLVSG+++L CV+ G + LAAYVWHARR PLIDL LL+I T Sbjct: 181 SALGCSLLMMGLATAGRHLVSGEVALTCVLAGLVFLAAYVWHARRASAPLIDLALLKIPT 240 Query: 262 LQAGVGGGSLFRLGIGAIPFLLPLMLQLGFGFSAFHSGLLTCASAAGAMFMKTIAAKFLK 321 L+AGV GGS +R+GIGAIPFLLPLMLQLGFG++ FHSG+LTCASAAGAMFMKTIAA+FL+ Sbjct: 241 LRAGVFGGSFYRVGIGAIPFLLPLMLQLGFGYTPFHSGMLTCASAAGAMFMKTIAARFLR 300 Query: 322 RYGFRRVMIVNGACGVMSLAAIGFFTPATPYAVMLIVLLIGGCFRSLQFTSLNAISYADV 381 RYGFRRV++VNGA GV+ L AI FTP TPY +M+++LLIGGCFRSLQFTSLNAISYADV Sbjct: 301 RYGFRRVLLVNGALGVLGLWAIATFTPQTPYLLMVVILLIGGCFRSLQFTSLNAISYADV 360 Query: 382 DNNRLSQATSIASVAQQLSVGMGVVLGGFALQMSNHIQGHATLVSQDFWPAFLTVAVAAS 441 D RLSQATS+ASVAQQLS+GMGVVL GFALQMSN IQGHATLV+QDFWPAFL V A+ Sbjct: 361 DKLRLSQATSMASVAQQLSIGMGVVLAGFALQMSNEIQGHATLVAQDFWPAFLVVGAVAA 420 Query: 442 FSIPLLMRLPPDAGAELAGRNQAK 465 ++ +L +LP DAGAE+AGR+ + Sbjct: 421 CALLMLRQLPHDAGAEMAGRDDNR 444 >B0UEC3.1 B0UEC3_METS4 Major facilitator superfamily MFS_1 Length = 471 Score = 545 bits (1405), Expect = e-153, Method: Compositional matrix adjust. Identities = 281/461 (60%), Positives = 345/461 (74%) Query: 9 IPLIVACALFMEQMDSTVISTSLPVLAIDMAVDPISLKLALTSYLVSLAVFIPISGWMAD 68 +PL+VA ALFME DSTVI+TSLP +A D+ DPI+LKLALTSYLVSLA+FIP+SGWMAD Sbjct: 7 VPLVVATALFMENTDSTVIATSLPAIAADLGEDPIALKLALTSYLVSLAIFIPVSGWMAD 66 Query: 69 RFGALTIFRSAICVFMLGSILCGVSQSLPEFVAARFFQGIGGAMMVPVGRLVILRSVDKA 128 RFGA T+FR A+ VFM GS+ C + SL FV ARF QG+GGAMMVPVGRLV+LRSV KA Sbjct: 67 RFGARTVFRLALAVFMGGSLACAAADSLGWFVGARFLQGMGGAMMVPVGRLVLLRSVPKA 126 Query: 129 NLVKALSYLTIPAMFGPVLGPPLGGFITTYFHWRWIFFINIPISILGLYLATRFIANAKS 188 LV+AL+ LTIPA+ GPV+GPPLGG ITT +WRWIFFIN+PI + G+ LATR+ A+ + Sbjct: 127 ELVQALATLTIPALVGPVIGPPLGGLITTTLNWRWIFFINLPIGLAGILLATRYFADLRE 186 Query: 189 ESVAPLDWVGFVLSALGCSMVMMGLATTGRHLVSGDISLACVVLGSLSLAAYVWHARRTE 248 PLD VGFVLS G + +M+GLA+ GRHL+ +S CV G LA Y HARRT Sbjct: 187 AERPPLDGVGFVLSGAGLASLMLGLASGGRHLLPASVSWGCVGAGLALLALYCGHARRTA 246 Query: 249 HPLIDLKLLRIETLQAGVGGGSLFRLGIGAIPFLLPLMLQLGFGFSAFHSGLLTCASAAG 308 HPLI L L+ T +A + GGSLFR+G GAIPFLLPLMLQLGFG HSGLLT A+AAG Sbjct: 247 HPLIRLDLMGYPTFRAAITGGSLFRIGTGAIPFLLPLMLQLGFGLDPLHSGLLTFAAAAG 306 Query: 309 AMFMKTIAAKFLKRYGFRRVMIVNGACGVMSLAAIGFFTPATPYAVMLIVLLIGGCFRSL 368 A+FMKT+AA+ L+ GFR V+ VN LAA G FTP+TP+A+++ VLLIGGCFRSL Sbjct: 307 ALFMKTLAARILRSLGFRTVLTVNAVLAACLLAANGLFTPSTPHALIVAVLLIGGCFRSL 366 Query: 369 QFTSLNAISYADVDNNRLSQATSIASVAQQLSVGMGVVLGGFALQMSNHIQGHATLVSQD 428 QFT++NAI+YADVD+ +S ATS+ASVAQQLS+ +GV G FAL+ + G A++ S+D Sbjct: 367 QFTAVNAIAYADVDSRDMSAATSLASVAQQLSLSIGVAFGAFALESAAQWHGRASVRSED 426 Query: 429 FWPAFLTVAVAASFSIPLLMRLPPDAGAELAGRNQAKAGSA 469 FWPAFL VA+ + S RL P AGAE++G + A A Sbjct: 427 FWPAFLAVALVSGLSAFAFARLAPTAGAEVSGHRRVTARPA 467 >B8IF45.1 B8IF45_METNO Drug resistance transporter, EmrB/QacA subfamily Length = 471 Score = 538 bits (1385), Expect = e-151, Method: Compositional matrix adjust. Identities = 277/461 (60%), Positives = 339/461 (73%) Query: 9 IPLIVACALFMEQMDSTVISTSLPVLAIDMAVDPISLKLALTSYLVSLAVFIPISGWMAD 68 +PL+VA ALFME DSTVI+TSLP +A D+ DPI+LKLALT+YLVSLA+FIP+SGWMAD Sbjct: 7 VPLVVATALFMENTDSTVIATSLPAIAADLGEDPIALKLALTAYLVSLAIFIPVSGWMAD 66 Query: 69 RFGALTIFRSAICVFMLGSILCGVSQSLPEFVAARFFQGIGGAMMVPVGRLVILRSVDKA 128 RFGA T+FR A+ VFM GS+ C + SL FV ARF QG+GGAMMVPVGRLV+LRSV KA Sbjct: 67 RFGARTVFRWALAVFMAGSLACAAADSLGWFVGARFLQGMGGAMMVPVGRLVLLRSVPKA 126 Query: 129 NLVKALSYLTIPAMFGPVLGPPLGGFITTYFHWRWIFFINIPISILGLYLATRFIANAKS 188 LV+AL+ LTIPA+ GPV+GPPLGGFITT HWRWIFFIN+PI G+ LAT + A+ + Sbjct: 127 ELVQALATLTIPALVGPVIGPPLGGFITTALHWRWIFFINLPIGFAGILLATHYFADLRE 186 Query: 189 ESVAPLDWVGFVLSALGCSMVMMGLATTGRHLVSGDISLACVVLGSLSLAAYVWHARRTE 248 PLD VGFVLS G + +M+GLA+ GRHL+ ++S C G L LA Y HARR Sbjct: 187 AERPPLDAVGFVLSGAGLASLMLGLASGGRHLLPPELSWGCTGAGLLLLALYWRHARRIA 246 Query: 249 HPLIDLKLLRIETLQAGVGGGSLFRLGIGAIPFLLPLMLQLGFGFSAFHSGLLTCASAAG 308 HPLI L LLR T +A + GGSLFR+G GAIPFLLPLMLQ+GFG SGLLT +AAG Sbjct: 247 HPLIRLDLLRYPTFRAAITGGSLFRIGTGAIPFLLPLMLQIGFGLDPLQSGLLTFVAAAG 306 Query: 309 AMFMKTIAAKFLKRYGFRRVMIVNGACGVMSLAAIGFFTPATPYAVMLIVLLIGGCFRSL 368 A+FMKT+AA+ L+ GFR V+ VN + L A G FTPATP+AV++ VLL+GGCFRSL Sbjct: 307 ALFMKTLAARILRALGFRTVLTVNAVIAAILLGANGLFTPATPHAVIVAVLLVGGCFRSL 366 Query: 369 QFTSLNAISYADVDNNRLSQATSIASVAQQLSVGMGVVLGGFALQMSNHIQGHATLVSQD 428 QFT++NAI+YADVD +S ATS+ASVAQQLS+ +GV G FAL+ + G + + D Sbjct: 367 QFTAVNAIAYADVDPRDMSAATSLASVAQQLSLSIGVAFGAFALESAAQWHGRTAVQAGD 426 Query: 429 FWPAFLTVAVAASFSIPLLMRLPPDAGAELAGRNQAKAGSA 469 FWPAFL VA+ + S RL P AGAE++G + A A Sbjct: 427 FWPAFLAVALVSGLSTLAFGRLAPTAGAEVSGHRRIAARPA 467 >Q7NSA2.1 Q7NSA2_CHRVO Probable multidrug efflux protein Length = 457 Score = 534 bits (1376), Expect = e-149, Method: Compositional matrix adjust. Identities = 291/454 (64%), Positives = 350/454 (77%) Query: 10 PLIVACALFMEQMDSTVISTSLPVLAIDMAVDPISLKLALTSYLVSLAVFIPISGWMADR 69 PLIVA ALFME MD+TVISTSLPV+A D+ VDPISLKLALTSYLVSLAVFIPISGWMADR Sbjct: 4 PLIVATALFMENMDATVISTSLPVIAQDLGVDPISLKLALTSYLVSLAVFIPISGWMADR 63 Query: 70 FGALTIFRSAICVFMLGSILCGVSQSLPEFVAARFFQGIGGAMMVPVGRLVILRSVDKAN 129 FGA IFRSAI VFMLGS+LC + SL FV ARF QGIGGAMMVPVGRLVILR++DKA+ Sbjct: 64 FGARRIFRSAILVFMLGSLLCAATGSLHGFVLARFLQGIGGAMMVPVGRLVILRTIDKAD 123 Query: 130 LVKALSYLTIPAMFGPVLGPPLGGFITTYFHWRWIFFINIPISILGLYLATRFIANAKSE 189 LV+ALSYLT+PA+ GPV+GPPLGGFI+TYFHWRWIF INIPI +LGL LA RFIAN K + Sbjct: 124 LVRALSYLTVPALLGPVIGPPLGGFISTYFHWRWIFLINIPIGLLGLALAGRFIANLKED 183 Query: 190 SVAPLDWVGFVLSALGCSMVMMGLATTGRHLVSGDISLACVVLGSLSLAAYVWHARRTEH 249 V LDW GF+L+ G SM+M+GLAT G+H++S S+ LG+ L AY+ H R+ H Sbjct: 184 EVPRLDWWGFLLTGTGLSMLMLGLATEGKHMLSATASIWLSALGAALLLAYLRHYRKQTH 243 Query: 250 PLIDLKLLRIETLQAGVGGGSLFRLGIGAIPFLLPLMLQLGFGFSAFHSGLLTCASAAGA 309 PL+DL LLR+ T AGV GG +FR+GIG IPFLLPLMLQLGFGFS F SGLLTC++A GA Sbjct: 244 PLLDLSLLRLPTFNAGVVGGFMFRIGIGTIPFLLPLMLQLGFGFSPFESGLLTCSTAMGA 303 Query: 310 MFMKTIAAKFLKRYGFRRVMIVNGACGVMSLAAIGFFTPATPYAVMLIVLLIGGCFRSLQ 369 M MKTI AK L+RYGFRRV++VN S+A F TP+ ++L+V ++GGC RSLQ Sbjct: 304 MGMKTIVAKVLQRYGFRRVLVVNSILAGCSVAVYSLFQADTPHWLLLLVFVLGGCMRSLQ 363 Query: 370 FTSLNAISYADVDNNRLSQATSIASVAQQLSVGMGVVLGGFALQMSNHIQGHATLVSQDF 429 FTSLNAI++ADVD +RLS ATS++SVAQQL+ G GV +G FALQ +QGH L + DF Sbjct: 364 FTSLNAITFADVDKDRLSHATSLSSVAQQLAAGFGVTVGAFALQSVAWLQGHQQLTAVDF 423 Query: 430 WPAFLTVAVAASFSIPLLMRLPPDAGAELAGRNQ 463 AFL + S ++L DAG +++ ++ Sbjct: 424 GHAFLIMGGLTMLSSLQFLKLERDAGRQVSAGHE 457 >A8II75.1 A8II75_AZOC5 Putative multidrug efflux protein Length = 483 Score = 530 bits (1366), Expect = e-148, Method: Compositional matrix adjust. Identities = 276/465 (59%), Positives = 341/465 (73%) Query: 2 ALQRTFTIPLIVACALFMEQMDSTVISTSLPVLAIDMAVDPISLKLALTSYLVSLAVFIP 61 AL R +PLIVACALFMEQ+DSTVISTSLP +A + DP++LKLALTSYL+SLAVFIP Sbjct: 5 ALPRHILVPLIVACALFMEQVDSTVISTSLPAIAASLHDDPVALKLALTSYLLSLAVFIP 64 Query: 62 ISGWMADRFGALTIFRSAICVFMLGSILCGVSQSLPEFVAARFFQGIGGAMMVPVGRLVI 121 SGW ADRFGA T+FRSAI +F LGSILCG+S SL +FV R QG+GGAMMVPVGRLVI Sbjct: 65 ASGWCADRFGARTVFRSAIVIFTLGSILCGLSTSLLDFVIYRIIQGMGGAMMVPVGRLVI 124 Query: 122 LRSVDKANLVKALSYLTIPAMFGPVLGPPLGGFITTYFHWRWIFFINIPISILGLYLATR 181 LRSV K+ +V AL++LTIPA+ GPV+GPPLGGFITTYF WR IFFIN+PI ILG+ LATR Sbjct: 125 LRSVPKSEIVSALAWLTIPALLGPVMGPPLGGFITTYFDWRLIFFINVPIGILGIILATR 184 Query: 182 FIANAKSESVAPLDWVGFVLSALGCSMVMMGLATTGRHLVSGDISLACVVLGSLSLAAYV 241 FI N + E V PLD G VLS +G S ++ GLA G+HLV + +G ++L YV Sbjct: 185 FIENVREEDVPPLDLHGLVLSGIGLSGLVFGLAVLGQHLVPYWAAAGVTAIGIVALGFYV 244 Query: 242 WHARRTEHPLIDLKLLRIETLQAGVGGGSLFRLGIGAIPFLLPLMLQLGFGFSAFHSGLL 301 HARRT H ++DL LLRI T +AGV GGSLFR+G+GA+PF LPLMLQL FG S F SG+L Sbjct: 245 RHARRTPHAVLDLSLLRIPTFRAGVVGGSLFRIGVGALPFALPLMLQLTFGLSPFASGML 304 Query: 302 TCASAAGAMFMKTIAAKFLKRYGFRRVMIVNGACGVMSLAAIGFFTPATPYAVMLIVLLI 361 T AS+AGA+ MKT A L+R+GF RV++VN + A FTP TP+A ++ VLL+ Sbjct: 305 TFASSAGALVMKTTARPILRRFGFWRVLVVNALISSAFIGANALFTPETPHAAIVAVLLM 364 Query: 362 GGCFRSLQFTSLNAISYADVDNNRLSQATSIASVAQQLSVGMGVVLGGFALQMSNHIQGH 421 GG FRSL+FT++NA+SYADV +S+ATS SVAQQ+S+ +GV L G L+ +G Sbjct: 365 GGFFRSLEFTAINALSYADVSQPEMSRATSFVSVAQQVSLSLGVALVGMVLEAMRSARGE 424 Query: 422 ATLVSQDFWPAFLTVAVAASFSIPLLMRLPPDAGAELAGRNQAKA 466 L DF PAFL VA ++ ++ M LP DAGAEL+G + + Sbjct: 425 TALQLADFTPAFLIVAGVSALAVFSFMNLPKDAGAELSGHKEKPS 469